KEGG   ENZYME: 3.5.4.40
Entry
EC 3.5.4.40                 Enzyme                                 

Name
aminodeoxyfutalosine deaminase;
AFL deaminase;
aminofutalosine deaminase;
mqnX (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
6-amino-6-deoxyfutalosine deaminase
Reaction(IUBMB)
6-amino-6-deoxyfutalosine + H2O = futalosine + NH3 [RN:R10695]
Reaction(KEGG)
R10695
Substrate
6-amino-6-deoxyfutalosine [CPD:C20773];
H2O [CPD:C00001]
Product
futalosine [CPD:C16999];
NH3 [CPD:C00014]
Comment
The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
History
EC 3.5.4.40 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18286  aminodeoxyfutalosine deaminase
K20810  aminodeoxyfutalosine deaminase
Genes
PCT: PC1_2898
HPY: HP_0267
HEO: C694_01350
HPJ: jhp_0252(orf1)
HPA: HPAG1_0269
HPS: HPSH_01390
HHP: HPSH112_01635
HHQ: HPSH169_01520
HHR: HPSH417_01350
HPG: HPG27_246
HPL: HPB8_1295
HEF: HPF16_0274(orf1)
HPF: HPF30_1029(orf1)
HEQ: HPF32_0276(orf1)
HEX: HPF57_0320(orf1)
HPZ: HPKB_0278
HPD: KHP_0265
HEY: MWE_0345
HPYO: HPOK113_0276(orf1)
HPYL: HPOK310_0271(orf1)
HPYR: K747_10020
HPYI: K750_02905
HPYU: K751_06105
HPYM: K749_04315
HEB: U063_0607
HEZ: U064_0608
HHE: HH_1764
HAC: Hac_0525
HMS: HMU14400
HCE: HCW_04960
HCM: HCD_02380
HCP: HCN_0995
WSU: WS1477
SUA: Saut_0709
SULC: CVO_06475
SULR: B649_02355
CJE: Cj0067
CJU: C8J_0060
CJI: CJSA_0061
CJM: CJM1_0069
CJS: CJS3_0067
CJEJ: N564_01795
CJEU: N565_01825
CJEN: N755_01830
CJEI: N135_00070
CJQ: UC78_0071
CJR: CJE0064
CFZ: CSG_16390
CLA: CLA_0229
CCQ: N149_0065
CCF: YSQ_00350
CCY: YSS_00350
CCOI: YSU_00335
CCOF: VC76_00335
CIS: CINS_0221
CVO: CVOL_0223
CPEL: CPEL_0232
CGRA: CGRAC_1950
CURE: CUREO_0286
CHYO: CHH_1542
CSPF: CSF_0889
CCUN: CCUN_1656
CLX: CLAN_1257
CAVI: CAV_0250
CAMY: CSUIS_1383
COJ: CORN_0232
CGEO: CGEO_0403
CCOR: CCORG_0434
CARM: CARM_0200
CMUC: CMCT_1379
CSHO: CSHOW_0395
CINF: CINF_1726
ABU: Abu_0489
ABT: ABED_0465
ATP: ATR_1506
ACIB: ACBT_0830
ACRE: ACRYA_1494
APOC: APORC_0398
AELL: AELL_0642
AAQI: AAQM_0538
ASUI: ASUIS_0604
ACLO: ACLO_0621
ALK: ALEK_0747
AMYT: AMYT_0593
AMAR: AMRN_0622
ACAA: ACAN_0642
AMOL: AMOL_0531
APAI: APAC_0521
HBV: ABIV_0572
HEBR: AEBR_0676
PACO: AACT_0742
ARC: ABLL_0629
SDL: Sdel_0289
SMUL: SMUL_0374
SHAL: SHALO_0374
SULJ: SJPD1_0339
HYO: NNO_1732
SUN: SUN_1037
NIS: NIS_0429
NAM: NAMH_1355
GSU: GSU1708
GME: Gmet_1645
GUR: Gura_2081
GLO: Glov_0961
GEO: Geob_2875
GEM: GM21_1241
GEB: GM18_2996
GBM: Gbem_3009
PCA: Pcar_1827
PPD: Ppro_3409
DEU: DBW_2046
DVU: DVU_2900
DVL: Dvul_0465
DVM: DvMF_1424
DDE: Dde_2963
DDS: Ddes_1874
DMA: DMR_02310
DGG: DGI_2625
DTR: RSDT_0849
DFL: DFE_2773
DAS: Daes_3197
DPI: BN4_11982
PPRF: DPRO_1770
DBA: Dbac_0252
DRT: Dret_2239
DSF: UWK_02737
DOL: Dole_1275
DAL: Dalk_0176
DLI: dnl_08250
ADE: Adeh_0370
SFU: Sfum_3087
DBR: Deba_2196
NOZ: DMB37_04450(add)
SCO: SCO5662(SC6A9.05)
SALB: XNR_1181
SMA: SAVERM_2595(add2)
SGR: SGR_1841
SGB: WQO_26305
