KEGG   ENZYME: 3.5.2.19
Entry
EC 3.5.2.19                 Enzyme                                 
Name
streptothricin hydrolase;
sttH (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
Sysname
streptothricin-F hydrolase
Reaction(IUBMB)
streptothricin-F + H2O = streptothricin-F acid [RN:R09657]
Reaction(KEGG)
R09657
Substrate
streptothricin F [CPD:C19785];
H2O [CPD:C00001]
Product
streptothricin F acid [CPD:C19786]
Comment
The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid [1]. The enzyme is responsible for streptothricin resistance in Streptomyces albulus and Streptomyces noursei [1,2].
History
EC 3.5.2.19 created 2011
Orthology
K20816  streptothricin hydrolase
Genes
PMOSO165_014065
PMOLCLJ08_22265
PENPSEEN1846
PSECCCOS191_1744
PXNHU772_008675
PMUYKSS95_18535
PMAMKSS90_09080
ADSFPL17_05630
AGYLFPL18_16095
PPULRO07_18935
AAKAA2016_0202
EADOV14_3469
EAHFA04_10315
RTRRTCIAT899_CH01190
RHRCKA34_04185
SGRSGR_517
SFASfla_4024
SBHSBI_05248
SVESVEN_0767
STRPF750_2699
SFISFUL_6857
SALLSAZ_31715
SVTSVTN_05300
SLCSL103_25620
SPRISPRI_1189
SCZABE83_01585
SCLFBB341_03190
SALWCP975_32885
SNRSNOUR_11545(sttH)
SNWBBN63_17435
SALFSMD44_00626
STROSTRMOE7_29990
SQZFQU76_29045
SCAVCVT27_31720
SRIMCP984_20310
SCINCP977_04795
STSUB7R87_29155
SGXH4W23_05770
SSPBCP982_39700
SATAC5746_23425
SLIAHA039_30130
SPEUCGZ69_31135
SGJIAG43_27755
SHKJ2N69_34975
STRYEQG64_32990
SINEKI385_34690
SAOVG3H79_35660
SDURM4V62_38470
LMOIVV02_21860
NAQUENKNEFLB_02319(sttH)
KFLKfla_2808
KQIF1D05_09075
PSEEFRP1_29220
PHHAFB00_10145
 » show all
Reference
1  [PMID:19897889]
  Authors
Maruyama C, Hamano Y
  Title
The biological function of the bacterial isochorismatase-like hydrolase SttH.
  Journal
Biosci Biotechnol Biochem 73:2494-500 (2009)
DOI:10.1271/bbb.90499
  Sequence
Reference
2  [PMID:16641084]
  Authors
Hamano Y, Matsuura N, Kitamura M, Takagi H
  Title
A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific.
  Journal
J Biol Chem 281:16842-8 (2006)
DOI:10.1074/jbc.M602294200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.2.19
IUBMB Enzyme Nomenclature: 3.5.2.19
ExPASy - ENZYME nomenclature database: 3.5.2.19
BRENDA, the Enzyme Database: 3.5.2.19

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