KEGG   ENZYME: 3.6.1.12
Entry
EC 3.6.1.12                 Enzyme                                 
Name
dCTP diphosphatase;
DCTPP1 (gene name);
deoxycytidine-triphosphatase;
dCTPase;
dCTP pyrophosphatase;
deoxycytidine triphosphatase;
deoxy-CTPase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
dCTP nucleotidohydrolase
Reaction(IUBMB)
dCTP + H2O = dCMP + diphosphate [RN:R01668]
Reaction(KEGG)
R01668;
(other) R01667
Substrate
dCTP [CPD:C00458];
H2O [CPD:C00001]
Product
dCMP [CPD:C00239];
diphosphate [CPD:C00013]
Comment
The mammalian enzyme also displays weak activity against dTTP and dATP, but none against dGTP. Activity is highest with analogs including 5-iodo-dCTP and 5-methyl-dCTP.
History
EC 3.6.1.12 created 1965
Pathway
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K16904  dCTP diphosphatase
K21503  Escherichia phage dCTP pyrophosphatase
Genes
HSA79077(DCTPP1)
PTR467948(DCTPP1)
PPS100980571(DCTPP1)
GGO101138322(DCTPP1)
PON112129388(DCTPP1)
NLE100584469(DCTPP1)
MCC710500(DCTPP1)
MCF102118443(DCTPP1)
MTHB126944255
CSAB103230924(DCTPP1)
PANU101023286(DCTPP1)
TGE112614007(DCTPP1)
RRO104681570(DCTPP1)
RBB108535403(DCTPP1)
TFN117087647(DCTPP1)
PTEH111525725(DCTPP1)
CJC100408453(DCTPP1)
SBQ101051189(DCTPP1)
CSYR103270176(DCTPP1)
MMUR105871087(DCTPP1)
LCAT123632737(DCTPP1)
OGA100966488(DCTPP1)
MMU66422(Dctpp1)
MCAL110298995(Dctpp1)
MPAH110333566(Dctpp1)
RNO192252(Dctpp1)
MCOC116100913(Dctpp1)
MUN110547975(Dctpp1)
CGE100769832(Dctpp1)
MAUA110339856(Dctpp1)
PLEU114704431(Dctpp1)
MORG121457746(Dctpp1)
MFOT126506769 126515893
AAMP119817500 119826835(Dctpp1)
NGI103726355(Dctpp1)
CPOC100729302(Dctpp1)
CCAN109682528(Dctpp1)
DORD105982043(Dctpp1)
DSP122096260(Dctpp1)
NCAR124970418
OCU100357182(DCTPP1)
OPI101536427(DCTPP1)
TUP102469976(DCTPP1)
CFA489903(DCTPP1)
CLUD112640096(DCTPP1)
VVP112929235(DCTPP1)
VLG121488164(DCTPP1)
AML100479684(DCTPP1)
UMR103657859(DCTPP1)
UAH113267679(DCTPP1)
UAR123784640(DCTPP1)
ELK111162272
LLV125090939
MPUF101689977(DCTPP1)
ORO101370099(DCTPP1)
EJU114214531(DCTPP1)
ZCA113932236(DCTPP1)
MLX117999599(DCTPP1)
NSU110589879(DCTPP1)
FCA101094313(DCTPP1)
PYU121022164(DCTPP1)
PBG122471452(DCTPP1)
LRUF124517981
PTG102950940(DCTPP1)
PPAD109258999(DCTPP1)
AJU106979130(DCTPP1)
HHV120242208(DCTPP1)
BTA614103(DCTPP1)
BOM102282512(DCTPP1)
BIU109578812(DCTPP1)
BBUB102413550(DCTPP1)
CHX102171294(DCTPP1)
OAS101121995(DCTPP1)
ODA120877392(DCTPP1)
CCAD122432991(DCTPP1)
SSC100621901(DCTPP1)
CFR102520187(DCTPP1)
CBAI105082806(DCTPP1)
CDK105102738(DCTPP1)
VPC102530076(DCTPP1)
BACU103015138(DCTPP1)
LVE103086998(DCTPP1)
OOR101278397(DCTPP1)
DLE111182144(DCTPP1)
PCAD102996735(DCTPP1)
PSIU116739494(DCTPP1)
ECB100065556(DCTPP1)
EPZ103547216(DCTPP1)
EAI106831921(DCTPP1)
MYB102241958 102244697(DCTPP1)
MYD102753729(DCTPP1)
MMYO118656764(DCTPP1)
MLF102436112(DCTPP1)
