KEGG   ENZYME: 3.5.4.37
Entry
EC 3.5.4.37                 Enzyme                                 
Name
double-stranded RNA adenine deaminase;
ADAR;
double-stranded RNA adenosine deaminase;
dsRAD;
dsRNA adenosine deaminase;
DRADA1;
double-stranded RNA-specific adenosine deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
double-stranded RNA adenine aminohydrolase
Reaction(IUBMB)
adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3 [RN:R13080]
Reaction(KEGG)
R13080
Substrate
adenine in double-stranded RNA [CPD:C22573];
H2O [CPD:C00001]
Product
hypoxanthine in double-stranded RNA [CPD:C22574];
NH3 [CPD:C00014]
Comment
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].
History
EC 3.5.4.37 created 2013
Orthology
K12968  double-stranded RNA-specific adenosine deaminase
Genes
HSA103(ADAR)
PTR457349(ADAR)
PPS100988581(ADAR)
GGO101134621(ADAR)
PON100457633(ADAR)
PPYG129018647(ADAR)
NLE100607902(ADAR)
HMH116469353(ADAR)
SSYN134733910(ADAR)
MCC718759(ADAR)
MCF101926284(ADAR)
MTHB126932999
MNI105497976(ADAR)
CSAB103223917(ADAR)
CATY105593498(ADAR)
PANU101026850(ADAR)
TGE112618205(ADAR)
MLEU105544819(ADAR)
RRO104663489(ADAR)
TFN117075904(ADAR)
PTEH111543727(ADAR)
CANG105502009(ADAR)
CJC100386367(ADAR)
SBQ101031414(ADAR)
CIMI108292456(ADAR)
ANAN105733713(ADAR)
CSYR103250006(ADAR)
MMUR105873198(ADAR)
LCAT123634032(ADAR)
PCOQ105821977(ADAR)
OGA100941374(ADAR)
MMU56417(Adar)
MCAL110291799(Adar)
MPAH110320021(Adar)
RNO81635(Adar)
MCOC116093186(Adar)
ANU117706678(Adar)
ASYL127683085(Adar)
MUN110562048(Adar)
CGE100760578(Adar)
MAUA101842183(Adar)
PROB127233035(Adar)
PLEU114707958(Adar)
MORG121450554(Adar)
MFOT126516145
AAMP119800877(Adar)
NGI103751329(Adar)
HGL101722209(Adar)
CPOC100731315(Adar)
CCAN109688036(Adar)
DORD105984887(Adar)
DSP122109246(Adar)
DMER138821490(Adar)
PLOP125360248(Adar)
NCAR124983355
MMMA107156744(Adar)
ITI101960499(Adar)
OCU100346984
OPI101527981(ADAR)
TUP102485185(ADAR)
GVR103608124(ADAR)
CFA100855668(ADAR)
CLUD112648962(ADAR)
VVP112918890(ADAR)
VLG121484976(ADAR)
NPO129509119(ADAR)
AML100470274(ADAR)
UMR103668714(ADAR)
UAH113245303(ADAR)
UAR123783391(ADAR)
ELK111138988
LLV125086092
MPUF101675332(ADAR)
MNP132025929(ADAR)
MLK131815090(ADAR)
NVS122918238(ADAR)
ORO101367365(ADAR)
EJU114198712(ADAR)
ZCA113932110(ADAR)
MLX118013854(ADAR)
NSU110573575(ADAR)
LWW102742882(ADAR)
FCA101084681(ADAR)
PYU121015666(ADAR)
PCOO112851718(ADAR)
PBG122476118(ADAR)
PVIV125154926(ADAR)
LRUF124521676
LGF123586706(ADAR)
AJU106988378
PPAD109256299(ADAR)
PUC125925735
PLEZ122211424(ADAR)
HHV120221535(ADAR)
BTA505134(ADAR)
BOM102267031(ADAR)
BBUB102413801(ADAR)
BBIS104987431(ADAR)
CHX102172585(ADAR)
BTAX128044728(ADAR)
