KEGG   ENZYME: 3.5.1.99
Entry
EC 3.5.1.99                 Enzyme                                 

Name
fatty acid amide hydrolase;
FAAH;
oleamide hydrolase;
anandamide amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
fatty acylamide amidohydrolase
Reaction(IUBMB)
(1) anandamide + H2O = arachidonic acid + ethanolamine [RN:R09536];
(2) oleamide + H2O = oleic acid + NH3 [RN:R09537]
Reaction(KEGG)
R09536 R09537
Substrate
anandamide [CPD:C11695];
H2O [CPD:C00001];
oleamide [CPD:C19670]
Product
arachidonic acid [CPD:C00219];
ethanolamine [CPD:C00189];
oleic acid [CPD:C00712];
NH3 [CPD:C00014]
Comment
Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia.
History
EC 3.5.1.99 created 2009
Orthology
K15528  fatty acid amide hydrolase
K19176  fatty acid amide hydrolase 2
Genes
HSA: 158584(FAAH2) 2166(FAAH)
PTR: 456559(FAAH) 465664(FAAH2)
PPS: 100983853(FAAH) 100992327(FAAH2)
GGO: 101139612 101154610(FAAH2)
PON: 100447062(FAAH2) 100453623(FAAH)
NLE: 100588233(FAAH) 100599307(FAAH2)
MCC: 705856(FAAH2) 708660
MCF: 102123918(FAAH2) 102134628(FAAH)
CSAB: 103224888 103232067(FAAH2)
CATY: 105571598 105573484 105594568
PANU: 101007015(FAAH) 108580392
RRO: 104662115(FAAH) 104664335(FAAH2)
RBB: 108535628
TFN: 117077354(FAAH2) 117092652(FAAH)
PTEH: 111535181(FAAH2) 111548786(FAAH)
CJC: 100410110(FAAH)
MMU: 14073(Faah)
MCAL: 110292620(Faah)
MPAH: 110323348(Faah)
RNO: 100911581(Faah)
MCOC: 116096447(Faah)
MUN: 110562618(Faah)
CGE: 100771171(Faah)
PLEU: 114706846(Faah)
NGI: 103730314(Faah)
HGL: 101713363(Faah2) 101722224(Faah)
CCAN: 109695802
OCU: 100343219(FAAH) 100353626(FAAH2)
TUP: 102489877(FAAH) 102498736
CFA: 475367 482510(FAAH)
AML: 100472602(FAAH) 105237751
ORO: 101371386
MLX: 118019458
FCA: 101081996 101095511(FAAH)
PYU: 121017615 121027061(FAAH)
PTG: 102951924 102971848(FAAH)
AJU: 106973395(FAAH) 106974116
BTA: 513210 540007(FAAH)
BOM: 102283473(FAAH) 102288085
CHX: 102174994(FAAH) 102175263
OAS: 101103356(FAAH) 101103602
SSC: 102164418 396949(FAAH)
CFR: 102503723 102503970(FAAH)
CBAI: 105064941(FAAH2) 105065741(FAAH) 105065993
CDK: 105090379(FAAH2) 105092923(FAAH) 105092977
BACU: 103004815(FAAH)
LVE: 103089901(FAAH)
OOR: 101280037(FAAH)
DLE: 111175768(FAAH)
PCAD: 102979321(FAAH)
ECB: 100051756(FAAH) 100070179
EPZ: 103560358(FAAH) 103561029
EAI: 106822606(FAAH) 106833445
MYB: 102261172(FAAH2)
MYD: 102752556(FAAH) 102752841 102769353(FAAH2)
MMYO: 118653949(FAAH2) 118675991(FAAH) 118676295
MNA: 107526752(FAAH) 107526753 107537281(FAAH2)
HAI: 109373802(FAAH) 109377891(FAAH2)
DRO: 112308190(FAAH2) 112314612(FAAH)
SHON: 118974533(FAAH2) 118982433(FAAH) 118996331
MMF: 118626420(FAAH) 118635787(FAAH2)
PALE: 102882624(FAAH2) 102893273(FAAH)
PGIG: 120599632(FAAH2) 120620255
RAY: 107517905(FAAH) 107521511(FAAH2)
MJV: 108404951(FAAH)
TOD: 119236276(FAAH)
LAV: 100662219(FAAH)
TMU: 101348749
PCW: 110200376(FAAH2) 110209302(FAAH)
OAA: 100084029(FAAH2) 103168217(FAAH)
GGA: 100859568(FAAH2) 395824(VDHAP) 424614(FAAH) 429098
PMOA: 120503145 120503313(FAAH) 120512692(FAAH2)
CLV: 102088919(FAAH2) 102098698(FAAH) 102098879
PSS: 102452773(FAAH2) 102455592(FAAH)
XLA: 100036968(faah.1.S) 108698280 108714290(faah.3.L) 108714987(faah.3.S) 108715582(faah.2.S)
XTR: 100145539(faah.3) 100487591(faah.1) 100488850(faah2) 496823(faah.2)
DRE: 436973(faah2a) 569067(faah) 768298(faah2b)
