KEGG   ENZYME: 3.5.99.5
Entry
EC 3.5.99.5                 Enzyme                                 
Name
2-aminomuconate deaminase;
amnD (gene name);
nbaF (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
Sysname
2-aminomuconate aminohydrolase
Reaction(IUBMB)
2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3 [RN:R03887]
Reaction(KEGG)
R03887
Substrate
2-aminomuconate [CPD:C02220];
H2O [CPD:C00001]
Product
(3E)-2-oxohex-3-enedioate;
NH3 [CPD:C00014]
Comment
2-Aminomuconate is an intermediate in the bacterial biodegradation of nitrobenzene. The enzyme has been isolated from several species, including Pseudomonas pseudocaligenes JS45, Pseudomonas fluorescens KU-7, Pseudomonas sp. AP3 and Burkholderia cenocepacia J2315. The reaction is spontaneous in acid conditions.
History
EC 3.5.99.5 created 2000, modified 2012
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K15067  2-aminomuconate deaminase
Genes
SLQM495_05195
PMEXH4W19_03330
PJPLAG73_06430
LABLA76x_2546(amnD)
LAQGLA29479_1095(amnD)
LCPLC55x_2796(amnD)
LGULG3211_2668(amnD)
LEZGLE_2674
LEMLEN_2361
LMBC9I47_1499
LYTDWG18_05825
LUEDCD74_03950
LYJFKV23_07535
LSOLGOY17_11470
LSXH8B22_00650
LAREHIV01_004045
LHXLYSHEL_30000
LCASLYSCAS_29970
LCICINQ41_07800
LAVIINQ42_07235
LLZLYB30171_01461(amnD)
LUMCNR27_08230
LUSE5843_08250
LUGFPZ22_13385
THESFHQ07_01255
THEHG7079_08035
TCNH9L16_12750
TBVH9L17_01810
XBCELE36_12515
RHDR2APBS1_1169
RGLCS053_05990
RTHLRK53_07360
DJICH75_03330
DJAHY57_09320
DYEEO087_08405
DCSISN74_04650
DTLH8F01_15800
DTADYST_01722
DKOI596_660
LRZBJI69_00890
LPYFIV34_14510
LANHKR767_20490
XBAC7S18_00565
PCQPcP3B5_23520(amnD)
PPWPputW619_2009
PKCPKB_3260(amnd1) PKB_3608(amnd3)
PSOSPOS17_2259
PSETTHL1_488
PSEPC4K39_5745
PTRTHU722_0015020
PTAENCTC10697_02307(amnD)
PAGRE2H98_06040
SWDSwoo_1409
SEURFM038_016460
COZA3Q34_02640
COLWA3Q33_02675
COVEKO29_05095
CBERB5D82_03520
THTE2K93_11180
THABLP316_08940
LALAT746_01270
SALHHMF8227_02736(amnD)
MMAIsS8_3505
WMAWM2015_1462
WOCBA177_12680
HCSFF32_08370
HALKCUU95_03810
HVNEI420_02120
KKOKkor_0381
KGETQ33_1985
KSDKS2013_2036
KPDCW740_01645
VMSLVJ82_11895
CRZD1345_11505
CHAECH06BL_23580
AQSDKK66_07200
RINACS15_4681(amnD)
REUReut_B5501
RMERmet_5203 Rmet_5211(amnD)
CBWRR42_m1051 RR42_m1060
CCUPBKK81_23325
CUPBKK80_32990
CUUBKK79_23875
COXE0W60_03795
BURBcep18194_C7642
BCJBCAM2131(nbaF)
BCEOI35_6013(nbaF)
BMULNP80_3863(amnD)
BSTLBBJ41_33950
BUGBC1001_3830
BXEBxe_A1148(amnD) Bxe_A1831
BXBDR64_3307(amnD) DR64_3993(amnD)
BPXBUPH_00405
BPYBphyt_1470
BFNOI25_253
PTERC2L65_38895
BRHRBRH_03004
PPKU875_06930
PPNODA70_24005
PPNMLV28_06700
PRBX636_02640
PPULRO07_00740
PSPUNA29_10885
PAPISG18_00955
PVEUC34_17035
POXMB84_21815
PFGAB870_04080
PNRAT302_15070
PANDDRB87_15745
PFIBPI93_010950
PCOMNTU39_18745
BAVBAV0553(amnE)
BHZACR54_00825(amnD_1)
BOJCBF45_16990
AXYAXYL_05540
AXONH44784_030381
AXNAX27061_5280
AXXERS451415_05309(amnD)
ADTAPT56_24285
AISBUW96_16330
ASWCVS48_11360
ACHRC2U31_27055
ACHBDVB37_23450
ADYHLG70_26340
PUTPT7_3612
PUDG9Q38_14245
CDNBN940_01151
PIGEGT29_10810 EGT29_21575 EGT29_23055
KGYEHF36_16930
PARKLSG25_00270 LSG25_19440
POLBpro_5138
DIHG7047_06940 G7047_08820
DRGH9K76_22890 H9K76_22955
HEEhmeg3_08030 hmeg3_19575
PKTAT984_18825
MXAMXAN_0920
MSDMYSTI_00938
MYMA176_006059
MFBMFUL124B02_05275
CCXCOCOR_00870(tdcF)
MFULILAB_04110
MMASMYMAC_000942
SURSTAUR_2724
AGEAA314_01333
AVMJQX13_18950
PCAYFRD00_12785
BBAEFRD01_10700
AAKAA2016_1095
SMAGAN936_00745
SMAZLH19_00755
STERAOA14_03890
SGISGRAN_3550(amnD)
SPHOC3E99_12565
SWISwit_3522
SPHDHY78_06670
SPKCKC8_11580
SYBTZ53_02820
SUFLFIL70_13985
