KEGG   ENZYME: 3.6.1.65
Entry
EC 3.6.1.65                 Enzyme                                 
Name
(d)CTP diphosphatase;
(d)CTP pyrophosphohydrolase;
(d)CTP diphosphohydrolase;
nudG (gene name)
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
(deoxy)cytidine 5'-triphosphate diphosphohydrolase
Reaction(IUBMB)
(1) CTP + H2O = CMP + diphosphate [RN:R00515];
(2) dCTP + H2O = dCMP + diphosphate [RN:R01668]
Reaction(KEGG)
R00515 R01668
Substrate
CTP [CPD:C00063];
H2O [CPD:C00001];
dCTP [CPD:C00458]
Product
CMP [CPD:C00055];
diphosphate [CPD:C00013];
dCMP [CPD:C00239]
Comment
The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP. It also acts on 5-methyl-dCTP, 5-hydroxy-dCTP and 8-hydroxy-dGTP.
History
EC 3.6.1.65 created 2013
Pathway
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K08320  (d)CTP diphosphatase
Genes
ECOb1759(nudG)
ECJJW1748(nudG)
ECDECDH10B_1897(nudG)
EBWBWG_1572(nudG)
ECOKECMDS42_1434(nudG)
ECEZ2791
ECSECs_2465(nudG)
ECFECH74115_2479(nudG)
ETWECSP_2327(nudG)
ELXCDCO157_2299
EOIECO111_2270(nudG)
EOJECO26_2534(nudG)
EOHECO103_1952(nudG)
ECOOECRM13514_2257
ECOHECRM13516_2162
ESLO3K_11165
ESOO3O_14450
ESMO3M_11145
ECKEC55989_1927(nudG)
ECGE2348C_1887(nudG)
EOKG2583_2205(nudG)
ELRECO55CA74_10595
ELHETEC_1791
ECWEcE24377A_1983(nudG)
EUNUMNK88_2225
ECPECP_1705
ENAECNA114_1805
ECOSEC958_1980(nudG)
ECVAPECO1_829(ynjG)
ECOAAPECO78_12630
ECXEcHS_A1843(nudG)
ECMEcSMS35_1430(nudG)
ECYECSE_1930
ECRECIAI1_1820(nudG)
ECQECED1_1961(nudG)
EUMECUMN_2048(nudG)
ECTECIAI39_1295(nudG)
EOCCE10_2039(nudG)
EBRECB_01728(nudG)
EBLECD_01728(nudG)
EBEB21_01716(nudG)
EBDECBD_1885
ECIUTI89_C1955(ynjG)
EIHECOK1_1880(nudG)
ECZECS88_1811(nudG)
ECCc2160
ELOEC042_1924(nudG)
ELNNRG857_08815
ESEECSF_1620
ECLEcolC_1873
EKOEKO11_2016
EKFKO11_13935(nudG)
EABECABU_c20160(nudG)
EDHEcDH1_1883
EDJECDH1ME8569_1703(nudG)
ELUUM146_08345
ELWECW_m1928(nudG)
ELLWFL_09460(nudG)
ELCi14_1979
ELDi02_1979
ELPP12B_c1324(nudG)
ELFLF82_1533(nudG)
ECOLLY180_09160
ECOIECOPMV1_01857(nudG)
ECOJP423_09365
EFEEFER_1306(nudG)
EALEAKF1_ch4290c(nudG)
EMAC1192_03500
ESZFEM44_23725
STYSTY1813
STTt1180
SEXSTBHUCCB_12670
SENTTY21A_05995
STMSTM1301
SEOSTM14_1579
SEVSTMMW_13081
SEYSL1344_1236
SEMSTMDT12_C13180
SEJSTMUK_1268
SEBSTM474_1305(nudg)
SEFUMN798_1357
SETUSTU288_02830
SETCCFSAN001921_10650
SENRSTMDT2_12341
SENDDT104_12771
SENICY43_06625
SEENSE451236_12370
SPTSPA1543
SEKSSPA1434
SPQSPAB_02043
SEISPC_2431
SECSCH_1323(nudG)
SEHSeHA_C1428
SHBSU5_01920
SENHCFSAN002069_02500
SEEHSEEH1578_15735
SEESNSL254_A1412
SENNSN31241_23740
SEWSeSA_A1395
SEASeAg_B1874
SENSQ786_08750
SEDSeD_A2045
SEGSG1815
SELSPUL_1115
SEGASPUCDC_1115
SETSEN1742
SENAAU38_09015
SENOAU37_09020
SENVAU39_09025
SENQAU40_10075
SENLIY59_09220
SENJCFSAN001992_05090
SEECCFSAN002050_12905
SEEBSEEB0189_013025
SEEPI137_05130
SENBBN855_13350
SENEIA1_06420
SENCSEET0819_13155
SESSARI_01678
SBGSBG_1154
SBZA464_1256
SBVN643_05505
SALZEOS98_12965
