KEGG ENZYME: 3.5.3.17

ENZYME: 3.5.3.17

Entry

EC 3.5.3.17                 Enzyme

Name

guanidinopropionase;
GPase;
GPH

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines

Sysname

3-guanidinopropanoate amidinopropionase

Reaction(IUBMB)

3-guanidinopropanoate + H2O = beta-alanine + urea [RN:R00913]

Reaction(KEGG)

R00913

Substrate

3-guanidinopropanoate [CPD:C03065];
H2O [CPD:C00001]

Product

beta-alanine [CPD:C00099];
urea [CPD:C00086]

Comment

Requires Mn2+. Also acts, more slowly, on taurocyamine and 4-guanidinobutanoate.

History

EC 3.5.3.17 created 1989

Orthology

K18459

guanidinopropionase

Genes

KLW:	DA718_06715(speB)

KGR:	JJJ10_06645(speB)

ROR:	RORB6_24330

RAO:	DSD31_05870(speB)

REE:	electrica_01072(gbh_1)

KOR:	AWR26_06155(speB)

KRD:	A3780_17860

GQU:	AWC35_06925 AWC35_09795

RBAD:

H2866_00730(speB)

PAE:	PA0288(gpuA)

PAEV:

N297_294(speB)

PAEI:

N296_294(speB)

PAU:	PA14_03770(speB1)

PAP:	PSPA7_0379(speB2)

PAG:	PLES_02841(gpuA)

PAF:	PAM18_0283(gpuA)

PNC:	NCGM2_0323(speB1)

PAEB:

NCGM1900_0284(speB1)

PDK:	PADK2_01430

PSG:	G655_01450

PRP:	M062_01420

PAEP:

PA1S_01445

PAER:

PA1R_gp3796

PAEM:

U769_01475

PAEL:

T223_01435

PAES:

SCV20265_0298

PAEU:

BN889_00343(gpuA)

PAEG:

AI22_02460

PAEC:

M802_293(speB)

PAEO:

M801_294(speB)

PRE:	PCA10_22720(gbuA)

PFUW:

KF707C_50130

PCQ:	PcP3B5_01170(gbh_1)

PMUI:

G4G71_02375(speB)

PNT:	G5B91_00440(speB)

PPAA:

B7D75_01410(speB)

PFL:	PFL_0325(gpuA)

PPRC:

PFLCHA0_c03300(gbh1)

PPRO:

PPC_0336(gpuA)

PDR:	H681_00510

PCZ:	PCL1606_16930

PSEM:

TO66_23435

PSET:

THL1_2244

PSEP:

C4K39_0337

PTW:	TUM18999_53280(gpuA)

NAX:	HC341_06330 HC341_06340(speB)

WOC:	BA177_04585

GAI:	IMCC3135_16295(gpuA_1) IMCC3135_23280(gpuA_2)

HAK:	KO116_00693

HAM:

HALO0709

HSI:	BOX17_06910

HALO:

BWR19_05055

HHH:	CLM76_07845(speB)

HSR:	HSBAA_59410

HAXI:

HAALTHF_15760n(gpuA)

HTT:	HZS52_08325(speB)

HQD:	K1Y77_14745(speB)

TSN:	W908_00925

THIN:

CRN91_01925

CRZ:	D1345_17160(speB)

CHAE:

CH06BL_34730(gpuA)

REU:	Reut_B5705

CUU:	BKK79_27425

BHG:	I6G56_28005(speB)

BCEN:

DM39_1662(speB)

BYI:	BYI23_C004650

BUL:	BW21_4532(speB)

BUD:	AQ610_30440

BUM:	AXG89_35490

BUI:	AX768_17000

BPH:

Bphy_6083

BPY:	Bphyt_6362

BCAI:

K788_0001273

PHS:	C2L64_39545(speB)

PTER:

C2L65_36830(speB)

PTRO:

G5S35_24635(speB) G5S35_28445(speB)

PPNO:

DA70_00350

PVE:	UC34_05085

PTX:	ABW99_15470

PAND:

DRB87_04530(speB)

BHZ:	ACR54_02441(gbh)

BBRO:

BAU06_23375

BFZ:	BAU07_19415

BPDZ:

BBN53_09980

AXO:	NH44784_019201

AXN:	AX27061_0275

AXX:	ERS451415_00275(gbh)

ADT:	APT56_01590

ASW:	CVS48_04510(speB)

ACHR:

C2U31_06350(speB)

ACHB:

DVB37_01320(speB)

DAC:

Daci_5122

DEL:	DelCs14_1490

DTS:	BI380_29660

DHK:	BO996_23620

DLA:	I6G47_30415(speB)

