KEGG   ENZYME: 3.5.4.40
Entry
EC 3.5.4.40                 Enzyme                                 
Name
aminodeoxyfutalosine deaminase;
AFL deaminase;
aminofutalosine deaminase;
mqnX (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
6-amino-6-deoxyfutalosine deaminase
Reaction(IUBMB)
6-amino-6-deoxyfutalosine + H2O = futalosine + NH3 [RN:R10695]
Reaction(KEGG)
R10695
Substrate
6-amino-6-deoxyfutalosine [CPD:C20773];
H2O [CPD:C00001]
Product
futalosine [CPD:C16999];
NH3 [CPD:C00014]
Comment
The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
History
EC 3.5.4.40 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18286  aminodeoxyfutalosine deaminase
K20810  aminodeoxyfutalosine deaminase
Genes
PCTPC1_2898
HPYHP_0267
HEOC694_01350
HPJjhp_0252(orf1)
HPAHPAG1_0269
HPSHPSH_01390
HHPHPSH112_01635
HHQHPSH169_01520
HHRHPSH417_01350
HPGHPG27_246
HPPHPP12_0266
HPBHELPY_0273
HPLHPB8_1295
HPCHPPC_01355
HCAHPPC18_01335
HPMHPSJM_01450
HPEHPELS_05410
HPOHMPREF4655_20509
HPIhp908_0281
HPQhp2017_0274
HPWhp2018_0277
HPUHPCU_01665
HEFHPF16_0274(orf1)
HPFHPF30_1029(orf1)
HEQHPF32_0276(orf1)
HEXHPF57_0320(orf1)
HPTHPSAT_01335
HPZHPKB_0278
HPVHPV225_0285
HPXHMPREF0462_0320
HENHPSNT_01520
HPHHPLT_01375
HEGHPGAM_01510
HPNHPIN_01205
HEPHPPN120_01350
HEUHPPN135_01380
HESHPSA_01355
HPYSHPSA20_0298
HCNHPB14_01320
HPDKHP_0265
HEYMWE_0345
HERC695_01345
HEIC730_01350
HPYAHPAKL117_01330
HPYKHPAKL86_02565
HPYOHPOK113_0276(orf1)
HPYLHPOK310_0271(orf1)
HPYBHPOKI102_01640
HPYCHPOKI112_01625
HPYDHPOKI128_01460
HPYEHPOKI154_01460
HPYFHPOKI422_01630
HPYGHPOKI673_01450
HPYHHPOKI828_01445
HPYJHPOKI898_01640
HPYRK747_10020
HPYIK750_02905
HPYUK751_06105
HPYMK749_04315
HEMK748_02740
HEBU063_0607
HEZU064_0608
HHEHH_1764
HACHac_0525
HMSHMU14400
HFEHFELIS_02560
HBIHBZC1_02140
HCEHCW_04960
HCMHCD_02380
HCPHCN_0995
HCBHCBAA847_0977
HHMBN341_12800
HTYBN2458_PEG1141
HBLXJ32_06385
HADCDV25_01035
HETBBW65_06505
HCLNCTC13205_00171
HWIA0Z60_05760
HSHNHP194022_14400(add)
WSUWS1477
TDNSuden_0686
SUASaut_0709
SULNFJR47_03155
SULGFJR48_08310
SULCCVO_06475
SPALFM071_02880
SSEIFJR45_03945
SBALHUE88_09000
SMASHUE87_04155
SKUSulku_0469
SULRB649_02355
CJECj0067
CJBBN148_0067
CJJCJJ81176_0105
CJUC8J_0060
CJICJSA_0061
CJMCJM1_0069
CJSCJS3_0067
CJPA911_00320
CJEJN564_01795
CJEUN565_01825
CJENN755_01830
CJEIN135_00070
CJVMTVDSCj20_0065
CJYQZ67_00074
CJQUC78_0071
