KEGG ENZYME: 3.5.4.37

ENZYME: 3.5.4.37

Entry

EC 3.5.4.37                 Enzyme

Name

double-stranded RNA adenine deaminase;
ADAR;
double-stranded RNA adenosine deaminase;
dsRAD;
dsRNA adenosine deaminase;
DRADA1;
double-stranded RNA-specific adenosine deaminase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines

Sysname

double-stranded RNA adenine aminohydrolase

Reaction(IUBMB)

adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3

Substrate

adenine in double-stranded RNA;
H2O [CPD:C00001]

Product

hypoxanthine in double-stranded RNA;
NH3 [CPD:C00014]

Comment

This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].

History

EC 3.5.4.37 created 2013

Orthology

K12968

double-stranded RNA-specific adenosine deaminase

Genes

HSA:

103(ADAR)

PTR:	457349(ADAR)

PPS:	100988581(ADAR)

GGO:	101134621(ADAR)

PON:	100457633(ADAR)

NLE:	100607902(ADAR)

MCC:	718759(ADAR)

MCF:	101926284(ADAR)

CSAB:

103223917(ADAR)

CATY:

105593498(ADAR)

PANU:

101026850(ADAR)

TGE:	112618205(ADAR)

RRO:	104663489(ADAR)

TFN:	117075904(ADAR)

PTEH:

111543727(ADAR)

CJC:	100386367(ADAR)

SBQ:	101031414(ADAR)

CSYR:

103250006(ADAR)

MMUR:

105873198(ADAR)

LCAT:

123634032(ADAR)

OGA:	100941374(ADAR)

MMU:	56417(Adar)

MCAL:

110291799(Adar)

MPAH:

110320021(Adar)

RNO:	81635(Adar)

MCOC:

116093186(Adar)

MUN:	110562048(Adar)

CGE:	100760578(Adar)

MAUA:

101842183(Adar)

PLEU:

114707958(Adar)

MORG:

121450554(Adar)

AAMP:

119800877(Adar)

NGI:	103751329(Adar)

HGL:	101722209(Adar)

CPOC:

100731315(Adar)

CCAN:

109688036(Adar)

DORD:

105984887(Adar)

DSP:	122109246(Adar)

NCAR:

124983355

OCU:	100346984(ADAR)

OPI:	101527981(ADAR)

TUP:	102485185(ADAR)

CFA:	100855668(ADAR)

CLUD:

112648962(ADAR)

VVP:	112918890(ADAR)

VLG:	121484976(ADAR)

AML:	100470274(ADAR)

UMR:	103668714(ADAR)

UAH:	113245303(ADAR)

UAR:	123783391(ADAR)

ELK:

111138988

LLV:

125086092

MPUF:

101675332(ADAR)

ORO:	101367365(ADAR)

EJU:	114198712(ADAR)

ZCA:	113932110(ADAR)

MLX:	118013854(ADAR)

FCA:	101084681(ADAR)

PYU:	121015666(ADAR)

PBG:	122476118(ADAR)

PPAD:

109256299(ADAR)

AJU:	106988378(ADAR)

HHV:	120221535(ADAR)

BTA:	505134(ADAR)

BOM:	102267031(ADAR)

BBUB:

102413801(ADAR)

CHX:	102172585(ADAR)

ODA:	120855758(ADAR)

CCAD:

122432929(ADAR)

SSC:	100523784(ADAR)

CFR:	102512737(ADAR)

CBAI:

105068180(ADAR)

CDK:	105089080(ADAR)

VPC:	102527263(ADAR)

BACU:

103018582(ADAR)

LVE:	103077270(ADAR)

OOR:	101278697(ADAR)

DLE:	111166955(ADAR)

PCAD:

102979811(ADAR)

PSIU:

116750910(ADAR)

ECB:	100056984(ADAR)

EPZ:	103555415(ADAR)

EAI:	106828524(ADAR)

MYB:	102242753(ADAR)

MYD:	102754391(ADAR)

