KEGG ENZYME: 3.6.1.71

ENZYME: 3.6.1.71

Entry

EC 3.6.1.71                 Enzyme

Name

adenosine-5'-diphospho-5'-[DNA] diphosphatase;
aprataxin;
5'-App5'-DNA adenylate hydrolase;
APTX (gene name);
HNT3 (gene name)

Class

Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides

Sysname

adenosine-5'-diphospho-5'-[DNA] hydrolase (adenosine 5'-phosphate-forming)

Reaction(IUBMB)

(1) adenosine-5'-diphospho-5'-[DNA] + H2O = AMP + phospho-5'-[DNA];
(2) adenosine-5'-diphospho-5'-(ribonucleotide)-[DNA] + H2O = AMP + 5'-phospho-(ribonucleotide)-[DNA]

Substrate

adenosine-5'-diphospho-5'-[DNA];
H2O [CPD:C00001];
adenosine-5'-diphospho-5'-(ribonucleotide)-[DNA]

Product

AMP [CPD:C00020];
phospho-5'-[DNA];
5'-phospho-(ribonucleotide)-[DNA]

Comment

Aprataxin is a DNA-binding protein involved in different types of DNA break repair. The enzyme acts (among other activities) on abortive DNA ligation intermediates that contain an adenylate covalently linked to the 5'-phosphate DNA terminus. It also acts when the adenylate is covalently linked to the 5'-phosphate of a ribonucleotide linked to a DNA strand, which is the result of abortive ligase activty on products of EC 3.1.26.4, ribonuclease H, an enzyme that cleaves RNA-DNA hybrids on the 5' side of the ribonucleotide found in the 5'-RNA-DNA-3' junction. Aprataxin binds the adenylate group to a histidine residue within the active site, followed by its hydrolysis from the nucleic acid and eventual release, leaving a 5'-phosphate terminus that can be efficiently rejoined. The enzyme also possesses the activities of EC 3.6.1.70, guanosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.6.1.72, DNA-3'-diphospho-5'-guanosine diphosphatase.

History

EC 3.6.1.71 created 2017 as EC 3.1.11.7, transferred 2019 to EC 3.6.1.71

Orthology

K10863

aprataxin

Genes

HSA:	54840(APTX)

PTR:	465037(APTX)

PPS:	100972572(APTX)

PON:	100439490(APTX)

PPYG:

129044706(APTX)

NLE:	100592983(APTX)

HMH:	116458480(APTX)

SSYN:

129490272(APTX)

MCC:	702671(APTX)

MCF:	102135987(APTX)

MTHB:

126937408

MNI:	105485653(APTX)

CSAB:

103219297(APTX)

CATY:

105590087(APTX)

PANU:

101024645(APTX)

TGE:	112608645(APTX)

MLEU:

105539640(APTX)

RRO:	104674274(APTX)

RBB:	108518241(APTX)

TFN:	117068911(APTX)

PTEH:

111529209(APTX)

CANG:

105526260(APTX)

CJC:	100410996(APTX)

SBQ:	101046890(APTX)

CIMI:

108317676(APTX)

ANAN:

105718776(APTX)

CSYR:

103270027(APTX)

MMUR:

105874377(APTX)

LCAT:

123646225(APTX)

PCOQ:

105820541(APTX)

OGA:	100962727(APTX)

MMU:	66408(Aptx)

MCAL:

110292499(Aptx)

MPAH:

110338795(Aptx)

RNO:	259271(Aptx)

MCOC:

116095822(Aptx)

ANU:	117702473 117708186(Aptx)

ASYL:

127680651(Aptx)

MUN:	110566705(Aptx)

CGE:	100774231(Aptx)

MAUA:

101825422(Aptx)

PROB:

127224507(Aptx)

PLEU:

114703261(Aptx)

MORG:

121458334(Aptx)

MFOT:

126503631

AAMP:

119826722(Aptx)

NGI:	103741597(Aptx)

HGL:	101719882(Aptx)

CPOC:

100722168(Aptx)

CCAN:

109681409(Aptx)

DORD:

105993389(Aptx)

DSP:	122123400(Aptx)

DMER:

138817843(Aptx)

