Entry
Name
ectoine hydrolase;
doeA (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
ectoine aminohydrolase
Reaction(IUBMB)
ectoine + H2O = (2S)-2-acetamido-4-aminobutanoate [RN:
R09800 ]
Reaction(KEGG)
Substrate
Product
(2S)-2-acetamido-4-aminobutanoate [CPD:
C19929 ]
Comment
The enzyme, found in some halophilic bacteria, is involved in the degradation of the compatible solute ectoine. The enzyme, which belongs to peptidase family M24, only acts in the direction of ectoine hydrolysis. It also produces smaller amounts of (2S)-4-acetamido-2-aminobutanoate, which is recycled back to ectoine by EC
4.2.1.108 , ectoine synthase.
History
EC 3.5.4.44 created 2017
Pathway
ec00260 Glycine, serine and threonine metabolism
ec01120 Microbial metabolism in diverse environments
Orthology
Genes
PPUD : DW66_0726 DW66_1185
PTAE : NCTC10697_00682(pepP_1)
GAI : IMCC3135_07185(doeA_1) IMCC3135_09905(doeA_2)
OCE : GU3_04560 GU3_08065 GU3_08085
ZDF : AN401_02320 AN401_02345
PARA : BTO02_06320 BTO02_27255
APET : ToN1_21090(doeA1) ToN1_21100(doeA2)
ACOM : CEW83_01835(doeA) CEW83_01840(doeA)
MLN : A9174_24825 A9174_29925 A9174_31385 A9174_32045
MCI : Mesci_2507 Mesci_4400
MCIC : A4R28_05060 A4R28_21570 A4R28_29720
MOP : Mesop_4848 Mesop_5921
MAMO : A6B35_17580 A6B35_24255
MESW : A9K65_013110 A9K65_024320 A9K65_031015 A9K65_031170
MESM : EJ066_12525 EJ066_28925(doeA)
MHUA : MCHK_0652(doeA) MCHK_1813
MJR : EB229_24905 EB229_30510(doeA) EB229_32010(doeA) EB229_32765
MERD : EB233_21625 EB233_26610(doeA) EB233_30455 EB233_30520
MOH : IHQ72_14425(doeA) IHQ72_31135
KMN : HW532_10920(doeA) HW532_14360
SMEL : SM2011_b20434(eutD)
RHI : NGR_a01460 NGR_a01470 NGR_b23250
SAME : SAMCFNEI73_pB0212 SAMCFNEI73_pB0218 SAMCFNEI73_pC1835
EMX : FKV68_23470 FKV68_31040(doeA) FKV68_31080 FKV68_31715(doeA)
REL : REMIM1_PC00109 REMIM1_PC00118(eutD-1) REMIM1_PC00148(eutD-2) REMIM1_PC00149 REMIM1_PE00247 REMIM1_PF00736(eutD-3)
REP : IE4803_PC00199(eutD)
REI : IE4771_PB00253 IE4771_PD00200(eutD)
RTR : RTCIAT899_PB01870 RTCIAT899_PB01900 RTCIAT899_PC08140(eutD)
RPUS : CFBP5875_19350(doeA)
RGA : RGR602_PC02175(eutD)
RPHA : AMC79_PD00407(eutD)
RAD : CO657_24830 CO657_26065(doeA)
RBQ : J2J99_22090(doeA) J2J99_30815 J2J99_30825 J2J99_30865 J2J99_31785 J2J99_31800
RBAN : J2J98_21075(doeA) J2J98_26260 J2J98_26275
RRG : J3P73_24735(doeA) J3P73_35965
RSUL : N2599_20835(doeA) N2599_21190
RLW : RlegWSM1455_24195(doeA)
NGL : RG1141_PA13040(eutD)
BIC : LMTR13_25345 LMTR13_25690 LMTR13_25715 LMTR13_25880 LMTR13_25960
BVV : BHK69_14645 BHK69_30100 BHK69_30125
MMED : Mame_00077 Mame_02830(pepQ_3)
AALA : IGS74_01715(doeA) IGS74_03140
NOH : G5V57_08425 G5V57_30425
RLI : RLO149_c026710(eutD)
OAR : OA238_c05420(eutD1) OA238_c23670(eutD2)
TPRO : Ga0080559_TMP1087 Ga0080559_TMP3721
SINL : DSM14862_03215(doeA)
SPSE : SULPSESMR1_03271(doeA)
RMM : ROSMUCSMR3_02212(doeA)
AHT : ANTHELSMS3_04452(doeA)
HAT : RC74_00115 RC74_18035
LVS : LOKVESSMR4R_00538(doeA)
SEDI : EBB79_11115 EBB79_14100
HTQ : FRZ44_00880 FRZ44_08400 FRZ44_35360
DWD : DSCW_13820 DSCW_13910
DALK : DSCA_33490 DSCA_33560
BFD : NCTC4823_03387 NCTC4823_03388(pepQ_2) NCTC4823_03395(pepQ_3)
GST : HW35_17680 HW35_17715
VIM : GWK91_09505 GWK91_12205
RUE : DT065_02165 DT065_13450
SALE : EPH95_01510 EPH95_13645
SEDD : ERJ70_06570 ERJ70_18310
GFE : Gferi_03360 Gferi_03415
GJI : H1R19_01230 H1R19_19420
PSEV : USB125703_01939(doeA)
» show all
Taxonomy
Reference
Authors
Schwibbert K, Marin-Sanguino A, Bagyan I, Heidrich G, Lentzen G, Seitz H, Rampp M, Schuster SC, Klenk HP, Pfeiffer F, Oesterhelt D, Kunte HJ
Title
A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.44
ExPASy - ENZYME nomenclature database: 3.5.4.44