Entry
Name
nucleoside-triphosphate phosphatase;
nucleoside-triphosphatase;
nucleoside triphosphate phosphohydrolase;
nucleoside-5-triphosphate phosphohydrolase;
nucleoside 5-triphosphatase;
unspecific diphosphate phosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
nucleoside-triphosphate phosphohydrolase
Reaction(IUBMB)
a nucleoside triphosphate + H2O = a nucleoside diphosphate + phosphate [RN:
R02319 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. Also hydrolyses nucleoside diphosphates, thiamine diphosphate and FAD. The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin [5].
History
EC 3.6.1.15 created 1972
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K06928 nucleoside-triphosphatase
K21517 Poxviridae nucleoside triphosphatase I
K22273 Hepatitis C virus serine protease / helicase NS3
K25328 Flavivirus serine protease NS3 catalytic subunit
K26798 Bovine viral diarrhea virus 1 serine protease NS3
Genes
RRO : 104681857 115892773 115899091(NTPCR)
CANG : 105503177 105507283(NTPCR)
CCAN : 109698133 109700555
NCAR : 124961054 124961200 124962269 124974102 124974572
NVS : 122900593(NTPCR) 122900658
PBG : 122489689 122492736(NTPCR)
PVIV : 125148046(NTPCR) 125165793
LRUF : 124518659 124529331
LGF : 123576462(NTPCR) 123608607
MBEZ : 129555873(NTPCR) 129558918
PGIG : 120587398 120592595(NTPCR)
BBUF : 120999722 120999723
CIDE : 127524820 127525437
PFOR : 103137650 103137652
DME : Dmel_CG10581(CG10581)
DSI : Dsimw501_GD12145(Dsim_GD12145)
DYA : Dyak_GE22362 Dyak_GE22954
CQU : CpipJ_CPIJ007414 CpipJ_CPIJ018409
PPYR : 116166825 116168717
ESN : 126992076 126994165 126994316 126994409 127001110
PPOI : 119113548 119114258
RPHI : 132745688 132747451
CSAT : 104727441 104746479 104762977
HSYR : 120152229 120153064 120183798
RCN : 112166497 112183514 112187070
CSAV : 115696636 115702609 133034699
SSPL : 121786064 121786502
LSV : 111906244 111914245 111915983
CCAV : 112504896 112519824
PSOM : 113289613 113298798
SMO : SELMODRAFT_48850 SELMODRAFT_48869 SELMODRAFT_49183 SELMODRAFT_59230
EHX : EMIHUDRAFT_250437 EMIHUDRAFT_253875
TVO : TVG0753265(TVG0753265)
» show all
Taxonomy
Reference
Authors
Brightwell R, Tappel AL.
Title
Lysosomal acid pyrophosphatase and acid phosphatase.
Journal
Reference
Authors
LEWIS M, WEISSMAN S.
Title
PROPERTIES OF A SOLUBLE NUCLEOSIDE TRIPHOSPHATASE ACTIVITY IN MAMMALIAN LIVER.
Journal
Reference
Authors
Matsushita S, Raacke ID.
Title
Purification of nucleoside triphosphatases from pea seedling ribosomes.
Journal
Reference
Authors
Tong CG, Dauwalder M, Clawson GA, Hatem CL, Roux SJ
Title
The major nucleoside triphosphatase in pea (Pisum sativum L.) nuclei and in rat liver nuclei share common epitopes also present in nuclear lamins.
Journal
Reference
Authors
Hsieh HL, Tong CG, Thomas C, Roux SJ
Title
Light-modulated abundance of an mRNA encoding a calmodulin-regulated, chromatin-associated NTPase in pea.
Journal
Sequence
Reference
Authors
Klinger C, Rossbach M, Howe R, Kaufmann M
Title
Thermophile-specific proteins: the gene product of aq_1292 from Aquifex aeolicus is an NTPase.
Journal
Sequence
Reference
Authors
Placzek WJ, Almeida MS, Wuthrich K
Title
NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.15
ExPASy - ENZYME nomenclature database: 3.6.1.15