CSUM138071397(ADAR)
ODA120855758(ADAR)
CCAD122432929(ADAR)
MREE136145095(ADAR)
OVR110133449(ADAR)
MBEZ129540595(ADAR)
SSC100523784(ADAR)
CFR102512737(ADAR)
CBAI105068180(ADAR)
CDK105089080(ADAR)
VPC102527263(ADAR)
BACU103018582(ADAR)
BMUS118896082(ADAR)
LVE103077270(ADAR)
OOR101278697(ADAR)
GMF115844747(ADAR)
DLE111166955(ADAR)
PCAD102979811(ADAR)
PSIU116750910(ADAR)
PPHC136137501(ADAR)
NASI112401692(ADAR)
ECB100056984(ADAR)
EPZ103555415(ADAR)
EAI106828524(ADAR)
MYB102242753(ADAR)
MYD102754391(ADAR)
MMYO118672760(ADAR)
MLF102433169(ADAR)
MDT132221115(ADAR)
MYUM138995937(ADAR)
PKL118721102(ADAR)
EFUS103298918(ADAR)
MNA107543857(ADAR)
DRO112316695(ADAR)
SHON118990185(ADAR)
AJM119061768(ADAR)
PDIC114488810(ADAR)
PHAS123804313(ADAR)
MMF118637050(ADAR)
PPAM129062342(ADAR)
RFQ117014567(ADAR)
PGIG120592241(ADAR)
PVP105296385(ADAR)
RAY107504718(ADAR)
MJV108393907(ADAR)
TOD119237217(ADAR)
SARA101553112(ADAR)
SFUM130032063(ADAR)
SETR126020695(ADAR)
TMU101360020
ETF101662936(ADAR)
DNM101424153(ADAR)
MDO100020840(ADAR)
GAS123247778(ADAR)
SHR100925968(ADAR)
AFZ127559850
PCW110211972(ADAR)
TVP118847489(ADAR)
PBRV138153636(ADAR)
MLAO141513501(ADAR)
OAA103167888(ADAR)
TACU119947360(ADAR)
GGA769675(ADAR)
PCOC116237321(ADAR)
MGP100541796(ADAR)
CJO107324489(ADAR)
TPAI128076609(ADAR)
LMUT125685837(ADAR)
NMEL110391260(ADAR)
APLA101796198(ADAR)
ACYG106048529(ADAR)
CATA118258445(ADAR)
AFUL116499616(ADAR)
TGU100220215(ADAR)
LSR110471526(ADAR)
SCAN103823962(ADAR)
PMOA120498974(ADAR)
OTC121332158(ADAR)
PRUF121352167(ADAR)
ATRC139605462(ADAR)
GFR102033970(ADAR)
FAB101806137(ADAR)
OMA130263191(ADAR)
PHI102105960(ADAR)
PMAJ107214561(ADAR)
CCAE111939463(ADAR)
CBRC103611252(ADAR)
ACOE138098734(ADAR)
ETL114068438(ADAR)
ZAB102064605(ADAR)
ZLE135457738(ADAR)
ACHL103811943(ADAR)
SVG106863375(ADAR)
MMEA130583192(ADAR)
HRT120764250(ADAR)
SATI136373030(ADAR)
CCIC134055056(ADAR)
FPG101910869(ADAR)
FCH102049629(ADAR)
CCRI104166054(ADAR)
NNT104404326(ADAR)
SHAB115602570(ADAR)
ACUN113490858(ADAR)
TALA104365296(ADAR)
ACHC115346426(ADAR)
HALD104311025(ADAR)
HLE104829655(ADAR)
AGEN126040778
HHAR128145382(ADAR)
GCL127026987
LDI104354195(ADAR)
MNB103776625
AVIT104271810
BRHI104500550(ADAR)
EGZ104127874(ADAR)
NNI104012041(ADAR)
PCRI104032628(ADAR)
PCAO104044916(ADAR)
PADL103920515(ADAR)
AFOR103905523(ADAR)
FGA104082798(ADAR)
GSTE104263802(ADAR)
CBOY140644107(ADAR)
CLV102086506(ADAR)
CNIC135999989(ADAR)
PGUU104465650
PLET104614193(ADAR)
EHS104507280
CMAC104481405(ADAR)
CUCA104058107(ADAR)
TEO104370056(ADAR)
BREG104629637(ADAR)
OHA104338094(ADAR)
ACAR104532166
CPEA104390604(ADAR)
CVF104290841(ADAR)
RTD128900922(ADAR)
CRID134525838(ADAR)
AAM106483717(ADAR)
AROW112973224(ADAR)