MNA107545786(DCTPP1)
PKL118704932(DCTPP1)
HAI109374219(DCTPP1)
DRO112304734(DCTPP1)
SHON119000462(DCTPP1)
AJM119058954 119058995
PDIC114499420(DCTPP1) 114506604
PHAS123825448 123825498
MMF118642168 118642506(DCTPP1)
RFQ117019421(DCTPP1)
PALE102878907(DCTPP1)
PGIG120620094(DCTPP1)
PVP105304534(DCTPP1)
RAY107515866(DCTPP1)
TOD119240174(DCTPP1)
SARA101541636(DCTPP1)
TMU101349736
DNM101427601(DCTPP1)
MDO100017749(DCTPP1)
GAS123231152(DCTPP1) 123249541
SHR100932588(DCTPP1)
PCW110223138(DCTPP1)
OAA100093573(DCTPP1)
CMY119566278(DCTPP1)
CPIC103306816(DCTPP1)
CABI116840192(DCTPP1)
MRV120403349(DCTPP1)
ACS100558769(dctpp1)
PVT110090066(DCTPP1)
SUND121932764(DCTPP1)
PBI103056195(DCTPP1)
PMUR107282745 107299273
CTIG120302307(DCTPP1)
TSR106557264(DCTPP1)
PGUT117666796(DCTPP1)
VKO123032254(DCTPP1)
PMUA114581674(DCTPP1)
ZVI118094306(DCTPP1)
GJA107106259(DCTPP1)
STOW125445091(DCTPP1)
XLA444233(dctpp1.L)
XTR493314(dctpp1)
NPR108803495(DCTPP1)
BBUF120982963(DCTPP1)
BGAR122945239(DCTPP1)
DRE393744(dctpp1)
SRX107745859(dctpp1)
SANH107695562 107695896
SGH107600637(dctpp1)
CAUA113044140(dctpp1)
PPRM120494586(dctpp1)
MAMB125272682(dctpp1)
IPU108260658(dctpp1)
PHYP113544246(dctpp1)
SMEO124381512(dctpp1)
TFD113649961(dctpp1)
AMEX103022470(dctpp1)
EEE113582232(dctpp1)
TRU101062264(dctpp1)
TNGGSTEN00004075G001
LCO104917965(dctpp1)
NCC104963069(dctpp1)
CGOB115014382(dctpp1)
ELY117255952(dctpp1)
EFO125885596(dctpp1)
PLEP121942310(dctpp1)
SLUC116034219(dctpp1)
ECRA117960131(dctpp1)
ESP116703917(dctpp1)
PFLV114572235(dctpp1)
GAT120825120(dctpp1)
PPUG119217525(dctpp1)
MSAM119898839(dctpp1)
CUD121508595(dctpp1)
ALAT119020394(dctpp1)
MZE101486589(dctpp1)
ONL100690302(dctpp1)
OAU116333718(dctpp1)
OLA101157671(dctpp1)
OML112137346(dctpp1)
XMA102238234(dctpp1)
XCO114143870(dctpp1)
XHE116719813(dctpp1)
PRET103457678(dctpp1)
PFOR103136413(dctpp1)
PLAI106949051(dctpp1)
PMEI106932187(dctpp1)
GAF122830392(dctpp1)
CVG107102830(dctpp1)
CTUL119774399(dctpp1)
GMU124868609(dctpp1)
NFU107395640(dctpp1)
KMR108237872(dctpp1)
ALIM106526180(dctpp1)
NWH119422469(dctpp1)
AOCE111562500(dctpp1)
MCEP125003787(dctpp1)
POV109638313(dctpp1)
SSEN122770517(dctpp1)
HHIP117761815(dctpp1)
HSP118125483(dctpp1)
LCF108893079
SDU111216683(dctpp1)
SLAL111655062(dctpp1)
XGL120800374(dctpp1)
HCQ109511341(dctpp1)
BPEC110167623(dctpp1)
MALB109955505(dctpp1)
BSPL114859044(dctpp1)
SASA100196870(xtp3a)
STRU115202222
OTW112235798(dctpp1) 112261303
OMY110497382(dctpp1) 110534510
OGO124001146 124013366
ONE115145603
SALP111958349 112071580
SNH120035039 120053044
CCLU121560267(dctpp1)
ELS105020920(dctpp1)
SFM108924365(dctpp1)
PKI111837229(dctpp1)
AANG118227868(dctpp1)
LOC102682302(dctpp1)
PSPA121306835(dctpp1)
ARUT117967163(dctpp1)
LCM102360709(DCTPP1)
BFO118425796
BBEL109467214 109482818
SPU574993
APLC110987035
SKO100372648
