EC                 Enzyme                                 

Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase;
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
CDP-choline phosphohydrolase
(1) CDP-choline + H2O = CMP + phosphocholine [RN:R09538];
(2) ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate [RN:R01054]
R01054 R09538
CDP-choline [CPD:C00307];
H2O [CPD:C00001];
ADP-D-ribose [CPD:C00301]
CMP [CPD:C00055];
phosphocholine [CPD:C00588];
AMP [CPD:C00020];
D-ribose 5-phosphate [CPD:C00117]
Requires Mn2+. Unlike EC, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-beta-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose [3]. In rat, the enzyme is found predominantly in thymus and spleen.
EC created 2008
K01517  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
HSA: 56985(ADPRM)
PTR: 745728(ADPRM)
PPS: 100989248(ADPRM)
GGO: 101139187(ADPRM)
PON: 100436862(ADPRM)
NLE: 100601662(ADPRM)
MCC: 717991(ADPRM)
MCF: 102147209(ADPRM)
CSAB: 103242388(ADPRM)
RRO: 104675129(ADPRM)
RBB: 108520319(ADPRM)
CJC: 100399298(ADPRM)
SBQ: 101035686(ADPRM)
MMU: 66358(Adprm)
MCAL: 110305174(Adprm)
MPAH: 110332174(Adprm)
RNO: 287406(Adprm)
MUN: 110552777(Adprm)
CGE: 100767531(Adprm)
NGI: 103752060(Adprm)
HGL: 101700336(Adprm)
CCAN: 109697084(Adprm)
OCU: 100350105(ADPRM)
TUP: 102478915(ADPRM)
CFA: 479504(ADPRM)
VVP: 112924903(ADPRM)
AML: 100484618(ADPRM)
UMR: 103660405(ADPRM)
UAH: 113271215(ADPRM)
ORO: 101374847(ADPRM)
ELK: 111161136
FCA: 101085161(ADPRM)
PTG: 102965979(ADPRM)
PPAD: 109245856(ADPRM)
AJU: 106983330(ADPRM)
BTA: 534038(ADPRM)
BOM: 102283155(ADPRM)
BIU: 109573878(ADPRM)
BBUB: 102391966(ADPRM)
CHX: 102181988(ADPRM)
OAS: 101113772(ADPRM)
SSC: 100519388(ADPRM)
CFR: 102511144(ADPRM)
CDK: 105095885(ADPRM)
BACU: 103010454(ADPRM)
LVE: 103089607(ADPRM)
OOR: 101271746(ADPRM)
DLE: 111186014(ADPRM)
PCAD: 102975974(ADPRM)
ECB: 100073085(ADPRM)
EPZ: 103557154(ADPRM)
EAI: 106845767(ADPRM)
MYB: 102260362(ADPRM)
MYD: 102759013(ADPRM) 102769086
MNA: 107544565(ADPRM)
HAI: 109389128(ADPRM)
DRO: 112308415(ADPRM)
PALE: 102882253(ADPRM)
RAY: 107498319(ADPRM)
MJV: 108392721(ADPRM)
LAV: 100672645(ADPRM)
TMU: 101361939
MDO: 100031391(ADPRM)
SHR: 100918137(ADPRM)
PCW: 110193957(ADPRM)
OAA: 100089526(ADPRM)
GGA: 768578(ADPRM)
MGP: 100544671(ADPRM)
CJO: 107321978(ADPRM)
NMEL: 110407346(ADPRM)
APLA: 101805114(ADPRM)
TGU: 100232304(ADPRM)
LSR: 110474918(ADPRM)
SCAN: 103823912(ADPRM)
GFR: 102037693(ADPRM)
FAB: 101822214(ADPRM)
PHI: 102102216(ADPRM)
PMAJ: 107212591(ADPRM)
CCAE: 111937534(ADPRM)
CCW: 104695677(ADPRM)
ETL: 114067596(ADPRM)
FPG: 101917811(ADPRM)
FCH: 102046962(ADPRM)
CLV: 102096818(ADPRM)
NNI: 104014562(ADPRM)
ACUN: 113490956(ADPRM)
PADL: 103925367(ADPRM)
AAM: 106496876(ADPRM)
ASN: 102378502(ADPRM)
AMJ: 102564317(ADPRM)
PSS: 102454910(ADPRM)
CMY: 102947863(ADPRM)
CPIC: 101938771(ADPRM)
ACS: 100557018(adprm)
PVT: 110075038(ADPRM)
PBI: 103062440(ADPRM)
PMUR: 107282490(ADPRM)
TSR: 106542940(ADPRM)
PMUA: 114590700(ADPRM)
XLA: 108701161 380120(adprm.L)
XTR: 100498212(adprm.2) 493375(adprm)
