KEGG ENZYME: 3.5.3.24

ENZYME: 3.5.3.24

Entry

EC 3.5.3.24                 Enzyme

Name

N1-aminopropylagmatine ureohydrolase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines

Sysname

N1-(aminopropyl)agmatine amidinohydrolase

Reaction(IUBMB)

N1-(aminopropyl)agmatine + H2O = spermidine + urea [RN:R10347]

Reaction(KEGG)

R10347

Substrate

N1-(aminopropyl)agmatine [CPD:C20560];
H2O [CPD:C00001]

Product

spermidine [CPD:C00315];
urea [CPD:C00086]

Comment

The enzyme, which has been characterized from the hyperthermophilic archaeon Pyrococcus kodakarensis and the thermophilic Gram-negative bacterium Thermus thermophilus, is involved in the biosynthesis of spermidine.

History

EC 3.5.3.24 created 2013

Pathway

ec00330

Arginine and proline metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K27683

N1-aminopropylagmatine ureohydrolase

Genes

MTHD:

A3224_01445

MICC:

AUP74_01208

MAGA:

Mag101_16220

MII:	BTJ40_01670(speB)

MICT:

FIU95_01435

MHYD:

GTQ55_02105(speB)

MCEL:

LPW13_17180(speB)

MICZ:

GL2_10430

MVB:	MJO52_01585(speB)

MPAF:

R5R33_11055(speB)

MBRG:

PVT68_12980(speB)

CBU:

CBU_0720

CBS:	COXBURSA331_A0838(speB)

CBD:	CBUD_0733(speB)

CBG:	CbuG_1282(sepB)

CBC:	CbuK_1536(sepB)

CEY:	CleRT_04840 CleRT_06280

CEA:	Z664_01060

CEND:

EGQ50_01050(speB)

RVI:	RVIR1_13610(speB)

CEQ:	B1F76_01050

MEJ:	Q7A_1603(speB)

MEC:

Q7C_156

MPIN:

LGT42_007720(speB)

MMAF:

GCM100_27900

MTHA:

VSX76_11330(speB)

CZA:	CYCME_0980(speB)

OAI:	OLEAN_C07180(speB)

BMAR:

HF888_00950(speB)

CHJ:	NCTC10426_00531(speB)

SUTR:

L0B52_02560(speB)

FIL:	BN1229_v1_2598(sepB)

FIY:	BN1229_v1_3319(sepB)

MMYR:

MXMO3_03319

PSF:

PSE_3138

SIL:	SPO0599(speB-1)

RUA:	D1823_00490(speB)

RUT:	FIU92_12480

RCON:

K3740_04340(speB)

RUY:	NOR97_11805(speB)

RID:	RIdsm_04344(speB_2)

HAT:	RC74_05710

SEDI:

EBB79_11790(speB)

PPSO:

QPJ95_16260(speB)

LIT:	FPZ52_16050(speB)

CACT:

HZ995_09900(speB)

CMAG:

CBW24_14770

ACRO:

K3J57_00205(speB)

PBAE:

P8S53_15730(speB)

RBG:	BG454_05085(speB)

FAQ:	G5B39_07865(speB)

MGM:

Mmc1_3564

PUB:	SAR11_0206(speB1)

PEG:	E5R92_05290(speB)

APM:	HIMB5_00000510

SNEA:

NBZ79_14815(speB)

DDS:

Ddes_0074

DFI:	AXF13_12800

DPG:	DESPIGER_1683

DEF:	CNY67_00405(speB)

DTR:	RSDT_0656(speB)

DFL:	DFE_2480(speB)

PSYF:

N1030_11505(speB)

DSB:	LN040_13495(speB)

DDE:

Dde_0574

DAS:

Daes_0891

DPI:

BN4_10686

PSEL:

GM415_00515(speB)

PPOR:

JCM14722_30420

PTHE:

LF599_07245(speB)

PBIZ:

LWC08_06640(speB)

DVU:

DVU_0421

DVL:

Dvul_2513

DVG:	Deval_0384

TMUR:

JBF11_02435(speB)

DBA:

Dbac_1609

DOA:	AXF15_00170

DESU:

NLA06_05810(speB)

DSF:

UWK_00574

DLM:	DPPLL_34050

DAK:	DaAHT2_0702

DEO:	CAY53_03650

DAL:

Dalk_3765

DAT:	HRM2_01390(speB)

DTO:	TOL2_C01070(speB)

DOV:	DSCO28_26540

DWD:	DSCW_22140

DMM:	dnm_078930(speB)

DEK:	DSLASN_30020

DAO:	Desac_0723

SFU:

Sfum_0721

DAX:	FDQ92_08135(speB)

DBR:

Deba_0052

DMP:

FAK_41170

TID:	Thein_1875

TOP:	TOPB45_0827

THET:

F1847_03290(speB)

CTHI:

THC_1640

TAV:	G4V39_01025(speB)

TMAI:

FVE67_02015(speB)

DAW:	HS1_000510

MZL:	GKS04_00980(speB)

DHR:	LGS26_09260(speB)

AYM:	YM304_25610(speB)

SYN:

sll0228

SYZ:

MYO_11320

SYY:	SYNGTS_0134(sll0228)

SYT:	SYNGTI_0134(sll0228)

SYS:	SYNPCCN_0134(sll0228)

SYQ:	SYNPCCP_0134(sll0228)

SYJ:	D082_04170(speB1)

SYO:	C7I86_00690(speB)

CYA:	CYA_0859(speB)

CYB:	CYB_1744(speB)

WNA:	KA717_33130(speB)

LET:	O77CONTIG1_01533

LEPT:

JVX88_12700(speB)

KOV:	K9N68_30965(speB)

LSC:	KIK02_18360(speB)

LSK:	J5X98_09740(speB)

THEU:

HPC62_18070(speB)

TOG:	HNI00_00625(speB)

GLP:	Glo7428_2736

CHON:

NIES4102_10530

GDU:	P0S91_23170(speB)

GEN:	GM3709_1637

CAN:	Cyan10605_2245

CSN:	Cyast_1901

CYL:	AA637_00575(speB)

SYP:	SYNPCC7002_A1109(speB)

SYV:	AWQ23_05705

SYL:	AWQ21_05605

LEP:	Lepto7376_2991

SYNN:

NIES970_14390(speB)

PIP:	FEK30_08820(speB)

MAR:

MAE_47100

MPK:

VL20_3367

MIQ:	B5D77_02095

MVZ:	myaer102_20580

CYC:	PCC7424_2696

CYJ:	Cyan7822_2343

TER:

Tery_3780

ARP:	NIES39_C03400

PAGH:

NIES204_23930

PPSU:

NO713_01520(speB1)

PRUN:

PCC7821_02885(speB1)

MVAG:

D0A34_22980(speB)

LFS:	HFV01_11360(speB)

LIX:	H2674_14535(speB)

ONI:	Osc7112_6201

PHOR:

JWS08_14590(speB)

MIC:	Mic7113_4680

CTHE:

Chro_5254

PLP:	Ple7327_0290

SCS:	Sta7437_3941

STAN:

STA3757_10880

HAU:

Haur_4857

CAP:	CLDAP_14200(speB)

KBB:	ccbrp13_59520

TTH:

TT_C0764

TTJ:	TTHA1129(TTHA1129)

TTS:	Ththe16_1138

TTL:	TtJL18_0931

TSC:	TSC_c09730(speB)

THC:	TCCBUS3UF1_13950

TOS:	Theos_1493

TAQ:

TO73_0744

TPAR:

AV541_05110

TBC:	A0O31_00191

TANT:

KNN15_09890(speB)

MHD:	Marky_1686

CCOT:

CCAX7_23490

PUV:	PUV_04450(speB1)

SNG:	SNE_A06120(speB1)

PPHT:

GA004_06945(speB)

TTF:

THTE_0363

SDYN:

Mal52_03100

KST:	KSMBR1_3789

BROC:

IPI25_04960(speB)

BPIT:

BPIT_21180

JET:	L3J17_03285(speB)

PBAS:

SMSP2_02853(speB_4)

ALUS:

STSP2_00844(pah)

VBL:	L21SP4_01465(speB_2)

SSM:	Spirs_0906

STA:	STHERM_c03000

STQ:	Spith_0284

SLR:	L21SP2_2371

OCK:	EXM22_00305(speB)