PVM113811682
PJA122244890
PCHN125033989
HAME121875073
PTRU123499862
PPOI119096815 119099506
ISCIscW_ISCW010553
DSV119446143
RSAN119390018
RMP119161364
VDE111246886
VJA111270085
DPTE113799359
DFR124492898 124500233
CSCU111618405
PTEP107455944
SDM118198095
LGILOTGIDRAFT_163415
PCAN112561110
BGT106053030
GAE121368264
HRF124128462 124133434
HRJ124256647
CRG105341436
MYI110452454
PMAX117329756
MMER123533978
OBI106878263 106878264
OSN115226079 115226080
LAK106152627
NVE5500722 5516876
EPA110250962
ATEN116293975
ADF107341540
AMIL114957627
PDAM113686406
SPIS111322689
HMG100201866
AQU100641006 100641260
ATHAT3G25400
ALY9321770
CRB17893269
CSAT104747081 104766450 104790097
EUSEUTSA_v10002718mg
BRP103828559
BNA106405862 106405863 111213284
BOE106306802
RSZ108862644
THJ104808635 104808811 104826650
CPAP110821737
CIT102607840 102620578 102624370
CICCICLE_v10006144mg CICLE_v10022875mg CICLE_v10032689mg
PVY116107741 116112979 116121545 116124394
MINC123203821 123204915 123204918 123204932 123210921 123216711 123221299 123222991
TCC18602584 18603250 18604767 18612647
GRA105775030 105788325 105790578 105796430 105803336 105804233
GHI107912523 107915870 107923131 107927354 107934822 107949257 107953463 107956611 107956868 121232099 121232152
GAB108472868 108475578 108485684 108486281 108486546
DZI111280017 111283907 111305468 111307263 111307408 111314446 111317569
EGR104414477 104425685 104425991 104456332
GMX100306684 100500214 100500294 100527076 100784040 106798062
GSJ114389644 114406367 114409473 114411829 114414086 114423680
PVUPHAVU_003G187100g PHAVU_008G1376001 PHAVU_010G031100g
VRA106758825 106767643 106773936
VAR108319209 108327961 108340421
VUN114166575 114177013 114183163
CCAJ109793847 109808527 109809928
APRC113850417 113851943
MTR11431912
CAM101508420
LJALj0g3v0107379.1(Lj0g3v0107379.1) Lj4g3v1683160.1(Lj4g3v1683160.1)
ADU107460276 107463489 107468380 107484717
AIP107608022 107619257 107637858
AHF112705749 112708497 112709899 112722548 112740426 112766665 112784070 112794303
LANG109352748 109359141 109359939 109362544
FVE101295813 101296657 101299723
RCN112174699 112179412 112198410 112200318
PPER18767882 18776906 18776965 18792420
PMUM103324073 103338459 103342826
PAVI110748989 110757036 110762368
PDUL117615292 117628500 117637846
MDM103408302 103412147 103415799 103435914 103437858 103455383 114824593
PXB103927095 103931104 103931371 103948695 103949595 103960372 103961366 103965659
ZJU107419174 107422862 107422874 107426632
MNT21386673 21398339 21398922
CSV101204836 101207880 101213795 105436154
CMO103483579 103494015 103494554 103497635
BHJ120070149 120070722 120072296 120083515 120085363
MCHA111006893 111008645 111014625 111019587 111024481
CMAX111471548 111479227 111479510 111484985 111488146 111492910 111497558
CMOS111429911 111432179 111441066 111452418 111455958 111457533 111461259