MMYO:

118672760(ADAR)

MLF:	102433169(ADAR)

MNA:	107543857(ADAR)

PKL:	118721102(ADAR)

DRO:	112316695(ADAR)

SHON:

118990185(ADAR)

AJM:	119061768(ADAR)

PDIC:

114488810(ADAR)

PHAS:

123804313(ADAR)

MMF:	118637050(ADAR)

RFQ:	117014567(ADAR)

PGIG:

120592241(ADAR)

PVP:	105296385(ADAR)

RAY:	107504718(ADAR)

MJV:	108393907(ADAR)

TOD:	119237217(ADAR)

SARA:

101553112(ADAR)

TMU:

101360020

DNM:	101424153(ADAR)

MDO:	100020840(ADAR)

GAS:	123247778(ADAR)

SHR:	100925968(ADAR)

PCW:	110211972(ADAR)

OAA:	103167888(ADAR)

GGA:	769675(ADAR)

PCOC:

116237321(ADAR)

MGP:	100541796(ADAR)

CJO:	107324489(ADAR)

NMEL:

110391260(ADAR)

APLA:

101796198(ADAR)

ACYG:

106048529(ADAR)

AFUL:

116499616(ADAR)

TGU:	100220215(ADAR)

LSR:	110471526(ADAR)

SCAN:

103823962(ADAR)

PMOA:

120498974(ADAR)

OTC:	121332158(ADAR)

PRUF:

121352167(ADAR)

GFR:	102033970(ADAR)

FAB:	101806137(ADAR)

PHI:	102105960(ADAR)

PMAJ:

107214561(ADAR)

CCAE:

111939463(ADAR)

CBRC:

103611252(ADAR)

ETL:	114068438(ADAR)

ZAB:	102064605(ADAR)

FPG:	101910869(ADAR)

FCH:	102049629(ADAR)

CLV:	102086506(ADAR)

EGZ:	104127874(ADAR)

NNI:	104012041(ADAR)

PLET:

104614193(ADAR)

PCRI:

104032628(ADAR)

ACUN:

113490858(ADAR)

TALA:

104365296(ADAR)

PADL:

103920515(ADAR)

ACHC:

115346426(ADAR)

HALD:

104311025(ADAR)

CCRI:

104166054(ADAR)

EHS:

104507280

CMAC:

104481405(ADAR)

FGA:	104082798(ADAR)

GSTE:

104263802(ADAR)

LDI:	104354195(ADAR)

MNB:

103776625

OHA:	104338094(ADAR)

AAM:	106483717(ADAR)

AROW:

112973224(ADAR)

NPD:	112955220(ADAR)

DNE:	112995108(ADAR)

ASN:	102377665(ADAR)

AMJ:	102575445(ADAR)

CPOO:

109324760(ADAR)

GGN:	109303498(ADAR)

PSS:	102449470(ADAR)

CMY:	102941128(ADAR)

CPIC:

101936755(ADAR)

TST:	117888546(ADAR)

CABI:

116830121(ADAR)

MRV:	120390168(ADAR)

ACS:

103281753

PVT:	110081003(ADAR)

SUND:

121915309(ADAR)

PBI:	103050667(ADAR)

PMUR:

107285169(ADAR)

TSR:	106546970(ADAR)

PGUT:

117657417(ADAR)

VKO:	123032540(ADAR)

PMUA:

114586089(ADAR)

ZVI:	118075835(ADAR)

GJA:	107117082(ADAR)

XLA:	394279(adar-a) 397992(adar.S)

XTR:	100493195(adar)

NPR:	108798342(ADAR)

RTEM:

120920674(ADAR)

BBUF:

120981415(ADAR)

BGAR:

122921756(ADAR)

DRE:	58119(adar)

SRX:	107714681 107723499

SANH:

107657642

SGH:

107582078

CCAR:

109069003

CAUA:

113059109 113116748

PPRM:

120484300(adar)

MAMB:

125242935(adar)

IPU:	108265537(adar)