NPR: 108800850 108801529(ADPRM)
DRE: 393393(adprm)
SANH: 107653999(adprm)
SGH: 107556466(adprm)
IPU: 108274373(adprm)
PHYP: 113527145(adprm)
EEE: 113570913(adprm)
LCO: 104919483(adprm)
NCC: 104963227(adprm)
MZE: 101478096(adprm)
ONL: 100710111(adprm)
XMA: 102227889(adprm)
XCO: 114151735(adprm)
PRET: 103481918(adprm)
CVG: 107096249(adprm)
KMR: 108235853(adprm)
ALIM: 106531924
AOCE: 111572502(adprm)
CSEM: 103382417(adprm)
POV: 109643054(adprm)
LCF: 108890898(adprm)
SDU: 111219537(adprm)
SLAL: 111667088(adprm)
HCQ: 109512603(adprm)
BPEC: 110154055(adprm)
MALB: 109966666(adprm)
SASA: 106589237(adprm)
SALP: 111967034(adprm)
ELS: 105023010(adprm)
PKI: 111856920(adprm)
LCM: 102354487(ADPRM)
CMK: 103175697(adprm)
RTP: 109912985 109912988(adprm)
BFO: 118429669
SKO: 100369075
TUT: 107361847
DPTE: 113799744
CSCU: 111636117
PTEP: 107445858
PCAN: 112566952
CRG: 105341087
OBI: 106867761
LAK: 106161328
EPA: 110231729
ADF: 107346478
AMIL: 114976828
ATH: AT4G24730
ALY: 9303721
CRB: 17878964
BRP: 108868780
RSZ: 108839677
THJ: 104824991
CPAP: 110814750
CIT: 102626985
TCC: 18604977
DZI: 111284677
EGR: 104417636
LJA: Lj0g3v0335139.1(Lj0g3v0335139.1) Lj0g3v0335139.2(Lj0g3v0335139.2)
FVE: 101314949
RCN: 112175288
PPER: 18777900
PMUM: 103337949
PAVI: 110745894
MDM: 103455068
PXB: 103952940
ZJU: 107418316
CSV: 101207870
CMO: 103483938
MCHA: 111009099
CMOS: 111431448
RCU: 8278270
JCU: 105640292
HBR: 110648058
MESC: 110617701
POP: 7484431
JRE: 108986726
QSU: 112033540
VVI: 100265684
SLY: 101246124
SPEN: 107012378
SOT: 102587466
CANN: 107862601
INI: 109180078
LSV: 111907042
CCAV: 112508842
DCR: 108206584
BVG: 104884525
SOE: 110802382
NNU: 104591517
PSOM: 113341967
DOSA: Os07t0688000-01(Os07g0688000) Os08t0557200-01(Os08g0557200)
OBR: 102712498
ATS: 109779171(LOC109779171) 109779172(LOC109779172) 109782101(LOC109782101)
PDA: 103719827
EGU: 105052964
MUS: 103970733
DCT: 110114792
ATR: 18442745
APRO: F751_1456
SMIN: v1.2.028698.t1(symbB.v1.2.028698.t1)
SPAR: SPRG_19962
PAGA: PAGA_a0239
PPH: Ppha_2785
PAA: Paes_0208
CTS: Ctha_1338
 » show all
1  [PMID:7819284]
Canales J, Pinto RM, Costas MJ, Hernandez MT, Miro A, Bernet D, Fernandez A, Cameselle JC
Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatases different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg(2+)-and/or Mn(2+)-dependent hydrolases acting on ADP-ribose.
Biochim Biophys Acta 1246:167-77 (1995)
2  [PMID:18352857]
Canales J, Fernandez A, Ribeiro JM, Cabezas A, Rodrigues JR, Cameselle JC, Costas MJ
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.
Biochem J 413:103-13 (2008)
3  [PMID:19379742]
Canales J, Fernandez A, Rodrigues JR, Ferreira R, Ribeiro JM, Cabezas A, Costas MJ, Cameselle JC
Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase.
FEBS Lett 583:1593-8 (2009)
4  [PMID:22848751]
Rodrigues JR, Fernandez A, Canales J, Cabezas A, Ribeiro JM, Costas MJ, Cameselle JC
Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.
PLoS One 7:e42249 (2012)
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