KEGG   ENZYME: 3.6.1.53
Entry
EC 3.6.1.53                 Enzyme                                 

Name
Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase;
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase;
ADPRibase-Mn
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
CDP-choline phosphohydrolase
Reaction(IUBMB)
(1) CDP-choline + H2O = CMP + phosphocholine [RN:R09538];
(2) ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate [RN:R01054]
Reaction(KEGG)
R01054 R09538
Substrate
CDP-choline [CPD:C00307];
H2O [CPD:C00001];
ADP-D-ribose [CPD:C00301]
Product
CMP [CPD:C00055];
phosphocholine [CPD:C00588];
AMP [CPD:C00020];
D-ribose 5-phosphate [CPD:C00117]
Comment
Requires Mn2+. Unlike EC 3.6.1.13, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-beta-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose [3]. In rat, the enzyme is found predominantly in thymus and spleen.
History
EC 3.6.1.53 created 2008
Orthology
K01517  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Genes
HSA: 56985(ADPRM)
PTR: 745728(ADPRM)
PPS: 100989248(ADPRM)
GGO: 101139187(ADPRM)
PON: 100436862(ADPRM)
NLE: 100601662(ADPRM)
MCC: 717991(ADPRM)
MCF: 102147209(ADPRM)
CSAB: 103242388(ADPRM)
CATY: 105581448(ADPRM)
PANU: 101011738(ADPRM)
RRO: 104675129(ADPRM)
RBB: 108520319(ADPRM)
TFN: 117067688(ADPRM)
PTEH: 111525452(ADPRM)
CJC: 100399298(ADPRM)
SBQ: 101035686(ADPRM)
MMUR: 105878313(ADPRM)
MMU: 66358(Adprm)
MCAL: 110305174(Adprm)
MPAH: 110332174(Adprm)
RNO: 287406(Adprm)
MCOC: 116077456(Adprm)
MUN: 110552777(Adprm)
CGE: 100767531(Adprm)
PLEU: 114693125(Adprm)
NGI: 103752060(Adprm)
HGL: 101700336(Adprm)
CCAN: 109697084(Adprm)
OCU: 100350105(ADPRM)
OPI: 101531379(ADPRM)
TUP: 102478915(ADPRM)
CFA: 479504(ADPRM)
VVP: 112924903(ADPRM)
VLG: 121499597(ADPRM)
AML: 100484618(ADPRM)
UMR: 103660405(ADPRM)
UAH: 113271215(ADPRM)
ORO: 101374847(ADPRM)
ELK: 111161136
MPUF: 101676533(ADPRM)
EJU: 114225347(ADPRM)
MLX: 118000074(ADPRM)
FCA: 101085161(ADPRM)
PYU: 121015893(ADPRM)
PBG: 122484963(ADPRM)
PTG: 102965979(ADPRM)
PPAD: 109245856(ADPRM)
AJU: 106983330(ADPRM)
HHV: 120231401(ADPRM)
BTA: 534038(ADPRM)
BOM: 102283155(ADPRM)
BIU: 109573878(ADPRM)
BBUB: 102391966(ADPRM)
CHX: 102181988(ADPRM)
OAS: 101113772(ADPRM)
ODA: 120865978(ADPRM)
CCAD: 122445103(ADPRM)
SSC: 100519388(ADPRM)
CFR: 102511144(ADPRM)
CBAI: 105077565(ADPRM)
CDK: 105095885(ADPRM)
BACU: 103010454(ADPRM)
LVE: 103089607(ADPRM)
OOR: 101271746(ADPRM)
DLE: 111186014(ADPRM)
PCAD: 102975974(ADPRM)
ECB: 100073085(ADPRM)
EPZ: 103557154(ADPRM)
EAI: 106845767(ADPRM)
MYB: 102260362(ADPRM)
MYD: 102759013(ADPRM) 102769086
MMYO: 118672158(ADPRM)
MNA: 107544565(ADPRM)
PKL: 118726904(ADPRM)
HAI: 109389128(ADPRM)
DRO: 112308415(ADPRM)
SHON: 118974743(ADPRM)
AJM: 119056602(ADPRM)
MMF: 118634441(ADPRM)
PALE: 102882253(ADPRM)