SHY: SHJG_6760
SMAL: SMALA_5597
SCT: SCAT_4464(add)
SFA: Sfla_1673
SBH: SBI_03435(add1)
SVE: SVEN_5327
SDV: BN159_2763(add1)
SALS: SLNWT_1596
STRP: F750_5180
SFI: SFUL_5594
STRE: GZL_03098
SLD: T261_2407
STRM: M444_25050
SPRI: SPRI_2221
SRW: TUE45_06164(add2)
SLE: sle_20140(sle_20140)
SRN: A4G23_04186(add2_2)
STRD: NI25_10965
SLAU: SLA_5534
SALJ: SMD11_1924
SLX: SLAV_11510(add2)
SFK: KY5_5817
SGE: DWG14_02405(add2)
SRJ: SRO_2175
SNF: JYK04_06085(add2)
SHUN: DWB77_02232(add2)
SCYG: S1361_28125(add2)
KSK: KSE_28020(add1)
MOY: CVS54_03661(atzA)
MICG: GJV80_07395(add)
NCA: Noca_1355
NDK: I601_2348(add2_2)
PSIM: KR76_08375
MUZ: H4N58_10210(add)
KFL: Kfla_5057
NDA: Ndas_5348
NAL: B005_1808
STRR: EKD16_00960(add2)
FAL: FRAAL1027
ACE: Acel_0264
NML: Namu_4607
SEN: SACE_2180(add)
AMD: AMED_6275(add)
AMN: RAM_32185
AMM: AMES_6184(add)
AMZ: B737_6184(add)
AOI: AORI_2275(add)
AMYC: CU254_17415(add)
AMYY: YIM_35720(add2)
AORI: SD37_12380
AMI: Amir_1459
ACTI: UA75_12890
ACAD: UA74_12810
SAQ: Sare_1766
MIL: ML5_2357
ASE: ACPL_6558(add2)
ACTN: L083_6087(add2)
AFS: AFR_31195
SNA: Snas_4101
BDE: BDP_0473
BDN: BBDE_0451
BSCA: BBSC_0562
RXY: Rxyl_1971
CWO: Cwoe_3597
AYM: YM304_15400(add)
CYT: cce_1718
HAU: Haur_0024
CAP: CLDAP_25200(add)
KBS: EPA93_01275(add)
DRA: DR_0824
DGE: Dgeo_0576
DFC: DFI_08635
TRA: Trad_0151
TTH: TT_C0517
TTJ: TTHA0872(TTHA0872)
TAQ: TO73_1078
MRB: Mrub_1743
MIN: Minf_1455(ssnA)
MKC: kam1_1471
MEAP: MTHMO_0956
RBA: RB8208(trzA)
PSL: Psta_4700
RUL: UC8_17230
AHEL: Q31a_46340
TTF: THTE_0883
PLM: Plim_3188
FTJ: FTUN_2853
IPA: Isop_1172
SACI: Sinac_6076
KST: KSMBR1_2154(atzA)
PCOR: KS4_11310
ACA: ACP_2020(add)
GRW: FTO74_04525(add)
TALB: FTW19_06895(add)
ABAS: ACPOL_2397
EDA: GWR55_18195(add)
SUS: Acid_7334
PFER: IRI77_15950(add)
ABAC: LuPra_04439(atzA)
GAU: GAU_0645
AFD: Alfi_1399
AIT: AI2BBH_09730(trzA)
DORI: FH5T_06070
CPI: Cpin_0441
FLN: FLA_6008
SGN: SGRA_1194
PHE: Phep_3845
MUC: MuYL_4155
TTK: TST_1675
CABY: Cabys_3283
CTHI: THC_0243
MOX: DAMO_2575
 » show all
Reference
1  [PMID:21098241]
  Authors
Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T
  Title
Diversity of the early step of the futalosine pathway.
  Journal
Antimicrob Agents Chemother 55:913-6 (2011)
DOI:10.1128/AAC.01362-10
  Sequence
[ace:Acel_0264] [sco:SCO5662]
Reference
2  [PMID:23972005]
  Authors
Goble AM, Toro R, Li X, Ornelas A, Fan H, Eswaramoorthy S, Patskovsky Y, Hillerich B, Seidel R, Sali A, Shoichet BK, Almo SC, Swaminathan S, Tanner ME, Raushel FM
  Title
Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes.
  Journal
Biochemistry 52:6525-36 (2013)
DOI:10.1021/bi400750a
  Sequence
[ace:Acel_0264] [sma:SAVERM_2595] [nis:NIS_0429] [dra:DR_0824]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.40
IUBMB Enzyme Nomenclature: 3.5.4.40
ExPASy - ENZYME nomenclature database: 3.5.4.40
BRENDA, the Enzyme Database: 3.5.4.40

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