CJLPJ17_00350
CJWPJ18_00350
CJRCJE0064
CJDJJD26997_0077
CJZM635_04705
CJXBN867_00590
CFFCFF8240_1504
CFTCFF04554_1516
CFVCFVI03293_1538
CFXCFV97608_1638
CFZCSG_16390
CAMPCFT03427_1464
CFPCR44_07420
CCVCCV52592_0362
CHACHAB381_1212
CCOCCC13826_0371
CCOCCCON33237_0519
CLACLA_0229
CLRUPTC16701_0236
CLMUPTC16712_0235
CLQUPTC4110_0229
CLNUPTC3659_0246
CLLCONCH_0227
CCOLBN865_04440
CCCG157_00325
CCQN149_0065
CCFYSQ_00350
CCYYSS_00350
CCOIYSU_00335
CCOFVC76_00335
CCOOATE51_00140
CAJCIG1485E_1454
CISCINS_0221
CVOCVOL_0223
CPELCPEL_0232
CAMRCAQ16704_0233
CSMCSUB8521_0238
CSFCSUB8523_0232
CGRACGRAC_1950
CURECUREO_0286
CHYOCHH_1542
CHVCHELV3228_1260
CSPFCSF_0889
CPINCPIN18020_1137
CCUNCCUN_1656
CLXCLAN_1257
CAVICAV_0250
CHWA2J15_005700
CAMZCVIC12175_0306
CAMYCSUIS_1383
COJCORN_0232
CUXCUP3940_0632
CRXCRECT_0251
CGEOCGEO_0403
CCORCCORG_0434
CARMCARM_0200
CMUCCMCT_1379
CSHOCSHOW_0395
CINFCINF_1726
CNVCNZW441b_0062
SDLSdel_0289
SBASulba_0309
SMULSMUL_0374
SHALSHALO_0374
SULSSdiek1_0338
SULJSJPD1_0339
SULTFA592_08790
ABUAbu_0489
ABTABED_0465
ABLA7H1H_0490
ASKEI285_07885
ATPATR_1506
ACIBACBT_0830
ACREACRYA_1494
ALANALANTH_0524
APOCAPORC_0398
AFCAFAEC_0643
ATHRATH_0384
ANTArnit_0752
AELLAELL_0642
AAQIAAQM_0538
ASUIASUIS_0604
ACLOACLO_0621
AVPAVENP_0739
ADZADFLV_0635
ARCABLL_0629
PACOAACT_0742
ALKALEK_0747
ALPLPB137_03265
AHSAHALO_0561
AMYTAMYT_0593
AMARAMRN_0622
ACAAACAN_0642
AMOLAMOL_0531
APAIAPAC_0521
HBVABIV_0572
HEBRAEBR_0676
AANAAANAER_0666
HYONNO_1732
NSANitsa_1349
SUNSUN_1037
SLHYH65_03960
SINUIMZ28_04685
NISNIS_0429
NAMNAMH_1355
NAPC3L23_07100
CMEDFE773_03885
CPAFC6V80_06825
GSUGSU1708
GSKKN400_1733
GMEGmet_1645
GPIGPICK_08120
GAOA2G06_08495
GBZJZM60_13380
GEMGM21_1241
GEBGM18_2996
GEFFO488_02120
GURGura_2081
GEOGeob_2875
GLOGlov_0961
GBMGbem_3009
GBNGEOBRER4_11920
GERKP004_05495
GSUBKP001_09960
GNTKP003_05245
GPLM1B72_15240
PCAPcar_1827
PACEA6070_07875
PEFA7E78_04065
PPDPpro_3409
DESDSOUD_1592
DEUDBW_2046
DVEDESUT3_23930
DEPAOP6_1470
DVUDVU_2900
DVLDvul_0465
DVMDvMF_1424
DVGDeval_2679
DDSDdes_1874
DFIAXF13_15555
DPGDESPIGER_0985
DEFCNY67_02835
DTRRSDT_0849
DFLDFE_2773
DSDGD606_13570
DMADMR_02310
DCBC3Y92_00760
DGGDGI_2625
DDEDde_2963
DSADesal_0018
DHYDESAM_20709
DAFDesaf_3137
DASDaes_3197
DPIBN4_11982
DEJAWY79_02585
PPRFDPRO_1770
PSELGM415_04355
DDNDND132_2446
PSEFPSDVSF_24530
DSXGD604_18165
DBADbac_0252