PGIG: 120589741(ADPRM)
RAY: 107498319(ADPRM)
MJV: 108392721(ADPRM)
TOD: 119230843(ADPRM)
LAV: 100672645(ADPRM)
TMU: 101361939
MDO: 100031391(ADPRM)
SHR: 100918137(ADPRM)
PCW: 110193957(ADPRM)
OAA: 100089526(ADPRM)
GGA: 768578(ADPRM)
PCOC: 116235560(ADPRM)
MGP: 100544671(ADPRM)
CJO: 107321978(ADPRM)
NMEL: 110407346(ADPRM)
APLA: 101805114(ADPRM)
TGU: 100232304(ADPRM)
LSR: 110474918(ADPRM)
SCAN: 103823912(ADPRM)
PMOA: 120498260(ADPRM)
OTC: 121348142(ADPRM)
PRUF: 121352717(ADPRM)
GFR: 102037693(ADPRM)
FAB: 101822214(ADPRM)
PHI: 102102216(ADPRM)
PMAJ: 107212591(ADPRM)
CCAE: 111937534(ADPRM)
CCW: 104695677(ADPRM)
ETL: 114067596(ADPRM)
FPG: 101917811(ADPRM)
FCH: 102046962(ADPRM)
CLV: 102096818(ADPRM)
NNI: 104014562(ADPRM)
ACUN: 113490956(ADPRM)
PADL: 103925367(ADPRM)
AAM: 106496876(ADPRM)
AROW: 112970885(ADPRM)
DNE: 112995542(ADPRM)
ASN: 102378502(ADPRM)
AMJ: 102564317(ADPRM)
CPOO: 109311086(ADPRM)
PSS: 102454910(ADPRM)
CMY: 102947863(ADPRM)
CPIC: 101938771(ADPRM)
TST: 117887304(ADPRM)
CABI: 116838534(ADPRM)
ACS: 100557018(adprm)
PVT: 110075038(ADPRM)
PBI: 103062440(ADPRM)
PMUR: 107282490(ADPRM)
TSR: 106542940(ADPRM)
PGUT: 117660436(ADPRM)
PMUA: 114590700(ADPRM)
ZVI: 118079905(ADPRM)
XLA: 108701161(adprm.2.L) 380120(adprm.L)
XTR: 100498212(adprm.2) 493375(adprm)
NPR: 108800850 108801529(ADPRM)
DRE: 393393(adprm)
SANH: 107653999(adprm)
SGH: 107556466(adprm)
CAUA: 113112013(adprm)
IPU: 108274373(adprm)
PHYP: 113527145(adprm)
EEE: 113570913(adprm)
LCO: 104919483(adprm)
NCC: 104963227(adprm)
CGOB: 115024397(adprm)
ELY: 117246741(adprm)
PLEP: 121958470(adprm)
SLUC: 116067530(adprm)
ECRA: 117936605(adprm)
PFLV: 114548639(adprm)
GAT: 120819488(adprm)
PPUG: 119212515(adprm)
MSAM: 119894653 119916291(adprm)
CUD: 121527869(adprm)
MZE: 101478096(adprm)
ONL: 100710111(adprm)
OAU: 116330879(adprm)
OML: 112153871(adprm)
XMA: 102227889(adprm)
XCO: 114151735(adprm)
XHE: 116726664(adprm)
PRET: 103481918(adprm)
CVG: 107096249(adprm)
CTUL: 119796022(adprm)
KMR: 108235853(adprm)
ALIM: 106531924
AOCE: 111572502(adprm)
CSEM: 103382417(adprm)
POV: 109643054(adprm)
LCF: 108890898(adprm)
SDU: 111219537(adprm)
SLAL: 111667088(adprm)
XGL: 120793977(adprm)
HCQ: 109512603(adprm)
BPEC: 110154055(adprm)
MALB: 109966666(adprm)
SASA: 106589237(adprm)
OTW: 112233704(adprm)
OMY: 110498890(adprm)
SALP: 111967034(adprm)
SNH: 120029905(adprm)
ELS: 105023010(adprm)
PKI: 111856920(adprm)
AANG: 118220164(adprm)
LOC: 102683124(adprm)
ARUT: 117423255(adprm) 117424544
LCM: 102354487(ADPRM)
CMK: 103175697(adprm)
RTP: 109912985 109912988(adprm)
BFO: 118429669
BBEL: 109483378
SCLV: 120330472
SKO: 100369075
DSV: 119453708
RSAN: 119399329
RMP: 119179522
TUT: 107361847
DPTE: 113799744
CSCU: 111636117
PTEP: 107445858
SDM: 118188538
PCAN: 112566952
GAE: 121375974
CRG: 105341087
OBI: 106867761