CPEP111778404 111779721 111789627 111790535 111793865 111807624
RCU8263755 8266766 8284483
JCU105632157 105640582
HBR110643453 110647948 110651061 110655560
MESC110601466 110612236 110617322 110627918 110629698 110630806
POP7459513 7468483 7473465 7475400 7488587
PEU105107698 105115787 105125701 105129433 105129910 105138391
PALZ118040736 118043847 118048862 118049961 118057381
JRE108987684 108991197 108996200 109010564 109011531 109011532 109011533 109017696 109019411 109020279
QSU111987019 112009978 112011113 112021061 112026408 112033465 112033471 112033473
QLO115950632 115950857 115959133 115965510 115965604
TWL119987546 119999796 120003148
VVI100241572 100247693 100263025 100266931
VRI117904456 117904771 117913861 117914944 117914997 117918876
SLY101255503 101256037 101256598 101266563
SPEN107022715 107022856 107030584 107030710
SOT102581660 102583324 102589138 102593064
SSTN125851381 125871549 125873035 125873399
CANN107855433 107864480 107866467 107874589
NTA107765557 107766741 107788382 107792941 107804914 107804932 107819551 107831666
NSY104212087 104227044 104246273 104247658
NTO104087000 104097054 104102260 104102261 104113637
NAU109205877 109210852 109221228 109221271
INI109149450 109162414 109173748 109173749 109175171 109175291
ITR116002863 116005058 116005063 116005179 116015492 116015581 116023131
SIND105157961 105166477 105170100 105171800
OEU111369236 111390570 111396645 111402690 111405925 111408248
EGT105955948 105959879
SSPL121762857
HAN110867777 110870449 110908631 110941891
ECAD122587143 122605931 122608129
LSV111883285 111887751 111896801 111903965
CCAV112514179 112518441 112523474
DCR108198715 108220743
CSIN114258536 114269991 114302655 114317937
BVG104887918 104889715 104893990 104894365
SOE110775089 110777408 110787342
CQI110700315 110700317 110711749 110718132 110727565 110733248
NNU104586285 104598028 104598499 104600908 104602822
MING122077484 122088407 122089863 122092026
TSS122655891 122657051 122659654 122669444
PSOM113283876 113314244 113314253 113314261
NCOL116249852 116266191
OSA4329363 4335533 4336398
DOSAOs02t0479300-01(Os02g0479300) Os04t0346800-01(Os04g0346800) Os04t0515400-00(Os04g0515400)
OBR102706375 102721832
BDI100839966 100840842
ATS109745662 109759876
TDC119354879 119355865 119364015 119365009
TAES123041311 123041697 123049667 123053065 123185761 123188971
TUA125539152 125541660
SBI8054275 8084526
ZMA100281061 100282064 103646230
SITA101753293 101759124 101782075
SVS117841595 117862909 117862990
PVIR120640577 120642569 120655733 120682616 120701761
PHAI112889045 112899722 112900283
PDA103700453 103703930 103716088
EGU105033616 105034711 105051224 105054481
MUS103968474 103971165 103981938 103982464 103983033 103984947 103987608
DCT110096720 110102748 110111666
PEQ110027711 110036494
