Entry
Name
phosphoribosyl-ATP diphosphatase;
phosphoribosyl-ATP pyrophosphatase;
phosphoribosyladenosine triphosphate pyrophosphatase;
1-(5-phosphoribosyl)-ATP diphosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
1-(5-phospho-beta-D-ribosyl)-ATP diphosphohydrolase
Reaction(IUBMB)
1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate [RN:
R04035 ]
Reaction(KEGG)
Substrate
1-(5-phospho-beta-D-ribosyl)-ATP [CPD:
C02739 ];
H2O [CPD:
C00001 ]
Product
1-(5-phospho-beta-D-ribosyl)-AMP [CPD:
C02741 ];
diphosphate [CPD:
C00013 ]
Comment
The Neurospora crassa enzyme also catalyses the reactions of EC
1.1.1.23 (histidinol dehydrogenase) and EC
3.5.4.19 (phosphoribosyl-AMP cyclohydrolase).
History
EC 3.6.1.31 created 1981
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K01523 phosphoribosyl-ATP pyrophosphohydrolase
K11755 phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase
K14152 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase / histidinol dehydrogenase
Genes
CSAT : 104741789 104757554 104777221
BNA : 106365613 106367164 106451798 125608753
PVY : 116129805 116135159 116141912
GRA : 105763505 105785904 105798642 105804188
GHI : 107888797 107922436 107945840
HSYR : 120124827 120163016
CCAJ : 109789639 109794896 109802925
LJA : Lj1g3v3918060.1(Lj1g3v3918060.1) Lj1g3v3918060.2(Lj1g3v3918060.2) Lj2g3v0911700.1(Lj2g3v0911700.1)
AHF : 112697078 112743567 112754968
PCIN : 129303512 129308760
MDM : 103413049 103418845 103427209
MSYL : 126590918 126615730
PXB : 103930643 103934311 103948885
CPEP : 111783531 111805641
QSU : 111990777 111992172 112036579
SSPL : 121794985 121800288
APAN : 127249039 127259516
MING : 122066053 122093268
PSOM : 113271416 113281309
DOSA : Os01t0276500-01(Os01g0276500)
TAES : 123061105 123069691 123078177
PVIR : 120673506 120706544
ZOF : 121992585 121994065 121996542 122031364
SMO : SELMODRAFT_409257 SELMODRAFT_411322
NCS : NCAS_0B08820(NCAS0B08820)
NDI : NDAI_0A00450(NDAI0A00450)
TPF : TPHA_0E03690(TPHA0E03690)
TDL : TDEL_0C06570(TDEL0C06570)
KAF : KAFR_0D00420(KAFR0D00420)
KNG : KNAG_0C00510(KNAG0C00510)
SPAA : SPAPADRAFT_141809(HIS2)
CAL : CAALFM_C400140CA(HIS4)
NTE : NEUTE1DRAFT150173(NEUTE1DRAFT_150173)
FPOA : FPOAC1_000917(HIS3)
BFU : BCIN_05g05260(Bchis4)
TML : GSTUM_00010427001 GSTUM_00010428001
SPO : SPBC1711.13(his2) SPBC29A3.02c(his7)
SOM : SOMG_01601(his7) SOMG_02196(his2)
CCAC : CcaHIS019_0202180(HIS4)
ABP : AGABI1DRAFT72979(AGABI1DRAFT_72979)
ABV : AGABI2DRAFT184772(AGABI2DRAFT_184772)
