| Entry |
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| Name |
UDP-2,3-diacylglucosamine diphosphatase;
lpxH (gene name);
UDP-2,3-diacylglucosamine hydrolase;
UDP-2,3-diacylglucosamine pyrophosphatase;
ybbF (gene name);
UDP-2,3-bis[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine 2,3-bis[(3R)-3-hydroxymyristoyl]-beta-D-glucosaminyl 1-phosphate phosphohydrolase (incorrect);
UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate phosphohydrolase
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| Class |
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
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| Sysname |
UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine 2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine-1-phosphate phosphohydrolase
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| Reaction(IUBMB) |
a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O = a lipid X + UMP
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| Reaction(KEGG) |
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| Substrate |
UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine [CPD: C22410];
H2O [CPD: C00001]
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| Product |
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| Comment |
The enzyme catalyses a step in the biosynthesis of lipid A.
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| History |
EC 3.6.1.54 created 2010, modified 2021
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| Pathway |
| ec00540 | Lipopolysaccharide biosynthesis |
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| Orthology |
| K03269 | UDP-2,3-diacylglucosamine hydrolase |
| K09949 | UDP-2,3-diacylglucosamine hydrolase |
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| Genes |
| ECOO: | ECRM13514_0313(ybbF) |
| ECOH: | ECRM13516_0512(ybbF) |
| ECW: | EcE24377A_0563(lpxH) |
| EDJ: | ECDH1ME8569_0509(lpxH) |
| ECOI: | ECOPMV1_00513(lpxH) |
| REE: | electrica_03824(lpxH) |
| RTG: | NCTC13098_05674(lpxH) |
| CLAP: | NCTC11466_01127(lpxH) |
| KIE: | NCTC12125_02509(lpxH) |
| AHN: | NCTC12129_03735(lpxH) |
| METY: | MRY16398_43180(lpxH) |
| PTF: | PROFFT_A_02460(lpxH) |
| PSHI: | SAMEA2665130_0950(lpxH) |
| MPHG: | MPHASIOC01_004097(lpxH) |
| YPG: | YpAngola_A1276(lpxH) |
| YPI: | YpsIP31758_3016(lpxH) |
| SMW: | SMWW4_v1c11330(lpxH) |
| SFJ: | SAMEA4384070_1193(lpxH) |
| SOF: | NCTC11214_00325(lpxH) |
| SERA: | Ser39006_009635(lpxH) |
| PAQU: | DMB82_0006880(lpxH) |
| DIC: | Dpoa569_0001020(lpxH) |
| EHD: | ERCIPSTX3056_335(lpxH) |
| TPTY: | NCTC11468_01120(lpxH) |
| PHEI: | NCTC12003_01102(lpxH) |
| PRJ: | NCTC6933_02936(lpxH) |
| LRI: | NCTC12151_02294(lpxH) |
| HIC: | NTHIC486_00249(lpxH) |
| HPIT: | NCTC13334_00875(lpxH) |
| HHZ: | NCTC10839_00426(lpxH) |
| HAEG: | NCTC8502_00323(lpxH) |
| PDAG: | 4362423_00398(lpxH) |
| ADP: | NCTC12871_00176(lpxH) |
| ALIG: | NCTC10568_02184(lpxH) |