DRTDret_2239
DSFUWK_02737
DAKDaAHT2_0568
DPRDespr_1798
DEOCAY53_06265
DOGHP555_10430
DBKDGMP_16160
DOLDole_1275
DMLDmul_31800
DALDalk_0176
DATHRM2_33140
DTOTOL2_C34520
DLIdnl_08250
DEKDSLASN_15600
ADEAdeh_0370
ACPA2cp1_0399
AFWAnae109_4208
ANKAnaeK_0398
VINAKJ08_0221
LLUAKJ09_06557
DAODesac_1408
SFUSfum_3087
DAXFDQ92_08515
DBRDeba_2196
HMRHipma_0327
DAVDESACE_04495
DHRLGS26_06795
NOHG5V57_32095
AARAcear_0510
NBRO3I_023170
NNONONO_c68210
NOZDMB37_04450(add)
NAHF5544_06340 F5544_22955
NWLNWFMUON74_17860
RHUA3Q40_03062
SCOSCO5662(SC6A9.05)
SALBXNR_1181
SMASAVERM_2595(add2)
SGRSGR_1841
SGBWQO_26305
SCBSCAB_25801
SSXSACTE_4848 SACTE_6096
SVLStrvi_1999
SHYSHJG_6760
SHOSHJGH_6520
SRCM271_15600
SMALSMALA_5597
SSOII1A49_31685
SFASfla_1673
SBHSBI_03435(add1)
SVESVEN_5327
SDVBN159_2763(add1)
SALSSLNWT_1596
STRPF750_5180
SFISFUL_5594
SCIB446_26550
SALUDC74_448 DC74_5764
SALLSAZ_02725 SAZ_30510
SLVSLIV_10315
SGUSGLAU_24370
SVTSVTN_27380
STREGZL_03098
SCWTU94_23890
SLDT261_2407
SLCSL103_27695
SXISXIM_44380
STRMM444_25050
STRCAA958_26170
SAMBSAM23877_5389
SPRISPRI_2221
SCZABE83_09105
SCXAS200_13845
SRWTUE45_06164(add2)
STRFASR50_25585
SLEsle_20140(sle_20140)
SRNA4G23_04186(add2_2)
SPAVSpa2297_23905
STRTA8713_23150
SCLFBB341_06050
SGSAVL59_09415
STSIA4E84_28935
SKYD0C37_07475
SALWCP975_26140
SGMGCM10017557_22180
SCADDN051_12055
SPHWNFX46_08190
SLSSLINC_6084
SNRSNOUR_13435
SPLULK06_024520
STRDNI25_10965
SNWBBN63_08490
SAUOBV401_31865
SSIAA7J05_10630
SVUB1H20_26785
SPUNBFF78_12795
SGVB1H19_28970
SLAUSLA_5534
SALFSMD44_06284
SALJSMD11_1924
SLXSLAV_11510(add2)
STROSTRMOE7_27670
SFKKY5_5817
SNZDC008_25425
SGEDWG14_02405(add2)
SRJSRO_2175
SLKSLUN_28715
SDXC4B68_11005
SGDELQ87_11350
SQZFQU76_25215
SCYAEJ357_33285
SASTCD934_08735
SNQCP978_24335
STIRDDW44_22370
SKACP970_11975
SGZC0216_06925
SVNCP980_09185
SNKCP967_08250
SHAWCEB94_29635
SRKFGW37_23850
SFICEIZ62_08180
SGALCP966_26420
SSPODDQ41_23835
SVRCP971_21405
SPADDVK44_26090
SFYGFH48_12475
SAQUEJC51_34465
SGFHEP81_02386
SCAVCVT27_25625
SSEOD0Z67_21315
SBYH7H31_07770
SRIMCP984_10840
SSUBCP968_09565
SPHVF9278_35640
SCINCP977_25100
SFUGCNQ36_28350
SPACB1H29_10405
STSUB7R87_25230
SCHACP983_12395
SGXH4W23_28860
SCOECP976_31170
SBATG4Z16_07685
SSPBCP982_30100
SNFJYK04_06085(add2)
SPLACP981_28060
SBROGQF42_30960
STUIGCM10017668_51500
SATAC5746_30100
SCHFIPT68_26840
SHUNDWB77_02232(add2)
