KEGG   ENZYME: 3.5.4.29
Entry
EC 3.5.4.29                 Enzyme                                 
Name
GTP cyclohydrolase IIa
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
GTP 8,9-hydrolase (phosphate-forming)
Reaction(IUBMB)
GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate [RN:R07306]
Reaction(KEGG)
R07306
Substrate
GTP [CPD:C00044];
H2O [CPD:C00001]
Product
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C15563];
phosphate [CPD:C00009]
Comment
Requires Mg2+. This enzyme catalyses the hydrolysis of the imidazole ring of guanosine 5'-triphosphate, N7-methylguanosine 5'-triphosphate or inosine 5'-triphosphate. Xanthosine 5'-triphosphate and ATP are not substrates. It also catalyses the hydrolysis of diphosphate to form two equivalents of phosphate. Unlike GTP cyclohydrolase II (EC 3.5.4.25), this enzyme does not release formate, but does hydrolyse the diphosphate from GTP to phosphate.
History
EC 3.5.4.29 created 2003, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K08096  GTP cyclohydrolase IIa
Genes
ABUTAmi103574_11595
MJAMJ_0145
MFEMefer_0498
MVUMetvu_1460
MFSMFS40622_0137
MIFMetin_0291
MJHJH146_0012
MESGMLAUSG7_0148(gch)
MESAMLASG1_1327(gch)
MIGMetig_0265
MMPMMP0405(gch3)
MMQMmarC5_1233
MMXMmarC6_0505
MMZMmarC7_1403
MMDGYY_02095
MMAKMMKA1_04240(gch3)
MMAOMMOS7_04200(gch3)
MMADMMJJ_06320
MAEMaeo_0818
MVNMevan_1393
MVOMvol_1650
MOKMetok_0352
METFCFE53_05915
MTHMTH_1017
MMGMTBMA_c13990(gch3)
METCMTCT_0925
MWOMWSIV6_1403(gch3)
METEtca_00978
METZMETMT2_1043
METKFVF72_06525
MTHMFZP57_06705
METJFZP68_03955
MSTMsp_1404(gch3)
METBAW729_08500
MRUmru_1845(arfA)
MSIMsm_0973
MEBAbm4_1486(arfA)
MMILsm9_1936(arfA)
MEYETL18_09135
MOLYLM1_1302
MAROMarbSA_16670
MELMetbo_2437
MEWMSWAN_0205
METHMBMB1_0199(gch3)
MFCBRM9_2101(arfA)
MFIDSM1535_1580(gch3)
MCUBMCBB_0214(gch3)
MSUBBK009_10790
METNBK008_06430
METTCIT01_02825
METOCIT02_06020
MEMEHYG87_04420
MFVMfer_0318
HALVNG_1011C VNG_1021C
HSLOE_2472F(gch3a) OE_2492F(gch3b)
HDLHALDL1_11210
HHBHhub_2223(gch3)
HAGSJT689_05390 JT689_05430
HABOJRZ79_03890 JRZ79_03930
HNOLT974_06010
HLULT972_07135
HANRLJ422_04150 LJ422_04190
HJEHacjB3_15030
HALHHTSR_0917
HHSRHSR6_0931(gch)
HSUHLASF_1555(gch)
HSFHLASA_1542(gch)
SALRFQU85_08800
HALREFA46_008365
HARAAArcS_0056(gch31) AArcS_1434(gch312)
HAADMW046_04520 MW046_05180
HALXM0R89_18045
HMArrnAC0115
HHIHAH_0868
HHNHISP_04485
HABSG26_12185
HTABVU17_04250
HALJG9465_17470
HSINKDQ40_09160
NPHNP_4142A(arfA)
NMONmlp_2421(gch3)
NHOHWV23_09295 HWV23_14935
NSALHWV07_19590
HUTHuta_1998
HMUHmuk_2633
HALZE5139_00445
HALLLC1Hm_1978(gch3)
HAZPGBQ70_00445
HALIBV210_09450 BV210_14835
HSNDV733_08805 DV733_11860
HDSHSR122_0414(gch31) HSR122_0948(gch312)
HRRHZS55_16335
HPELHZS54_19100
HLTI7X12_14885 I7X12_19560
HARCHARCEL1_06920
HDOMUK72_04340 MUK72_14300
HWAHQ_2427A(arfA)
