Entry
Name
bis(5'-nucleosyl)-tetraphosphatase (symmetrical);
diadenosinetetraphosphatase (symmetrical);
dinucleosidetetraphosphatasee (symmetrical);
symmetrical diadenosine tetraphosphate hydrolase;
adenosine tetraphosphate phosphodiesterase;
Ap4A hydrolase;
bis(5'-adenosyl) tetraphosphatase;
diadenosine tetraphosphate hydrolase;
diadenosine polyphosphate hydrolase;
diadenosine 5',5'''-P1,P4-tetraphosphatase;
diadenosinetetraphosphatase (symmetrical);
1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase
Reaction(IUBMB)
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP [RN:
R00125 ]
Reaction(KEGG)
Substrate
P1,P4-bis(5'-adenosyl) tetraphosphate;
H2O [CPD:
C00001 ]
Product
Comment
Also acts on bis(5'-guanosyl) tetraphosphate and bis(5'-adenosyl) pentaphosphate and, more slowly, on some other polyphosphates, forming a nucleoside bisphosphate as one product in all cases [cf. EC
3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)].
History
EC 3.6.1.41 created 1986
Pathway
Orthology
K01525 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
Genes
TBG : TbgDal_IV4420 TbgDal_VIII8370
ECOO : ECRM13514_0052(apaH)
ECOH : ECRM13516_0054(apaH)
ELR : ECO55CA74_00255(apaH)
ECW : EcE24377A_0053(apaH)
EDJ : ECDH1ME8569_0048(apaH)
ECOI : ECOPMV1_00052(apaH)
SEM : STMDT12_C00890(apaH)
SETC : CFSAN001921_16980(apaH)
SEEN : SE451236_06450(apaH)
SENH : CFSAN002069_08790(apaH)
SEEH : SEEH1578_09470(apaH)
SENJ : CFSAN001992_10585(apaH)
SEEC : CFSAN002050_06890(apaH)
SEEB : SEEB0189_018945(apaH)
SENC : SEET0819_07325(apaH)
REE : electrica_04289(apaH)
RTG : NCTC13098_06263(apaH_2)
CLAP : NCTC11466_03870(apaH)
KIE : NCTC12125_02988(apaH)
AHN : NCTC12129_04216(apaH)
METY : MRY16398_47730(apaH)
PTF : PROFFT_A_01300(apaH)
PSHI : SAMEA2665130_2679(apaH)
SMW : SMWW4_v1c07080(apaH)
SERS : SERRSCBI_03235(apaH)
SFJ : SAMEA4384070_0744(apaH)
SOF : NCTC11214_00813(apaH)
SSAR : SSARUM_000650(apaH)
SERA : Ser39006_005945(apaH)
PAQU : DMB82_0017380(apaH)
PARL : PEC302110_05610(apaH)
DIC : Dpoa569_000561(apaH)
EHD : ERCIPSTX3056_006(apaH)
BAPF : BUMPF009_CDS00453(apah)
BAPG : BUMPG002_CDS00454(apah)
BAPU : BUMPUSDA_CDS00452(apah)
BAPW : BUMPW106_CDS00453(apah)
TPTY : NCTC11468_03130(apaH_1)
PHEI : NCTC12003_03110(apaH)
PRJ : NCTC6933_03210(apaH)
LRI : NCTC12151_02652(apaH)
HIC : NTHIC486_00438(apaH)
HPIT : NCTC13334_00263(apaH)
HHZ : NCTC10839_00606(apaH)
HAEG : NCTC8502_00586(apaH)
PDAG : 4362423_02098(apaH)
ADP : NCTC12871_00786(apaH)
ALIG : NCTC10568_00671(apaH)
ASEG : NCTC10977_00263(apaH)
AVT : NCTC3438_01966(apaH)
PAET : NCTC13378_00130(apaH)
XFU : XFF4834R_chr08650(apaH)
XPH : XppCFBP6546_07210(XppCFBP6546P_07210)
XHD : LMG31886_34800(apaH)
LLZ : LYB30171_02139(apaH)
VAU : VANGNB10_cI0317c(apaH)
VPL : SA104470976_02269(apaH)
VIB : VspSTUT11_26330(apaH)
VIS : VspSTUT16_27480(apaH)
PAEB : NCGM1900_0606(apaH)
PPRC : PFLCHA0_c56040(apaH)