CSER:

CCO03_06560

HYC:	E5678_02105(speB)

HPSE:

HPF_16675(gbh3)

ACOM:

CEW83_15355(speB)

MLN:	A9174_02870

MCI:	Mesci_0570

MCIC:

A4R28_14885 A4R28_25530 A4R28_30595

MOP:	Mesop_0580

MAM:	Mesau_00508

MAMO:

A6B35_05545

MESW:

A9K65_002865

MESM:

EJ066_08350(speB) EJ066_29585(speB)

MESP:

C1M53_09680(speB)

MHUA:

MCHK_5963(speB)

MJR:	EB229_02915(speB)

MERD:

EB233_03015(speB) EB233_20970(speB)

MESR:

FGU64_08205(speB)

MOH:	IHQ72_02570(speB)

MESO:

BSQ44_18055

HOE:	IMCC20628_01133

AAK:	AA2016_0453 AA2016_5072

AMIH:

CO731_00441(gbh_1)

PHT:	BLM14_27725 BLM14_28325

PHYL:

HB779_24145(speB)

NIY:	FQ775_08365(speB)

KMN:	HW532_11760(speB) HW532_16230

SMK:	Sinme_2549

SMQ:	SinmeB_2329

SMX:	SM11_chr2655(speB2)

SMI:	BN406_02348(speB2)

SMEG:

C770_GR4Chr2601

SMEL:

SM2011_c01967(speB2)

SMER:

DU99_13905

SMD:

Smed_2410

RHI:	NGR_c25370(speB)

SFH:	SFHH103_02398(speb3)

SFD:	USDA257_c49630(gbh)

SAME:

SAMCFNEI73_Ch2870(speB)

SINO:

SS05631_c26460

ESJ:	SJ05684_b52370 SJ05684_c25960

EAK:	EKH55_2550 EKH55_3458

EMX:	FKV68_16290(speB)

EAD:	OV14_4065(speB)

EAH:	FA04_13310

ARA:	Arad_9121(speB)

AGC:	BSY240_3777(speB)

ALF:	CFBP5473_18815(speB)

AVV:	RvVAT039_23670(gpuA) RvVAT039_34190

AVF:	RvVAR031_10940(gpuA) RvVAR031_21060

AVI:	Avi_1009(speB) Avi_2473(speB)

REC:	RHECIAT_CH0002201(speBch2) RHECIAT_PC0000732(speBc)

REL:	REMIM1_CH02153(speB-2) REMIM1_PF00378

REP:	IE4803_CH02155(speB-2)

REI:	IE4771_CH02242(speB-2)

RLT:	Rleg2_4643 Rleg2_4872

RLG:	Rleg_3988 Rleg_6439

RLB:	RLEG3_02260 RLEG3_30990

RLU:	RLEG12_20780 RLEG12_29935

RTR:	RTCIAT899_PC06540 RTCIAT899_PC07825

RHL:	LPU83_pLPU83c0187(speB) LPU83_pLPU83c0428(gpuA) LPU83_pLPU83d1764

RGA:	RGR602_PC00744(speB-2)

RHN:	AMJ98_CH02194(speB-2)

RPHA:

AMC79_CH02274(speB-2)

RHX:	AMK02_CH02205(speB-2)

RHK:	Kim5_CH01327 Kim5_CH02252(speB-2)

REZ:	AMJ99_CH02272(speB-2)

RHR:	CKA34_33270(speB)

RGR:	FZ934_21210(speB)

RII:	FFM53_014750(speB) FFM53_035725(speB)

RHID:

FFM81_001215(speB) FFM81_010125(speB) FFM81_025920(speB)

RBQ:	J2J99_11730(speB) J2J99_20725(speB)

RLN:	J0663_14680(speB)

RBAN:

J2J98_05870(speB)

RRG:	J3P73_07530(speB) J3P73_23045(speB)

RLS:	HB780_07195(speB)

RROS:

D4A92_02005(speB)

RAW:	NE851_06150(speB) NE851_31565(speB)

RSUL:

N2599_22855(speB)

RLW:	RlegWSM1455_20105(speB) RlegWSM1455_33750(speB)

NGL:	RG1141_PA02050

NGG:	RG540_PA02150

NEO:	CYG48_20435(speB)

NEN:	NCHU2750_31210(gpuA) NCHU2750_45330(speB)

RHT:	NT26_3023(AGMAT)

RFV:	RFYW14_03104

SHZ:	shn_25160 shn_29260

SOJ:	K6301_21095(speB)

KAI:	K32_27750(gpuA)

OCR:	HGK82_16195(speB)