SHARHUT13_22210
SCYGS1361_28125(add2)
SFEUIM697_34970
SLIAHA039_08885
SDWK7C20_26745
SVDCP969_27215
SCALI6J39_26645
SAUHSU9_025470
SFBCP974_22575
SMOBJ7W19_23725
SPRACP972_25595
SPEUCGZ69_26355
SROIIAG44_10820
SXNIAG42_09435
SGJIAG43_23340
SHKJ2N69_27080
SANUK7396_10110
STRYEQG64_26645
SDDD9753_09830
SACTDMT42_28215
SMAOCAG99_04635
SGOBtest1122_20560
SINEKI385_32000
SLFJEQ17_14135
SDECL3078_32695
SAOVG3H79_09480
SDURM4V62_13070
SYANNRK68_24965
SCTSCAT_4464(add)
SCYSCATT_44580
KSKKSE_28020(add1)
KABB7C62_27540
KAUB6264_16010
KITCFP65_2589
STRIC7M71_009995
STRHGXP74_06575 GXP74_29165(add)
ABRYNYE86_26550
MTSMTES_1559 MTES_2328
MIXAB663_000766
MIHBJP65_09165
MOYCVS54_03661(atzA)
RFSC1I64_16490
RTEGSU10_15090
CUMNI26_13935
CUBBJK06_10540
CUGC1N91_14270
CQFGBG65_04330
SALAESZ53_12275
HUWFPZ11_05795
LEULeucomu_06105
LTREVS81_02165
LVIG7068_02985
LLUTK1X41_03435
AGXAGREI_3106
MIKFOE78_02595
MICGGJV80_07395(add)
NCANoca_1355
NDKI601_2348(add2_2)
NOYEXE57_17590
NOIFCL41_04485
NOOFE634_05085
NDPE2C04_05245
NSNEXE58_01930
NANOG5V58_04205
NMESH9L09_03020
NAROCFH99_08020
NPIG7071_18545
NAQUENKNEFLB_03425(add2_1)
NROK8W59_14645
NOQLN652_07155
NCQK6T13_12705
NPSKRR39_13760
PSIMKR76_08375
AERAERYTH_16115
AEZC3E78_00355
AEBC6I20_15125
AEFGEV26_00600
MUZH4N58_10210(add)
KFLKfla_5057
KQIF1D05_07630
THAONI17_021065
TALXFOF52_18205
NDANdas_5348
NALB005_1808
NGVCDO52_03270
NFEHUT17_01065
NEXNE857_33605(add)
STRREKD16_00960(add2)
SAIUJ4H86_15520
ACTWF7P10_41115
AGRAAGRA3207_007832
SROSros_6019 Sros_6873 Sros_8785
NOABKM31_05485
NOWGBF35_33020
NCXNocox_26905
NGNLCN96_36125
FRAFrancci3_0534
FREFranean1_2196 Franean1_6098
FRIFraEuI1c_2183
FALFRAAL1027
FSYFsymDg_0807 FsymDg_4011
ACEAcel_0264
NMLNamu_4607
SENSACE_2180(add)
AMDAMED_6275(add)
AMNRAM_32185
AMMAMES_6184(add)
AMZB737_6184(add)
AOIAORI_2275(add)
AMYCCU254_17415(add)
AMYBBKN51_03960
AABA4R43_41340
AMYYYIM_35720(add2)
AORISD37_12380
AROONQK81_10980(add)
APRECNX65_07240
AMIAmir_1459
SSYIEKG83_32345
KPHYAOZ06_14325
LEDBBK82_01670 BBK82_44150
AHMTL08_11975
ACTIUA75_12890
ACADUA74_12810
AHGAHOG_12095
PMADBAY61_10595
SACEGIY23_11185
STPStrop_1779
SAQSare_1766
MAUMicau_2245
MILML5_2357
MICBMicB006_4944 MicB006_5310
MTUACSH63_13540
MICHFJK98_10535
MTEMGCE86_04665
MCABHXZ27_11635
MSAGGCM10017556_45910
VMAVAB18032_14465
MCRAID554_02550 ID554_11855(add)
ASEACPL_6558(add2)
AMSAMIS_63020
