KEGG   ENZYME: 3.5.4.44
Entry
EC 3.5.4.44                 Enzyme                                 

Name
ectoine hydrolase;
doeA (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
ectoine aminohydrolase
Reaction(IUBMB)
ectoine + H2O = (2S)-2-acetamido-4-aminobutanoate [RN:R09800]
Reaction(KEGG)
R09800
Substrate
ectoine [CPD:C06231];
H2O [CPD:C00001]
Product
(2S)-2-acetamido-4-aminobutanoate [CPD:C19929]
Comment
The enzyme, found in some halophilic bacteria, is involved in the degradation of the compatible solute ectoine. The enzyme, which belongs to peptidase family M24, only acts in the direction of ectoine hydrolysis. It also produces smaller amounts of (2S)-4-acetamido-2-aminobutanoate, which is recycled back to ectoine by EC 4.2.1.108, ectoine synthase.
History
EC 3.5.4.44 created 2017
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15783  ectoine hydrolase
Genes
CAMA: F384_12935
IZH: FEM41_17295(doeA)
SMAF: D781_2283
SRZ: AXX16_2864
SERM: CLM71_11810(doeA)
SRHZ: FO014_21980(doeA)
VAG: N646_3801
VEX: VEA_000632
VNA: PN96_17665
VEJ: VEJY3_17226
VAF: D1115_22165(doeA)
VNL: D3H41_20745(doeA)
GHO: AL542_02290(doeA)
SALY: E8E00_14710(doeA)
SKS: FCN78_14010(doeA)
SCOT: HBA18_14650(doeA)
PAP: PSPA7_4378(eutD)
PMK: MDS_0056
PMUI: G4G71_02705(doeA)
PPU: PP_4432
PPT: PPS_0719
PPI: YSA_00599
PPUH: B479_04040
PMON: X969_02015
PMOT: X970_02005
PMAN: OU5_4501
PSTT: CH92_00105
PALL: UYA_00160
PUM: HGP31_27400(doeA)
PLAL: FXN65_00110(doeA)
PSEJ: HNQ25_01235(doeA)
PKH: JLK41_00140(doeA)
PTY: JWV26_10520(doeA)
PMAO: PMYSY11_0800(doeA)
GAI: IMCC3135_07185(doeA_1) IMCC3135_09905(doeA_2)
CSA: Csal_2732
HEL: HELO_3665(doeA)
HAM: HALO1223
HHH: CLM76_01780(doeA)
HBE: BEI_2959(doeA)
HAF: C8233_14545(doeA)
HALK: CUU95_10305(doeA)
HVN: EI420_15845(doeA)
HMD: CTT34_14385(doeA)
HTT: HZS52_10955(doeA)
HCAM: I4484_15860(doeA)
HPIZ: GYM47_13615(doeA)
KUY: FY550_04105(doeA)
PAUR: FGL86_17275(doeA)
BCN: Bcen_5803
BCJ: BCAS0027
BCEN: DM39_6671(eutD)
BCEW: DM40_5477(eutD)
BCEO: I35_7026
BAM: Bamb_6020
BMJ: BMULJ_05387(pepQ)
BMU: Bmul_6143
BMK: DM80_6599(eutD)
BMUL: NP80_5360(eutD)
BCED: DM42_6398(eutD)
BDL: AK34_5360(eutD)
BLAT: WK25_18050
BTEI: WS51_29690
BPSL: WS57_18495
BXE: Bxe_C0063
BXB: DR64_8362(eutD)
BPH: Bphy_3862
BFN: OI25_3926(eutD)
PTER: C2L65_27875(doeA)
PGP: CUJ91_28295(doeA)
PTS: CUJ90_21845(doeA)
CABA: SBC2_38090(doeA)
VEI: Veis_2149
APET: ToN1_21090(doeA1) ToN1_21100(doeA2)
ACOM: CEW83_01835(doeA) CEW83_01840(doeA)
AHS: AHALO_1645(doeA)
AMAR: AMRN_1667(doeA)
ACAA: ACAN_1695(doeA)
DMS: E8L03_14000(doeA)
MLO: mlr7141
MESP: C1M53_04395(doeA)
MHUA: MCHK_0652(doeA) MCHK_1813
RPOD: E0E05_14125(doeA)
NIY: FQ775_21085(doeA)
NKI: KW403_16725(doeA)
ORM: HTY61_13210(doeA)
SME: SM_b20434(eutD)
SMX: SM11_pD1188(eutD)
SMEL: SM2011_b20434(eutD)
SMER: DU99_31140
SMD: Smed_3693
SIX: BSY16_5544(eutD)
