KEGG   ENZYME: 3.5.4.44
Entry
EC 3.5.4.44                 Enzyme                                 

Name
ectoine hydrolase;
doeA (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
ectoine aminohydrolase
Reaction(IUBMB)
ectoine + H2O = (2S)-2-acetamido-4-aminobutanoate [RN:R09800]
Reaction(KEGG)
R09800
Substrate
ectoine [CPD:C06231];
H2O [CPD:C00001]
Product
(2S)-2-acetamido-4-aminobutanoate [CPD:C19929]
Comment
The enzyme, found in some halophilic bacteria, is involved in the degradation of the compatible solute ectoine. The enzyme, which belongs to peptidase family M24, only acts in the direction of ectoine hydrolysis. It also produces smaller amounts of (2S)-4-acetamido-2-aminobutanoate, which is recycled back to ectoine by EC 4.2.1.108, ectoine synthase.
History
EC 3.5.4.44 created 2017
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15783  ectoine hydrolase
Genes
CAMA: F384_12935
IZH: FEM41_17295(doeA)
SMAF: D781_2283
SRZ: AXX16_2864
SERM: CLM71_11810(doeA)
SRHZ: FO014_21980(doeA)
VAG: N646_3801
VEX: VEA_000632
VNA: PN96_17665
VEJ: VEJY3_17226
VSC: VSVS12_01930
VAF: D1115_22165(doeA)
VNL: D3H41_20745(doeA)
VKA: BTD91_20440
GHO: AL542_02290(doeA)
SALY: E8E00_14710(doeA)
SKS: FCN78_14010(doeA)
SCOT: HBA18_14650(doeA)
PAP: PSPA7_4378(eutD)
PMK: MDS_0056
PFUW: KF707C_22180
PCQ: PcP3B5_00230
PMUI: G4G71_02705(doeA)
PPU: PP_4432
PPT: PPS_0719
PPI: YSA_00599
PPUH: B479_04040
PPUD: DW66_0726 DW66_1185
PFV: Psefu_0029
PMON: X969_02015
PMOT: X970_02005
PPJ: RK21_04289
PCI: PCH70_18590
PFE: PSF113_4816
PMAN: OU5_4501
PCG: AXG94_20235
PSTT: CH92_00105
PBA: PSEBR_a4653
PBC: CD58_05095
PDR: H681_00255
PALL: UYA_00160
PUM: HGP31_27400(doeA)
PLAL: FXN65_00110(doeA)
PSEJ: HNQ25_01235(doeA)
PKH: JLK41_00140(doeA)
PTY: JWV26_10520(doeA)
PMAO: PMYSY11_0800(doeA)
GAI: IMCC3135_07185(doeA_1) IMCC3135_09905(doeA_2)
CSA: Csal_2732
HEL: HELO_3665(doeA)
HCS: FF32_01830
HAK: KO116_01203
HAM: HALO1223
HHU: AR456_15085
HCO: LOKO_00473
HSI: BOX17_04125
HALO: BWR19_14485
HHH: CLM76_01780(doeA)
HBE: BEI_2959(doeA)
HAG: BB497_00065
HAF: C8233_14545(doeA)
HALK: CUU95_10305(doeA)
HVN: EI420_15845(doeA)
HOL: HORIV_52460
HSR: HSBAA_50420
HMD: CTT34_14385(doeA)
HAXI: HAALTHF_21760n
HTT: HZS52_10955(doeA)
HCAM: I4484_15860(doeA)
HPIZ: GYM47_13615(doeA)
HAA: A5892_06415
CMAI: BFX80_03185
KUS: B9G99_10900
KMA: B9H00_03900
KUY: FY550_04105(doeA)
PAUR: FGL86_17275(doeA)
NIK: F5I99_17985
OCE: GU3_04560 GU3_08065 GU3_08085