| ASEG: | NCTC10977_00036(lpxH) |
| AVT: | NCTC3438_00877(lpxH) |
| RPNE: | NCTC8284_03933(lpxH) |
| MSEP: | CEP49_00035(lpxH) CEP49_08660(lpxH) |
| PAET: | NCTC13378_01404(lpxH) |
| XFU: | XFF4834R_chr10400(lpxH) |
| XPH: | XppCFBP6546_06285(lpxH) |
| XHD: | LMG31886_33100(lpxH) |
| SINC: | DAIF1_08740(lpxH_2) |
| LLZ: | LYB30171_02010(lpxH) |
| DTX: | ATSB10_12600 ATSB10_34980 |
| VAU: | VANGNB10_cI1678(lpxH) |
| VPL: | SA104470976_01563(lpxH) |
| VIB: | VspSTUT11_18960(lpxH) |
| VIS: | VspSTUT16_19890(lpxH) |
| PVD: | CFBP1590__3729(lpxH) |
| PPRC: | PFLCHA0_c39740(lpxH) |
| PMUD: | NCTC8068_03101(lpxH) |
| PFW: | PF1751_v1c33010(lpxH) |
| PPUU: | PputUW4_01777(lpxH) |
| PTRT: | HU722_0018240(lpxH) |
| PTW: | TUM18999_20050(lpxH) |
| PTAE: | NCTC10697_03183(lpxH) |
| MSHE: | MAALD49_15740(lpxH) |
| PSYC: | DABAL43B_0767(lpxH) |
| MCAT: | MC25239_00643(lpxH) |
| MCUN: | NCTC10297_01324(lpxH) |
| SCAA: | TUM17387_25140(lpxH) |
| SALH: | HMF8227_01943(lpxH) |
| CBS: | COXBURSA331_A1668(lpxH) |
| LLG: | 44548918_01529(lpxH) |
| LJR: | NCTC11533_01489(lpxH) NCTC11533_02458 |
| LCJ: | NCTC11976_02169(lpxH) |
| LWA: | SAMEA4504053_1786(lpxH) |
| LSS: | NCTC12082_00801(lpxH) |
| LADL: | NCTC12735_00991(lpxH) |
| LANT: | TUM19329_18790(lpxH) |
| MEEF: | JWZ97_08165(lpxH) JWZ97_15620(lpxI) |
| MISZ: | MishRS11D_11490(lpxH) |
| TIB: | THMIRHAM_13640(lpxH) |
| TSE: | THMIRHAS_11130(lpxH) |
| TZO: | THMIRHAT_15720(lpxH) |
| TLR: | Thiosp_02660(lpxH_1) |
| TFRI: | Thiofri_02343(lpxH_1) |
| TWG: | Thiowin_01999(lpxH_2) |
| TNI: | TVNIR_3183(lpxH_[H]) |
| GAI: | IMCC3135_21885(lpxH) |
| THIC: | TspCOW1_10690(lpxH) |
| HAAH: | HALA3H3_840036(lpxH) |
| ALCA: | ASALC70_00233(lpxH) |
| AEL: | NCTC12917_02586(lpxH) |
| CHJ: | NCTC10426_00460(lpxH) |
| CDIZ: | CEDIAZO_02000(lpxH) |
| NMM: | NMBM01240149_1559(lpxH) |
| NMS: | NMBM01240355_0542(lpxH) |
| NMQ: | NMBM04240196_1621(lpxH) |
| NMZ: | NMBNZ0533_0582(lpxH) |
| NWE: | SAMEA3174300_1225(lpxH) |
| NZO: | SAMEA4504057_0798(lpxH) |
| NCI: | NCTC10296_01091(lpxH) |
| NCZ: | NCTC10294_00194(lpxH) |
| NANI: | NCTC12227_01500(lpxH) |
| VIT: | ADP71_07900 ADP71_22590 |
| VST: | LVJ81_02565 LVJ81_08920 |
| ECOR: | SAMEA4412678_0618(lpxH) |
| REH: | H16_A1217(h16_A1217) |
| BMV: | BMASAVP1_A2163(lpxH) |
| BML: | BMA10229_A3152(lpxH) |
| BPM: | BURPS1710b_2685(lpxH) |
| BPL: | BURPS1106A_2600(lpxH) |
| POLT: | TUM22923_07540(lpxH) |
| PLG: | NCTC10937_03691(lpxH) |
| HYF: | DTO96_101429(lpxH_2) |
| LMIR: | NCTC12852_02057(lpxH) |
| BUO: | BRPE64_ACDS17900(lpxH) |
| BUE: | BRPE67_ACDS17860(lpxH) |
| VTR: | MYVALT_F_02590(lpxH) |
| BTRM: | SAMEA390648700061(lpxH) |
| AXX: | ERS451415_04437(lpxH) |
| PVAC: | HC248_01132(lpxH_1) |
| LIM: | L103DPR2_02219(lpxH_2) |
| LIH: | L63ED372_01640(lpxH_1) |
| SMIO: | CATMQ487_21670(lpxH) |
| URU: | DSM104443_01592(lpxH_1) |
| UPL: | DSM104440_01498(lpxH_1) |
| THAG: | CKCBHOJB_01297(lpxH_1) |
| FPHO: | SHINM1_004450(lpxH) |
