Entry
Name
1-aminocyclopropane-1-carboxylate deaminase;
1-aminocyclopropane-1-carboxylate endolyase (deaminating);
ACC deaminase;
1-aminocyclopropane carboxylic acid deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
BRITE hierarchy
Sysname
1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)
Reaction(IUBMB)
1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3 (overall reaction) [RN:
R00997 ];
(1a) 1-aminocyclopropane-1-carboxylate = 2-aminobut-2-enoate;
(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);
(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)
Reaction(KEGG)
Substrate
1-aminocyclopropane-1-carboxylate [CPD:
C01234 ];
H2O [CPD:
C00001 ];
2-aminobut-2-enoate [CPD:
C17234 ];
2-iminobutanoate [CPD:
C20905 ]
Product
Comment
A pyridoxal 5'-phosphate enzyme. The enzyme, found in certain soil bacteria and fungi, catalyses the ring opening of 1-aminocyclopropane-1-carboxylate, the immediate precursor to ethylene, an important plant hormone that regulates fruit ripening and other processes. The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination. The latter reaction, which can occur spontaneously, can also be catalysed by EC
3.5.99.10 , 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme has been used to make fruit ripening dependent on externally added ethylene, as it removes the substrate for endogenous ethylene formation.
History
EC 3.5.99.7 created 1981 as EC 4.1.99.4, transferred 2002 to EC 3.5.99.7, modified 2014
Pathway
ec00270 Cysteine and methionine metabolism
Orthology
K01505 1-aminocyclopropane-1-carboxylate deaminase
Genes
NTE : NEUTE1DRAFT77478(NEUTE1DRAFT_77478)
TMN : UCRPA7_6776 UCRPA7_8603
FGR : FGSG_02678 FGSG_12669
FPU : FPSE_00385 FPSE_04922
FVR : FVEG_06024 FVEG_09029 FVEG_12620
FOX : FOXG_08649 FOXG_10376
NHE : NECHADRAFT_33030 NECHADRAFT_42931 NECHADRAFT_73296 NECHADRAFT_94838
FFC : NCS54_00223500 NCS54_00817600
PLJ : VFPFJ_01132 VFPFJ_04280
CFJ : CFIO01_05429 CFIO01_07978
PSCO : LY89DRAFT_634093 LY89DRAFT_645306
AFM : AFUA_2G01030 AFUA_5G03420
NFI : NFIA_033330 NFIA_038690
AOR : AO090102000551 AO090701000360
ANG : ANI_1_1508084(An09g05780)
AFV : AFLA_004869 AFLA_011976
ALUC : AKAW2_40586S AKAW2_71024A
ACHE : ACHE_40040S ACHE_50699A
APUU : APUU_10369S APUU_21867S
PCS : Pc21g15960 Pc22g25060
PDP : PDIP_48910 PDIP_83250
SCM : SCHCO_02637136(SCHCODRAFT_02637136) SCHCO_02663997(SCHCODRAFT_02663997)
TPTY : NCTC11468_02224(acdS)
VGA : BSQ33_15620 BSQ33_17790
VSR : Vspart_01476 Vspart_04070(acdS)
POR : APT59_10785 APT59_13705
PST : PSPTO_3675 PSPTO_3802
PSYR : N018_17270 N018_17875
PSP : PSPPH_1673 PSPPH_1761
PSAV : PSA3335_19975 PSA3335_20380
PAMG : BKM19_010890 BKM19_011295
PCI : PCH70_15870 PCH70_34300
PAVL : BKM03_10025 BKM03_10715
PVD : CFBP1590__3585(acdS) CFBP1590__3782
PCAB : JGS08_09165 JGS08_09740
PCOF : POR16_15695 POR16_16375
PTRE : I9H09_09585 I9H09_16490
PSYI : MME58_08175 MME58_09185
PAST : N015_08910 N015_09735
PLIJ : KQP88_07645 KQP88_16325
PFE : PSF113_3500(acdS) PSF113_3906
PMUD : NCTC8068_03143(acdS)
PFW : PF1751_v1c33520(acdS)
PBA : PSEBR_a1823 PSEBR_a2187
PBC : CD58_03895 CD58_20330
PPUU : PputUW4_01743 PputUW4_04154(acdS)
PSK : U771_20585 U771_27330
PSES : PSCI_3966 PSCI_5555
PPSL : BJP27_02080 BJP27_04665
PVK : EPZ47_09915 EPZ47_21715
PBZ : GN234_08120 GN234_14305
PZA : HU749_010925 HU749_012565
PTAE : NCTC10697_01991(dcyD)
PCAV : D3880_05460 D3880_14545
ALR : DS731_08355 DS731_16000
GAG : Glaag_0758 Glaag_1353
PAEW : KIH87_05260 KIH87_18755
LCJ : NCTC11976_02473(acdS)
LWA : SAMEA4504053_1541(acdS)
TZO : THMIRHAT_13850(dcyD)
MARD : IBG28_03740 IBG28_10415
MRHI : KDW99_09835 KDW99_17260
GSN : YC6258_02550 YC6258_03996
AEL : NCTC12917_00307(acdS)
CDIZ : CEDIAZO_02428(acdS)
RPJ : N234_27825 N234_37345
COX : E0W60_07215 E0W60_18485