SCM : SCHCO_02621953(SCHCODRAFT_02621953)
PSTR : Pst134EA_005041 Pst134EA_032370
ECF : ECH74115_2959(hisIE)
ECOO : ECRM13514_2747(hisI)
ECOH : ECRM13516_2615(hisI)
ECW : EcE24377A_2317(hisIE)
EDJ : ECDH1ME8569_1962(hisI)
ECOI : ECOPMV1_02181(hisE)
EAL : EAKF1_ch3988c(hisIE)
SBC : SbBS512_E1206(hisIE)
ECLS : LI67_011410 LI67_015750
REE : electrica_01700(hisE)
RTG : NCTC13098_02351(hisE)
CTEL : GBC03_12220 GBC03_14095
CLAP : NCTC11466_01528(hisE)
KIE : NCTC12125_00642(hisE)
AHN : NCTC12129_03338(hisI)
METY : MRY16398_18190(hisE)
PSHI : SAMEA2665130_2145(hisE)
YPG : YpAngola_A3176(hisIE)
YPI : YpsIP31758_2435(hisI)
SMW : SMWW4_v1c15920(hisI)
SFJ : SAMEA4384070_1651(hisE)
SOF : NCTC11214_05307(hisE)
PAQU : DMB82_0008960(hisIE)
BAPF : BUMPF009_CDS00489(hisi)
BAPG : BUMPG002_CDS00490(hisi)
BAPU : BUMPUSDA_CDS00488(hisi)
BAPW : BUMPW106_CDS00489(hisi)
TPTY : NCTC11468_02380(hisE)
PHEI : NCTC12003_02830(hisE)
PRJ : NCTC6933_01243(hisE)
LRI : NCTC12151_01564(hisE)
HIC : NTHIC486_00511(hisE)
HPIT : NCTC13334_01117(hisE)
HAEG : NCTC8502_00659(hisE)
PDAG : 4362423_02102(hisI)
ALIG : NCTC10568_02428(hisI)
AVT : NCTC3438_00672(hisE)
RPNE : NCTC8284_00204(hisI)
PAET : NCTC13378_01333(hisI)
XFU : XFF4834R_chr19800(hisIE)
XPH : XppCFBP6546_19975(XppCFBP6546P_19975)
XHD : LMG31886_24700(hisI)
LLZ : LYB30171_01623(hisI)
LAUX : LA521A_23350(hisIE)
VAU : VANGNB10_cI1074(hisI)
PAEB : NCGM1900_5823(hisE)
PVD : CFBP1590__4943(hisE)
PPRC : PFLCHA0_c04300(hisE)
PMUD : NCTC8068_00393(hisE)
PFW : PF1751_v1c03610(hisE)
PPUU : PputUW4_00322(hisE)
PTW : TUM18999_56360(hisE)
PTAE : NCTC10697_04213(hisE)
MSHE : MAALD49_33860(hisE)
PSYC : DABAL43B_2617(hisI)
ASJ : AsACE_CH02622(hisIE)
MCAT : MC25239_00165(hisE)
MCUN : NCTC10297_00529(hisE)
SCAA : TUM17387_18080(hisI)
HJA : BST95_03850 BST95_10490
KIM : G3T16_02025(hisE) G3T16_10780
LLG : 44548918_01232(hisI)
LJR : NCTC11533_01699(hisE)
LCJ : NCTC11976_02571(hisI)
LWA : SAMEA4504053_1416(hisE)
LSS : NCTC12082_00885(hisI)
LANT : TUM19329_14920(hisI)
MISZ : MishRS11D_04910(hisE)
TIB : THMIRHAM_01920(hisE)
TSE : THMIRHAS_01880(hisE)
TZO : THMIRHAT_02150(hisE)
TNI : TVNIR_0068(hisE_[H])
GAI : IMCC3135_32130(hisE)
THIC : TspCOW1_23600(hisE)
NCU : F0U83_06710(hisI) F0U83_16525
AEL : NCTC12917_02044(hisE)
CDIZ : CEDIAZO_01930(hisI)
NMQ : NMBM04240196_1562(hisE)
NMZ : NMBNZ0533_0647(hisE)
NMX : NMA510612_0906(hisE)
NWE : SAMEA3174300_0049(hisE)
NZO : SAMEA4504057_1544(hisE)
NCI : NCTC10296_00203(hisE)
NANI : NCTC12227_01336(hisE)