NPD112955220(ADAR)
TGT104578290(ADAR)
DNE112995108(ADAR)
SCAM104141639(ADAR)
ASN102377665(ADAR)
AMJ102575445(ADAR)
CPOO109324760(ADAR)
GGN109303498(ADAR)
PSS102449470(ADAR)
CMY102941128(ADAR)
CCAY125625912(ADAR)
DCC119847935(ADAR)
CPIC101936755(ADAR)
TST117888546(ADAR)
CABI116830121(ADAR)
MRV120390168(ADAR)
ACS103281753
ASAO132764090(ADAR)
PVT110081003(ADAR)
SUND121915309(ADAR)
PBI103050667(ADAR)
PMUR107285169(ADAR)
CTIG120317049(ADAR)
TSR106546970(ADAR)
PGUT117657417(ADAR)
PCAE139322346(ADAR)
APRI131186639(ADAR)
PTEX113452865 113452866 113452867 113452869
VKO123032540(ADAR)
PMUA114586089(ADAR)
PRAF128404468(ADAR)
ZVI118075835(ADAR)
HCG128336966(ADAR)
GJA107117082(ADAR)
EMC129340054(ADAR)
XLA394279(adar-a) 397992(adar.S)
XTR100493195(adar)
NPR108798342(ADAR)
RTEM120920674(ADAR)
ACAT141116794(ADAR)
BBUF120981415(ADAR)
BGAR122921756(ADAR)
DTC141082849(ADAR)
PWL138268501(ADAR) 138303493
MUO115456983(ADAR)
GSH117350477(ADAR)
DRE58119(adar)
SRX107714681 107723499
SANH107657642
SGH107582078
CCAR109069003
CAUA113059109 113116748
CGIB127974704 128030703
PTET122359966(adar)
LROH127178907(adar)
GRF141342294(adar)
OMC131521259(adar)
PPRM120484300(adar)
RKG130101759(adar)
MAMB125242935(adar)
CIDE127497916
CERY137035762(adar)
MASI127452888 127453546
TROS130557837(adar)
TDW130432719(adar)
MANU129447957(adar)
PDAB135743349(adar)
IPU108265537
IFU128606893(adar)
PHYP113545404(adar)
SMEO124384211(adar)
TFD113646833(adar)
TVC132846196(adar)
CGAR128520099(adar)
NGRA132886596(adar)
TRN134310348(adar)
AMEX103023414(adar)
CMAO118823416(adar)
EEE113591712(adar)
CHAR105891921(adar)
SPIL134083035(adar)
TRU101073967(adar)
TFS130532486(adar)
LCO104922500(adar)
NCC104958853(adar)
TBEN117480134(adar)
CGOB115020800(adar)
PGEO117460355(adar)
GACU117553954(adar)
EMAC134861645(adar)
ELY117265724(adar)
EFO125892828(adar)
PLEP121945375(adar)
SLUC116049564(adar)
ECRA117946697(adar)
ESP116690802(adar)
PFLV114556855(adar)
GAT120810483(adar)
PPUG119197717(adar)
AFB129108995(adar)
CLUM117745058(adar)
PSWI130212778(adar)
CANA137780894(adar)
CVE137891225(adar)
MSAM119897576(adar)
SCHU122882168(adar)
CUD121513229(adar)
SPUL138584441(adar)
LMIX132983900(adar)
ALAT119005863(adar)
ASTR137601185(adar)
MZE101475397(adar)
ONL100707103(adar)
OAU116315701(adar)
OLA101155879(adar)
OML112143394(adar)
CSAI133432394(adar)
XMA102217978(adar)
XCO114141750(adar)
XHE116717193(adar)
PRET103478179(adar)
PFOR103140790(adar)
PLAI106962090(adar)
PMEI106930146(adar)
GAF122830951(adar)
PPRL129371300(adar)
CVG107088416(adar)
CTUL119786711(adar)
GMU124866009(adar)
NFU107374479(adar)
KMR108241070(adar)
ALIM106517188(adar)
NWH119409734(adar) 119410066
AOCE111582754(adar)
EJA138194193(adar)
