KEGG   ENZYME: 3.5.4.44Help
Entry
EC 3.5.4.44                 Enzyme                                 

Name
ectoine hydrolase;
doeA (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
ectoine aminohydrolase
Reaction(IUBMB)
ectoine + H2O = (2S)-2-acetamido-4-aminobutanoate [RN:R09800]
Reaction(KEGG)
Substrate
ectoine [CPD:C06231];
H2O [CPD:C00001]
Product
(2S)-2-acetamido-4-aminobutanoate [CPD:C19929]
Comment
The enzyme, found in some halophilic bacteria, is involved in the degradation of the compatible solute ectoine. The enzyme, which belongs to peptidase family M24, only acts in the direction of ectoine hydrolysis. It also produces smaller amounts of (2S)-4-acetamido-2-aminobutanoate, which is recycled back to ectoine by EC 4.2.1.108, ectoine synthase.
History
EC 3.5.4.44 created 2017
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K15783  ectoine hydrolase
Genes
CAMA: F384_12935
IZH: FEM41_17295(doeA)
SMAF: D781_2283
SRZ: AXX16_2864
SERM: CLM71_11810(doeA)
VAG: N646_3801
VEX: VEA_000632
VNA: PN96_17665
VEJ: VEJY3_17226
VSC: VSVS12_01930
VAF: D1115_22165(doeA)
GHO: AL542_02290(doeA)
SALY: E8E00_14710(doeA)
SKS: FCN78_14010(doeA)
PAP: PSPA7_4378(eutD)
PMK: MDS_0056
PPU: PP_4432
PPT: PPS_0719
PPI: YSA_00599
PPUH: B479_04040
PMON: X969_02015
PMOT: X970_02005
PMAN: OU5_4501
PSTT: CH92_00105
GAI: IMCC3135_07185(doeA_1) IMCC3135_09905(doeA_2)
CSA: Csal_2732
HEL: HELO_3665(doeA)
HAM: HALO1223
HHH: CLM76_01780(doeA)
HBE: BEI_2959(doeA)
HAF: C8233_14545(doeA)
HALK: CUU95_10305(doeA)
HVN: EI420_15845(doeA)
BCN: Bcen_5803
BCJ: BCAS0027
BCEN: DM39_6671(eutD)
BCEW: DM40_5477(eutD)
BCEO: I35_7026
BAM: Bamb_6020
BMU: Bmul_6143
BMJ: BMULJ_05387(pepQ)
BMK: DM80_6599(eutD)
BMUL: NP80_5360(eutD)
BCED: DM42_6398(eutD)
BDL: AK34_5360(eutD)
BLAT: WK25_18050
BTEI: WS51_29690
BPSL: WS57_18495
BXE: Bxe_C0063
BXB: DR64_8362(eutD)
BPH: Bphy_3862
BFN: OI25_3926(eutD)
PTER: C2L65_27875(doeA)
PGP: CUJ91_28295(doeA)
PTS: CUJ90_21845(doeA)
VEI: Veis_2149
ACOM: CEW83_01835(doeA) CEW83_01840(doeA)
AHS: AHALO_1645(doeA)
MLO: mlr7141
MESM: EJ066_28925(doeA)
MESP: C1M53_04395(doeA)
RPOD: E0E05_14125(doeA)
SME: SM_b20434
SMX: SM11_pD1188(eutD)
SMEL: SM2011_b20434(eutD)
SMER: DU99_31140
SMD: Smed_3693
SIX: BSY16_5544(eutD)
ATU: Atu4757
ATF: Ach5_44890(doeA)
ARO: B0909_16545(doeA)
AGT: EYD00_19140(doeA)
REL: REMIM1_PC00118(eutD-1) REMIM1_PC00148(eutD-2) REMIM1_PF00736(eutD-3)
REP: IE4803_PC00199(eutD)
REI: IE4771_PD00200(eutD)
RLE: pRL120054
RLG: Rleg_5242
RGA: RGR602_PC02175(eutD)
RHN: AMJ98_PE00274(eutD)
RPHA: AMC79_PD00407(eutD)
RHT: NT26_3906
RHX: AMK02_PD00140(eutD)
RHK: Kim5_PC00184(eutD)
REZ: AMJ99_PD00274(eutD)
RJG: CCGE525_32200(doeA)
NGL: RG1141_PA13040(eutD)
NGG: RG540_PA14020(eutD)
NEO: CYG48_20840(doeA)
SHZ: shn_23130
OAN: Oant_3467
OAH: DR92_3019(eutD)
OCH: CES85_4623(eutD)
MIV: C4E04_10105(doeA)
PHL: KKY_228
MMED: Mame_00077 Mame_02830(pepQ_3)
BRN: D1F64_10805(doeA)
HDI: HDIA_2075
RBM: TEF_15100
SIL: SPO1140(doeA)
JAN: Jann_0850
RDE: RD1_3474
RLI: RLO149_c026710(eutD)
PDE: Pden_0287
PYE: A6J80_21895(doeA)
PZH: CX676_02845(doeA)
PARO: CUV01_01765(doeA)
PARS: DRW48_07115(doeA)
PGD: Gal_02709
OAT: OAN307_c10570(eutD)
OAR: OA238_c05420(eutD1) OA238_c23670(eutD2)
OTM: OSB_17100
LEJ: ETW24_15270(doeA)
CID: P73_1149
MALG: MALG_03274
RSU: NHU_01997(eutD)
RHC: RGUI_3313
LABR: CHH27_05510(doeA)
YPAC: CEW88_15400(doeA)
SPSE: SULPSESMR1_03271(doeA)
SULI: C1J05_07235(doeA)
RMM: ROSMUCSMR3_02212(doeA)
LVS: LOKVESSMR4R_00538(doeA)
AHT: ANTHELSMS3_04452(doeA)
HML: HmaOT1_18505(doeA)
TXI: TH3_02590
THAC: CSC3H3_02845(doeA)
TII: DY252_18730(doeA)
SMAL: SMALA_8299
LMOI: VV02_11300
SERJ: SGUI_0402
 » show all
Taxonomy
Reference
1  [PMID:20849449]
  Authors
Schwibbert K, Marin-Sanguino A, Bagyan I, Heidrich G, Lentzen G, Seitz H, Rampp M, Schuster SC, Klenk HP, Pfeiffer F, Oesterhelt D, Kunte HJ.
  Title
A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581(T).
  Journal
Environ Microbiol (2010)
DOI:10.1111/j.1462-2920.2010.02336.x
  Sequence
[hel:HELO_3665]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.44
IUBMB Enzyme Nomenclature: 3.5.4.44
ExPASy - ENZYME nomenclature database: 3.5.4.44
BRENDA, the Enzyme Database: 3.5.4.44

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