PLOP:

125355383 125362898(Aptx)

NCAR:

124964881

MMMA:

107147857(Aptx)

ITI:	101959048(Aptx)

OCU:	100351115 103348750

OPI:	101523019(APTX)

TUP:	102475725(APTX)

GVR:	103593729(APTX)

CFA:	442943(APTX)

CLUD:

112650187(APTX)

VVP:	112927557(APTX)

VLG:	121494579(APTX)

NPO:	129494764(APTX)

AML:	100477925(APTX)

UMR:	103667027(APTX)

UAH:	113260533(APTX)

UAR:	123781088(APTX)

ELK:

111145935

LLV:

125083990

MPUF:

101687373(APTX)

MNP:	132024673(APTX)

MLK:	131812528(APTX)

NVS:	122917533(APTX)

ORO:	101386234(APTX)

EJU:	114218165(APTX)

ZCA:	113934489(APTX)

MLX:	118018030(APTX)

NSU:	110581448(APTX)

LWW:	102726820(APTX)

FCA:	101097680(APTX)

PYU:	121034559(APTX)

PCOO:

112858802(APTX)

PBG:	122474586(APTX)

PVIV:

125150589(APTX)

LRUF:

124501277

LGF:	123593154(APTX)

AJU:

106976035

PTG:	102950944(APTX)

PPAD:

109252050(APTX)

PUC:

125918690

PLEZ:

122205609(APTX)

HHV:	120241765(APTX)

BTA:	359714(APTX)

BOM:	102268362(APTX)

BIU:	109563163(APTX)

BBUB:

102391016(APTX)

BBIS:

104988714(APTX)

CHX:	102186869(APTX)

OAS:	101105385(APTX)

BTAX:

128052460(APTX)

CSUM:

138081196(APTX)

ODA:	120860350 120866131

CCAD:

122431966(APTX)

MREE:

136176773(APTX)

OVR:	110140278(APTX)

MBEZ:

129556927(APTX)

SSC:	387596(APTX)

CFR:	102516533(APTX)

CBAI:

105078742(APTX)

CDK:	105085570(APTX)

VPC:	102530854(APTX)

BACU:

102997771(APTX)

BMUS:

118896724(APTX)

LVE:	103085186(APTX)

OOR:	101283923(APTX)

LALB:

132523710(APTX)

GMF:	115840167(APTX)

DLE:	111163193(APTX)

PCAD:

102980098(APTX)

PSIU:

116755262(APTX)

PPHC:

136124115(APTX)

NASI:

112405402(APTX)

ECB:	100068091(APTX)

EPZ:	103555028(APTX)

EAI:	106841467(APTX)

MYB:	102241189(APTX)

MYD:	102760132(APTX)

MMYO:

118667400(APTX)

MLF:	102436912(APTX)

MDT:	132212066(APTX)

MYUM:

139021125(APTX)

PKL:	118716418(APTX)

EFUS:

103286484(APTX)

MNA:	107544998(APTX)

DRO:	112304535(APTX)

SHON:

118979822(APTX)

AJM:	119060017(APTX)

PDIC:

114509072(APTX)

PHAS:

123820200(APTX)

MMF:	118630120(APTX)

PPAM:

129078217(APTX)

HAI:	109371794(APTX)

RFQ:	117031482(APTX)

PALE:

102880269(APTX)

PGIG:

120612920(APTX)

PVP:	105306410(APTX)

RAY:	107502755(APTX)

MJV:	108404115(APTX)

TOD:	119230949(APTX) 119253332

SARA:

101557569(APTX)

SFUM:

130026380(APTX)

SETR:

126009357(APTX)

LAV:	100660757(APTX)

TMU:

101342573

ETF:	101641453(APTX)

DNM:	101412215(APTX)

MDO:	100020823(APTX)

GAS:	123231259(APTX)

SHR:	100934939(APTX)

AFZ:

127560706

PCW:	110204302 110220574(APTX)

TVP:	118833805(APTX)

PBRV:

138161288(APTX)

MLAO:

141502581(APTX)

OAA:	100075506(APTX)

TACU:

119923918 119948131

GGA:	395173(APTX)

PCOC:

116239465(APTX)

MGP:	100543078 104915326

CJO:	107306647(APTX)

TPAI:

128089756(APTX)

LMUT:

125686501(APTX)

NMEL:

110389533(APTX)

APLA:

101792244(APTX)

ACYG:

106040205(APTX)

CATA:

118256254(APTX)

AFUL:

116501093(APTX)

TGU:	100226520(APTX)

LSR:	110474048(APTX)

SCAN:

103821836(APTX)

PMOA:

120513600(APTX)

OTC:	121332676(APTX)

PRUF:

121363767(APTX)

ATRC:

139588832(APTX)

GFR:	102042023(APTX)

FAB:	101807349(APTX)

OMA:	130265356(APTX)

PHI:	102109622(APTX)

PMAJ:

107216303(APTX)

CCAE:

111941318(APTX)

CCW:	104689793(APTX)

CBRC:

103616367(APTX)

ACOE:

138103897(APTX)

ETL:	114057879(APTX)

ZAB:	102065002(APTX)

ZLE:	135460082(APTX)

ACHL:

103811265(APTX)

SVG:	106860354(APTX)

MMEA:

130577569(APTX)

HRT:	120765890(APTX)

SATI:

136373505(APTX)

CCIC:

134056549(APTX)

FPG:	101917451(APTX)

FCH:	102057105(APTX)

CCRI:

104167170(APTX)

NNT:	104400753(APTX)

SHAB:

115601390(APTX)

ACUN:

113490307(APTX)

TALA:

104365643(APTX)

ACHC:

115337047(APTX)

HALD:

104317211(APTX)

HLE:	104838394(APTX)

AGEN:

126036524

HHAR:

128136772(APTX)

GCL:

127027262

CSTI:

104556112(APTX)

LDI:	104350347(APTX)

MNB:	103770359(APTX)

DPUB:

104299410(APTX)

PPUS:

135173587(APTX)

AVIT:

104278130(APTX)

BRHI:

104490040(APTX)

EGZ:	104123062(APTX)

NNI:	104022636(APTX)

PCRI:

104030234(APTX)

PCAO:

104044133(APTX)

PADL:

103921041(APTX)

AFOR:

103903770(APTX)

FGA:	104074319(APTX)

GSTE:

104252030 104258213(APTX)

CBOY:

140651281(APTX)

CLV:	102086630(APTX)

CNIC:

136002597(APTX)

MUI:	104542617(APTX)

PGUU:

104465194(APTX)

PLET:

104615124(APTX)

CMAC:

104483870(APTX)

CUCA:

104059495(APTX)

TEO:	104374633(APTX)

BREG:

104632076(APTX)

OHA:	104338450(APTX)

ACAR:

104529960(APTX)

CPEA:

104391678(APTX)

CVF:	104282564(APTX)

RTD:	128902664(APTX)

CRID:

134509046(APTX)

AAM:	106495965(APTX)

AROW:

112975299(APTX)

NPD:	112948931(APTX)

TGT:	104578637(APTX)

DNE:	112989808(APTX)

SCAM:

104144367(APTX)

ASN:	102386580(APTX)

AMJ:	102559093(APTX)

CPOO:

109323595(APTX)

GGN:	109297436(APTX)

PSS:	102460401(APTX)

CMY:	102939347(APTX)

CCAY:

125636522(APTX)

DCC:	119855458(APTX)

CPIC:

101943978(APTX)

TST:	117878704(APTX)

CABI:

116828220(APTX)

MRV:	120393934 120407752

ACS:	100558032(aptx)

ASAO:

132768141(APTX)

PVT:	110087361(APTX)

SUND:

121921205(APTX)

PBI:	103066205(APTX)

PMUR:

107285612(APTX)

CTIG:

120303828(APTX)

TSR:	106548867(APTX)

PGUT:

117661721(APTX)

PCAE:

139313106(APTX)

APRI:

131189774(APTX)

PTEX:

113444172(APTX)

NSS:	113415475(APTX)

VKO:	123017519(APTX)

PMUA:

114587702(APTX)

PRAF:

128404823(APTX)

ZVI:	118097514(APTX)

HCG:	128345082(APTX)

