KEGG   ENZYME: 3.5.2.20
Entry
EC 3.5.2.20                 Enzyme                                 

Name
isatin hydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
Sysname
isatin amidohydrolase
Reaction(IUBMB)
isatin + H2O = isatinate [RN:R11181]
Reaction(KEGG)
R11181
Substrate
isatin [CPD:C11129];
H2O [CPD:C00001]
Product
isatinate [CPD:C21155]
Comment
Requires Mn2+. This enzyme, found in several bacterial species, is involved in the degradation of indole-3-acetic acid.
History
EC 3.5.2.20 created 2014
Orthology
K01475  isatin hydrolase
Genes
MLO: mlr5444
MLN: A9174_00460
MCI: Mesci_0097
MOP: Mesop_0095
MAM: Mesau_00095
MAMO: A6B35_07205
MESW: A9K65_000460
MESM: EJ066_10680
MHUA: MCHK_6468
MJR: EB229_00465
OAN: Oant_4027
OAH: DR92_4228
PLEO: OHA_1_04291(kynB)
MMED: Mame_00264
PSF: PSE_p0022
 » show all
Reference
1
  Authors
Sommer, M.R. and Jochimsen, B.
  Title
Identification of enzymes involved in indole-3-acetic acid degradation.
  Journal
Plant Soil 186:143-149 (1996)
Reference
2  [PMID:24917679]
  Authors
Bjerregaard-Andersen K, Sommer T, Jensen JK, Jochimsen B, Etzerodt M, Morth JP
  Title
A proton wire and water channel revealed in the crystal structure of isatin hydrolase.
  Journal
J Biol Chem 289:21351-9 (2014)
DOI:10.1074/jbc.M114.568824
Other DBs
ExplorEnz - The Enzyme Database: 3.5.2.20
IUBMB Enzyme Nomenclature: 3.5.2.20
ExPASy - ENZYME nomenclature database: 3.5.2.20
BRENDA, the Enzyme Database: 3.5.2.20

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