SFLSF1466
SFXS1581
SFVSFV_1459
SFESFxv_1654(nudG)
SFNSFy_2095
SFSSFyv_2149
SFTNCTC1_01577(nudG)
SSNSSON_1397
SBOSBO_1330
SDYSDY_1516
SDZAsd1617_02025
SHQA0259_12855
ENCECL_02458
ENLA3UG_08970
ECLGEC036_17290
ECLEECNIH2_09580
ECLNECNIH4_13690
ECLIECNIH5_08635
ECLXLI66_08955
ECLYLI62_09730
ECLZLI64_09020
ECLOENC_14560
EHMAB284_16070
EXFBFV63_08990
ECLAECNIH3_08645
ECLCECR091_08620
EAUDI57_09935
EKBBFV64_09060
ENOECENHK_08960
EECEcWSU1_01770(nudG)
ELGBH714_05195
ECANCWI88_13455
ERNBFV67_08510
ECLSLI67_010015
ECHGFY206_10365
ESHC1N69_09110
ENTEnt638_1687
EASEntas_1704
ENRH650_04435
ENXNI40_009075
ENFAKI40_2720
LNICWR52_03220
EBGFAI37_20375
ENDA4308_13655
ENZG0034_08780
ENSHWQ15_17105
ENKLOC22_19365
EHUD5067_0013765
EMORL6Y89_08650
ESAESA_02159
CSKES15_2309(nudG)
CSZCSSP291_10245
CSJCSK29544_03445
CCONAFK62_08285
CDMAFK67_08405
CSIP262_03343
CMJAFK66_011285
CUIAFK65_08240
CMWAFK63_10210
CTUCTU_18130(nudG)
KPNKPN_01211(nudG)
KPUKP1_2239(nudG)
KPMKPHS_21070
KPPA79E_2975
KPHKPNIH24_18075
KPZKPNIH27_10260
KPVKPNIH29_10765
KPWKPNIH30_11010
KPYKPNIH31_10390
KPGKPNIH32_10850
KPCKPNIH10_10455
KPQKPR0928_10625
KPTVK055_1247
KPRKPR_2256
KPJN559_3070
KPID364_06280
KPAKPNJ1_03298
KPSKPNJ2_03290
KPXPMK1_03590(nudG)
KPBFH42_01920
KPNEKU54_015650
KPNULI86_15960
KPNKBN49_2345
KVAKvar_3103
KPEKPK_3232(nudG)
KPKA593_20785
KVDKR75_18630
KVQSP68_25075
KOXKOX_18090
KOEA225_2474
KOYJ415_19545
KOMHR38_16380
KMIVW41_08810
KOKKONIH1_11885
KOCAB185_24110
KQUAVR78_15440
EAEEAE_21650
EARCCG29605
KQVB8P98_16285
KLLBJF97_12435
KLWDA718_16540
KARLGL98_14940
KGRJJJ10_16435
RORRORB6_08610
RONTE10_12180
RPLNB1209_15960
RAODSD31_15190
RTGNCTC13098_04217(nudG)
REEelectrica_03020(nudG)
CROROD_12991(nudG)
CKOCKO_01786
CFDCFNIH1_16170
CBRAA6J81_02600
CWECO701_11820
CYOCD187_13695
CPOTFOB25_01465
CFQC2U38_13680
CSEDJY391_12360
CAMAF384_05870
CAFAL524_16450
CIFAL515_10675
CFARCI104_11735
CIRC2U53_20940
CIEAN232_19445
CPARCUC49_06260
CTELGBC03_18840
CITZE4Z61_03635
CARSE1B03_11705
EBTEBL_c23440(nudG)
CNTJT31_03780
CEMLH23_14460
CENLH86_13640
CLAPNCTC11466_02677(nudG)
PGELG71_18500
ESCEntcl_2598
KLEAO703_09225
KSAC813_05065
KORAWR26_14900
KRDA3780_09295
KCOBWI95_15030
KOTEH164_12955
KPSEIP581_09770
KGOCEW81_14295
KIENCTC12125_01678(nudG)
KASKATP_26020
LAXAPT61_13225
LEIC2U54_14515
LEHC3F35_02255
LEEDVA44_14290
LERGNG29_09360
LEAGNG26_09020
LPNUKQ929_11800
LAZA8A57_08840
LEFLJPFL01_1716
LEWDAI21_17800
BUFD8682_24895
BAGEBADSM9389_24810
BFTMNO13_14925
METYMRY16398_22170(nudG)
AHNNCTC12129_02264(nudG)
ASUBNLZ15_12250
YREHEC60_04120
SGOEA8O29_013700
KINAB182_10015
PDZHHA33_12620
IZHFEM41_15975
PSHISAMEA2665130_2102(nudG_2)
PSGCG163CM_15360(nudG)
EBFD782_2568
EBCC2U52_20590
EBUCUC76_04640
YPEYPO2167(nudG)
YPKy2154
YPHYPC_2144(nudG)
YPAYPA_1524
YPNYPN_1633
YPMYP_1967(nudG)
YPPYPDSF_0967
YPGYpAngola_A2341(nudG)
YPZYPZ3_1678(nudG)
YPTA1122_15320
YPDYPD4_1905(nudG)
YPXYPD8_1644(nudG)
YPWCH59_3956(nudG)
