KEGG   ENZYME: 3.5.4.32
Entry
EC 3.5.4.32                 Enzyme                                 

Name
8-oxoguanine deaminase;
8-OGD
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
8-oxoguanine aminohydrolase
Reaction(IUBMB)
8-oxoguanine + H2O = urate + NH3 [RN:R09876]
Reaction(KEGG)
R09876
Substrate
8-oxoguanine [CPD:C20155];
H2O [CPD:C00001]
Product
urate [CPD:C00366];
NH3 [CPD:C00014]
Comment
Zn2+ is bound in the active site. 8-Oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions.
History
EC 3.5.4.32 created 2012
Orthology
K18456  8-oxoguanine deaminase
Genes
BUF: D8682_11865
BAGE: BADSM9389_34870
SGOE: A8O29_016390
RAH: Rahaq_0416
RAA: Q7S_02075
RACE: JHW33_18720
RBAD: H2866_06145
EBI: EbC_00100
PVA: Pvag_2879
PAO: Pat9b_5500
ETR: ETAE_2164
ETD: ETAF_1956
ETE: ETEE_0149(atzB)
PPR: PBPRA2267(SCO6213)
PAE: PA0142
PAEV: N297_148
PAEI: N296_148
PAEP: PA1S_00750
PAEM: U769_00735
PAEL: T223_00725
PAEG: AI22_03175
PAEC: M802_148
PAEO: M801_148
PMY: Pmen_3705
PMK: MDS_4016
PPSE: BN5_0831(atzB)
PPU: PP_2584(oguA)
PPF: Pput_3132
PPT: PPS_2135
PPI: YSA_00396
PPX: T1E_3327(atzB)
PPUH: B479_11105
PPUT: L483_10405
PPUN: PP4_32700
PMON: X969_09005
PMOT: X970_08665
PST: PSPTO_0765(atzB)
PSB: Psyr_0669
PSYR: N018_03750
PFL: PFL_0724
PPRO: PPC_0739
PFS: PFLU_0669
PFB: VO64_3744
PMAN: OU5_2776
PEN: PSEEN0675
PSA: PST_3078(atzB)
PSZ: PSTAB_3125(atzB)
PSR: PSTAA_3241(atzB)
PSTT: CH92_16050
PSEM: TO66_03465
PSOS: POS17_0716
PANR: A7J50_0652
PSET: THL1_1903
PSIL: PMA3_25940
PALL: UYA_19335
PDW: BV82_2914
ACI: ACIAD0761
AUG: URS_0147
SPSW: Sps_03950
PAT: Patl_2224
AAUS: EP12_05760
GPS: C427_3020
CJA: CJA_0540
HCH: HCH_01106
HEL: HELO_1075
HBE: BEI_0049
TOL: TOL_3302
OAI: OLEAN_C32740(atzB)
NJP: NEJAP_3708(atzB)
OCE: GU3_03980
RSO: RSc2119
RSN: RSPO_c01317(atzB)
RSE: F504_2072
RPI: Rpic_2259
REH: H16_A1363(h16_A1363)
CNC: CNE_1c13890(atzB)
RME: Rmet_1186(atzB)
CGD: CR3_1619(ssnA)
BPS: BPSL2112
BPM: BURPS1710b_2526(atzB)
BPSE: BDL_3437
BPSM: BBQ_1225
BPSU: BBN_1352
BPSD: BBX_1838
BPK: BBK_2855
BPSH: DR55_2474
BPSA: BBU_54
BPSO: X996_2064
BUT: X994_489
BTE: BTH_I2073
BTQ: BTQ_1837
BTJ: BTJ_518
BTZ: BTL_1757
BTD: BTI_1525
BTV: BTHA_1912
BTHE: BTN_3009
BTHM: BTRA_2038
BTHA: DR62_3157
BTHL: BG87_1982
BOK: DM82_1663
BOC: BG90_3046
BVE: AK36_1923
BCN: Bcen_6122
BCJ: BCAL2029
BCEN: DM39_1928
BCEW: DM40_2610
BCEO: I35_1953
BAM: Bamb_1943
BMJ: BMULJ_01933(atzB)
BMU: Bmul_1313
BMK: DM80_3012
BMUL: NP80_2022
BCT: GEM_1468
BCED: DM42_3141
BDL: AK34_1165
BCON: NL30_13005
BUB: BW23_3030
BLAT: WK25_09500
BTEI: WS51_20180
BSEM: WJ12_09820
BPSL: WS57_28350
BMEC: WJ16_10030
BSTG: WT74_10250
BGU: KS03_2281
BGO: BM43_3751
BUK: MYA_1757
BUL: BW21_1665
BGP: BGL_1c23970(atzB)
BXE: Bxe_A1936
BXB: DR64_4095
BPH: Bphy_1293
BFN: OI25_3233
PPNO: DA70_05050
PPNM: LV28_01215
PPUL: RO07_20135
PSPU: NA29_17080
PAPI: SG18_19240
CABA: SBC2_15270
AFQ: AFA_09215
DAC: Daci_1591
CTES: O987_24140