SBU:	SpiBuddy_1496

SGP:	SpiGrapes_2928

SASS:

MUG09_08275

OSP:	Odosp_2566

BUY:	D8S85_13980(speB)

BVIR:

I6J59_02095(speB)

BFH:	F1611_15400(speB)

TTZ:	FHG85_06005(speB)

MBAS:

ALGA_4367

AGD:	FRZ59_14400(speB)

FLM:	MY04_4888(speB)

FYA:	KMW28_26520(speB)

GFO:	GFO_3624(speB)

GRL:	LPB144_09020

GFL:

GRFL_1788

GRS:	C7S20_03900(speB)

RBI:	RB2501_05260

ZPR:

ZPR_4205

CAT:	CA2559_00520

MARM:

YQ22_09760

MART:

BTR34_09830

MARB:

CJ263_06450(speB)

MARE:

EJ994_11895(speB)

CAO:	Celal_1833

CLY:	Celly_2063

CLH:	IX49_10245

CBAL:

M667_06545

CBAT:

M666_06565

COMN:

PBN93_10255(speB)

KDI:	Krodi_0259

DOK:	MED134_05894

DDO:

I597_2168

DOD:	DCS32_10900(speB)

LAN:	Lacal_0653

LVN:	BWR22_13830

LACI:

CW733_10405(speB)

LACW:

FG167_03250(speB)

ZGA:	ZOBELLIA_2015(speB)

ZLA:	Q5W13_09980(speB)

ASL:	Aeqsu_0821

AEV:	EI546_09245(speB)

AIC:	JK629_06770(speB)

AEQU:

QCQ61_06630(speB)

PTQ:	P700755_002304

NDO:	DDD_1958(speB)

NOM:	AAT17_04635

NSD:	BST91_01250

NOB:	CW736_02425(speB)

NOJ:	EJ995_04820(speB)

NUL:	R1T42_13810(speB)

NMF:

NMS_0351

POB:	LPB03_02135

PRN:	BW723_13675

POLA:

BXQ17_02935

POA:	CW731_02415(speB)

PHAL:

H9I45_02975(speB)

PLIT:

K8354_06160(speB)

PPEC:

H9W90_04690(speB)

PBAT:

JL193_00240(speB)

PCEA:

J3359_03680(speB)

PUN:	NQP51_03305(speB)

PHG:	KCTC32516_01656

WIJ:	BWZ20_06785

AHZ:	APS56_08090

SYI:	SB49_10760

TEN:	LPB136_04040

TJE:	TJEJU_2081

TMAR:

MARIT_0342

TMP:	F9Y86_11450(speB)

TRT:	PG912_06285(speB)

TPAC:

PG913_09395(speB)

TTG:	P8625_14190(speB)

TSIG:

D6T69_14610(speB)

LUL:	LPB138_14925

WFU:	AXE80_03640

FOR:	FORMB_26360

FOP:	FNB79_06140(speB)

SALT:

AO058_06000

SMIS:

LDL76_03295(speB)

SEON:

BWZ22_12380

AALG:

AREALGSMS7_01797

OLL:	CW732_06375(speB)

OAQ:	DZC78_12910(speB)

TAJ:	C1A40_08635(speB)

AUE:	C5O00_07435(speB)

KOS:	KORDIASMS9_02410

KAN:	IMCC3317_47340

MARF:

CJ739_903

AQD:	D1816_01020(speB)

AQE:	NBT05_07955(speB)

AQR:	HN014_13705(speB)

EMAR:

D1013_02775(speB)

MUR:	EQY75_00335(speB)

PSYN:

E9099_03790(speB)

PPON:

MUN68_014330(speB)

AFLA:

FHG64_10875(speB)

ANP:	FK178_11160(speB)

OCI:	FEZ18_04295(speB)

MESQ:

C7H62_0678

GAA:	HX109_15015(speB)

CAGG:

HYG79_06070(speB)

ALTI:

ALE3EI_0559

MARX:

INR76_06220(speB)

LPAL:

LDL79_10245(speB)

SINH:

LS482_20410(speB)

MRS:	Murru_0164

MLT:

VC82_1629

MUT:	GVT53_09730(speB)

MAQI:

LDL77_00940(speB)

SABU:

MBM09_03875(speB)

ZSP:	MQE36_13855(speB)

BIA:	GMA17_10730(speB)

FBE:	FF125_13800(speB)

FBM:	MQE35_17640(speB)

SAHN:

JRG66_09280(speB)

LUY:	QZH61_08040(speB)

MANG:

RBH95_15455(speB)

MCAA:

R3L15_01275(speB)

HWS:	RNZ46_04460(speB)

MGEL:

G5B37_07610(speB)

ORH:	Ornrh_0038

ORI:	Q785_00185

BBL:	BLBBGE_059(rocF)

BPI:	BPLAN_574(speB)

BMM:	MADAR_546(speB)

BCP:	BLBCPU_058(rocF)

BBG:	BGIGA_567(speB)

BBQ:	BLBBOR_061

BLP:	BPAA_573(rocF)

BLU:

K645_306

BLCK:

DM815_00295(speB)

BPUN:

DM780_00295(speB)

CRM:	K6119_16865(speB)

CHYD:

H4K34_05570(speB)

SHYR:

LA303_12095(speB)

MRO:

MROS_2717

DAP:	Dacet_2598

CABY:

Cabys_1232

DTH:	DICTH_1308

DTU:

Dtur_1414

NDE:	NIDE3972(speB)

NMV:	NITMOv2_4297(speB)

NIO:	NITINOP_0495(speB)

NJA:	NSJP_0528(speB)

NKF:	Nkreftii_000406

NIF:	W02_19890(speB)

PFU:

PF1957

PFI:

PFC_08795

PHO:	PH0083(PH0083)

PAB:	PAB0050(speB)

PYN:

PNA2_0622

PYA:	PYCH_14880

PYS:

Py04_0182

PYC:	TQ32_06315

TKO:

TK0882

TON:

TON_0425

TGA:	TGAM_0431(speB)

TSI:

TSIB_0246

TBA:	TERMP_00038

THE:

GQS_03075

THA:

TAM4_548

THM:

CL1_0263

TLT:

OCC_09666

THS:

TES1_0144

TNU:

BD01_0281

TEU:

TEU_07130

TGY:	X802_06105

THV:	ADU37_CDS01850

TCH:	CHITON_0236

TPEP:

A0127_00670

TPIE:

A7C91_08140

TGG:	A3K92_07230

TCE:	A3L02_09225

TBS:	A3L01_02835

THH:	CDI07_02790(speB)

TSL:	A3L11_06790

TTD:	A3L14_04395

TPRF:

A3L09_10035

TRL:	A3L10_03740

TPAF:

A3L08_05815

THY:	A3L12_05920

TIC:	FH039_05175(speB)

TCQ:	TIRI35C_0794

THEM:

FPV09_04005(speB)

THEI:

K1720_04355(speB)

PPAC:

PAP_01660

FLT:	Sv326_0934

» show all

Reference

1 [PMID:15983049]

Authors

Ohnuma M, Terui Y, Tamakoshi M, Mitome H, Niitsu M, Samejima K, Kawashima E, Oshima T

Title

N1-aminopropylagmatine, a new polyamine produced as a key intermediate in polyamine biosynthesis of an extreme thermophile, Thermus thermophilus.

Journal

J Biol Chem 280:30073-82 (2005)
DOI:10.1074/jbc.M413332200

Sequence

[tth:TT_C0764]

Reference

2 [PMID:20675472]

Authors

Morimoto N, Fukuda W, Nakajima N, Masuda T, Terui Y, Kanai T, Oshima T, Imanaka T, Fujiwara S

Title

Dual biosynthesis pathway for longer-chain polyamines in the hyperthermophilic archaeon Thermococcus kodakarensis.

Journal

J Bacteriol 192:4991-5001 (2010)
DOI:10.1128/JB.00279-10

Sequence

[tko:TK0882]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.3.24

IUBMB Enzyme Nomenclature:

3.5.3.24

ExPASy - ENZYME nomenclature database:

3.5.3.24

BRENDA, the Enzyme Database:

3.5.3.24

DBGET integrated database retrieval system