VFF : VITFI_CDS0186 VITFI_CDS0187
CCUP : BKK81_00090 BKK81_18460
BMV : BMASAVP1_A3247(hisE)
BML : BMA10229_A1796(hisE)
BPM : BURPS1710b_3685(hisE)
BPL : BURPS1106A_3716(hisE)
BUE : BRPE67_ACDS24450(hisE)
PLG : NCTC10937_00578(hisE)
LMIR : NCTC12852_00134(hisE)
VTR : MYVALT_E_00510(hisE)
BTRM : SAMEA390648701081(hisE)
AXX : ERS451415_00188(hisE)
LIM : L103DPR2_00743(hisE)
LIH : L63ED372_02581(hisE)
URU : DSM104443_03677(hisE)
UPL : DSM104440_03205(hisE)
FPHO : SHINM1_013250(hisE)
RBS : RHODOSMS8_03141(hisE)
SMEL : SM2011_c02568(hisE)
SFD : USDA257_c59130(hisE)
SAME : SAMCFNEI73_Ch0050(hisE)
AGR : AGROH133_02848(hisE)
AVV : RvVAT039_16980(hisE)
AVF : RvVAR031_04100(hisE)
REC : RHECIAT_CH0000043(hisE)
REL : REMIM1_CH00041(hisE)
REP : IE4803_CH00040(hisE)
REI : IE4771_CH00041(hisE)
RTR : RTCIAT899_CH00225(hisE)
RGA : RGR602_CH00042(hisE)
RPHA : AMC79_CH00043(hisE)
NEN : NCHU2750_37620(hisE)
BIO : BR141012304_10651(hisE)
BJA : blr0655(hisE) blr1323(his2)
BJU : BJ6T_06230 BJ6T_13740
BJP : RN69_03060 RN69_06800
BRA : BRADO0217(hisE) BRADO6579
BBT : BBta_0141(hisE) BBta_0957
BRS : S23_01800(hisE) S23_64770(his2)
BRC : BCCGELA001_00875 BCCGELA001_04570
BRAD : BF49_0188 BF49_3338
BIC : LMTR13_00090 LMTR13_35085
BRO : BRAD285_6631 BRAD285_7497(hisE)
BRK : CWS35_06085 CWS35_10805(hisE)
BOT : CIT37_07435(hisE) CIT37_11140
BRQ : CIT40_28710(hisE) CIT40_32170
BGQ : X265_00970 X265_05610(hisE)
BGZ : XH91_01175 XH91_05615(hisE)
BSYM : CIT39_27725(hisE) CIT39_31215
BBET : F8237_11755(hisE) F8237_15345
BARH : WN72_00965 WN72_04675(hisE)
BVZ : BRAD3257_0187(hisE) BRAD3257_8378(hisE)
BEL : BE61_07950(hisE) BE61_88590(his2)
BDG : LPJ38_04315 LPJ38_08865(hisE)
BSEP : HAP48_0015430 HAP48_0020380(hisE)
BQB : J4P68_0019400 J4P68_0023880(hisE)
BSEI : KMZ68_00865 KMZ68_04340(hisE)
BBAN : J4G43_001090 J4G43_006285(hisE)
BCAN : BcanWSM471_01100 BcanWSM471_34455(hisE)
BAUT : QA635_00980 QA635_37635(hisE)
BBRA : QA636_00970 QA636_39030(hisE)
BGK : IC762_00885 IC762_04405(hisE)
BCOU : IC761_00920 IC761_04870(hisE)
BPAH : QA639_00930 QA639_38005(hisE)
BXN : I3J27_00895 I3J27_04330(hisE)
RPA : TX73_001630 TX73_024445(hisE)
RPX : Rpdx1_0312 Rpdx1_4880
RBK : E0H22_01410 E0H22_05245(hisE)
OCA : OCAR_4400(hisE) OCAR_7373
OCG : OCA5_c01310(hisE) OCA5_c07460
OCO : OCA4_c01310(hisE) OCA4_c07450
PCAX : AFIC_000181 AFIC_000628(hisE)
VGO : GJW-30_1_00518(hisE_1) GJW-30_1_04305(hisE_2)
TRB : HB776_21035(hisE) HB776_24185
BOP : AXW83_14735 AXW83_19600