HPSE: HPF_05425
MPT: Mpe_A0782
MMS: mma_0509
HSE: Hsero_3260(atzB)
HRB: Hrubri_3275(atzB)
CFU: CFU_3458(atzB)
CARE: LT85_3971
LCH: Lcho_1140
KAI: K32_36500
BJA: bll6159(bll6159)
BRA: BRADO1738
BBT: BBta_2050
BRS: S23_21350
AOL: S58_58060
BRAD: BF49_5470
BARH: WN72_34335
BOS: BSY19_863
XAU: Xaut_2741
SNO: Snov_3892
MDI: METDI2371(atzB) METDI3796
MET: M446_2144
MNO: Mnod_1111
MOR: MOC_4773
MAQU: Maq22A_1p37370(ssnA)
HDI: HDIA_3953
SIL: SPO2957
JAN: Jann_1234
RDE: RD1_2007(atzB)
DSH: Dshi_2773
PGD: Gal_01214
OTM: OSB_09020
LAQU: R2C4_11435
CID: P73_1526
MALG: MALG_00850
MALU: KU6B_37500
RCP: RCAP_rcc00875(atzB)
PDE: Pden_3916
RSU: NHU_03176
RHC: RGUI_0690
PAMO: BAR1_11295
SECH: B18_07175
ALB: AEB_P2978
GOH: B932_2939
GDI: GDI1732(guaD)
GDJ: Gdia_3513
ASZ: ASN_2833
GGH: GHH_c21590(atzB)
PSAB: PSAB_07415
CBK: CLL_A0628
CBT: CLH_0589
CBE: Cbei_2067
CBZ: Cbs_2067
CBEI: LF65_02233
CTYK: CTK_C13900
OVA: OBV_20370
CAD: Curi_c04060(atzB)
MUL: MUL_2914
MMI: MMAR_2844
MPSE: MPSD_29320
MSHO: MSHO_42560
MAB: MAB_2927c
MABB: MASS_2862
MCHE: BB28_14745
MSTE: MSTE_02896
ASD: AS9A_4193
NFA: NFA_52410
NSR: NS506_04280(mtaD)
RHA: RHA1_ro04508(atzB)
RER: RER_21130
REY: O5Y_10085
ROP: ROP_44280
RHB: NY08_3486
GBR: Gbro_1810
SCO: SCO6213(SC9G1.03)
SALB: XNR_0632
SGR: SGR_1307
SGB: WQO_28735
SHY: SHJG_7273
SMAL: SMALA_6026
SCT: SCAT_4780
SFA: Sfla_1050
SBH: SBI_02949
SVE: SVEN_6095
SALS: SLNWT_0614
STRP: F750_5795
SFI: SFUL_6173
STRM: M444_27200
SPRI: SPRI_1550
SLE: sle_14660(sle_14660)
STRD: NI25_08280
SLAU: SLA_6163
SALF: SMD44_06846(atzB)
SALJ: SMD11_1430(atzB)
SFK: KY5_6546
SRJ: SRO_1625
KSK: KSE_63350
ART: Arth_3425
ACH: Achl_3205
IDO: I598_1220
BLIN: BLSMQ_0075
NCA: Noca_1626
NDA: Ndas_2226
NAL: B005_4596
SRO: Sros_2776
TBI: Tbis_1336
FAL: FRAAL1474
NML: Namu_0260
GOB: Gobs_0197
MMAR: MODMU_0210
KRA: Krad_4281
SEN: SACE_1262(atzB)
AMD: AMED_1921
AMN: RAM_09745
AMM: AMES_1906
AMZ: B737_1907
AOI: AORI_5954(atzB)
AMQ: AMETH_1597(atzB)
AMYY: YIM_11200
AORI: SD37_29180
PDX: Psed_1761
PSEA: WY02_01200
PSEE: FRP1_13140
PSEH: XF36_09365
SESP: BN6_30000
KAL: KALB_4510
ALO: CRK55969
ACTN: L083_6155
AFS: AFR_31530
CAI: Caci_4734
SNA: Snas_2541
RXY: Rxyl_2838
ATM: ANT_01210
BRM: Bmur_2304
BPW: WESB_0501
BIP: Bint_0846
THYD: TTHT_1384(atzB)
TME: Tmel_1728
TAF: THA_25
THER: Y592_00075
PMO: Pmob_1736
MARN: LN42_05260
KOL: Kole_2066
ASAC: ATHSA_0581
CEX: CSE_02290
 » show all
Reference
1  [PMID:20088583]
  Authors
Hall RS, Fedorov AA, Marti-Arbona R, Fedorov EV, Kolb P, Sauder JM, Burley SK, Shoichet BK, Almo SC, Raushel FM
  Title
The hunt for 8-oxoguanine deaminase.
  Journal
J Am Chem Soc 132:1762-3 (2010)
DOI:10.1021/ja909817d
  Sequence
[pae:PA0142]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.32
IUBMB Enzyme Nomenclature: 3.5.4.32
ExPASy - ENZYME nomenclature database: 3.5.4.32
BRENDA, the Enzyme Database: 3.5.4.32

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