OCM: CBP12_08025
OPF: CBP31_10115
ZDF: AN401_02320 AN401_02345
TSN: W908_02365
THIN: CRN91_07760
BVI: Bcep1808_5462
BCN: Bcen_5803
BCH: Bcen2424_6167
BCM: Bcenmc03_6648
BCJ: BCAS0027
BCEN: DM39_6671(eutD)
BCEW: DM40_5477(eutD)
BCEO: I35_7026
BAM: Bamb_6020
BAC: BamMC406_5776
BMJ: BMULJ_05387(pepQ)
BMU: Bmul_6143
BMK: DM80_6599(eutD)
BMUL: NP80_5360(eutD)
BCED: DM42_6398(eutD)
BDL: AK34_5360(eutD)
BDF: WI26_29885
BLAT: WK25_18050
BTEI: WS51_29690
BPSL: WS57_18495
BUG: BC1001_4311
BGF: BC1003_5085
BYI: BYI23_B003710
BUE: BRPE67_BCDS06280
BUQ: AC233_27920
BXE: Bxe_C0063
BXB: DR64_8362(eutD)
BPH: Bphy_3862
BGE: BC1002_4838
BPX: BUPH_00896
BFN: OI25_3926(eutD)
BCAI: K788_0000262
PSPW: BJG93_22495
PARA: BTO02_06320 BTO02_27255
PTER: C2L65_27875(doeA)
PGP: CUJ91_28295(doeA)
PTS: CUJ90_21845(doeA)
CABA: SBC2_38090(doeA)
BUO: BRPE64_BCDS09550
BOH: AKI39_12960
PIG: EGT29_03410
VEI: Veis_2149
APET: ToN1_21090(doeA1) ToN1_21100(doeA2)
ACOM: CEW83_01835(doeA) CEW83_01840(doeA)
ANT: Arnit_1221
AHS: AHALO_1645(doeA)
AMAR: AMRN_1667(doeA)
ACAA: ACAN_1695(doeA)
DMS: E8L03_14000(doeA)
DWD: DSCW_13820 DSCW_13910
DALK: DSCA_33490 DSCA_33560
MLO: mlr7141
MLN: A9174_24825 A9174_29925 A9174_31385 A9174_32045
MCI: Mesci_2507 Mesci_4400
MOP: Mesop_4848 Mesop_5921
MAM: Mesau_05393
MAMO: A6B35_17580 A6B35_24255
MESO: BSQ44_02090
MESW: A9K65_013110 A9K65_024320 A9K65_031015 A9K65_031170
MESM: EJ066_12525 EJ066_28925(doeA)
MESP: C1M53_04395(doeA)
MHUA: MCHK_0652(doeA) MCHK_1813
MJR: EB229_24905 EB229_30510(doeA) EB229_32010(doeA) EB229_32765
MERD: EB233_21625 EB233_26610(doeA) EB233_30455 EB233_30520
HOE: IMCC20628_03272
RPOD: E0E05_14125(doeA)
NIY: FQ775_21085(doeA)
NKI: KW403_16725(doeA)
ORM: HTY61_13210(doeA)
KMN: HW532_10920(doeA) HW532_14360
SME: SM_b20434(eutD)
SMK: Sinme_3746
SMQ: SinmeB_4242
SMX: SM11_pD1188(eutD)
SMI: BN406_06240
SMEG: C770_GR4pD1177
SMEL: SM2011_b20434(eutD)
SMER: DU99_31140
SMD: Smed_3693
RHI: NGR_a01460 NGR_a01470 NGR_b23250
SFH: SFHH103_04917
SFD: USDA257_c31390
SIX: BSY16_5544(eutD)
SAME: SAMCFNEI73_pB0212 SAMCFNEI73_pB0218 SAMCFNEI73_pC1835
SINO: SS05631_b62080
EAD: OV14_b1416
EAH: FA04_31170
ESJ: SJ05684_b43240
EAK: EKH55_4170
EMX: FKV68_23470 FKV68_31040(doeA) FKV68_31080 FKV68_31715(doeA)
ATU: Atu4757
ATA: AWN88_05985
AGR: AGROH133_09405
ATF: Ach5_44890(doeA)
ARO: B0909_16545(doeA)
AGT: EYD00_19140(doeA)
RET: RHE_PF00180
REC: RHECIAT_PC0000374