GJA:	107118361(APTX)

STOW:

125436187(APTX)

EMC:	129334344(APTX)

XLA:	398657(aptx.L)

XTR:	403092(aptx)

NPR:	108798251(APTX)

RTEM:

120915189(APTX)

ACAT:

141107770(APTX)

BBUF:

120989625(APTX)

BGAR:

122946091(APTX)

DTC:	141049133(APTX)

PWL:	138299313(APTX)

MUO:	115463637(APTX)

GSH:	117347377(APTX)

DRE:	405797(aptx)

SRX:	107746089 107757069

SANH:

107657991(aptx)

SGH:	107570816(aptx)

CCAR:

109051898 109065131

CAUA:

113062249(aptx)

CGIB:

128020466

PTET:

122353186(aptx)

LROH:

127181094(aptx)

GRF:	141336496(aptx)

OMC:	131549216(aptx)

PPRM:

120489166(aptx)

RKG:	130082381(aptx)

MAMB:

125271853(aptx)

CIDE:

127515746

CERY:

137032224(aptx)

MASI:

127443800

TROS:

130552750(aptx)

TDW:	130412746(aptx)

MANU:

129444056(aptx)

PDAB:

135785734(aptx)

IPU:

108260610

IFU:	128604337(aptx)

PHYP:

113524515(aptx)

SMEO:

124381552(aptx)

TVC:	132841634(aptx)

CGAR:

128514155(aptx)

NGRA:

132883542(aptx)

TRN:	134326488(aptx)

AMEX:

103046803(aptx)

CMAO:

118804207(aptx)

EEE:	113583868(aptx)

CHAR:

122129827(aptx)

SPIL:

134068709(aptx)

TRU:	445995(aptx)

TFS:	130527790(aptx)

TNG:	GSTEN00020002G001

LCO:	104930177(aptx)

NCC:	104954692(aptx)

TBEN:

117474567(aptx)

CGOB:

115007814(aptx)

PGEO:

117442322(aptx)

GACU:

117561997(aptx)

EMAC:

134864459(aptx)

ELY:	117255455(aptx)

EFO:	125885520(aptx)

PLEP:

121942280(aptx)

SLUC:

116034375(aptx)

ECRA:

117955575(aptx)

ESP:	116699444(aptx)

PFLV:

114569374(aptx)

GAT:	120825231(aptx)

PPUG:

119218279(aptx)

AFB:	129095936(aptx)

CLUM:

117729669(aptx)

PSWI:

130189818(aptx)

CANA:

137793112(aptx)

CVE:	137884745(aptx)

MSAM:

119898995(aptx)

SCHU:

122873000(aptx)

CUD:	121508519(aptx)

SPUL:

138595090(aptx)

LMIX:

132990724(aptx)

ALAT:

119020302(aptx)

ASTR:

137600189(aptx)

MZE:	101466233(aptx)

ONL:	100708465(aptx)

OAU:	116334497(aptx)

OLA:	101162025(aptx)

OML:	112157141(aptx)

CSAI:

133450796(aptx)

XMA:	102232898(aptx)

XCO:	114144368(aptx)

XHE:	116719650(aptx)

PRET:

103465988(aptx)

PFOR:

103137845 103137850

PLAI:

106943046 106943049

PMEI:

106911873 106919284

GAF:	122829406(aptx)

PPRL:

129367030(aptx)

CVG:	107097703(aptx)

CTUL:

119774729(aptx)

GMU:	124868597(aptx)

NFU:	107375251(aptx)

KMR:	108237716(aptx)

ALIM:

106517163(aptx)

NWH:	119408079(aptx)

AOCE:

111579518(aptx)

EJA:	138209554(aptx)

BFRE:

138630009(aptx)

MCEP:

125003494(aptX)

CSEM:

103383834(aptx)

POV:	109637835(aptx)

SSEN:

122770473(aptx)

SSOE:

131467132(aptx)

HHIP:

117766804(aptx)

HSP:	118123134(aptx)

PPLT:

128436664(aptx)

SMAU:

118312646(aptx)

LCF:

108896493

SDU:	111231416(aptx)

SLAL:

111664047(aptx)

XGL:	120800216(aptx)