PHYP:

113545404(adar)

SMEO:

124384211(adar)

TFD:	113646833(adar)

AMEX:

103023414(adar)

EEE:	113591712(adar)

TRU:	101073967(adar)

LCO:	104922500(adar)

NCC:	104958853(adar)

CGOB:

115020800(adar)

ELY:	117265724(adar)

EFO:	125892828(adar)

PLEP:

121945375(adar)

SLUC:

116049564(adar)

ECRA:

117946697(adar)

PFLV:

114556855(adar)

GAT:	120810483(adar)

PPUG:

119197717(adar)

MSAM:

119897576(adar)

CUD:	121513229(adar)

ALAT:

119005863(adar)

MZE:	101475397(adar)

ONL:	100707103(adar)

OAU:	116315701(adar)

OLA:	101155879(adar)

OML:	112143394(adar)

XMA:	102217978(adar)

XCO:	114141750(adar)

XHE:	116717193(adar)

PRET:

103478179(adar)

PFOR:

103140790(adar)

PLAI:

106962090(adar)

PMEI:

106930146(adar)

GAF:	122830951(adar)

CVG:	107088416(adar)

CTUL:

119786711(adar)

GMU:	124866009(adar)

NFU:	107374479(adar)

KMR:	108241070(adar)

ALIM:

106517188(adar)

NWH:	119409734(adar) 119410066

AOCE:

111582754(adar)

MCEP:

125016365(adar)

CSEM:

103388211(adar)

POV:	109633429(adar)

SSEN:

122774816(adar)

HHIP:

117776470(adar)

HSP:	118113545(adar)

LCF:	108885934(adar)

SDU:	111230122(adar)

SLAL:

111656978(adar)

XGL:	120784244(adar)

HCQ:	109521078(adar)

BPEC:

110162987

MALB:

109964118(adar)

BSPL:

114843501(adar)

SASA:

106605901(adar)

OTW:	112238065 112238838

OMY:	110520838(adar) 110534250

OGO:	123998210 124005167

ONE:

115124133

SALP:

112075075

SNH:	120042113 120048755

CCLU:

121542729(adar)

ELS:	105024448(adar)

SFM:	108925759(adar)

PKI:	111840888(adar)

AANG:

118224938(adar)

PSPA:

121306932(adar)

LCM:	102360746(ADAR)

RTP:	109912767(adar)

BBEL:

109468498

CIN:

100183336

SPU:

584058

PCLA:

123770612

RSAN:

119405262

RMP:

119180667

VJA:

111272658

SDM:

118189760

CEL:	CELE_T20H4.4(adr-2)

CRG:	105330468 105341503

PMAX:

117334379

MMER:

123531101

NVE:

5508360

ATEN:

116286315

MIS:	MICPUN_105848

» show all

Reference

1 [PMID:8144588]

Authors

Hough RF, Bass BL

Title

Purification of the Xenopus laevis double-stranded RNA adenosine deaminase.

Journal

J Biol Chem 269:9933-9 (1994)

Reference

2 [PMID:9614652]

Authors

O'Connell MA, Gerber A, Keegan LP

Title

Purification of native and recombinant double-stranded RNA-specific adenosine deaminases.

Journal

Methods 15:51-62 (1998)
DOI:10.1006/meth.1998.0605

Reference

3 [PMID:11421361]

Authors

Wong SK, Sato S, Lazinski DW

Title

Substrate recognition by ADAR1 and ADAR2.

Journal

RNA 7:846-58 (2001)
DOI:10.1017/s135583820101007x

Reference

4 [PMID:16141067]

Authors

Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL

Title

Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.

Journal

Science 309:1534-9 (2005)
DOI:10.1126/science.1113150

Sequence

[hsa:104]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.4.37

IUBMB Enzyme Nomenclature:

3.5.4.37

ExPASy - ENZYME nomenclature database:

3.5.4.37

BRENDA, the Enzyme Database:

3.5.4.37

DBGET integrated database retrieval system