| Entry |
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| Name |
5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase;
Dcp2;
NUDT16;
D10 protein;
D9 protein;
D10 decapping enzyme;
decapping enzyme;
m7GpppN-mRNA hydrolase;
m7GpppN-mRNA m7GDP phosphohydrolase
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| Class |
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
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| Sysname |
5'-(N7-methylguanosine 5'-triphospho)-[mRNA] N7-methylguanosine-5'-diphosphate phosphohydrolase
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| Reaction(IUBMB) |
a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O = N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA] [RN: R10815]
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| Reaction(KEGG) |
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| Substrate |
5'-(N7-methylguanosine 5'-triphospho)-[mRNA] [CPD: C02339];
H2O [CPD: C00001]
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| Product |
N7-methylguanosine 5'-diphosphate [CPD: C20183];
5'-phospho-[mRNA] [CPD: C20863]
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| Comment |
Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) [3]. The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ [5].
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| History |
EC 3.6.1.62 created 2012, modified 2013
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| Orthology |
| K12613 | mRNA-decapping enzyme subunit 2 |
| K16855 | U8 snoRNA-decapping enzyme |
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| Genes |
» show all
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| Reference |
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| Authors |
Xu J, Yang JY, Niu QW, Chua NH |
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| Title |
Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lu G, Zhang J, Li Y, Li Z, Zhang N, Xu X, Wang T, Guan Z, Gao GF, Yan J |
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| Title |
hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Seraphin B |
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| Title |
Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Parrish S, Resch W, Moss B |
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| Title |
Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression. |
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| Journal |
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| Reference |
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| Authors |
Souliere MF, Perreault JP, Bisaillon M |
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| Title |
Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism. |
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| Journal |
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| Reference |
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| Authors |
Parrish S, Moss B |
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| Title |
Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses. |
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| Journal |
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| Reference |
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| Authors |
Song MG, Li Y, Kiledjian M |
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| Title |
Multiple mRNA decapping enzymes in mammalian cells. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.6.1.62 |
| ExPASy - ENZYME nomenclature database: | 3.6.1.62 |
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