PMUD : NCTC8068_04853(apaH)
PFW : PF1751_v1c50050(apaH)
PPUU : PputUW4_04940(apaH)
PTW : TUM18999_07480(apaH)
PTAE : NCTC10697_00456(apaH)
MSHE : MAALD49_34880(apaH)
PSYC : DABAL43B_1359(apaH)
MCAT : MC25239_01020(apaH)
MCUN : NCTC10297_01526(apaH)
SCAA : TUM17387_09300(apaH)
SALH : HMF8227_00445(apaH)
CBS : COXBURSA331_A0097(apaH)
LLG : 44548918_02653(apaH)
LJR : NCTC11533_02810(apaH)
LCJ : NCTC11976_00752(apaH)
LWA : SAMEA4504053_3446(apaH)
LSS : NCTC12082_01972(apaH)
LADL : NCTC12735_01751(apaH)
LANT : TUM19329_34490(apaH)
MMT : Metme_0099 Metme_2676
MDN : JT25_006825 JT25_008835
MDH : AYM39_08885 AYM39_19455
MKO : MKLM6_1852 MKLM6_3936
METL : U737_01320 U737_21085
MPAD : KEF85_00965 KEF85_14175
MELL : IVG45_05870 IVG45_15565
MMOT : QZJ86_01265 QZJ86_18445
MEEP : JWZ98_19385 JWZ98_21060
MEEC : PL263_03890 PL263_16625
MEUP : QC632_01055 QC632_03435
MPSY : CEK71_00365 CEK71_17945
MISZ : MishRS11D_18130(apaH)
FTR : NE061598_02625(apaH)
TIB : THMIRHAM_06350(apaH)
TSE : THMIRHAS_07370(apaH)
TZO : THMIRHAT_07530(apaH)
RHEI : ATY27_06635(apaH) ATY27_18225(apaH)
TFRI : Thiofri_02069(apaH)
TNI : TVNIR_2212(apaH_[H])
GAI : IMCC3135_10510(apaH)
THIC : TspCOW1_29050(apaH_2)
HAAH : HALA3H3_680013(apaH)
HAXI : HAALTHF_22560n(apaH)
ALCA : ASALC70_03229(apaH)
AEL : NCTC12917_03420(apaH)
CHJ : NCTC10426_00743(apaH)
CDIZ : CEDIAZO_00747(apaH)
NMQ : NMBM04240196_1505(apaH)
NMZ : NMBNZ0533_0708(apaH)
NMX : NMA510612_0961(apaH)
NWE : SAMEA3174300_1220(apaH_1)
NZO : SAMEA4504057_1661(apaH)
NCI : NCTC10296_01369(apaH_2)
NCZ : NCTC10294_00294(apaH)
NANI : NCTC12227_01351(apaH_1)
ECOR : SAMEA4412678_0773(apaH)
REH : H16_A2910(h16_A2910)
BPL : BURPS1106A_3142(apaH)
BUE : BRPE67_ACDS21590(apaH)
PLG : NCTC10937_04940(apaH)
LMIR : NCTC12852_02542(apaH)
BUO : BRPE64_ACDS22030(apaH)
VTR : MYVALT_G_02000(apaH)
BTRM : SAMEA390648700737(apaH)
AXO : NH44784_006571 NH44784_015631
AXN : AX27061_0628 AX27061_1331
AXX : ERS451415_00619(apaH_1) ERS451415_01328(apaH_2)
AIS : BUW96_12300 BUW96_22765
ASW : CVS48_03260 CVS48_18750
ACHB : DVB37_02550 DVB37_13530
ACHO : H4P35_02625 H4P35_13490
AMUI : PE062_10205 PE062_26620
ACHM : V6V88_02595 V6V88_13955
LIM : L103DPR2_02366(apaH)
LIH : L63ED372_02442(apaH)
SMIO : CATMQ487_18970(apaH)
URU : DSM104443_04229(apaH)
UPL : DSM104440_03750(apaH)
THAG : CKCBHOJB_00742(apaH)
FPHO : SHINM1_007660(apaH)
» show all
Taxonomy
Reference
Authors
Barnes LD, Culver CA.
Title
Isolation and characterization of diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase from Physarum polycephalum.
Journal
Reference
Authors
Guranowski A, Jakubowski H, Holler E
Title
Catabolism of diadenosine 5',5"'-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5',5"'-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12.
Journal
J Biol Chem 258:14784-9 (1983)
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.41
ExPASy - ENZYME nomenclature database: 3.6.1.41