AOF109824555 109839691
ATR18434935 18438491 18447181 18447991 18447993 18447994
SMOSELMODRAFT_105525 SELMODRAFT_115605 SELMODRAFT_98770
PPP112286416 112292825
VCNVOLCADRAFT_47255
CVRCHLNCDRAFT_14766
MISMICPUN_113203(XTP3A)
FGRFGSG_09100
FPUFPSE_06770
NHENECHADRAFT_93899
TETTTHERM_00522540
PTMGSPATT00006322001
FCYFRACYDRAFT_254541
AAFAURANDRAFT_30607
SPARSPRG_03566
EHXEMIHUDRAFT_58748 EMIHUDRAFT_66958
GTTGUITHDRAFT_113648
NGRNAEGRDRAFT_5223
VJPNP165_18905
PPUNPP4_47220
PSAVPSA3335_04500
PFLPFL_3843
PSEMTO66_12470
PBZGN234_21930
PVWHU752_028825
PALVKSS97_25555
MSXAU14_02600
MARQMARGE09_P2510
TSYTHSYN_16685
TBOGLT988_11425
TGRTgr7_0591
TNITVNIR_1788
TTITHITH_08055
WMAWM2015_2838
THICTspCOW1_24220
EPSL0Y14_15895
ENMEBS_0088(mazG)
CVCBKX93_11315
CHAECH06BL_25240
DTKK4H28_15670
DTSBI380_08260
DHKBO996_13880
DLAI6G47_08300
CODOLAD35_09585
JASFJQ89_21230
JLVG3257_04370
HSEHsero_0516
HSZACP92_02565
HRBHrubri_0506
HHFE2K99_03010
HFRG5S34_02640
MNRACZ75_15785
MASYDPH57_23715
MUMFCL38_23825
MPLIE1742_19385
DUGHH213_14235
FKUFGKAn22_14820
SULFCAP31_09545
AIQAzoinq_03395
EBAebA6173
ABREpbN1_37350
APETToN1_49610
ACOMCEW83_07045
AZDCDA09_12385
AZQG3580_09690
DBKDGMP_29940
DEKDSLASN_03180
MFOLDXT68_01060
MCHNHCR76_15940
LVIG7068_11580
CEJGC089_00590
CELHGXP71_19995
CDONKKR89_16290
CFENKG102_00640
JMEEEW87_008910
PEIH9L10_07455
DEMLGT36_012795
KQIF1D05_37575
IPAIsop_1194
SACISinac_2833
CAQAMICH65_0258
 » show all
Reference
1  [PMID:13788541]
  Authors
ZIMMERMAN SB, KORNBERG A.
  Title
Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Eschrichia coli.
  Journal
J Biol Chem 236:1480-6 (1961)
Reference
2  [PMID:15740738]
  Authors
Moroz OV, Murzin AG, Makarova KS, Koonin EV, Wilson KS, Galperin MY
  Title
Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions.
  Journal
J Mol Biol 347:243-55 (2005)
DOI:10.1016/j.jmb.2005.01.030
Reference
3  [PMID:17320107]
  Authors
Wu B, Liu Y, Zhao Q, Liao S, Zhang J, Bartlam M, Chen W, Rao Z
  Title
Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis.
  Journal
J Mol Biol 367:1405-12 (2007)
DOI:10.1016/j.jmb.2007.01.057
  Sequence
[mmu:66422]
Reference
4  [PMID:19220460]
  Authors
Nonaka M, Tsuchimoto D, Sakumi K, Nakabeppu Y
  Title
Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine.
  Journal
FEBS J 276:1654-66 (2009)
DOI:10.1111/j.1742-4658.2009.06898.x
Reference
5  [PMID:24467396]
  Authors
Requena CE, Perez-Moreno G, Ruiz-Perez LM, Vidal AE, Gonzalez-Pacanowska D
  Title
The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells.
  Journal
Biochem J 459:171-80 (2014)
DOI:10.1042/BJ20130894
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.12
IUBMB Enzyme Nomenclature: 3.6.1.12
ExPASy - ENZYME nomenclature database: 3.6.1.12
BRENDA, the Enzyme Database: 3.6.1.12
CAS: 9024-87-7

DBGET integrated database retrieval system