BFRE138619436(adar)
MCEP125016365(adaR)
CSEM103388211(adar)
POV109633429(adar)
SSEN122774816(adar)
SSOE131471011(adar)
HHIP117776470(adar)
HSP118113545(adar)
PPLT128449023(adar)
SMAU118301480(adar)
LCF108885934
SDU111230122(adar)
SLAL111656978(adar)
XGL120784244(adar)
HCQ109521078(adar)
SSCV125975343(adar)
SBIA133500882(adar)
PEE133401320(adar)
PTAO133479566(adar)
BPEC110162987
ENY140373496 140373653
MALB109964118(adar)
BSPL114843501(adar)
SJO128366442(adar)
SSCO133983514(adar)
GMH115553616(adar)
SASA106605901(adar)
STRU115177204 115177266
OTW112238065 112238838
OMY110520838(adar) 110534250
OGO123998210 124005167
ONE115124133
OKI109866698 116376524
OKE118373734 118373735(adar)
OMM135520708 135521797
OCLA139388283 139420983
SALP112075075
SNH120042113 120048755
CCLU121542729(adar)
ELS105024448(adar)
OEP134023685(adar)
SFM108925759(adar)
PKI111840888(adar)
AANG118224938(adar)
AROT135265172(adar)
CCOG133130682(adar)
PSPA121306932(adar)
PSEX120535574(adar)
LCM102360746(ADAR)
RTP109912767(adar)
CPLA122544712(adar)
HOC132805587(adar)
LERI129715307(adar)
HAKA140735769(adar)
PMRN116950849(ADAR) 116954936
LRJ133344079 133354150 133361043
CIN100183336
RSAN119405262
RMP119180667
VJA111272658
GOE100908780
ABRU129956562
UDV129217469
SDM118189760
CELCELE_T20H4.4(adr-2)
CRQGCK72_008630
PVUL126824549
LSAX138970652
CRG105330468 105341503
CANU128176028 128176031
CVN111130123
OED125649394
PMAX117334379
AIRR138333596 138333597 138333598 138333601
MMER123531101
RPHI132722439 132754534
DPOL127856227
MAEA128232125
LJP135468418 135479773
NVE5508360
ATEN116286315
MFOO137972195
HSY130656587
MISMICPUN_105848
 » show all
Reference
1  [PMID:8144588]
  Authors
Hough RF, Bass BL
  Title
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase.
  Journal
J Biol Chem 269:9933-9 (1994)
Reference
2  [PMID:9614652]
  Authors
O'Connell MA, Gerber A, Keegan LP
  Title
Purification of native and recombinant double-stranded RNA-specific adenosine deaminases.
  Journal
Methods 15:51-62 (1998)
DOI:10.1006/meth.1998.0605
Reference
3  [PMID:11421361]
  Authors
Wong SK, Sato S, Lazinski DW
  Title
Substrate recognition by ADAR1 and ADAR2.
  Journal
RNA 7:846-58 (2001)
DOI:10.1017/s135583820101007x
Reference
4  [PMID:16141067]
  Authors
Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL
  Title
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
  Journal
Science 309:1534-9 (2005)
DOI:10.1126/science.1113150
  Sequence
[hsa:104]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.37
IUBMB Enzyme Nomenclature: 3.5.4.37
ExPASy - ENZYME nomenclature database: 3.5.4.37
BRENDA, the Enzyme Database: 3.5.4.37

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