KEGG   ENZYME: 3.6.1.15Help
Entry
EC 3.6.1.15                 Enzyme                                 

Name
nucleoside-triphosphate phosphatase;
nucleoside-triphosphatase;
nucleoside triphosphate phosphohydrolase;
nucleoside-5-triphosphate phosphohydrolase;
nucleoside 5-triphosphatase;
unspecific diphosphate phosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
nucleoside-triphosphate phosphohydrolase
Reaction(IUBMB)
a nucleoside triphosphate + H2O = a nucleoside diphosphate + phosphate [RN:R02319]
Reaction(KEGG)
R02319 > R00086;
(other) R00615
Show
Substrate
nucleoside triphosphate [CPD:C00201];
H2O [CPD:C00001]
Product
nucleoside diphosphate [CPD:C00454];
phosphate [CPD:C00009]
Comment
The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. Also hydrolyses nucleoside diphosphates, thiamine diphosphate and FAD. The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin [5].
History
EC 3.6.1.15 created 1972
Pathway
ec00230  Purine metabolism
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K06928  nucleoside-triphosphatase
K21517  nucleoside triphosphatase I
Genes
HSA: 84284(NTPCR)
PTR: 744714(NTPCR)
PPS: 100970719(NTPCR)
GGO: 101128290(NTPCR)
PON: 100451516(NTPCR)
NLE: 100583728(NTPCR)
MCC: 712959(NTPCR)
MCF: 102132556(NTPCR)
CSAB: 103230767(NTPCR)
RRO: 104681857(NTPCR)
RBB: 108530014(NTPCR)
CJC: 100397107(NTPCR)
SBQ: 101045439(NTPCR)
MMU: 66566(Ntpcr)
RNO: 361443(Ntpcr)
CGE: 100763065(Ntpcr)
NGI: 103744139(Ntpcr)
HGL: 101704716(Ntpcr)
OCU: 100348163(NTPCR)
TUP: 102500534(NTPCR)
CFA: 607237(NTPCR)
AML: 100473617(NTPCR)
UMR: 103661885(NTPCR)
ORO: 101366225(NTPCR)
FCA: 101088956(NTPCR)
PTG: 107180370(NTPCR)
AJU: 106981645(NTPCR)
BTA: 521103(NTPCR)
BOM: 102274649(NTPCR)
BIU: 109553867(NTPCR)
PHD: 102335100(NTPCR)
CHX: 102190853(NTPCR)
OAS: 101112698(NTPCR)
SSC: 100152811(NTPCR)
CFR: 102504330(NTPCR)
CDK: 105091195(NTPCR)
BACU: 103002536(NTPCR)
LVE: 103086970(NTPCR)
OOR: 101284531(NTPCR)
ECB: 100059958(NTPCR)
EPZ: 103555751(NTPCR)
EAI: 106839674(NTPCR)
MYB: 102260440(NTPCR)
MYD: 102754315(NTPCR)
HAI: 109387742(NTPCR)
RSS: 109435212(NTPCR)
LAV: 100661911(NTPCR)
TMU: 101360478
MDO: 100021763(NTPCR)
SHR: 100924835(NTPCR)
GGA: 428588(NTPCR)
MGP: 100539803(NTPCR)
CJO: 107311404(NTPCR)
APLA: 101802010(NTPCR)
ACYG: 106048051(NTPCR)
TGU: 100190207(NTPCR)
GFR: 102042018(NTPCR)
FAB: 101817327(NTPCR)
PHI: 102099376(NTPCR)
PMAJ: 107201783(NTPCR)
CCW: 104684449(NTPCR)
FPG: 101915161(NTPCR)
FCH: 102052088(NTPCR)
CLV: 102088824(NTPCR)
EGZ: 104131051(NTPCR)
AAM: 106487311(NTPCR)
ASN: 102381737(NTPCR)
AMJ: 102565001(NTPCR)
PSS: 102463075(NTPCR)
CMY: 102936311(NTPCR)
CPIC: 101938101(NTPCR)
ACS: 100565747(ntpcr)
PVT: 110075482(NTPCR)
PBI: 103062293(NTPCR)
GJA: 107123955(NTPCR)
XLA: 108705638
XTR: 100492066(ntpcr)
NPR: 108801483(NTPCR)
DRE: 445069(ntpcr)
SRX: 107719699(ntpcr)
SANH: 107676305(ntpcr)
SGH: 107557727
CCAR: 109096865(ntpcr)