VGO:	GJW-30_1_00690(gbh)

BOP:	AXW83_02340

BOS:	BSY19_1908(speB)

BVV:	BHK69_13860

BOI:	BLM15_11530

BOF:	FQV39_09735(speB)

SNO:	Snov_1551 Snov_2246

STAR:

G3545_02460(speB) G3545_28420(speB)

LNE:	FZC33_26010(speB)

ANC:	GBB76_03375(speB) GBB76_06115(speB)

APRA:

G3A50_18220(speB) G3A50_21340(speB)

APOL:

K9D25_13625(speB) K9D25_16905(speB) K9D25_18415(speB)

MEA:	Mex_1p4303

MDI:

METDI4914

MEX:

Mext_3924

MCH:

Mchl_4292

MPO:

Mpop_4397

MZA:	B2G69_01515

MET:

M446_6964

MNO:

Mnod_7678

META:

Y590_19515

MAQU:

Maq22A_c26500(speB)

MEE:	DA075_02765(speB)

METD:

C0214_21630(speB)

METS:

DK389_01195(speB)

METI:

DK427_25925(speB)

MTEA:

DK419_07575(speB)

MIND:

mvi_07240

MOG:	MMB17_01295(speB)

MOC:	BB934_01150 BB934_35805

MIV:	C4E04_10215(speB)

CHEL:

AL346_21375

CDQ:	BOQ54_17845

MSC:

BN69_1128

PLEO:

OHA_1_00424(gbh_1)

HDI:	HDIA_3294(gbh)

AUA:	M673_18795

AALA:

IGS74_01650(speB)

AALM:

LUX29_03095(speB)

AUZ:	Sa4125_24250(gpuA)

BRN:	D1F64_18045

THD:	BHV28_10990

NOH:	G5V57_06235(speB) G5V57_06930(speB) G5V57_10045 G5V57_15845 G5V57_15900(speB) G5V57_17415

TSO:	IZ6_12680(gpuA)

RBM:

TEF_01635

PPHR:

APZ00_15400 APZ00_25340

LABR:

CHH27_07480

LABP:

FJ695_05445(speB) FJ695_15460(speB)

SIL:	SPOA0234 SPOA0235(speB-4)

RUA:	D1823_02730 D1823_02735

RUT:	FIU92_10505(gbh2) FIU92_10510(gbh3)

JAN:

Jann_1967

RLI:	RLO149_c017320

RPON:

G3256_11905(speB)

PGA:	PGA1_c00300 PGA1_c00310

PGL:	PGA2_c30540 PGA2_c30550

PGD:	Gal_00164 Gal_00165

PPIC:

PhaeoP14_03021 PhaeoP14_03022

PHQ:	D1820_10930(speB) D1820_10935

OAT:	OAN307_c18240

OAR:	OA238_c21110

LEJ:	ETW24_17085 ETW24_17090

LEV:	ETW23_00875 ETW23_00880

RED:	roselon_03059

MALG:

MALG_03124

CON:	TQ29_15845

YPAC:

CEW88_01780(speB)

YAN:	AYJ57_08800

TPRO:

Ga0080559_TMP2029

PABY:

Ga0080574_TMP2134

SULI:

C1J05_11285

RMM:	ROSMUCSMR3_02397(gpuA)

ROK:	RAK1035_0786

RID:	RIdsm_03121(gbh_2) RIdsm_04641(gbh_3)

ROM:	EI983_02250(speB) EI983_08170

ROH:	FIU89_01805(gbh)

AHT:	ANTHELSMS3_01436 ANTHELSMS3_01720

SAGU:

CDO87_08930(speB)

OCD:	FHY55_16995(speB)

ROT:	FIV09_00725(gbh)

MALU:

KU6B_51400(gpuA)

TGL:	HFZ77_06095

PALX:

GQA70_01685(speB)

LSAL:

KBK07_04260(speB)

RSH:	Rsph17029_3474

RSK:	RSKD131_3977

RCP:	RCAP_rcc02271(speB2)

RBL:	B6K69_15690

PDE:

Pden_5116

PZH:	CX676_15095(speB)

PARO:

CUV01_04210(speB)

PARS:

DRW48_15500(speB)

PKD:	F8A10_18655(speB)

PMEH:

JWJ88_18545(speB)

DAA:	AKL17_1883

THW:	BMG03_09900

TEC:	AKL02_009455(speB)

LVS:	LOKVESSMR4R_03207(gpuA)

GEH:	HYN69_06240 HYN69_19165(speB)

GFU:	KM031_07840 KM031_17550(speB)

TAW:	EI545_05515

SALO:

EF888_11930(speB)

HML:	HmaOT1_10155(speB)

BOO:	E2K80_07630

PPRU:

FDP22_03060(speB) FDP22_13070 FDP22_19665(speB)

PAED:

G5B38_07080(speB) G5B38_09130(speB) G5B38_10895(speB) G5B38_12485(speB)

MON:	G8E03_00380

POZ:	I0K15_06555(speB)

PGV:	SL003B_1579(speB-4)

CACT:

HZ995_08440(speB)

GCE:	KYE46_11835(speB)

NSM:	JO391_14240

ACRO:

K3J57_07400

AMYL:

QBD29_12690(speB)

AMAQ:

GO499_14245(speB)

SSAN:

NX02_14850

SECH:

B18_06455

SBIN:

SBA_ch1_16530(speB)

ACR:

Acry_2769

AMV:	ACMV_31000(speB)

AACE:

A0U92_10080 A0U92_10100

SRF:	LHU95_17105(speB)

SHUM:

STHU_04370(gpuA) STHU_29050(speB)

SVC:	STVA_05920(gpuA) STVA_21800(gbuA)

STEL:

STAQ_39790(gpuA)

AZL:	AZL_b03550(speB) AZL_b03770(speB) AZL_b03840(speB)

ABS:	AZOBR_p440056(AGMAT)

ABQ:	ABAZ39_31345

ABF:	AMK58_26940

ATI:	AL072_29130

AZT:	TSH58p_21110(speB)

AOZ:	HUE56_07520(speB)

AARE:

D3093_27510(speB)

NAO:	Y958_14995

SKT:	IGS68_13105(speB) IGS68_28405(speB)

SMUC:

JL100_022555(speB)

SROE:

JL101_001015(speB)

FER:	FNB15_13680(speB)

HTQ:	FRZ44_12440(gpuA) FRZ44_27900(gpuA) FRZ44_36600(gpuA)

HADH:

FRZ61_12500(gpuA) FRZ61_19620(gpuA) FRZ61_35670(gpuA)

TMO:

TMO_c0500

TXI:

TH3_07450

TII:	DY252_10375(speB) DY252_20120(speB)

THAI:

IT893_01410(speB) IT893_10885(speB)

NACI:

NUH88_06000(speB)

ANT:	Arnit_0325

GEM:

GM21_0557

GEB:

GM18_3812

GUR:

Gura_2353

GBM:

Gbem_0545

GBN:	GEOBRER4_05500

GER:	KP004_01965

GSUB:

KP001_13525

GNT:	KP003_01600

GPL:	M1B72_19005

SAT:

SYN_01147

AGE:	AA314_09904

SCU:	SCE1572_36630

BBA:	Bd3436(speB)

BBAT:

Bdt_3350(speB)

BBW:

BDW_12730

BBAC:

EP01_02370

BDQ:	CIK05_02330(speB)

BDC:	DOE51_16885(speB)

BDZ:	DOM22_17790(speB)

BDK:	HW988_16900(speB)

BREY:

MNR06_14080(speB)

BEX:

A11Q_500

OIH:

OB2551

VIR:	X953_14385

VHL:	BME96_13745

VIL:	CFK37_11220

VNE:	CFK40_06545

VIM:	GWK91_15495

BBEV:

BBEV_1101(speB-2)

BSE:

Bsel_2476

QDO:	H9Q78_09830

SAY:	TPY_2990(speB)

SAP:	Sulac_0901

BPRS:

CK3_19250

MRH:	MycrhN_5773

MMOR:

MMOR_42350(speB_2)

NAH:	F5544_13520

RKO:	JWS14_42805

SXI:	SXIM_30480

SAQU:

EJC51_45520

CWO:

Cwoe_4275

SACI:

Sinac_4136

SBR:

SY1_11040

MBN:

Mboo_2035

HARA:

AArcS_0561(speB)

POG:

Pogu_0725

» show all

Reference

Authors

Yorifuji, T., Sugai, I., Matsumoto, H. and Tabuchi, A.

Title

Characterization of 3-guanidinopropionate amidinohydrolase from Pseudomonas aeruginosa and a comparative study with 4-guanidinobutyrate amidinohydrolase from another Pseudomonas.

Journal

Agric Biol Chem 46:1361-1363 (1982)

Other DBs

ExplorEnz - The Enzyme Database:

3.5.3.17

IUBMB Enzyme Nomenclature:

3.5.3.17

ExPASy - ENZYME nomenclature database:

3.5.3.17

BRENDA, the Enzyme Database:

3.5.3.17

CAS:	68821-77-2

DBGET integrated database retrieval system