REL: REMIM1_PC00109 REMIM1_PC00118(eutD-1) REMIM1_PC00148(eutD-2) REMIM1_PC00149 REMIM1_PE00247 REMIM1_PF00736(eutD-3)
REP: IE4803_PC00199(eutD)
REI: IE4771_PB00253 IE4771_PD00200(eutD)
RLE: pRL120054
RLT: Rleg2_5521
RLG: Rleg_5242
RLB: RLEG3_09340
RLU: RLEG12_04775
RTR: RTCIAT899_PB01870 RTCIAT899_PB01900 RTCIAT899_PC08140(eutD)
RIR: BN877_II1096
RPUS: CFBP5875_19350(doeA)
RHL: LPU83_pLPU83d1324
RGA: RGR602_PC02175(eutD)
RHN: AMJ98_PE00274(eutD)
RPHA: AMC79_PD00407(eutD)
RHX: AMK02_PD00140(eutD)
RHV: BA939_21235
RHK: Kim5_PC00184(eutD)
REZ: AMJ99_PD00274(eutD)
RJG: CCGE525_32200(doeA)
RHR: CKA34_29665(doeA)
RAD: CO657_24830 CO657_26065(doeA)
ROY: G3A56_16940(doeA)
RHID: FFM81_023130(doeA)
RBQ: J2J99_22090(doeA) J2J99_30815 J2J99_30825 J2J99_30865 J2J99_31785 J2J99_31800
RLN: J0663_22890(doeA)
RBAN: J2J98_21075(doeA) J2J98_26260 J2J98_26275
RRG: J3P73_24735(doeA) J3P73_35965
NGL: RG1141_PA13040(eutD)
NGG: RG540_PA14020(eutD)
NEO: CYG48_20840(doeA)
RHT: NT26_3906
RFV: RFYW14_03940
SHZ: shn_23130 shn_29350
ABAW: D5400_05160
BRJ: BKD03_11990
OIN: IAR37_18905(doeA)
BIO: BR141012304_10758
OAN: Oant_3467
OAH: DR92_3019(eutD)
OPS: A8A54_16015
OCH: CES85_4623(eutD)
OCR: HGK82_19825(doeA)
OCL: GTN27_18040(doeA)
BRC: BCCGELA001_29725
BIC: LMTR13_25345 LMTR13_25690 LMTR13_25715 LMTR13_25880 LMTR13_25960
BARH: WN72_09825
BVV: BHK69_14645 BHK69_30100 BHK69_30125
BOI: BLM15_05205
BOF: FQV39_24130
LNE: FZC33_33975(doeA)
MOC: BB934_24610
MIV: C4E04_10105(doeA)
CHEL: AL346_21850
CDQ: BOQ54_17555
PHL: KKY_228
DEA: FPZ08_18115(doeA)
MMYR: MXMO3_03371
HDI: HDIA_2075
MEY: TM49_08170
MAAD: AZF01_00750
MMED: Mame_00077 Mame_02830(pepQ_3)
AALA: IGS74_01715(doeA) IGS74_03140
BRN: D1F64_10805(doeA)
NOH: G5V57_08425 G5V57_30425
RBM: TEF_15100
LAP: ACP90_14950
LAGG: B0E33_26780
LABR: CHH27_05510(doeA)
LABP: FJ695_10260(doeA)
LABT: FIU93_20645(pepQ2)
SIW: GH266_08155(doeA)
SIL: SPO1140(doeA)
SIT: TM1040_1921
RUA: D1823_06465
RUT: FIU92_06570
RMB: K529_004490
JAN: Jann_0850
RDE: RD1_3474
RLI: RLO149_c026710(eutD)
RPON: G3256_07570
PGA: PGA1_c07820
PGL: PGA2_c07600
PGD: Gal_02709
PHP: PhaeoP97_02538
PPIC: PhaeoP14_00703
PHQ: D1820_16985
OAT: OAN307_c10570(eutD)
OAR: OA238_c05420(eutD1) OA238_c23670(eutD2)
OTM: OSB_17100
OCT: FTO60_07550
LMD: METH_14375
LEJ: ETW24_15270(doeA)
LAQU: R2C4_20340(doeA)
RED: roselon_00427
CID: P73_1149
MALG: MALG_03274
CON: TQ29_09645
YPAC: CEW88_15400(doeA)
YAN: AYJ57_18830
TPRO: Ga0080559_TMP1087 Ga0080559_TMP3721