IPU: 100528829(ntpcr)
AMEX: 103029342(ntpcr)
TRU: 101076458(ntpcr)
LCO: 104924453(ntpcr)
NCC: 104961233(ntpcr)
MZE: 101473730(ntpcr)
OLA: 101170786(ntpcr)
XMA: 102232682(ntpcr)
PRET: 103477250(ntpcr)
NFU: 107375420(ntpcr)
CSEM: 103387604(ntpcr)
LCF: 108885783(ntpcr)
HCQ: 109516261(ntpcr)
BPEC: 110157223(ntpcr)
SASA: 100196233(ntpcr)
ELS: 105006537(ntpcr)
SFM: 108927052(ntpcr)
LCM: 102347611(NTPCR)
CMK: 103179258(ntpcr)
CIN: 104266877
SPU: 592174
APLC: 110983206
SKO: 100376182
DME: Dmel_CG10581(CG10581)
DSI: Dsimw501_GD12145(Dsim_GD12145)
MDE: 101887492
AME: 725299
BIM: 105681498
BTER: 105666647
SOC: 105198653
AEC: 105150645
ACEP: 105627197
PBAR: 105427019
HST: 105180904
CFO: 105252351
LHU: 105677404
PGC: 109854897
TCA: 103315262
DPA: 109541322
NVL: 108559022
BMOR: 693091
PMAC: 106718228
PRAP: 110994735
ZNE: 110837904
CRG: 105321370
MYI: 110457776
OBI: 106883627
LAK: 106176105
SHX: MS3_08136
EPA: 110241010
ADF: 107339794
AQU: 100636451
ATH: AT5G66005
CRB: 17875687
THJ: 104826441
CPAP: 110825333
CIT: 102631298
TCC: 18610649
GRA: 105800632
DZI: 111292649
EGR: 104419575
GMX: 100527302
VRA: 106777265
VAR: 108335421
CCAJ: 109800047
CAM: 101498470
LJA: Lj2g3v1613110.1(Lj2g3v1613110.1) Lj2g3v1613110.2(Lj2g3v1613110.2)
ADU: 107487404
AIP: 107642506
LANG: 109333095
FVE: 101299226
PPER: 18769765
PMUM: 103340320
PAVI: 110748910
MDM: 103425028
PXB: 103950159
CSV: 101203894
CMO: 103490648
MCHA: 111014875
CMAX: 111470238
CMOS: 111448271
CPEP: 111800612
RCU: 8281312
JCU: 105628568
HBR: 110672875
POP: 18099100
VVI: 100255709
SLY: 101263792
SPEN: 107012704
SOT: 102603687
CANN: 107868242
NSY: 104240840
NTO: 104093765
INI: 109172443
SIND: 105176007
OEU: 111376318
HAN: 110909094
BVG: 104907880
SOE: 110789891
NNU: 104603772
DOSA: Os03t0130750-01(Os03g0130750)
BDI: 100831212
ATS: 109750338(LOC109750338)
SBI: 8061434
ZMA: 103631588
SITA: 101782829
PDA: 103720917
EGU: 105042666
MUS: 103975805
AOF: 109825021
ATR: 18445534
SMIN: v1.2.017002.t1(symbB.v1.2.017002.t1)
CBO: CBO2894
CBA: CLB_2858
CBH: CLC_2791
CBY: CLM_3290
CBL: CLK_2288
CBK: CLL_A0631
CBB: CLD_1648
CBI: CLJ_B3148
CBT: CLH_0592
CBF: CLI_2950
CBM: CBF_2942
CSQ: CSCA_2473
ROB: CK5_22810
DSY: DSY3088
DHD: Dhaf_4258
OVA: OBV_18660
ADG: Adeg_0940
EUC: EC1_03700
STRE: GZL_00528
SLD: T261_0219
AAE: aq_1292
HTH: HTH_0822
TAL: Thal_0164
TTK: TST_1574
TMA: TM0036
TMW: THMA_0032
TMQ: THMB_0032
TMX: THMC_0032
TPT: Tpet_0887
TRQ: TRQ2_0909
TNA: CTN_0656
TNP: Tnap_0667
PMO: Pmob_1742
MARN: LN42_09715
KOL: Kole_1146
CABY: Cabys_2102
DTU: Dtur_1583
MJA: MJ_1559
MAC: MA_3402
MBAR: MSBR2_0874
METM: MSMTP_1291
MTHE: MSTHC_0065
MTHR: MSTHT_0655
MHOR: MSHOH_2791
MMET: MCMEM_1233
MCJ: MCON_1365
MHI: Mhar_0011
MEMA: MMAB1_1847
MPL: Mpal_0729
MTH: MTH_1068
METC: MTCT_0969
METE: tca_01032
MFC: BRM9_1820
MKA: MK0827
AFU: AF_0814
FPL: Ferp_1308
GAC: GACE_1317
GAH: GAH_00092
TAC: Ta0998
TVO: TVG0753265(TVG0753265)
PTO: PTO0219
