KEGG   ENZYME: 3.5.3.26
Entry
EC 3.5.3.26                 Enzyme                                 

Name
(S)-ureidoglycine aminohydrolase;
UGlyAH;
UGHY;
ylbA (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
Sysname
(S)-ureidoglycine aminohydrolase
Reaction(IUBMB)
(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH3 [RN:R05554]
Reaction(KEGG)
R05554
Substrate
(S)-2-ureidoglycine;
H2O [CPD:C00001]
Product
(S)-ureidoglycolate [CPD:C00603];
NH3 [CPD:C00014]
Comment
Binds Mn2+. This enzyme, found in plants and bacteria, is part of the ureide pathway, which enables the recycling of the nitrogen in purine compounds. In plants it is localized in the endoplasmic reticulum.
History
EC 3.5.3.26 created 2013
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14977  (S)-ureidoglycine aminohydrolase
Genes
ATH: AT4G17050(UGLYAH)
ALY: 9304160
CRB: 17880024
CSAT: 104718647 104723399 104731876
EUS: EUTSA_v10026866mg
BRP: 103860892 103868931
BNA: 106425359 106437389 106440141 106440260
BOE: 106303721 106344891
RSZ: 108852929
THJ: 104807929
CIT: 102624772
PVY: 116133094
TCC: 18606154
GRA: 105765058
GAB: 108477327
DZI: 111315163
EGR: 104441965
VRA: 106769133
VAR: 108319681
VUN: 114177293
CCAJ: 109811810
APRC: 113849824
CAM: 101499522
LJA: Lj0g3v0272899.1(Lj0g3v0272899.1) Lj0g3v0272899.2(Lj0g3v0272899.2)
ADU: 107484713
AIP: 107629124
LANG: 109331682
FVE: 101309352
RCN: 112180629
PPER: 18777393
PMUM: 103342603
PAVI: 110756484
PDUL: 117628701
PXB: 103937908
ZJU: 107430343
MNT: 21406162
CSV: 101218090
CMO: 103491151
BHJ: 120089918
MCHA: 111022624
CMAX: 111498454
CMOS: 111454479
CPEP: 111800312
RCU: 8269033
JCU: 105632356
MESC: 110629761
PALZ: 118062948
JRE: 109019866
QLO: 115971243
TWL: 120016816
VRI: 117934409
SLY: 101248901
SPEN: 107026852
SOT: 102579476
CANN: 107868552
NSY: 104224652
NTO: 104106488
NAU: 109231303
INI: 109174807
ITR: 116030182
SIND: 105178742
OEU: 111372362
EGT: 105951906
HAN: 110922124
LSV: 111907387
CCAV: 112527450
DCR: 108209423
CSIN: 114271327
BVG: 104892831
SOE: 110781772
NNU: 104606373
MING: 122066798
NCOL: 116252216
OSA: 4343286
DOSA: Os07t0495000-01(Os07g0495000)
OBR: 102715318
BDI: 100839183
ATS: 109763127
SBI: 8077471
ZMA: 100217019
SITA: 101757632
PHAI: 112882695
PDA: 103710779
EGU: 105043786
MUS: 103984459
DCT: 110105240
AOF: 109838862
ATR: 18429130
PPP: 112286678
MNG: MNEG_6401
APRO: F751_2384
MAW: MAC_04358
MAJ: MAA_02873
ECO: b0515(allE)
ECJ: JW0503(ylbA)
ECD: ECDH10B_0471(ylbA)
EBW: BWG_0391(ylbA)
ECOK: ECMDS42_0408(ylbA)
ECE: Z0670(ylbA)
ECS: ECs0577
ETW: ECSP_0589(ylbA)
EOI: ECO111_0547(ylbA)
EOJ: ECO26_0548(ylbA)
EOH: ECO103_0487(ylbA)
ECOO: ECRM13514_0321(ylbA)
ECOH: ECRM13516_0504(ylbA)
ESL: O3K_18925
ESO: O3O_06370
ESM: O3M_18900
ECK: EC55989_0529(ylbA)
ECG: E2348C_0448(ylbA)
EOK: G2583_0635(ylbA)
ELH: ETEC_0567
ECP: ECP_0575
ENA: ECNA114_0492(ylbA)
ECOS: EC958_0653(ylbA)
ECV: APECO1_1500(ylbA)
ECY: ECSE_0540
ECR: ECIAI1_0517(ylbA)
