KEGG   ENZYME: 3.5.4.37
Entry
EC 3.5.4.37                 Enzyme                                 

Name
double-stranded RNA adenine deaminase;
ADAR;
double-stranded RNA adenosine deaminase;
dsRAD;
dsRNA adenosine deaminase;
DRADA1;
double-stranded RNA-specific adenosine deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
double-stranded RNA adenine aminohydrolase
Reaction(IUBMB)
adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3
Substrate
adenine in double-stranded RNA;
H2O [CPD:C00001]
Product
hypoxanthine in double-stranded RNA;
NH3 [CPD:C00014]
Comment
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].
History
EC 3.5.4.37 created 2013
Orthology
K12968  double-stranded RNA-specific adenosine deaminase
Genes
HSA: 103(ADAR)
PTR: 457349(ADAR)
PPS: 100988581(ADAR)
GGO: 101134621(ADAR)
PON: 100457633(ADAR)
NLE: 100607902(ADAR)
MCC: 718759(ADAR)
MCF: 101926284(ADAR)
CSAB: 103223917(ADAR)
CATY: 105593498(ADAR)
PANU: 101026850(ADAR)
RRO: 104663489(ADAR)
TFN: 117075904(ADAR)
PTEH: 111543727(ADAR)
CJC: 100386367(ADAR)
SBQ: 101031414(ADAR)
MMUR: 105873198(ADAR)
MMU: 56417(Adar)
MCAL: 110291799(Adar)
MPAH: 110320021(Adar)
RNO: 81635(Adar)
MCOC: 116093186(Adar)
MUN: 110562048(Adar)
CGE: 100760578(Adar)
PLEU: 114707958(Adar)
NGI: 103751329(Adar)
HGL: 101722209(Adar)
CCAN: 109688036(Adar)
OCU: 100346984(ADAR)
TUP: 102485185(ADAR)
CFA: 100855668(ADAR)
VVP: 112918890(ADAR)
VLG: 121484976(ADAR)
AML: 100470274(ADAR)
UMR: 103668714(ADAR)
UAH: 113245303(ADAR)
ORO: 101367365(ADAR)
ELK: 111138988
MPUF: 101675332(ADAR)
EJU: 114198712(ADAR)
MLX: 118013854(ADAR)
FCA: 101084681(ADAR)
PPAD: 109256299(ADAR)
AJU: 106988378(ADAR)
HHV: 120221535(ADAR)
BTA: 505134(ADAR)
BOM: 102267031(ADAR)
BBUB: 102413801(ADAR)
CHX: 102172585(ADAR)
ODA: 120855758(ADAR)
SSC: 100523784(ADAR)
CFR: 102512737(ADAR)
CBAI: 105068180(ADAR)
CDK: 105089080(ADAR)
BACU: 103018582(ADAR)
LVE: 103077270(ADAR)
OOR: 101278697(ADAR)
DLE: 111166955(ADAR)
PCAD: 102979811(ADAR)
ECB: 100056984(ADAR)
EPZ: 103555415(ADAR)
EAI: 106828524(ADAR)
MYB: 102242753(ADAR)
MYD: 102754391(ADAR)
MMYO: 118672760(ADAR)
MNA: 107543857(ADAR)
DRO: 112316695(ADAR)
SHON: 118990185(ADAR)
AJM: 119061768(ADAR)
MMF: 118637050(ADAR)
PGIG: 120592241(ADAR)
RAY: 107504718(ADAR)
MJV: 108393907(ADAR)
TOD: 119237217(ADAR)
TMU: 101360020
MDO: 100020840(ADAR)
SHR: 100925968(ADAR)
PCW: 110211972(ADAR)
OAA: 103167888(ADAR)
GGA: 769675(ADAR)
PCOC: 116237321(ADAR)
MGP: 100541796(ADAR)
CJO: 107324489(ADAR)
NMEL: 110391260(ADAR)
APLA: 101796198(ADAR)
ACYG: 106048529(ADAR)
TGU: 100220215(ADAR)
LSR: 110471526(ADAR)
SCAN: 103823962(ADAR)
PMOA: 120498974(ADAR)
GFR: 102033970(ADAR)
FAB: 101806137(ADAR)
PHI: 102105960(ADAR)
PMAJ: 107214561(ADAR)
CCAE: 111939463(ADAR)
ETL: 114068438(ADAR)
FPG: 101910869(ADAR)
FCH: 102049629(ADAR)
CLV: 102086506(ADAR)
EGZ: 104127874(ADAR)
NNI: 104012041(ADAR)
ACUN: 113490858(ADAR)
PADL: 103920515(ADAR)