OSN: 115231016
LAK: 106161328
EPA: 110231729
ADF: 107346478
AMIL: 114976828
ATH: AT4G24730
ALY: 9303721
CRB: 17878964
BRP: 108868780
RSZ: 108839677
THJ: 104824991
CPAP: 110814750
CIT: 102626985
PVY: 116137190
MINC: 123211286
TCC: 18604977
DZI: 111284677
EGR: 104417636
LJA: Lj0g3v0335139.1(Lj0g3v0335139.1) Lj0g3v0335139.2(Lj0g3v0335139.2)
FVE: 101314949
RCN: 112175288
PPER: 18777900
PMUM: 103337949
PAVI: 110745894
PDUL: 117627823
MDM: 103455068
PXB: 103952940
ZJU: 107418316
MNT: 21401927
CSV: 101207870
CMO: 103483938
BHJ: 120082712
MCHA: 111009099
CMOS: 111431448
RCU: 8278270
JCU: 105640292
HBR: 110648058
MESC: 110617701
POP: 7484431
PALZ: 118044772
JRE: 108986726
QSU: 112033540
QLO: 115964155
TWL: 119985279
VVI: 100265684
VRI: 117904811
SLY: 101246124
SPEN: 107012378
SOT: 102587466
CANN: 107862601
INI: 109180078
ITR: 116010271
ECAD: 122590303
LSV: 111907042
CCAV: 112508842
DCR: 108206584
BVG: 104884525
SOE: 110802382
NNU: 104591517
MING: 122079719
PSOM: 113341967
NCOL: 116250524
DOSA: Os07t0688000-01(Os07g0688000) Os08t0557200-01(Os08g0557200)
OBR: 102712498
PDA: 103719827
EGU: 105052964
MUS: 103970733
DCT: 110114792
ATR: 18442745
APRO: F751_1456
SMIN: v1.2.028698.t1(symbB.v1.2.028698.t1)
SPAR: SPRG_19962
PAGA: PAGA_a0239
PPH: Ppha_2785
PAA: Paes_0208
CTS: Ctha_1338
 » show all
Reference
1  [PMID:7819284]
  Authors
Canales J, Pinto RM, Costas MJ, Hernandez MT, Miro A, Bernet D, Fernandez A, Cameselle JC
  Title
Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatases different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg(2+)-and/or Mn(2+)-dependent hydrolases acting on ADP-ribose.
  Journal
Biochim Biophys Acta 1246:167-77 (1995)
DOI:10.1016/0167-4838(94)00191-I
Reference
2  [PMID:18352857]
  Authors
Canales J, Fernandez A, Ribeiro JM, Cabezas A, Rodrigues JR, Cameselle JC, Costas MJ
  Title
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.
  Journal
Biochem J 413:103-13 (2008)
DOI:10.1042/BJ20071471
  Sequence
[rno:287406]
Reference
3  [PMID:19379742]
  Authors
Canales J, Fernandez A, Rodrigues JR, Ferreira R, Ribeiro JM, Cabezas A, Costas MJ, Cameselle JC
  Title
Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase.
  Journal
FEBS Lett 583:1593-8 (2009)
DOI:10.1016/j.febslet.2009.04.023
  Sequence
[rno:287406]
Reference
4  [PMID:22848751]
  Authors
Rodrigues JR, Fernandez A, Canales J, Cabezas A, Ribeiro JM, Costas MJ, Cameselle JC
  Title
Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.
  Journal
PLoS One 7:e42249 (2012)
DOI:10.1371/journal.pone.0042249
  Sequence
[dre:393393]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.53
IUBMB Enzyme Nomenclature: 3.6.1.53
ExPASy - ENZYME nomenclature database: 3.6.1.53
BRENDA, the Enzyme Database: 3.6.1.53

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