PABY: Ga0080574_TMP3094
SUAM: BOO69_15095
SPSE: SULPSESMR1_03271(doeA)
SULZ: C1J03_19360
SULI: C1J05_07235(doeA)
SULD: B5M07_16365
SPOT: G6548_05620(doeA)
TOM: BWR18_17445
RMM: ROSMUCSMR3_02212(doeA)
ROK: RAK1035_0974
RID: RIdsm_05126
ROM: EI983_17935
ROH: FIU89_20095
AHT: ANTHELSMS3_04452(doeA)
SAGU: CDO87_04685
OCD: FHY55_15520
MARU: FIU81_12470
ROT: FIV09_16800
MALU: KU6B_39230
TGL: HFZ77_11085
RSQ: Rsph17025_3177
PDE: Pden_0287
PYE: A6J80_21895(doeA)
PZH: CX676_02845(doeA)
PARO: CUV01_01765(doeA)
PARS: DRW48_07115(doeA)
PARR: EOJ32_08975(doeA)
PKD: F8A10_17635(doeA)
PLIA: E4191_06420(doeA)
PSAN: HGN31_00605(doeA)
PTP: RCA23_c24340
RSU: NHU_01997(eutD)
RHM: B5V46_09455
RHC: RGUI_3313
HAT: RC74_00115 RC74_18035
DAA: AKL17_0186
DON: BSK21_06450
THW: BMG03_16185
TEC: AKL02_015690
LVS: LOKVESSMR4R_00538(doeA)
RBG: BG454_09340
SALO: EF888_15660
SEDI: EBB79_11115 EBB79_14100
HML: HmaOT1_18505(doeA)
LIT: FPZ52_11025(doeA)
PPRU: FDP22_11890
PAED: G5B38_12865
MON: G8E03_07580(doeA)
PSHQ: F3W81_04280
PALW: PSAL_009750(doeA)
PPAF: I8N54_09435
PGV: SL003B_2647
RBZ: B9057_07075
THAS: C6Y53_13270
HDH: G5B40_08315(doeA)
CMAG: CBW24_12515
FAQ: G5B39_06375(doeA)
PALG: HFP57_02005
SHUM: STHU_07270
ATI: AL072_17685
HTQ: FRZ44_00880 FRZ44_08400 FRZ44_35360
HADH: FRZ61_08310
TXI: TH3_02590
THAC: CSC3H3_02845(doeA)
TII: DY252_18730(doeA)
PUB: SAR11_1338(y4tM)
PEG: E5R92_06560
APM: HIMB5_00009770
GST: HW35_17680 HW35_17715
BBEV: BBEV_1548(pepP)
BFD: NCTC4823_03387 NCTC4823_03388(pepQ_2) NCTC4823_03395(pepQ_3)
BCO: Bcell_3360
BMEG: BG04_5939
PARH: I5S86_22750(doeA)
BCL: ABC0020
BLE: BleG1_4014
BKW: BkAM31D_11445
BON: A361_15545
OCN: CUC15_04445
GTN: GTNG_2272 GTNG_2288
HHD: HBHAL_4917
HMN: HM131_02830
HLI: HLI_13335
VIR: X953_14790
VHL: BME96_14130
VIL: CFK37_11340
VNE: CFK40_15750
VIM: GWK91_09505 GWK91_12205
LAO: AOX59_17770
SJE: AAV35_007875
AQT: FN924_17770
GRC: GI584_02830
RUE: DT065_02165 DT065_13450
SALE: EPH95_01510 EPH95_13645
SEDD: ERJ70_06570 ERJ70_18310
STEA: C0679_03045
SHV: AAT16_02010
PBJ: VN24_22255
PRT: AUC31_05560
PANA: BBH88_16750
PDG: BCM40_12125
PHC: BBI08_16660
PMAR: B0X71_04260
PPLA: BBI15_00160
PLX: CW734_05910
PMAT: BBI11_05385
PDEC: H1Q58_04530
PANC: E2636_15860
KPUL: GXN76_11640
KEB: GXN75_13265
CACE: CACET_c38080
CFM: BJL90_04765
AMT: Amet_1194
GFE: Gferi_03360 Gferi_03415
DMI: Desmer_3359
FWA: DCMF_21820
ACAE: HYG86_07860
HPK: Hprae_0064
MGO: AFA91_27080
MBAI: MB901379_01124
MSM: MSMEG_2494