AAM: 106483717(ADAR)
ASN: 102377665(ADAR)
AMJ: 102575445(ADAR)
CPOO: 109324760(ADAR)
GGN: 109303498(ADAR)
PSS: 102449470(ADAR)
CMY: 102941128(ADAR)
CPIC: 101936755(ADAR)
TST: 117888546(ADAR)
CABI: 116830121(ADAR)
ACS: 103281753
PVT: 110081003(ADAR)
PBI: 103050667(ADAR)
PMUR: 107285169(ADAR)
TSR: 106546970(ADAR)
PGUT: 117657417(ADAR)
PMUA: 114586089(ADAR)
ZVI: 118075835(ADAR)
GJA: 107117082(ADAR)
XLA: 394279(adar-a) 397992(adar.S)
XTR: 100493195(adar)
NPR: 108798342(ADAR)
DRE: 58119(adar)
SANH: 107657642
SGH: 107582078
CCAR: 109069003
IPU: 108265537(adar)
PHYP: 113545404(adar)
AMEX: 103023414(adar)
EEE: 113591712(adar)
TRU: 101073967(adar)
LCO: 104922500(adar)
NCC: 104958853(adar)
CGOB: 115020800(adar)
ELY: 117265724(adar)
PLEP: 121945375(adar)
SLUC: 116049564(adar)
ECRA: 117946697(adar)
PFLV: 114556855(adar)
GAT: 120810483(adar)
MSAM: 119897576(adar)
CUD: 121513229(adar)
MZE: 101475397(adar)
ONL: 100707103(adar)
OAU: 116315701(adar)
OLA: 101155879(adar)
OML: 112143394(adar)
XMA: 102217978(adar)
XCO: 114141750(adar)
XHE: 116717193(adar)
PRET: 103478179(adar)
CVG: 107088416(adar)
CTUL: 119786711(adar)
NFU: 107374479(adar)
KMR: 108241070(adar)
ALIM: 106517188(adar)
AOCE: 111582754(adar)
CSEM: 103388211(adar)
POV: 109633429(adar)
LCF: 108885934(adar)
SDU: 111230122(adar)
SLAL: 111656978(adar)
XGL: 120784244(adar)
HCQ: 109521078(adar)
BPEC: 110162987
MALB: 109964118(adar)
SASA: 106605901(adar)
OMY: 110520838(adar) 110534250
SALP: 112075075
ELS: 105024448(adar)
SFM: 108925759(adar)
PKI: 111840888(adar)
AANG: 118224938(adar)
PSPA: 121306932(adar)
LCM: 102360746(ADAR)
RTP: 109912767(adar)
CIN: 100183336
SPU: 584058
RSAN: 119405262
RMP: 119180667
VJA: 111272658
SDM: 118189760
CEL: CELE_T20H4.4(adr-2)
CBR: CBG24155(Cbr-adr-2)
BGT: 106055960
GAE: 121368013
PMAX: 117334379
NVE: 5508360
ATEN: 116286315
 » show all
Reference
1  [PMID:8144588]
  Authors
Hough RF, Bass BL
  Title
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase.
  Journal
J Biol Chem 269:9933-9 (1994)
Reference
2  [PMID:9614652]
  Authors
O'Connell MA, Gerber A, Keegan LP
  Title
Purification of native and recombinant double-stranded RNA-specific adenosine deaminases.
  Journal
Methods 15:51-62 (1998)
DOI:10.1006/meth.1998.0605
Reference
3  [PMID:11421361]
  Authors
Wong SK, Sato S, Lazinski DW
  Title
Substrate recognition by ADAR1 and ADAR2.
  Journal
RNA 7:846-58 (2001)
DOI:10.1017/s135583820101007x
Reference
4  [PMID:16141067]
  Authors
Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL
  Title
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
  Journal
Science 309:1534-9 (2005)
DOI:10.1126/science.1113150
  Sequence
[hsa:104]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.37
IUBMB Enzyme Nomenclature: 3.5.4.37
ExPASy - ENZYME nomenclature database: 3.5.4.37
BRENDA, the Enzyme Database: 3.5.4.37

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