| Entry |
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| Name |
double-stranded RNA adenine deaminase;
ADAR;
double-stranded RNA adenosine deaminase;
dsRAD;
dsRNA adenosine deaminase;
DRADA1;
double-stranded RNA-specific adenosine deaminase
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
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| Sysname |
double-stranded RNA adenine aminohydrolase
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| Reaction(IUBMB) |
adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3
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| Substrate |
adenine in double-stranded RNA;
H2O [CPD: C00001]
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| Product |
hypoxanthine in double-stranded RNA;
NH3 [CPD: C00014]
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| Comment |
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].
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| History |
EC 3.5.4.37 created 2013
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| Orthology |
| K12968 | double-stranded RNA-specific adenosine deaminase |
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| Genes |
» show all
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| Reference |
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| Authors |
Hough RF, Bass BL |
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| Title |
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase. |
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| Journal |
J Biol Chem 269:9933-9 (1994) |
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| Reference |
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| Authors |
O'Connell MA, Gerber A, Keegan LP |
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| Title |
Purification of native and recombinant double-stranded RNA-specific adenosine deaminases. |
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| Journal |
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| Reference |
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| Authors |
Wong SK, Sato S, Lazinski DW |
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| Title |
Substrate recognition by ADAR1 and ADAR2. |
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| Journal |
RNA 7:846-58 (2001) |
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| Reference |
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| Authors |
Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL |
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| Title |
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.5.4.37 |
| ExPASy - ENZYME nomenclature database: | 3.5.4.37 |
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