EEE: 113570363(faah) 113578287 113588330(faah2)
TRU: 101076695(faah2) 101078866(faah)
LCO: 104918497(faah) 104932919(faah2)
NCC: 104958183(faah2) 104966252(faah)
CGOB: 115007202
ELY: 117246475(faah2b) 117253881
PLEP: 121941427 121961965(faah2b)
SLUC: 116043269(faah2b) 116063409
ECRA: 117934692(faah2b) 117950614
PFLV: 114545670(faah2) 114561928(faah)
CUD: 121504781(faah2b) 121511815
OLA: 101174015(faah) 101174537(faah2)
OML: 112150630 112155777(faah2b)
XMA: 102218255(faah) 102231440(faah2)
XCO: 114151407(faah) 114157703(faah2)
XHE: 116725544(faah) 116733262(faah2)
PRET: 103463588(faah) 103475965(faah2)
CVG: 107081965(faah) 107085234(faah2)
CTUL: 119773371(faah2b) 119773701
NFU: 107377256(faah2) 107393233(faah)
KMR: 108230777 108245930(faah2b)
ALIM: 106513893(faah) 106526421(faah2)
CSEM: 103388435(faah2) 103397391(faah)
POV: 109625288(faah) 109642469(faah2)
LCF: 108877404(faah) 108903078(faah2)
SDU: 111232168(faah) 111235627(faah2)
SLAL: 111647188(faah2) 111656310(faah)
XGL: 120790331 120797403(faah2b)
HCQ: 109508392(faah2) 109532416(faah)
BPEC: 110167803(faah) 110171974(faah2)
MALB: 109964053(faah) 109971428(faah2)
SFM: 108925886(faah2)
PKI: 111836787(faah2) 111841569(faah)
AANG: 118225632 118228225(faah2a) 118232341(faah2b)
LOC: 102682920(faah) 102690325(faah2)
PSPA: 121294639(faah2b) 121326543
ARUT: 117409628(faah2b) 117416883
CMK: 103177607(faah2) 103182725(faah)
APLC: 110981466
DME: Dmel_CG5112(CG5112) Dmel_CG7900(CG7900) Dmel_CG7910(CG7910) Dmel_CG8839(CG8839)
DSI: Dsimw501_GD18511(Dsim_GD18511) Dsimw501_GD18512(Dsim_GD18512) Dsimw501_GD19357(Dsim_GD19357) Dsimw501_GD21221(Dsim_GD21221) Dsimw501_GD25848(Dsim_GD25848)
CSOL: 105362956
API: 100159751
DNX: 107167432
AGS: 114128414
RMD: 113553832
CEL: CELE_B0218.1(faah-1) CELE_B0218.2(faah-2) CELE_Y41C4A.2(faah-6) CELE_Y53F4B.18(Y53F4B.18) CELE_Y56A3A.12(faah-4)
BMY: BM_BM6759(Bm6759) BM_BM6873(Bm6873)
ATEN: 116300803
ADF: 107334260
DGT: 114519087
ANG: ANI_1_154104(An12g01020)
ABE: ARB_00251
TVE: TRV_07872
SMIN: v1.2.003599.t1(symbB.v1.2.003599.t1) v1.2.008889.t1(symbB.v1.2.008889.t1)
PSOS: POS17_3792
DAL: Dalk_2766
SCL: sce1749(gatA2) sce3727
BBA: Bd2708
BBAT: Bdt_2627
BBAC: EP01_09700
BEX: A11Q_2195
BFD: NCTC4823_02293(gatA_5)
OIH: OB2363
PSL: Psta_2396
LCRE: Pla8534_66100(gatA_4)
AAGG: ETAA8_38510(gatA_2)
BVO: Pan97_42140(gatA_2)
PND: Pla175_45940(aam)
 » show all
Reference
1  [PMID:11128635]
  Authors
Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF
  Title
Fatty acid amide hydrolase substrate specificity.
  Journal
Bioorg Med Chem Lett 10:2613-6 (2000)
DOI:10.1016/S0960-894X(00)00528-X
Reference
2  [PMID:9790682]
  Authors
Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF
  Title
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site  for oligomerization.
  Journal
Biochemistry 37:15177-87 (1998)
DOI:10.1021/bi981733n
Reference
3  [PMID:11352748]
  Authors
Patricelli MP, Cravatt BF
  Title
Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase.
  Journal
Biochemistry 40:6107-15 (2001)
DOI:10.1021/bi002578r
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.99
IUBMB Enzyme Nomenclature: 3.5.1.99
ExPASy - ENZYME nomenclature database: 3.5.1.99
BRENDA, the Enzyme Database: 3.5.1.99

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