Entry
Name
2-hydroxy-dATP diphosphatase;
NUDT1;
MTH1;
MTH2;
oxidized purine nucleoside triphosphatase;
(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
2-hydroxy-dATP diphosphohydrolase
Reaction(IUBMB)
2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate [RN:
R09833 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme hydrolyses oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC
3.6.1.55 , 8-oxo-dGTP diphosphatase) [3].
History
EC 3.6.1.56 created 2011
Orthology
K17816 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase
Genes
ANAN : 105729921(NUDT1) 135268091
MAUA : 101835425 121142025(Nudt1)
PLEU : 114685114(Nudt1) 114709696
MORG : 121446149(Nudt1) 121464959
DORD : 105990862 105990957(Nudt1)
CCAD : 122433382(NUDT1) 122451103
OAA : 100079078 100086526(NUDT1)
MGP : 100549281 104913432(NUDT1)
SRX : 107753577(nudt1) 107758325
SANH : 107674605 107703398
SGH : 107581785(nudt1) 107592807
GMU : 124863278(nudt1) 124864801
PPLT : 128459195(nudt1) 128459197
OKI : 109893346(nudt1) 109893363
OKE : 118365295 118384513(nudt1)
OMM : 135554080 135555681(nudt1)
CCLU : 121550611 121569546
SPU : 115918659 115924232 587752
PFLL : 139151154 139151156
BCOO : 119081315 119084125
LHT : 122499227 122501323 122505945
PPYR : 116177664 116178722
DPX : DAPPUDRAFT_306869 DAPPUDRAFT_316258
PPOI : 119092247 119092697
MCAZ : 138059223 138059459
CCAC : CcaHIS019_0209630(CcaverHIS019_0209630)
ABP : AGABI1DRAFT108808(AGABI1DRAFT_108808)
ABV : AGABI2DRAFT187240(AGABI2DRAFT_187240)
SRE : PTSG_08698 PTSG_08699
SPAR : SPRG_02929 SPRG_02930
» show all
Taxonomy
Reference
Authors
Sakumi K, Furuichi M, Tsuzuki T, Kakuma T, Kawabata S, Maki H, Sekiguchi M
Title
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.
Journal
J Biol Chem 268:23524-30 (1993)
Sequence
Reference
Authors
Kakuma T, Nishida J, Tsuzuki T, Sekiguchi M
Title
Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution.
Journal
Sequence
Reference
Authors
Fujikawa K, Kamiya H, Yakushiji H, Fujii Y, Nakabeppu Y, Kasai H
Title
The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein.
Journal
Sequence
Reference
Authors
Sakai Y, Furuichi M, Takahashi M, Mishima M, Iwai S, Shirakawa M, Nakabeppu Y
Title
A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1.
Journal
Sequence
Reference
Authors
Fujikawa K, Kamiya H, Yakushiji H, Nakabeppu Y, Kasai H
Title
Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.56
ExPASy - ENZYME nomenclature database: 3.6.1.56