HCQ:	109519905(aptx)

SSCV:

125968431(aptx)

SBIA:

133506158(aptx)

PEE:	133403998(aptx)

PTAO:

133477492(aptx)

BPEC:

110165402(aptx)

ENY:	140377192(aptx)

MALB:

109961360(aptx)

BSPL:

114858911(aptx)

SJO:	128372350(aptx)

SSCO:

133992481(aptx)

GMH:	115540319(aptx)

SASA:

100194567(aptx)

STRU:

115164986(aptx)

OTW:	112248313(aptx)

OMY:	100136186(aptx)

OGO:	124034660(aptx)

ONE:	115111255(aptx)

OKI:	109875154(aptx)

OKE:	118392862(aptx)

OMM:	135514669(aptx)

OCLA:

139410608

SALP:

111975108(aptx)

SNH:	120044128(aptx)

CCLU:

121584387(aptx)

ELS:	105014574(aptx)

OEP:	134033417(aptx)

SFM:	108925927(aptx)

PKI:	111844213(aptx)

AANG:

118226770(aptx)

AROT:

135255895(aptx)

CCOG:

133130288(aptx)

LOC:	102690326(aptx)

PSPA:

121296574(aptx)

ARUT:

117408685(aptx)

PSEX:

120532292(aptx)

LCM:	102345286(APTX)

CMK:	103187207(aptx)

RTP:	109926966(aptx)

CPLA:

122563017(aptx)

HOC:	132824760(aptx)

LERI:

129695494(aptx)

HAKA:

140729128(aptx)

PMRN:

116937213 116950843(APTX)

LRJ:	133354179(APTX)

BFO:

118428322

BBEL:

109477827

CIN:	445730(aptx)

SCLV:

120333816

SPU:

592796

LPIC:

129279646

APLC:

110981744

ARUN:

117298530

AAMU:

139945026

AFIL:

140157577

PFLL:

139119036

DME:	Dmel_CG5316(Aptx)

DER:	6554045 6554047

DSE:

6619074

DSI:	Dsimw501_GD19289(Dsim_GD19289)

DYA:	Dyak_GE25605 Dyak_GE27392 Dyak_GE28076 Dyak_GE29197

DSR:

110188279

DPO:

4803259

DPE:

6594229

DMN:	108153848 117187387

DWI:

6650256

DGR:	116806024 116806025 116806026 116806027 116806028 116806306 122322685 122322686 122322689 6569964

DMO:	Dmoj_GI16920 Dmoj_GI23101 Dmoj_GI23102

DAZ:	108608649 108614288 108614368

DNV:	108659192 108660069

DHE:	111596201 111596208

CCAT:

101462718

BDR:

105232164

AOQ:

129239547

ALUD:

128859016

TDA:

119677349

MDE:

101891634

SCAC:

106087202

LCQ:

111683105

CVJ:	135964048(Aptx)

ECOE:

129940612

AGA:	1268842 3290958

ACOZ:

120951911 120961674

AARA:

120897054 120901540

AMER:

121590176 121590404

ASTE:

118502892 118504672

AMAP:

126565556 126566760

AFUN:

125763320 125774808

AMOU:

128297066 128298194

AMRS:

128708675 128718075

ACOS:

131265533

AAG:

5565705

AALB:

109623040

CQU:	CpipJ_CPIJ001673 CpipJ_CPIJ001675

CPII:

120418370 120418385

CBRI:

134833947

CNS:

116343672

LLL:

129788029

PPAP:

129798411

AME:

408601

ACER:

107994706

ALAB:

122718623

ADR:

102671514

AFLR:

100864058

BIM:

100747480

BBIF:

117204527

BVK:

117235196

BVAN:

117153638

BHUN:

126871104

BTER:

100644640

BAFF:

126924228

BPYO:

122569562

BPAS:

132916403

FVI:

122535622

CCAL:

108629642

OBB:

114875389

OLG:

117603987

MGEN:

117223654

NMEA:

116430515

CGIG:

122395240

SOC:

105202804

MPHA:

105835091

AEC:

105144914

ACOC:

108689621

MZT:	108729385(Aptx)

PBAR:

105426048

VEM:

105561077

COBS:

139102113(Aptx)

TLN:	139821443(Aptx)

HST:

105186905

CFO:

105258852

FEX:

115234801

PMEC:

138939357(Aptx)

LHU:

105672859

PGC:

109859789

OBO:

105275839

PCF:

106788572

PFUC:

122514504 122520652

VPS:

122628408

VCRB:

124421989

VVE:

124954081

NVI:

100115496

TPRE:

106652645

LHT:

122508514

LBD:

127277577

VCAN:

122408122

CCIN:

107264919

DSM:

124413131

NPT:	124221672(Aptx)

NFB:

124184669

NLO:

107223048

NVG:

124307619

AROA:

105692967

TCA:

658572

TMOL:

138138622(Aptx)

DPA:

109535577

ESIM:

136413157(Aptx)

EFOR:

136343912(Aptx)

ATD:

109596255

CSET:

123306810

HAXR:

123671068

AGB:

108903797

LDC:

111503849

DVV:

126892910

NVL:

108559963

APLN:

108734079 108740333

PPYR:

116180344

OTU:

111427537

BMOR:

101744383

BMAN:

114241482

MSEX:

115439968

DPL:	KGM_213605

BANY:

112043144

MJU:

123868435

NIQ:

126774250

VCD:

124536248

MCIX:

123659720

PMAC:

106719089

PPOT:

106109714

PXU:

106121456

BPHI:

137919222(Aptx)

PRAP:

111003738

PBX:

123715748

PNAP:

125057287

ZCE:

119840816

CCRC:

123694330

LSIN:

126972505

AAGE:

121738685

HAW:

110379623

HZE:

124635171

TNL:

113501361

SLIU:

111359010

OFU:

114361662

ONU:

135077611

ATRA:

106134973

GMW:

113521343

PXY:

105386421

PGW:

126372319

LGLY:

125232072

CSTB:

134745267

CFUM:

141430348

CFEL:

113366552

API:

100569003

DNX:

107166542

AGS:

114120898

RMD:

113549244

ACOO:

126838214

DVT:

126895298

BTAB:

109035556

CLEC:

106663263

HHAL:

106690133

NLU:	111049854 120348853

HVI:

124354159

MQU:	129004079 129005571

PHU:	Phum_PHUM320100

FOC:

113204005

TPAL:

117651313

ZNE:

110834505

CSEC:

111867597

PAME:

138713277(Aptx)

SGRE:

126354777

BROR:

134542696

IEL:

124165459

HAMR:

139693042(Aptx)

DMK:

116917474

PVM:	113816347(Aptx)

PJA:

122252788

PCHN:

125036254

PMOO:

119572271

HAME:

121856541

PCLA:

123755880(Aptx)

CQD:	128700442(Aptx)

PTRU:

123507555

ESN:

126994306

MNZ:

135203667

MRJ:	136853055(Aptx)

PORN:

139750805(Aptx)

HAZT:

108673937

EAF:

111697217

LSM:	121119440 121130830

TCF:

131893350

VJA:

111265003

GOE:

100909193

CSCU:

111627534

CVS:	136973268(Aptx)

PTEP:

107449666

ABRU:

129966711

UDV:

129222386

SDM:

118191500

PMEO:

129585019

HRO:	HELRODRAFT_62577

LGI:	LOTGIDRAFT_186969

PVUL:

126828177

PCAN:

112555301

LSAX:

138946346

BGT:

106056408

GAE:

121367307

HRF:

124110391

HRJ:

124278883

HASI:

137281532

HCRA:

139447427

CRG:

105322078

CANU:

128181071

CVN:

111136704

OED:

125659175

MYI:

110446209

PMAX:

117342125

AIRR:

138306890

MCAF:

127738928

MMER:

123538359

RPHI:

132741096

DPOL:

127836357

MAEA:

128220154

OBI:

106880390

OSN:

115222296

LJP:

135479506

LAK:	106154458 106163822

OVI:	T265_08155

LLON:

135494885

HMG:

100206030

HSY:

130622398

TAD:	TRIADDRAFT_18245

AQU:

100640625

ATH:	AT5G01310(APTX)