ECQ: ECED1_0534(ylbA)
EUM: ECUMN_0555(ylbA)
ECT: ECIAI39_0478(ylbA)
EOC: CE10_0489(ylbA)
EBR: ECB_00465(ylbA)
EBL: ECD_00465(allE)
EBE: B21_00470(ylbA)
EBD: ECBD_3143
ECI: UTI89_C0543(ylbA)
ECZ: ECS88_0514(ylbA)
ECC: c0629(ylbA)
ESE: ECSF_0477
EAB: ECABU_c05940(ylbA)
EDJ: ECDH1ME8569_0499(ylbA)
ELW: ECW_m0586(ylbA)
ELL: WFL_02905
ELC: i14_0605(ylbA)
ELD: i02_0605(ylbA)
ELF: LF82_3524(ylbA)
ECOI: ECOPMV1_00503(ylbA)
ECOJ: P423_02620
ESZ: FEM44_17145(allE)
STY: STY0574
STT: t2335
STM: STM0526(ylbA)
SEO: STM14_0616(ylbA)
SEY: SL1344_0519(ylbA)
SEJ: STMUK_0533(ylbA)
SPT: SPA2197(ylbA)
SEK: SSPA2042
SEI: SPC_0540(ylbA)
SEC: SCH_0565(ylbA)
SHB: SU5_01219
SENS: Q786_02595
SED: SeD_A0574
SEG: SG0538(ylbA)
SEL: SPUL_2434
SET: SEN0507(ylbA)
SENA: AU38_02585
SENO: AU37_02580
SENV: AU39_02585
SENQ: AU40_02840
SENL: IY59_02635
SEEP: I137_11095
SENB: BN855_5250
SENE: IA1_02775
SFL: SF0449(ylbA)
SFX: S0457(ylbA)
SFV: SFV_0476(ylbA)
SFN: SFy_0572
SFS: SFyv_0610
SFT: NCTC1_00463(ylbA)
KPU: KP1_1371
KPP: A79E_3792
CARS: E1B03_07340(allE)
YIN: CH53_63
SMAR: SM39_0492
SERF: L085_22970
SURI: J0X03_18280(allE)
RAA: Q7S_01490
EAME: GXP68_18210(allE)
ERWI: GN242_15855(allE)
MHAT: B824_16620
MHAM: J450_02310
MVE: X875_8740
PAE: PA1140
PAEV: N297_1180
PAEI: N296_1180
PAU: PA14_49650(ylbA)
PNC: NCGM2_2012(ylbA)
PAEB: NCGM1900_1455(ylbA)
PAEP: PA1S_20185
PAEM: U769_20060
PAEL: T223_21360
PAEU: BN889_01214(ylbA)
PAEG: AI22_13765
PAEC: M802_1176
PAEO: M801_1180
PMY: Pmen_1325
PMK: MDS_1354
PPSE: BN5_3034
PPU: PP_3530(allE)
PPF: Pput_2243
PPT: PPS_3024
PPI: YSA_00055
PPX: T1E_0015
PPUH: B479_15040
PPUT: L483_18490
PPUN: PP4_23070
PPUD: DW66_3293
PMON: X969_14495
PMOT: X970_14140
PFL: PFL_3803
PPRO: PPC_3902
PEN: PSEEN2925
PSA: PST_2947
PSOS: POS17_3919
PSET: THL1_1773
PALL: UYA_06285
PDW: BV82_1386
MHC: MARHY2911
MBS: MRBBS_0850(ylbA)
GPS: C427_4927
GAI: IMCC3135_20530(allE)
HCH: HCH_01149
CSA: Csal_0079
HEL: HELO_1600(allE)
HAM: HALO1153
HBE: BEI_3026(ylbA)
OCE: GU3_01240
SALN: SALB1_0858
NANI: NCTC12227_00791(ylbA)
RPI: Rpic_3617
REH: H16_B2457(h16_B2457)
BVE: AK36_3131
BCN: Bcen_5420
BCJ: BCAM2638
BCEN: DM39_5225
BCEW: DM40_3237
BCEO: I35_6532
BAM: Bamb_4787
BMU: Bmul_3330
BMK: DM80_4711
BMUL: NP80_3213
BCT: GEM_5758
BCED: DM42_5339
BDL: AK34_3241
BCON: NL30_16965
BUB: BW23_3827
BLAT: WK25_28775
BTEI: WS51_09930
BSEM: WJ12_33095
BPSL: WS57_01110
BMEC: WJ16_31565
BSTG: WT74_31845
BUK: MYA_3265
PPNO: DA70_03515
PPNM: LV28_02800
PPUL: RO07_21700
PSPU: NA29_15435
PAPI: SG18_20635
BUO: BRPE64_CCDS02760(ylbA)
AMIM: MIM_c01260
AFQ: AFA_02535
SUTT: SUTMEG_17430(ylbA)
MLO: mll5131
MHUA: MCHK_6184
MES: Meso_2830
SME: SM_b20684
SMER: DU99_26595
SMD: Smed_4304
SFD: USDA257_c15150(ylbA)
ATU: Atu3205
ARA: Arad_7142
AVI: Avi_5006
RLE: pRL110462
RLG: Rleg_6664
NEN: NCHU2750_47550(ylbA)
RHT: NT26_2991
SHZ: shn_16330
BME: BMEI1578
BMEL: DK63_1912
BMEE: DK62_1041
BMF: BAB1_0374
BABO: DK55_391
BABR: DO74_1496