ACTNL083_6087(add2)
AFSAFR_31195
ACTSACWT_5392 ACWT_6427
AIHAiant_02720 Aiant_22570
ACTRAsp14428_71220
PLKCIK06_10955
PLABC6361_23640
PLATC6W10_32520
PFLAPflav_005960
PSUUPsuf_058600 Psuf_062840
VERHUT12_10575
ATLAthai_62840
ASERAsera_12580 Asera_63930
PRYPrubr_37020 Prubr_48300
CATICS0771_36100
DVCDvina_36360
CCAZCOUCH_12960
CAICaci_7773 Caci_8056
SNASnas_4101
NAVJQS30_02625
SOOFBF35_00350
BDEBDP_0473
BDNBBDE_0451
BKAAH68_02005
BSCABBSC_0562
BGXESN35_08805
BLEMBL8807_06495
BEUBE0216_05095
GVGHMPREF0421_20381
GVHHMPREF9231_1174
GPTK9E43_04470
EKEEK0264_10040
JTLM6D93_01715
RXYRxyl_1971
RUBGBA63_12570
RMARGBA65_06815
CWOCwoe_3597
AYMYM304_15400(add)
ERZER308_12800
EUZDVS28_a4285 DVS28_a4593
CYTcce_1718
HAUHaur_0024
LEKhrd7_30670
CAPCLDAP_25200(add)
KBSEPA93_01275(add)
DRADR_0824
DGEDgeo_0576
DDRDeide_06650
DMRDeima_1472
DPTDeipr_1281
DGODGo_CA2345
DPDDeipe_0125
DSWQR90_07480
DCHSY84_02345
DABAUC44_09450
DPUSU48_03690
DEZDKM44_08775
DWUDVJ83_07165
DFCDFI_08635
DEINDAAJ005_13600
DGADEGR_18040
DPHEHF33_01820
DRDLMT64_05950
DRBN0D28_09085
TRATrad_0151
TTHTT_C0517
TTJTTHA0872(TTHA0872)
TTSThthe16_0874
TTLTtJL18_1175
TSCTSC_c13360
THCTCCBUS3UF1_11580
TOSTheos_1558
TAQTO73_1078
TBCA0O31_02226
TANTKNN15_11435
MRBMrub_1743
MREK649_13840
MSVMesil_1825
MTAIMtai_v1c12160
OPROcepr_1071
MHDMarky_1173
FGIOP10G_1351
NPYNPRO_17460
XIIAMD24_00760
MINMinf_1455(ssnA)
MKCkam1_1471
MEAPMTHMO_0956
RBARB8208(trzA)
PSLPsta_4700
PIRVN12_03375
RULUC8_17230
RMLFF011L_23210
MFFMFFC18_33790
ROLCA51_37650
AHELQ31a_46340
LCREPla8534_48010
AAGGETAA8_47920
BVOPan97_36520
TTFTHTE_0883
LPAVPLANPX_3096
AMUCPan181_26810
PNDPla175_20870
AMOBHG15A2_28370
PLMPlim_3188
PEHSpb1_39160
PBSPlabr_1777
PLSVT03_09770
PLHVT85_13665
FMRFuma_00618
GMRGmarT_04730
GIMF1728_11785
GPNPan110_05330
MRIMal4_49970
SDYNMal52_16530
PLONPla110_04240
GESVT84_30495
GOGC1280_35235
GMSSOIL9_00390
TIMGMBLW1_14380
LRSPX52LOC_06745
FTJFTUN_2853
TSPHKIH39_05930
IPAIsop_1172
SACISinac_6076
PBORBSF38_00880
AGVOJF2_17990
KSTKSMBR1_2154(atzA)
BROCIPI25_09205
BPITBPIT_08580
JETL3J17_03990
PHMPSMK_02450
PCORKS4_11310
MCADPan265_07110
HBSIPV69_12045
ABAAcid345_0045
ACAACP_2020(add)
ACMAciX9_3469
GMAAciX8_0415
GRWFTO74_04525(add)
GRBGOB94_08365(add)
TRSTerro_0789
TALBFTW19_06895(add)
ABASACPOL_2397
EDAGWR55_18195(add)
ADINH7849_18195(add)
SUSAcid_7334
PFERIRI77_15950(add)