BOS : BSY19_200(hisE) BSY19_484(hisE)
BVV : BHK69_04895 BHK69_29340
BOI : BLM15_21045 BLM15_23290
BOF : FQV39_19310 FQV39_22590(hisE)
BVES : QO058_13450(hisE) QO058_16315
STAR : G3545_18630 G3545_22735(hisE)
ANC : GBB76_10530(hisE) GBB76_12930
APRA : G3A50_10030 G3A50_15070(hisE)
APOL : K9D25_05745 K9D25_08090(hisE)
MAQU : Maq22A_1p33380(hisI)
MOG : MMB17_05850 MMB17_25155(hisE)
MTUN : MTUNDRAET4_3020(hisE)
RHJ : HZY79_04600(hisE) HZY79_06700
FIL : BN1229_v1_1050(hisE)
FIY : BN1229_v1_1052(hisE)
RHZ : RHPLAN_02690 RHPLAN_61060
DEQ : XM25_17715 XM25_19017
BLAG : BLTE_31560(hisE2) BLTE_32330(hisE)
CMET : K6K41_08815(hisE) K6K41_14150
PSIN : CAK95_04675 CAK95_08785
TSO : IZ6_00680(hisE) IZ6_01280(hisE2)
PHR : C6569_15730 C6569_17310(hisE)
PSTG : E8M01_11305(hisE) E8M01_14015
BVY : NCTC9239_00351(hisE)
TSV : DSM104635_00444(hisE)
RLI : RLO149_c026230(hisE)
PHP : PhaeoP97_00888(hisE)
PPIC : PhaeoP14_00843(hisE)
SINL : DSM14862_02250(hisE)
SPSE : SULPSESMR1_01977(hisE)
RMM : ROSMUCSMR3_00831(hisE)
AHT : ANTHELSMS3_04068(hisE)
LALG : LentiSH36_00821(hisE)
LVS : LOKVESSMR4R_00973(hisE)
PBAE : P8S53_02055(hisE) P8S53_13395
SBIN : SBA_ch1_10950(hisE)
SFLA : SPHFLASMR4Y_03091(hisE)
SPHS : ETR14_18210 ETR14_18230(hisD)
GTI : FXF46_02085 FXF46_08565
GSP : IGS75_02885 IGS75_09590
GFA : MKW11_02590 MKW11_08415
KNA : B0W47_06615 B0W47_10210
KEU : S101446_01786(hisE) S101446_02508
KSC : CD178_00913(hisE_1) CD178_01623(hisE_2)
KRE : GWK63_01085 GWK63_12100
NCH : A0U93_01900 A0U93_14470
NTN : D5366_02725 D5366_10305
SSAM : E3D00_06515 E3D00_09990
LCK : HN018_16130 HN018_17075
PARZ : DTQ13_05865 DTQ13_06610
AZL : AZL_021610 AZL_028770(hisI)
ALI : AZOLI_1649(hisE2) AZOLI_2222(hisE3) AZOLI_3053(hisE1)
ATI : AL072_04635 AL072_08090 AL072_11470
AHU : A6A40_08690 A6A40_12255
AZM : DM194_08120(hisE) DM194_11810
AZZ : DEW08_07440 DEW08_13410(hisE) DEW08_23715(hisE)
AOZ : HUE56_10490 HUE56_13805(hisE)
AZS : E6C72_00775(hisE) E6C72_04345 E6C72_11475(hisE)
SKT : IGS68_09780(hisE) IGS68_26915
SMUC : JL100_017410(hisE) JL100_028965
SROE : JL101_016290(hisE) JL101_027775
HCB : HCBAA847_1355(hisIE)
HPUL : NCTC13154_00630(hisIE)
CJV : MTVDSCj20_1561(hisIE)
CFT : CFF04554_0300(hisIE)
CFV : CFVI03293_0301(hisIE)
CFX : CFV97608_0303(hisIE)
CAMP : CFT03427_0308(hisIE)
CCV : CCV52592_0853(hisIE)
CCO : CCC13826_2107(hisIE)
CCOC : CCON33237_0271(hisIE)
CLR : UPTC16701_0113(hisIE)
CLM : UPTC16712_0114(hisIE)
CLQ : UPTC4110_0106(hisIE)
CLN : UPTC3659_0122(hisIE)
CAJ : CIG1485E_0314(hisIE)