SBARH5V43_15200
KSCCD178_01496(amnD_1)
NCBC0V82_23415
BDQCIK05_11250
MGOAFA91_00025
CEECENDO_03485(amnD)
NTPCRH09_30235
RERRER_04720 RER_59350
REYO5Y_02270
REBXU06_02470
RQIC1M55_02655
RHODAOT96_13020
RRT4535765_01256(amnD)
REQREQ_05060
GOCCXX93_11300
TOYFO059_00310
SCBSCAB_15171(amnE)
SSXSACTE_4112
STRTA8713_24470
SVUB1H20_29085
SGEDWG14_08259(amnD_2)
SNKCP967_06835
SSUBCP968_28060
SPLACP981_35190
SCALI6J39_28935
SROIIAG44_01275
MVDAWU67_16695
AGYATC03_02575
AMAUDSM26151_04160(amnD)
ASOIMTP13_01925
LTREVS81_03250
ARZAUT26_08865
KFLKfla_5492
KQIF1D05_11670
ACTWF7P10_40035
AGRAAGRA3207_000778
SROSros_9111
NOABKM31_47345
NCXNocox_40760(amnD)
NGNLCN96_28050 LCN96_54775
FRIFraEuI1c_1244
AMYCCU254_17670
PMADBAY61_16760
STPStrop_3523
SAQSare_3898
MAUMicau_4936
MILML5_3359
MICBMicB006_3968
MTUACSH63_33410
MTEMGCE86_19375
MCABHXZ27_25035
VMAVAB18032_17775 VAB18032_28736
MCRAID554_21675 ID554_30885
PLKCIK06_22400
PFLAPflav_027510
PSUUPsuf_082370
VERHUT12_13550 HUT12_26045
PRYPrubr_10580 Prubr_59270
CATICS0771_01250
NHYJQS43_06625
MFFMFFC18_36450(amnD)
GESVT84_05910(amnD)
GMSSOIL9_56630
ABAAcid345_0684
CTMCabther_A0369
CVLJ8C06_09220
CHLOJ8C02_01805
SCORJ3U87_19660
PGOFSB84_28990
HSWHsw_3527
HYMN008_11740
HYDPK28_15270
HYEAM218_01200
HYGAUC43_08340
HYHD3Y59_16475
HYJFHG12_12060
HRSHER32_07450
HBNGUY19_17415
HTSHMJ29_03665
HMTMTP16_01815
HTBMTX78_19080
PKOPKOR_08740
PACTCA264_19620
RUFTH63_01400
RTIDC20_11895
RUDTH61_09900
NIBGU926_15625
MTTFtrac_3614
CHKD4L85_04080
FUVJR347_17250
CATCA2559_07405
KDIKrodi_1917
DOKMED134_12921
DDOI597_1378(amnD)
DODDCS32_02245
LANLacal_1455
LVNBWR22_12895
LACICW733_09600
ASLAeqsu_0472
AEVEI546_00340
AICJK629_01355
NDODDD_1880
NOMAAT17_05195
NSDBST91_00685
NOBCW736_06510
POMMED152_12764
POBLPB03_06880
PRNBW723_00745
POLABXQ17_06210
POACW731_07315
PHALH9I45_07190
PLITK8354_01545
PPECH9W90_08165
PBATJL193_14265
PCEAJ3359_06230
WINWPG_2049
WIJBWZ20_05985
TENLPB136_00555
TJETJEJU_1408(amnD)
TMARMARIT_1043(amnD)
TMPF9Y86_12500
FORFORMB_05910
FOHFORMA_06680
OLLCW732_07065
OAQDZC78_13420
FEKC1H87_06605
TAJC1A40_02555
AUEC5O00_08950
KOSKORDIASMS9_02220(amnD)
KANIMCC3317_39790(amnD)
MARFCJ739_784
PSYNE9099_03020
OCIFEZ18_11755
MGELG5B37_13145
MESQC7H62_1605
ALTIALE3EI_0272
MARXINR76_01205
SABUMBM09_05735
BIAGMA17_09780
FBEFF125_14710
FTEFluta_1229
FLUCHH17_16640
CRMK6119_11800
OHOOweho_2577
CHYDH4K34_08860
PTANCRYO30217_03027(amnD)
BBAUAEM51_09070
 » show all
Reference
1  [PMID:9471964]
  Authors
He Z, Spain JC.
  Title
Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde.
  Journal
Appl Environ Microbiol 63:4839-43 (1997)
DOI:10.1128/AEM.63.12.4839-4843.1997
Reference
2  [PMID:9573204]
  Authors
He Z, Spain JC.
  Title
A novel 2-aminomuconate deaminase in the nitrobenzene degradation pathway of Pseudomonas pseudoalcaligenes JS45.
  Journal
J Bacteriol 180:2502-6 (1998)
DOI:10.1128/JB.180.9.2502-2506.1998
Reference
3  [PMID:11081795]
  Authors
Takenaka S, Murakami S, Kim YJ, Aoki K
  Title
Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3.
  Journal
Arch Microbiol 174:265-72 (2000)
DOI:10.1007/s002030000203
  Sequence
Reference
4  [PMID:12620844]
  Authors
Muraki T, Taki M, Hasegawa Y, Iwaki H, Lau PC
  Title
Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7.
  Journal
Appl Environ Microbiol 69:1564-72 (2003)
DOI:10.1128/AEM.69.3.1564-1572.2003
Other DBs
ExplorEnz - The Enzyme Database: 3.5.99.5
IUBMB Enzyme Nomenclature: 3.5.99.5
ExPASy - ENZYME nomenclature database: 3.5.99.5
BRENDA, the Enzyme Database: 3.5.99.5
CAS: 201098-29-5

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