KEGG   ENZYME: 3.6.1.64Help
Entry
EC 3.6.1.64                 Enzyme                                 

Name
inosine diphosphate phosphatase;
(deoxy)inosine diphosphatase;
NUDT16
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
inosine diphosphate phosphatase
Reaction(IUBMB)
(1) IDP + H2O = IMP + phosphate [RN:R00961];
(2) dIDP + H2O = dIMP + phosphate [RN:R10235]
Reaction(KEGG)
Substrate
IDP [CPD:C00104];
H2O [CPD:C00001];
dIDP [CPD:C01344]
Product
IMP [CPD:C00130];
phosphate [CPD:C00009];
dIMP [CPD:C06196]
Comment
The human enzyme also hydrolyses GDP and dGDP, and to a lesser extent ITP, dITP and XTP.
History
EC 3.6.1.64 created 2013
Pathway
ec00230  Purine metabolism
Orthology
K16855  U8 snoRNA-decapping enzyme
Genes
HSA: 131870(NUDT16)
PTR: 107966544(NUDT16) 460696(NUDT16P1)
PPS: 100972453(NUDT16)
GGO: 101147310 109026149(NUDT16)
PON: 100433503 100434247
NLE: 100607601(NUDT16)
MCC: 717914(NUDT16) 717946
MCF: 101865654(NUDT16) 102141246
CSAB: 103241683
RRO: 104675668(NUDT16)
RBB: 108522243(NUDT16)
CJC: 100406671 100410770(NUDT16)
SBQ: 101048719(NUDT16) 101049032
MMU: 73532(1700080E11Rik) 75686(Nudt16)
RNO: 363129(Nudt16) 688828
CGE: 100768978(Nudt16) 100769259
HGL: 101709761(Nudt16) 101717221
CCAN: 109700639(Nudt16)
TUP: 102479774(NUDT16)
CFA: 610721(NUDT16)
AML: 100482941(NUDT16)
ORO: 101364270(NUDT16)
FCA: 101094947(NUDT16)
PTG: 102951403(NUDT16)
AJU: 106971584(NUDT16)
BTA: 512320(NUDT16)
BOM: 102264435(NUDT16)
PHD: 102318311(NUDT16)
CHX: 102175719(NUDT16)
OAS: 654329(NUDT16)
SSC: 100152693(NUDT16)
CFR: 102519457
CDK: 105088763(NUDT16)
BACU: 103000667(NUDT16)
LVE: 103090159(NUDT16)
OOR: 101280616(NUDT16)
ECB: 100064676(NUDT16)
EPZ: 103552688(NUDT16)
EAI: 106841819(NUDT16)
MYB: 102252289(NUDT16)
MYD: 102769718(NUDT16)
HAI: 109378247(NUDT16)
RSS: 109444504(NUDT16)
PALE: 102891676(NUDT16)
LAV: 100666216(NUDT16)
TMU: 101360252
MDO: 100029401(NUDT16)
SHR: 100921288(NUDT16)
MGP: 104916418
CJO: 107307442
TGU: 100190266(NUDT16L1)
ASN: 102373084
AMJ: 109283987
CPIC: 101939820(NUDT16)
ACS: 100563390(nudt16)
PVT: 110078648
PBI: 103066411(NUDT16)
PMUR: 107284197(NUDT16)
GJA: 107108063
XLA: 414677(nudt16.L)
XTR: 100327255(nudt16)
NPR: 108784477
DRE: 449987(zgc:103759)
SGH: 107562457
IPU: 108276081
PHYP: 113530952
AMEX: 103041050
TRU: 101075218
LCO: 104930759(nudt16)
NCC: 104952901
MZE: 101466673(nudt16)
OLA: 101171079
XMA: 102224429
PRET: 103466890
NFU: 107391353
KMR: 108233051
CSEM: 103384574
LCF: 108882689
SDU: 111230747
BPEC: 110158096
MALB: 109970390
SASA: 106581882
OTW: 112224924
SALP: 111959754
ELS: 105018732
SFM: 108918382
LCM: 102358340
CMK: 103191283
API: 100166838
DNX: 107169586
ZNE: 110828423
FCD: 110851310
CRG: 109618305
OBI: 106869713
EPA: 110242528
ADF: 107343838
PDAM: 113668722
SPIS: 111334884
HMG: 100204487
AQU: 100632565
SULR: B649_03915
 » show all
Taxonomy
Reference
1  [PMID:20385596]
  Authors
Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M, Nakabeppu Y
  Title
NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.
  Journal
Nucleic Acids Res 38:4834-43 (2010)
DOI:10.1093/nar/gkq249
  Sequence
[hsa:131870] [mmu:75686]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.64
IUBMB Enzyme Nomenclature: 3.6.1.64
ExPASy - ENZYME nomenclature database: 3.6.1.64
BRENDA, the Enzyme Database: 3.6.1.64

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