MSG: MSMEI_2434
MSB: LJ00_12415
MSN: LI99_12415
MSH: LI98_12420
NNO: NONO_c26800
RHB: NY08_428
RFA: A3L23_03751(doeA)
RHS: A3Q41_04489(doeA)
GBR: Gbro_4077
GPO: GPOL_c44040
GOR: KTR9_4008
GTA: BCM27_21060
GRU: GCWB2_20415
GOM: D7316_04409(doeA)
GAV: C5O27_07690
GOD: GKZ92_19335
GJI: H1R19_01230 H1R19_19420
SMAL: SMALA_8299
AGG: C1N71_08255
PSEV: USB125703_01939(doeA)
ACRY: AC20117_04245
GLU: F0M17_16010
KPL: KPaMU14_00695
KFV: AS188_01275
KRS: EQG70_03255
KOD: HBK84_10630
LMOI: VV02_11300
ARS: ADJ73_04465
SERJ: SGUI_0402
ORN: DV701_10760
ORZ: FNH13_14110
BLY: A2T55_10320
BLIN: BLSMQ_2278
BCAU: I6G59_13850
PBO: PACID_31230
AACI: ASQ49_06565
AJI: C0Z10_01005
MIK: FOE78_15800
MICG: GJV80_09825
SSM: Spirs_0573
IPO: Ilyop_0097
HDL: HALDL1_11275
HJE: HacjB3_03825
HGI: ABY42_16910
HALE: G3A49_07505
HLA: Hlac_1051
HALQ: Hrr1229_000995
SRUB: C2R22_00565
HALG: HUG10_11110
HALU: HUG12_01630
HAH: Halar_1735
HTU: Htur_2943
HDA: BB347_08890
HJT: DVR14_13195
HALY: HYG82_09925
HSAL: JMJ58_13720
HLO: J0X27_13500
NMG: Nmag_3760
HXA: Halxa_0592
NPE: Natpe_0777
NVR: FEJ81_04025
NOU: Natoc_1848
HLR: HALLA_02180
NAG: AArcMg_2880
NAN: AArc1_0822
NBG: DV706_10725
NAS: GCU68_01335
 » show all
Reference
1  [PMID:20849449]
  Authors
Schwibbert K, Marin-Sanguino A, Bagyan I, Heidrich G, Lentzen G, Seitz H, Rampp M, Schuster SC, Klenk HP, Pfeiffer F, Oesterhelt D, Kunte HJ
  Title
A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T.
  Journal
Environ Microbiol 13:1973-94 (2011)
DOI:10.1111/j.1462-2920.2010.02336.x
  Sequence
[hel:HELO_3665]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.44
IUBMB Enzyme Nomenclature: 3.5.4.44
ExPASy - ENZYME nomenclature database: 3.5.4.44
BRENDA, the Enzyme Database: 3.5.4.44

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Pathway (7)   
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   KEGG MODULE (1)   
Chemical substance (3)   
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Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (18195)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (548)   
   KEGG MGENES (15446)   
   RefGene (2200)   
Protein sequence (3258)   
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DNA sequence (6467)   
   RefSeq(nuc) (6033)   
   GenBank (298)   
   EMBL (136)   
Protein domain (5)   
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All databases (27937)   

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