ATU: Atu4757
ATF: Ach5_44890(doeA)
ARO: B0909_16545(doeA)
AGT: EYD00_19140(doeA)
REP: IE4803_PC00199(eutD)
RLE: pRL120054
RLG: Rleg_5242
RPUS: CFBP5875_19350(doeA)
RGA: RGR602_PC02175(eutD)
RHN: AMJ98_PE00274(eutD)
RPHA: AMC79_PD00407(eutD)
RHX: AMK02_PD00140(eutD)
RHK: Kim5_PC00184(eutD)
REZ: AMJ99_PD00274(eutD)
RJG: CCGE525_32200(doeA)
RHR: CKA34_29665(doeA)
ROY: G3A56_16940(doeA)
RHID: FFM81_023130(doeA)
RLN: J0663_22890(doeA)
NGL: RG1141_PA13040(eutD)
NGG: RG540_PA14020(eutD)
NEO: CYG48_20840(doeA)
RHT: NT26_3906
OIN: IAR37_18905(doeA)
OAN: Oant_3467
OAH: DR92_3019(eutD)
OCH: CES85_4623(eutD)
OCR: HGK82_19825(doeA)
OCL: GTN27_18040(doeA)
BARH: WN72_09825
LNE: FZC33_33975(doeA)
MIV: C4E04_10105(doeA)
PHL: KKY_228
DEA: FPZ08_18115(doeA)
HDI: HDIA_2075
MMED: Mame_00077 Mame_02830(pepQ_3)
BRN: D1F64_10805(doeA)
RBM: TEF_15100
LABR: CHH27_05510(doeA)
LABP: FJ695_10260(doeA)
LABT: FIU93_20645(pepQ2)
SIW: GH266_08155(doeA)
SIL: SPO1140(doeA)
JAN: Jann_0850
RDE: RD1_3474
RLI: RLO149_c026710(eutD)
PGD: Gal_02709
OAT: OAN307_c10570(eutD)
OAR: OA238_c05420(eutD1) OA238_c23670(eutD2)
OTM: OSB_17100
LEJ: ETW24_15270(doeA)
LAQU: R2C4_20340(doeA)
CID: P73_1149
MALG: MALG_03274
YPAC: CEW88_15400(doeA)
SPSE: SULPSESMR1_03271(doeA)
SULI: C1J05_07235(doeA)
SPOT: G6548_05620(doeA)
RMM: ROSMUCSMR3_02212(doeA)
AHT: ANTHELSMS3_04452(doeA)
MALU: KU6B_39230
PDE: Pden_0287
PYE: A6J80_21895(doeA)
PZH: CX676_02845(doeA)
PARO: CUV01_01765(doeA)
PARS: DRW48_07115(doeA)
PARR: EOJ32_08975(doeA)
PKD: F8A10_17635(doeA)
PLIA: E4191_06420(doeA)
PSAN: HGN31_00605(doeA)
RSU: NHU_01997(eutD)
RHC: RGUI_3313
LVS: LOKVESSMR4R_00538(doeA)
HML: HmaOT1_18505(doeA)
LIT: FPZ52_11025(doeA)
MON: G8E03_07580(doeA)
PALW: PSAL_009750(doeA)
HDH: G5B40_08315(doeA)
FAQ: G5B39_06375(doeA)
SHUM: STHU_07270
TXI: TH3_02590
THAC: CSC3H3_02845(doeA)
TII: DY252_18730(doeA)
PUB: SAR11_1338(y4tM)
BBEV: BBEV_1548(pepP)
BMEG: BG04_5939
PARH: I5S86_22750(doeA)
BCL: ABC0020
HLI: HLI_13335
AMT: Amet_1194
RHB: NY08_428
RFA: A3L23_03751(doeA)
RHS: A3Q41_04489(doeA)
GBR: Gbro_4077
GOR: KTR9_4008
GOM: D7316_04409(doeA)
SMAL: SMALA_8299
PSEV: USB125703_01939(doeA)
LMOI: VV02_11300
SERJ: SGUI_0402
BLIN: BLSMQ_2278
HLA: Hlac_1051
HTU: Htur_2943
NMG: Nmag_3760
 » show all
Reference
1  [PMID:20849449]
  Authors
Schwibbert K, Marin-Sanguino A, Bagyan I, Heidrich G, Lentzen G, Seitz H, Rampp M, Schuster SC, Klenk HP, Pfeiffer F, Oesterhelt D, Kunte HJ
  Title
A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T.
  Journal
Environ Microbiol 13:1973-94 (2011)
DOI:10.1111/j.1462-2920.2010.02336.x
  Sequence
[hel:HELO_3665]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.44
IUBMB Enzyme Nomenclature: 3.5.4.44
ExPASy - ENZYME nomenclature database: 3.5.4.44
BRENDA, the Enzyme Database: 3.5.4.44

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