BSEM : WJ12_16335 WJ12_21885
BUG : BC1001_3713 BC1001_PA6430(acdS)
BUE : BRPE67_CCDS15320(acdS)
BGE : BC1002_3979 BC1002_7065
BPX : BUPH_00279 BUPH_04726
PARB : CJU94_23115 CJU94_24710
PDIO : PDMSB3_1894.1(acdS)
PLG : NCTC10937_01765(acdS)
AXX : ERS451415_01542(acdS_1)
CFU : CFU_0114(acdS) CFU_2070
CARE : LT85_0090 LT85_2957 LT85_3582
MOH : IHQ72_01685 IHQ72_34015 IHQ72_34080
SAME : SAMCFNEI73_pB0147(acdS)
STEG : QA637_29935 QA637_29975
AVV : RvVAT039_41650(acdS)
AVF : RvVAR031_34140(acdS)
REL : REMIM1_PE00376(acdS)
REI : IE4771_PB00118(acdS)
RTR : RTCIAT899_PB01615(acdS)
RGA : RGR602_PB00298(acdS)
RLN : J0663_02415 J0663_29835
MAQU : Maq22A_c09240(acdS)
SPSE : SULPSESMR1_04053(acdS)
CCOC : CCON33237_1268(acd)
CPIN : CPIN18020_1098(acd)
CAMZ : CVIC12175_0960(acd)
MAUU : NCTC10437_00425(acdS)
MSAL : DSM43276_01566(acdS)
SCO : SCO5247(2SC7G11.09c)
SANL : KZO11_22180 KZO11_25620
SGRF : SGFS_043570 SGFS_087640
SCB : SCAB_30061 SCAB_70301
SVL : Strvi_1041 Strvi_5075
SRC : M271_20625 M271_47330 M271_50365
SMAL : SMALA_0166 SMALA_4608
SSOI : I1A49_04260 I1A49_27100
SDV : BN159_3129 BN159_6597(acdS)
SVT : SVTN_09145 SVTN_25415
SCX : AS200_17495 AS200_33665
SRW : TUE45_02395(acdS_1) TUE45_05762(acdS_2)
SLE : sle_24920(sle_24920)
SCLF : BB341_08230 BB341_22545
SKY : D0C37_09535 D0C37_23690
SLS : SLINC_2191 SLINC_5641
STRD : NI25_12935 NI25_29675
SNW : BBN63_10495 BBN63_33655
SAUO : BV401_04565 BV401_26890
SNZ : DC008_07705 DC008_23325
SGE : DWG14_02889(dcyD) DWG14_06484(acdS)
SGD : ELQ87_13165 ELQ87_29955
SCYA : EJ357_10985 EJ357_30970
SKA : CP970_14285 CP970_33580
SHAW : CEB94_10155 CEB94_27575
SGAL : CP966_08180 CP966_24400
SPAD : DVK44_01140 DVK44_23850
SFY : GFH48_14805 GFH48_30600
SAQU : EJC51_12695 EJC51_32280
SPHV : F9278_09575 F9278_33365
SPAC : B1H29_12315 B1H29_27915
SCHA : CP983_14415 CP983_33115
SGX : H4W23_09590 H4W23_26970
SCOE : CP976_10915 CP976_28870
SBRO : GQF42_12350 GQF42_28795
STUI : GCM10017668_15030 GCM10017668_47770
SATA : C5746_27790 C5746_31275
SFEU : IM697_12650 IM697_37360
SVD : CP969_10560 CP969_25640
SROI : IAG44_13095 IAG44_30820
SLF : JEQ17_16270 JEQ17_35345
SDEC : L3078_11080 L3078_30730
SAOV : G3H79_11600 G3H79_28880
SDUR : M4V62_15350 M4V62_31935
SRUG : F0345_07970 F0345_20295
SAKB : K1J60_14570 K1J60_34465
STAA : LDH80_13895 LDH80_29795
SVIO : HWN34_08475 HWN34_22165
SCAE : IHE65_14085 IHE65_34555
SSPN : LXH13_09855 LXH13_26690
SXT : KPP03845_105019(dcyD)
SLON : LGI35_13125 LGI35_29000
SANT : QR300_18100 QR300_40230
AMAU : DSM26151_06750(acdS)
KQI : F1D05_29460 F1D05_33110
SEN : SACE_1968 SACE_2778(acd)
AAB : A4R43_11595 A4R43_14385
AMYY : YIM_28185(dcyD1) YIM_31550(acdS)
KUT : JJ691_06750 JJ691_98740
KBU : Q4V64_11900 Q4V64_35070
CROS : N8J89_03905 N8J89_09625
SBAE : DSM104329_03227(acdS)
NSPH : BDGGKGIB_01209(dcyD)
SMIZ : 4412673_02379(dcyD_2)
SDJ : NCTC13534_03438(dcyD_3)
STHA : NCTC11429_03443(dcyD)
PHG : KCTC32516_00314(dcyD)
AALG : AREALGSMS7_00522(acdS)
KOS : KORDIASMS9_01984(dcyD)
KAN : IMCC3317_21400(dcyD)
CGLE : NCTC11432_02054(dcyD)
CTAI : NCTC12078_03369(dcyD)
CTAK : 4412677_01003(dcyD)
CJG : NCTC13459_01365(dcyD)
CANT : NCTC13489_02740(acdS)
PTAN : CRYO30217_00255(dcyD)
» show all
Taxonomy
Reference
1
Authors
Honma, M. and Shimomura, T.
Title
Metabolism of 1-aminocyclopropane-1-carboxylic acid.
Journal
Agric Biol Chem 42:1825-1831 (1978)
Reference
Authors
Yao M, Ose T, Sugimoto H, Horiuchi A, Nakagawa A, Wakatsuki S, Yokoi D, Murakami T, Honma M, Tanaka I.
Title
Crystal structure of 1-aminocyclopropane-1-carboxylate deaminase from Hansenula saturnus.
Journal
Reference
Authors
Thibodeaux CJ, Liu HW
Title
Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.5.99.7
ExPASy - ENZYME nomenclature database: 3.5.99.7
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.99.7