| MESU: | LHFGNBLO_004040(lpxI) |
| NGL: | RG1141_CH15440(lpxI) |
| BSEP: | HAP48_0040390(lpxI) |
| BCAN: | BcanWSM471_21620(lpxI) |
| BHS: | BM1374165_00620(cdsA2) |
| BTX: | BM1374166_00860(cdsA2) |
| LNE: | FZC33_11060 FZC33_11065 |
| SINL: | DSM14862_01346(lpxI) |
| AALK: | LGT41_0013010(lpxI) |
| CFV: | CFVI03293_0328(lpxH) |
| CCOC: | CCON33237_1447(lpxH) |
| CLR: | UPTC16701_1338(lpxH) |
| CLM: | UPTC16712_1363(lpxH) |
| CHV: | CHELV3228_1397(lpxH) |
| CPIN: | CPIN18020_1486(lpxH) |
| CAMZ: | CVIC12175_0264(lpxH) |
| GBN: | GEOBRER4_05840(lpxH) |
| VIN: | AKJ08_1845 AKJ08_1901 |
| ELUT: | CKA38_10675 CKA38_10780 |
| ROO: | G5S37_06105 G5S37_17425 |
| PLH: | VT85_08655 VT85_19575(lpxH) |
| SACI: | Sinac_2699 Sinac_5300 |
| PBOR: | BSF38_04097 BSF38_04442(lpxH_2) |
| AGV: | OJF2_38860 OJF2_52840(lpxH) |
| TPLA: | ElP_31570 ElP_51940 |
| ALUS: | STSP2_02242 STSP2_03329 |
| BTHO: | Btheta7330_04599(lpxH) |
| BCEL: | BcellWH2_02190(lpxH) |
| PCRE: | NCTC12858_00088(lpxH) |
| PCAG: | NCTC12856_00563(lpxH) |
| POC: | NCTC13071_02551(lpxH) |
| SMIZ: | 4412673_00436(lpxH) |
| SDJ: | NCTC13534_00445(lpxH) |
| STHA: | NCTC11429_00911(lpxH_1) |
| PSEZ: | HME7025_00994(lpxH) |
| FOK: | KK2020170_04570(lpxH) |
| PHG: | KCTC32516_00608(lpxH) |
| AANR: | KCTC52924_01459(lpxH) |
| KOS: | KORDIASMS9_01014(lpxH) |
| KAN: | IMCC3317_29830(lpxH) |
| SPON: | HME9304_01419(lpxH) |
| CGLE: | NCTC11432_02446(lpxH) |
| CTAI: | NCTC12078_01178(lpxH) |
| CTAK: | 4412677_02019(lpxH_2) |
| CJG: | NCTC13459_01173(lpxH) |
| CANT: | NCTC13489_01191(lpxH) |
| PTAN: | CRYO30217_02485(lpxH_2) |
| PROC: | Ptc2401_02056(lpxH) |
| MSCH: | N508_001599(lpxI) N508_001974 |
| SELM: | TAMA11512_19720(lpxI) |
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| Reference |
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| Authors |
Babinski KJ, Ribeiro AA, Raetz CR |
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| Title |
The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Babinski KJ, Kanjilal SJ, Raetz CR |
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| Title |
Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Okada C, Wakabayashi H, Kobayashi M, Shinoda A, Tanaka I, Yao M. |
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| Title |
Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Cho J, Lee CJ, Zhao J, Young HE, Zhou P. |
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| Title |
Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Arenas J, Pupo E, de Jonge E, Perez-Ortega J, Schaarschmidt J, van der Ley P, Tommassen J. |
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| Title |
Substrate specificity of the pyrophosphohydrolase LpxH determines the asymmetry of Bordetella pertussis lipid A. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.6.1.54 |
| ExPASy - ENZYME nomenclature database: | 3.6.1.54 |
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