YPJCH55_571(nudG)
YPVBZ15_1373(nudG)
YPLCH46_2946(nudG)
YPSYPTB2093(nudG)
YPOBZ17_371(nudG)
YPIYpsIP31758_1977(nudG)
YPYYPK_2086
YPBYPTS_2157
YPQDJ40_212(nudG)
YPUBZ21_1373(nudG)
YPRBZ20_17(nudG)
YPCBZ23_1656(nudG)
YPFBZ19_1449(nudG)
YENYE2255(nudG)
YEPYE105_C2293
YEYY11_11171
YELLC20_02530
YEWCH47_1682(nudG)
YETCH48_3944(nudG)
YEFFORC2_1925
YEEYE5303_17571(nudG)
YSIBF17_19510
YALAT01_535(nudG)
YFRAW19_1095(nudG)
YINCH53_3857(nudG)
YKRCH54_567
YROCH64_459(nudG)
YRUBD65_236(nudG)
YRBUGYR_01260
YMADA391_10675
YHID5F51_09400
YCAF0T03_11490
YMOHRD69_14980
SMARSM39_2189(nudG)
SMACSMDB11_1985(nudG)
SMWSMWW4_v1c27290(nudG)
SPESpro_2716
SRRSerAS9_2747
SRLSOD_c25580(nudG)
SRYM621_13960
SPLYQ5A_014175(nudG)
SRSSerAS12_2748
SRASerAS13_2749
SMAFD781_2464
SLQM495_13620
SERFL085_15165
SERSSERRSCBI_12815
SFWWN53_22310
SFGAV650_18140
SRZAXX16_2663
SERMCLM71_12810
SQUE4343_02490
SFJSAMEA4384070_2761(nudG)
SOFNCTC11214_04164(nudG)
SSURATE40_010280
SURIJ0X03_10310
SRHZFO014_20885
SENPKHA73_13420
SFOZ042_00485
RAHRahaq_2058
RACEJHW33_06535
RAQRahaq2_2191
RAAQ7S_10440
ROXBV494_05020
RVCJ9880_19190
GQUAWC35_00110
EAMEGXP68_09885
RBADH2866_18235
SGLSG1362
SODSant_1823(nudG)
EICNT01EI_1652
ETRETAE_1495(nudG)
ETDETAF_1388
ETEETEE_3499
ETCETAC_07035
EDWQY76_12445
EDLAAZ33_07765
EHOA9798_09530
HAVAT03_10085
HPARAL518_13500
OPODSM2777_10135
LPVHYN51_00160
PFQQQ39_11215
PRAGEKN56_04855
LRINCTC12151_01462(nudG)
PGBH744_2c2750
PGHFH974_10805
FBLFbal_0702
TKMTK90_2491
TVRTVD_00210
DEKDSLASN_26880
PMETG4Y79_08730
TMEDDWB79_06215
TPERIWA51_07860
SASSMUG09_10230
SGNSGRA_2437(nudG)
DAPDacet_2915
CTHITHC_0949
 » show all
Reference
1  [PMID:11053429]
  Authors
O'Handley SF, Dunn CA, Bessman MJ
  Title
Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP.
  Journal
J Biol Chem 276:5421-6 (2001)
DOI:10.1074/jbc.M004100200
  Sequence
[eco:b1759]
Reference
2  [PMID:12509230]
  Authors
Fujikawa K, Kasai H
  Title
The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently  by the Escherichia coli recombinant Orf135 protein.
  Journal
DNA Repair (Amst) 1:571-6 (2002)
DOI:10.1016/S1568-7864(02)00057-5
  Sequence
[eco:b1759]
Reference
3  [PMID:15381107]
  Authors
Kamiya H, Iida E, Harashima H
  Title
Important amino acids in the phosphohydrolase module of Escherichia coli Orf135.
  Journal
Biochem Biophys Res Commun 323:1063-8 (2004)
DOI:10.1016/j.bbrc.2004.08.201
  Sequence
[eco:b1759]
Reference
4  [PMID:15823026]
  Authors
Iida E, Satou K, Mishima M, Kojima C, Harashima H, Kamiya H
  Title
Amino acid residues involved in substrate recognition of the Escherichia coli Orf135 protein.
  Journal
Biochemistry 44:5683-9 (2005)
DOI:10.1021/bi048071o
  Sequence
[eco:b1759]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.65
IUBMB Enzyme Nomenclature: 3.6.1.65
ExPASy - ENZYME nomenclature database: 3.6.1.65
BRENDA, the Enzyme Database: 3.6.1.65

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