HWCHqrw_2717(arfA)
HVOHVO_1284(gch3)
HMEHFX_1350
HGIABY42_06270
HALEG3A49_09620
HBOHbor_19420
HAQDU484_08965
HAJDU500_09215
HAERDU502_06285
HRAEI982_06960
HLMDV707_08865
HALMFCF25_13050
HLAHlac_2188
HALPDOS48_10475
HALBEKH57_07645 EKH57_14865
HEZZEO776_11305
HALQHrr1229_011200
HSAIHPS36_10190
HAZZKI388_08310 KI388_09725
SRUBC2R22_08140
HAEhalTADL_2942
HALNB4589_000910
HALGHUG10_05900
HALUHUG12_11030
HMPK6T50_03195
HREK6T36_03080
HRMK6T25_12245
HACBHbl1158_11005
HDFAArcSl_0927(gch3) AArcSl_2529(gch32)
HAHHalar_1491
HTUHtur_1598
HDABB347_04080
HJTDVR14_02985
HALYHYG82_14310 HYG82_14370 HYG82_17370
HSALJMJ58_00645
HLOJ0X27_02160
HAKZJ0X25_14815
NMGNmag_3329(gch3)
HXAHalxa_3150
NATNJ7G_0632 NJ7G_3305
NPENatpe_2601
NVRFEJ81_11955
NPLFGF80_01095 FGF80_10980
NAYHYG81_14765
NGENatgr_3410
HRUHalru_1555
NOUNatoc_1516
SALIL593_10970
SAIMK0C01_07415 K0C01_11305
HLRHALLA_10870
HLCCHINAEXTREME16115
NAJB1756_02415
NAGAArcMg_1652 AArcMg_4012
NANAArc1_1987 AArc1_5063
NBGDV706_13020
NASGCU68_13760
APEAPE_1365.1
ACJACAM_0863
SMRSmar_0486
SHCShell_0316
IHOIgni_1352
IISEYM_01970
PFMPyrfu_1597
PDLPyrde_2004
STOSTK_03950
SOHD1869_01695
SSOSSO0399
SOLSsol_1377
SSOASULA_1423
SSOLSULB_1424
SSOFSULC_1422
SSHIJ5U23_03036
SCASSACC_06280
SAISaci_0819
SISLS215_1832
SIAM1425_1704
SIMM1627_1820
SIDM164_1751
SIYYG5714_1820
SINYN1551_1106
SIILD85_1961
SIHSiH_1679
SIRSiRe_1600
SICSiL_1592
SULABFU36_03810
SULEGFS03_09565
SULOGFS33_01380
SULLEWF20_03165
MSEMsed_0049
MCNMcup_0048
MHKDFR87_07225
MPRUDFR88_06440
MTENGWK48_04940
MJNMjAS7_0636
AHOAhos_0727
AMANB6F84_07075
ABRIDFR85_07865
ASULDFR86_06135
AAMBD1866_11425
ACIHHS5_21020
SACDHS1genome_0323
SAZOD1868_02455
CSTYKN1_19780
STEPIC006_1494
SAHSHS7_02920
PAIPAE2984
PISPisl_0384
PCLPcal_1123
PASPars_1351
PYRP186_1548
POGPogu_0863
TNETneu_1743
PYWPYWP30_01862
TTNTTX_1009
TUZTUZN_0675
VDIVdis_0343
VMOVMUT_1288
ASCASAC_0813
ACIASE86_05725
CLGCalag_0338
NMRNmar_1614
NIRNSED_08735
NKRNKOR_08785
NIDNPIRD3C_0439(gch)
NINNADRNF5_0270(gch)
NIWNisw_05820
NCLC5F47_08460
NOXC5F49_08345
NUEC5F50_07110 C5F50_11725
NIPNsoK4_00190
NCTNMSP_1555(gch3)
CSYCENSYa_1757
NGANgar_c32640(gch3)
NVNNVIE_021890(gch)
NEVNTE_03547
TAANMY3_03741
NFNNFRAN_1030(gch)
NCVNCAV_0049(gch)
NBVT478_1328
TAHSU86_005140
NIUDSQ19_00910
NDVNDEV_1968(gch)
CCAINAS2_0573
 » show all
Reference
1  [PMID:12475257]
  Authors
Graham DE, Xu H, White RH
  Title
A member of a new class of GTP cyclohydrolases produces formylaminopyrimidine nucleotide monophosphates.
  Journal
Biochemistry 41:15074-84 (2002)
DOI:10.1021/bi0268798
  Sequence
[mja:MJ_0145]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.29
IUBMB Enzyme Nomenclature: 3.5.4.29
ExPASy - ENZYME nomenclature database: 3.5.4.29
BRENDA, the Enzyme Database: 3.5.4.29

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