KEGG   ENZYME: 3.6.1.68Help
Entry
EC 3.6.1.68                 Enzyme                                 

Name
geranyl diphosphate phosphohydrolase;
NUDX1 (gene name)
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
geranyl-diphosphate phosphohydrolase
Reaction(IUBMB)
geranyl diphosphate + H2O = geranyl phosphate + phosphate [RN:R11551]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
geranyl phosphate [CPD:C21203];
phosphate [CPD:C00009]
Comment
The enzyme, characterized from roses, is involved in a cytosolic pathway for the biosynthesis of free monoterpene alcohols that contribute to fragrance. In vitro the enzyme also acts on (2E,6E)-farnesyl diphosphate.
History
EC 3.6.1.68 created 2015 as EC 3.1.3.98, transferred 2016 to EC 3.6.1.68
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20986  geranyl diphosphate phosphohydrolase
Genes
FVE: 101310019 101310310
PPER: 18792770
PMUM: 103341413
MDM: 103402740 103451694
PXB: 103929214 103946941
Taxonomy
Reference
1  [PMID:26138978]
  Authors
Magnard JL, Roccia A, Caissard JC, Vergne P, Sun P, Hecquet R, Dubois A, Hibrand-Saint Oyant L, Jullien F, Nicole F, Raymond O, Huguet S, Baltenweck R, Meyer S, Claudel P, Jeauffre J, Rohmer M, Foucher F, Hugueney P, Bendahmane M, Baudino S
  Title
PLANT VOLATILES. Biosynthesis of monoterpene scent compounds in roses.
  Journal
Science 349:81-3 (2015)
DOI:10.1126/science.aab0696
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.68
IUBMB Enzyme Nomenclature: 3.6.1.68
ExPASy - ENZYME nomenclature database: 3.6.1.68
BRENDA, the Enzyme Database: 3.6.1.68

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