BABT: DK49_154
BABB: DK48_1736
BABU: DK53_381
BABS: DK51_1083
BABC: DO78_298
BMS: BR0346
BSZ: DK67_1285
BOV: BOV_0362
BCAR: DK60_438
BCAS: DA85_01680
BMR: BMI_I351
BPP: BPI_I380
BPV: DK65_1001
OAN: Oant_0448
OAH: DR92_2491
BJA: blr0253(blr0253)
BRA: BRADO2840
BBT: BBta_5334
BRS: S23_28400
AOL: S58_47690
RPA: RPA0553
RPT: Rpal_0555
MDI: METDI2415
MEX: Mext_1741
MCH: Mchl_2060
MPO: Mpop_1072
MNO: Mnod_7819
MOR: MOC_3377
META: Y590_08295
PHL: KKY_2244
MMED: Mame_00412
PSF: PSE_0753
SIL: SPO0876
JAN: Jann_2601
RDE: RD1_1128
DSH: Dshi_3200
KVL: KVU_0492
KVU: EIO_0975
KRO: BVG79_00757(ylbA)
PGD: Gal_02954
OTM: OSB_04190
LAQU: R2C4_20935
CID: P73_3912
MALG: MALG_04363
RMM: ROSMUCSMR3_02728(allE)
AHT: ANTHELSMS3_04160(allE)
MALU: KU6B_04940
RSP: RSP_1553
PDE: Pden_3794
RSU: NHU_01702
RHC: RGUI_3394
LVS: LOKVESSMR4R_02829(allE)
PAMO: BAR1_03695
PALW: PSAL_028330(allE)
SECH: B18_17390
BLI: BL01096
BLD: BLi01128(ylbA1)
BSON: S101395_03701(ylbA)
LSP: Bsph_2899
PSYO: PB01_10330
SCA: SCA_2055
SARL: SAP2_02410
SSIM: SAMEA4384339_0260(ylbA)
SSTE: SAMEA4384403_0161(ylbA)
LFE: LAF_0162
LHIL: G8J22_00246(allE)
EFA: EF2996
EFL: EF62_0081
EFS: EFS1_2430
EFN: DENG_02885(ylbA)
EFQ: DR75_1725
ENE: ENT_27400
ECAS: ECBG_00214
CRN: CAR_c17750(ylbA)
CML: BN424_1732(ylbA)
CARC: NY10_822
CSQ: CSCA_5011
DSY: DSY4160
DHD: Dhaf_1181
PUF: UFO1_0276
STED: SPTER_11390(allE)
MID: MIP_02762
MYO: OEM_17510
MIR: OCQ_18310
MGI: Mflv_3172
MVQ: MYVA_3213
MARZ: MARA_06990
MBOK: MBOE_42790
GOR: KTR9_1121
TPR: Tpau_2030
ART: Arth_3435
ARR: ARUE_c35460(ylbA)
AAU: AAur_3409
ACH: Achl_3214
KRH: KRH_19830
KVR: CIB50_0001100(allE)
LMOI: VV02_25750
SERJ: SGUI_3181
BLIN: BLSMQ_0840
NML: Namu_0241
SEN: SACE_7229
AMYY: YIM_33595
PSEE: FRP1_03155
DRA: DR_1152
DGE: Dgeo_2608
DGO: DGo_PA0232(glxB)
TRA: Trad_1506
MRB: Mrub_1387
MIN: Minf_2339(glxB)
MEAP: MTHMO_0398(glxB)
ABAS: ACPOL_2455
SUS: Acid_0363
CPI: Cpin_6771
SLI: Slin_3322
HSW: Hsw_2655
 » show all
Reference
1  [PMID:20038185]
  Authors
Serventi F, Ramazzina I, Lamberto I, Puggioni V, Gatti R, Percudani R
  Title
Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria.
  Journal
ACS Chem Biol 5:203-14 (2010)
DOI:10.1021/cb900248n
  Sequence
[ath:AT4G17050] [ag:ADH04165]
Reference
2  [PMID:19935661]
  Authors
Werner AK, Romeis T, Witte CP
  Title
Ureide catabolism in Arabidopsis thaliana and Escherichia coli.
  Journal
Nat Chem Biol 6:19-21 (2010)
DOI:10.1038/nchembio.265
  Sequence
[ath:AT4G17050] [eco:b0515]
Reference
3  [PMID:22493446]
  Authors
Shin I, Percudani R, Rhee S
  Title
Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana.
  Journal
J Biol Chem 287:18796-805 (2012)
DOI:10.1074/jbc.M111.331819
  Sequence
[ath:AT4G17050]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.3.26
IUBMB Enzyme Nomenclature: 3.5.3.26
ExPASy - ENZYME nomenclature database: 3.5.3.26
BRENDA, the Enzyme Database: 3.5.3.26

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