FAI: FAD_1425
CDIV: CPM_1188
MARC: AR505_1165
PHO: PH0792(PH0792)
PAB: PAB1537
PFU: PF0501
PFI: PFC_01625
PYN: PNA2_1433
PYS: Py04_0684
TKO: TK0557
TON: TON_0933
TGA: TGAM_1555
TSI: TSIB_1458
THE: GQS_00350
THA: TAM4_1678
THM: CL1_1773
TLT: OCC_04068
TNU: BD01_0894
TEU: TEU_10290
PPAC: PAP_06255
ABI: Aboo_0296
ACJ: ACAM_0548
SMR: Smar_1253
IHO: Igni_1066
IIS: EYM_06965
DKA: DKAM_0812
TAG: Tagg_0153
IAG: Igag_0020
HBU: Hbut_0898
STO: STK_21570
SSO: SSO2171
SOL: Ssol_2900
SSOA: SULA_2912
SSOL: SULB_2912
SSOF: SULC_2909
SAI: Saci_0011
SID: M164_2769
SII: LD85_3116
SIH: SiH_2746
SIR: SiRe_2683
SIC: SiL_2629
MSE: Msed_0721
AHO: Ahos_0262
PAI: PAE3292
PIS: Pisl_0548
PCL: Pcal_1760
PAS: Pars_1717
PYR: P186_1317
POG: Pogu_0417
TNE: Tneu_1537
CMA: Cmaq_0312
TUZ: TUZN_1663
TTN: TTX_1870
VDI: Vdis_0241
VMO: VMUT_1405
TPE: Tpen_1005
ASC: ASAC_0212
NCV: NCAV_0734
KCR: Kcr_1509
BARC: AOA65_0495
BARB: AOA66_1040
 » show all
Taxonomy
Reference
1  [PMID:5661608]
  Authors
Brightwell R, Tappel AL.
  Title
Lysosomal acid pyrophosphatase and acid phosphatase.
  Journal
Arch Biochem Biophys 124:333-43 (1968)
DOI:10.1016/0003-9861(68)90335-4
Reference
2  [PMID:14320490]
  Authors
LEWIS M, WEISSMAN S.
  Title
PROPERTIES OF A SOLUBLE NUCLEOSIDE TRIPHOSPHATASE ACTIVITY IN MAMMALIAN LIVER.
  Journal
Arch Biochem Biophys 109:490-8 (1965)
DOI:10.1016/0003-9861(65)90393-0
Reference
3  [PMID:4301913]
  Authors
Matsushita S, Raacke ID.
  Title
Purification of nucleoside triphosphatases from pea seedling ribosomes.
  Journal
Biochim Biophys Acta 166:707-10 (1968)
DOI:10.1016/0005-2787(68)90380-8
Reference
4  [PMID:7508630]
  Authors
Tong CG, Dauwalder M, Clawson GA, Hatem CL, Roux SJ
  Title
The major nucleoside triphosphatase in pea (Pisum sativum L.) nuclei and in rat liver nuclei share common epitopes also present in nuclear lamins.
  Journal
Plant Physiol 101:1005-11 (1993)
Reference
5  [PMID:8616230]
  Authors
Hsieh HL, Tong CG, Thomas C, Roux SJ
  Title
Light-modulated abundance of an mRNA encoding a calmodulin-regulated, chromatin-associated NTPase in pea.
  Journal
Plant Mol Biol 30:135-47 (1996)
  Sequence
Reference
6  [PMID:14503925]
  Authors
Klinger C, Rossbach M, Howe R, Kaufmann M
  Title
Thermophile-specific proteins: the gene product of aq_1292 from Aquifex aeolicus  is an NTPase.
  Journal
BMC Biochem 4:12 (2003)
DOI:10.1186/1471-2091-4-12
  Sequence
[aae:aq_1292]
Reference
7  [PMID:17291528]
  Authors
Placzek WJ, Almeida MS, Wuthrich K
  Title
NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase.
  Journal
J Mol Biol 367:788-801 (2007)
DOI:10.1016/j.jmb.2007.01.001
  Sequence
[hsa:84284]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.15
IUBMB Enzyme Nomenclature: 3.6.1.15
ExPASy - ENZYME nomenclature database: 3.6.1.15
BRENDA, the Enzyme Database: 3.6.1.15
CAS: 9075-51-8

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