KEGG   ENZYME: 3.5.99.15
Entry
EC 3.5.99.15                Enzyme                                 
Name
deacetylisoipecoside synthase;
deacetylisoipecoside dopamine-lyase;
deacetylisoipecoside dopamine-lyase (secologanin-forming)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
Sysname
deacetylisoipecoside dopamine-hydolase (secologanin-forming)
Reaction(IUBMB)
deacetylisoipecoside + H2O = dopamine + secologanin [RN:R05750]
Reaction(KEGG)
R05750
Substrate
deacetylisoipecoside [CPD:C07304];
H2O [CPD:C00001]
Product
dopamine [CPD:C03758];
secologanin [CPD:C01852]
Comment
The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 3.5.99.16, deacetylipecoside synthase. The product is rapidly converted to demethylisoalangiside.
History
EC 3.5.99.15 created 2000 as EC 4.3.3.3, transferred 2024 to EC 3.5.99.15
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
DeEknamkul W, Ounaroon A, Tanahashi T, Kutchan T, Zenk MH.
  Title
Enzymatic condensation of dopamine and secologanin by cell-free extracts of Alangium lamarckii.
  Journal
Phytochemistry 45:477-484 (1997)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.99.15
IUBMB Enzyme Nomenclature: 3.5.99.15
ExPASy - ENZYME nomenclature database: 3.5.99.15
BRENDA, the Enzyme Database: 3.5.99.15
CAS: 192827-94-4

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
All databases (11)   

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