CAMR : CAQ16704_0105(hisIE)
CSM : CSUB8521_0116(hisIE)
CSF : CSUB8523_0110(hisIE)
CHV : CHELV3228_0261(hisIE)
CAMZ : CVIC12175_0245(hisIE)
SMAB : LN246_01425(hisIE) LN246_13970(hisIE)
GBN : GEOBRER4_36080(hisE)
BAZ : BAMTA208_17675(hisI)
BTHR : YBT1520_08155(hisE)
BTHU : YBT1518_08085(hisE)
BFD : NCTC4823_03057(hisE)
PARG : PspKH34_03950(hisI)
LYC : FH508_0019965(hisIE)
MLIT : KDJ21_008870(hisIE)
BLEN : NCTC4824_01223(hisE)
SAX : USA300HOU_2673(hisIE)
SAA : SAUSA300_2605(hisIE)
SUQ : HMPREF0772_10514(hisE)
SUX : SAEMRSA15_25780(hisIE)
SUF : SARLGA251_24450(hisIE)
SAUV : SAI7S6_1020040(hisI)
SAUW : SAI5S5_1019980(hisI)
SAUX : SAI6T6_1019990(hisI)
SAUY : SAI8T7_1020020(hisI)
SDP : NCTC12225_00293(hisIE)
SPIC : SAMEA4384060_1936(hisIE)
SSH : NCTC13712_02628(hisE)
SSIM : SAMEA4384339_2467(hisI)
SSTE : SAMEA4384403_0770(hisIE)
LMOC : LMOSLCC5850_0554(hisE)
LMW : LMOSLCC2755_0566(hisE)
LMX : LMOSLCC2372_0570(hisE)
LMZ : LMOSLCC2482_0563(hisE)
LMON : LMOSLCC2376_0540(hisE)
LMOS : LMOSLCC7179_0537(hisE)
LMOO : LMOSLCC2378_0585(hisE)
LMOY : LMOSLCC2479_0568(hisE)
LMOT : LMOSLCC2540_0566(hisE)
LMOA : LMOATCC19117_0591(hisE)
LGZ : NCTC10812_00666(hisE)
EAT : EAT1b_0089 EAT1b_0090
EXM : U719_12990 U719_12995
EXU : ESP131_15100 ESP131_15105
EAUR : NMQ00_08760(hisE) NMQ00_08765(hisI)
BAYD : BSPP4475_02385(hisIE)
PPQ : PPSQR21_001740(hisI)
COHN : KCTCHS21_05050(hisI)
SGG : SGGBAA2069_c14860(hisE)
SVB : NCTC12167_01162(hisE)
SFER : NCTC12278_01235(hisE)
LHO : LOOC260_121470(hisE)
LNN : F0161_01520(hisI) F0161_01525(hisE)
ECEC : NCTC12421_00917(hisE)
CGEL : psyc5s11_37040(hisE)
OVA : OBV_42050(hisI_hisIE)
SMAN : C12CBH8_06950(hisE)
PFAA : MM59RIKEN_11810(hisI)
LASA : L9O85_06995(hisI) L9O85_07000(hisE)
BPRO : PMF13cell1_01204(hisE)
CSCI : HDCHBGLK_03068(hisI)
PDF : CD630DERM_15540(hisI)
CBAR : PATL70BA_0104(hisIE)
THEP : DYI95_002735 DYI95_002760(hisD)
ETM : CE91St48_14740(hisI)
CDIA : CaldiYA01_10460(hisI)
CNAG : OTJ99_001244(hisIE)
CMOR : OTK00_001087(hisIE)
VRM : 44547418_00140(hisE)
VDN : NCTC11831_00127(hisE)
DHO : Dia5BBH33_18630(hisI)
MANA : MAMMFC1_03054(hisE)
PFAC : PFJ30894_00671(hisE)
FIT : Fi14EGH31_16680(hisI)
MBO : BQ2027_MB2146C(hisE)
MMAE : MMARE11_30260(hisE)
MBAI : MB901379_02874(hisE)
MHEK : JMUB5695_02240(hisE)
MKY : IWGMT90018_26810(hisE)
MPHL : MPHLCCUG_03239(hisE)
MTHN : 4412656_01917(hisE)
MAUU : NCTC10437_03355(hisE)
MFLV : NCTC10271_02073(hisE)
MSAL : DSM43276_01845(hisE)
MTER : 4434518_01723(hisE)
CDIP : ERS451417_01257(hisE)