KEGG   ENZYME: 3.6.1.18
Entry
EC 3.6.1.18                 Enzyme                                 
Name
FAD diphosphatase;
FAD pyrophosphatase;
riboflavin adenine dinucleotide pyrophosphatase;
flavin adenine dinucleotide pyrophosphatase;
riboflavine adenine dinucleotide pyrophosphatase;
flavine adenine dinucleotide pyrophosphatase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
FAD nucleotidohydrolase
Reaction(IUBMB)
FAD + H2O = AMP + FMN [RN:R00160]
Reaction(KEGG)
R00160
Substrate
FAD [CPD:C00016];
H2O [CPD:C00001]
Product
AMP [CPD:C00020];
FMN [CPD:C00061]
Comment
The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme hydrolyses NAD+ and CoA at about half of the rate of hydrolysis of FAD. May be identical with EC 3.6.1.9 nucleotide diphosphatase.
History
EC 3.6.1.18 created 1972
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K18453  ADP-ribose/FAD diphosphatase
Genes
ATHAT2G42070(NUDX23)
ALY9316033
CRB17887807
CSAT104782695 104785169 104793124
EUSEUTSA_v10017043mg
BRP103858010 103866609
BNA106385468 106390989 106428102 106450637
BOE106329362 106339762
RSZ108806323
THJ104802583 104824477
CPAP110811796
CIT102624667
CICCICLE_v10013558mg
PVY116114527
MINC123222905
TCC18599110
GRA105799553
GHI107887230 107889499 107891253 121203763
GAB108456960 108474919
HSYR120202029
DZI111311580
EGR104425498
GMX100777180 100783108 100808417
GSJ114366876 114400577 114406783
PVUPHAVU_001G142700g PHAVU_007G260200g
VRA106757709 106771021
VAR108324319 108327071
VUN114163854 114190221
VUM124830465 124838798
CCAJ109791355 109797714
APRC113863012 113872759
MTR11437937
TPRA123892625
CAM101510027
PSAT127126226
VVO131621550
LJALj1g3v4327730.1(Lj1g3v4327730.1) Lj1g3v4327730.2(Lj1g3v4327730.2)
ADU107464793 107492889
AIP107619422 107645415
AHF112696122 112710398 112754995 112779666
LANG109328857
PCIN129305071
FVE101313330
RCN112193132
PPER18771727
PMUM103339411
PAVI110770737
PDUL117633436
MDM103411488 114821097
MSYL126594388 126600927
PXB103958904
MNT112094478
CSAV115701105
CSV101220971
CMO103486759
BHJ120091125
MCHA111024856
CMAX111481706
CMOS111441496
CPEP111790315
RCU8267074
JCU105646524
HBR110668396 110668419
MESC110620131
POP7455643 7483972
PEU105111228 105117323 105131764
PALZ118043890 118052516
JRE109011950
CILL122277555
CAVE132162592
QSU112015319
QLO115954112
TWL119995661 120012786
VVI100245297
VRI117919763
SLY101263980
SPEN107014865
SOT102605083
SSTN125859727
SDUL129870659
LBB132635625
NTA107813369 107829675
NSY104249700
NTO104089616
NAU109235668
INI109180922
ITR116006039
SIND105162491
OEU111380209 111384273
EGT105976763
SSPL121746837 121750506
SMIL130988800
APAN127257956
HAN110897573 110936585
ECAD122581838
LSV111908841
CCAV112512286 112513475
DCR108224652
CSIN114269621
RVL131323171
AEW130781375 130785364
BVG104889186
SOE110806030
CQI110689228 110734505
ATRI130814999
MOF131167969
NNU104603559
MING122064594 122088429
TSS122641500 122643848
PSOM113310051 113320838
OSA4347801
DOSAOs09t0553300-01(Os09g0553300)
OBR102702690
OGL127784484
BDI100829230
ATS109772291
TDC119302839 119311529
TAES123104747 123113034 123122545
TUA125510369
LPER127325920
LRD124654883 124655677
SBI8074182
ZMA100192798 100272585
SITA101755363
SVS117846615
PVIR120658396 120686365
PHAI112881392
PDA103717961 103723373
EGU105055262 105058872
MUS103970625 104000488
ZOF121971374 121976292
DCT110092687
PEQ110021215 110036702
AOF109850360
MSIN131236970
NCOL116260270
ATR18445418
SMOSELMODRAFT_127731 SELMODRAFT_80228
PPP112289210
CRECHLRE_06g285200v5
VCNVOLCADRAFT_44814
MNGMNEG_7550
CSLCOCSUDRAFT_10765 COCSUDRAFT_40300
CVRCHLNCDRAFT_18991
APROF751_4893
 » show all
Reference
1  [PMID:5810832]
  Authors
Ravindranath SD, Rao NA.
  Title
Nucleotidases in plants. 3. Effect of metabolites on the enzyme hydrolyzing flavine adenine dinucleotide (FAD) from Phaseolus radiatus.
  Journal
Arch Biochem Biophys 133:54-9 (1969)
DOI:10.1016/0003-9861(69)90487-1
Reference
2  [PMID:2848456]
  Authors
Shin HJ, Mego JL.
  Title
A rat liver lysosomal membrane flavin-adenine dinucleotide phosphohydrolase: purification and characterization.
  Journal
Arch Biochem Biophys 267:95-103 (1988)
DOI:10.1016/0003-9861(88)90012-4
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.18
IUBMB Enzyme Nomenclature: 3.6.1.18
ExPASy - ENZYME nomenclature database: 3.6.1.18
BRENDA, the Enzyme Database: 3.6.1.18
CAS: 37289-30-8

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