CTMCabther_A0571
ABACLuPra_04439(atzA)
SCORJ3U87_16290
GAUGAU_0645
AFDAlfi_1399
ALDGFH31_08510
AOKA3BBH6_13710
ACOUA5CBH24_13320
AITAI2BBH_09730(trzA)
RBCBN938_1024
TTZFHG85_12160
BLQL21SP5_02422
BACCBRDCF_p1332
DORIFH5T_06070
DRCG0Q07_19810
MCOSGM418_12240
CPICpin_0441
CBAECOR50_06640
CHITFW415_05500
CHIHGWR21_17855
CFILMYF79_02275
NKONiako_5743
NSONIASO_18095
NIAA8C56_19075
FLASY85_18760
FGGFSB75_18310
ARBA9P82_09150
ARKD6B99_16575
AGIFSB73_09290
ARACE0W69_013485
ATEEK9M52_09725
FLNFLA_6008
PSEGD3H65_25700
PGINFRZ67_13935
PGOFSB84_09085
FLSGLV81_00555
LACSH4075_18930
FLPLK994_05655
FLCKJS93_14035
FLVKJS94_10625
HHYHalhy_2406
SGNSGRA_1194
PHEPhep_3845
PEPAQ505_02325
PCMAY601_4587
PSTYBFS30_07045
PGSCPT03_16355
PEJFYC62_11475
PEKFFJ24_019490
PROEH9L23_20285
PSNPedsa_3264
SHGSph21_1139
SHTKO02_02130
SPHNBV902_03660
SMIZ4412673_03519
SPSCE2P86_16105
SPHZE3D81_14940
SPHEGFH32_16045
SPDRG6053_02405
SDJNCTC13534_04976
STHANCTC11429_01115
SSPII6J01_10230
SMUII6J00_19155
SSIYJVX97_00940
SCNSolca_4336
MUPA0256_03685
MUCMuYL_4155
MGOTMgSA37_04342
MUHHYN43_020200
MGINFRZ54_00400
MGKFSB76_18500
MRUBDEO27_020295
MGOSDIU38_021335
MMABHQ865_18075
MGIKGO620_011470
MDJLLH06_18490
AGDFRZ59_00835
OLIFKG96_02640
SBXCA265_19060
TTKTST_1675
TAMTheam_0359
DTEDester_1267
DINSelin_2228
CABYCabys_3283
TIDThein_1034
TOPTOPB45_0270
TCMHL41_07410
THETF1847_08450
CTHITHC_0243
TAVG4V39_03355
TMAIFVE67_02825
NLIG3M70_07485
MOXDAMO_2575
 » show all
Reference
1  [PMID:21098241]
  Authors
Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T
  Title
Diversity of the early step of the futalosine pathway.
  Journal
Antimicrob Agents Chemother 55:913-6 (2011)
DOI:10.1128/AAC.01362-10
  Sequence
[ace:Acel_0264] [sco:SCO5662]
Reference
2  [PMID:23972005]
  Authors
Goble AM, Toro R, Li X, Ornelas A, Fan H, Eswaramoorthy S, Patskovsky Y, Hillerich B, Seidel R, Sali A, Shoichet BK, Almo SC, Swaminathan S, Tanner ME, Raushel FM
  Title
Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes.
  Journal
Biochemistry 52:6525-36 (2013)
DOI:10.1021/bi400750a
  Sequence
[ace:Acel_0264] [sma:SAVERM_2595] [nis:NIS_0429] [dra:DR_0824]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.40
IUBMB Enzyme Nomenclature: 3.5.4.40
ExPASy - ENZYME nomenclature database: 3.5.4.40
BRENDA, the Enzyme Database: 3.5.4.40

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