ALY:

9307002

CRB:

17882450

CSAT:

104708982 104734171 104768332

BRP:

103847505

BNA:

106435153

BOE:

106319492

RSZ:

108818268

THJ:

104816650

CPAP:

110809488

CIT:

102619121

CIC:	CICLE_v10011130mg

PVY:	116115203 116138719 116138755

MINC:

123223030

TCC:

18597500

GRA:

105779441

GHI:	107899563 121215903

GAB:

108460140

HSYR:

120151012

DZI:	111295225 111310664

EGR:

104423355

RARG:

115745723

GMX:

100786762

GSJ:

114415910

PVU:

137818484

VRA:

106772894

VAR:

108346640

VUN:

114167226

VUM:

124821021

CCAJ:

109806112

APRC:

113849311

MTR:

11415306

TPRA:

123902418

CAM:

101510807

PSAT:

127093482

VVO:

131596661

LJA:

130717800

ADU:

107475347

AIP:

107625784

AHF:	112728031 112750636

LANG:

109361051

PCIN:

129289633 129297600

QSA:	O6P43_026253

FVE:

101306149

AANS:

126801024

RCN:

112192537

PPER:

18775191

PMUM:

103341550

PAVI:

110768433

PDUL:

117632708

MDM:

103425917

MSYL:

126618598

PXB:	103965126 103965157

PCOX:

137723796

ZJU:

107430895

MNT:

21395270

CSAV:

115697032

CSV:

101216867

CMO:

103486269

BHJ:

120091955

MCHA:

111015060

CMAX:

111470189

CMOS:

111452802

CPEP:

111801005

RCU:

8283140

MEAN:

126677147

HBR:

110662752

MESC:

110623086

POP:

7460370

PEU:

105141363

PALZ:

118037517 118045838

PNZ:

133676536

JRE:

108995190

CILL:

122279587

CAVE:

132191376

AGLU:

133874170

QSU:

112040136

QLO:

115957312

TWL:

119987513

VVI:

100259037

VRI:

117920967

SLY:

101257206

SPEN:

107031205

SOT:

102578604

SSTN:

125871177

SDUL:

129882428

CANN:

107842536

LBB:

132630876

NTA:	107789889 107826076

NSY:

104236796

NTO:

104118789

NAU:

109219272

INI:

109181766

ITR:

116005567

SIND:

105174593

OEU:	111392531 111392550

EGT:

105953116

SSPL:

121795633 121800888

SMIL:

131022668

SHIS:

125216934

APAN:

127252118

PEBU:

140826236

HAN:

110896008

ECAD:

122594469

LSV:

111908638

CCAV:

112504614

DCR:

108208832

CSIN:

114261388

RVL:

131326051

AEW:	130764481 130773662

DLT:

127788689

BVG:

104892527

SOE:

110791642

CQI:	110710710 110733905

ATRI:

130800018

MOF:

131168392

NNU:

104594951

MING:

122067314

TSS:

122671691

PSOM:

113291612 113310226 113322015

OSA:

4332518

OBR:

102709720

OGL:

127769025

BDI:

100839576

ATS:

109733434

TDC:	119285405 119296426

TAES:

123085582 123092448 123097769

TUA:	125552066 125552070

LPER:

127295805

LRD:	124695466 124698004

SBI:

8084030

ZMA:

103634500

MFLO:

136546687

SITA:

101776352

SVS:

117836048

PVIR:

120652712 120687912

PHAI:

112877291

PAUA:

133912276

TANG:

140775771

PDA:

103706712

EGU:

105057122

ZOF:	122052160 122056649

DCT:

110096109

PEQ:

110028380

AOF:

109842914

MSIN:

131223632

ACAK:

137942456

NCOL:

116254085

ATR:

18444741

CJF:

131028958

SMO:	SELMODRAFT_104482 SELMODRAFT_89021

PPP:

112288900

CRE:	CHLRE_06g297904v5

VCN:	VOLCADRAFT_120448

MNG:

MNEG_4264

CSL:	COCSUDRAFT_42402

CVR:	CHLNCDRAFT_136358

BPG:	Bathy05g04070

MIS:	MICPUN_84536

MPP:	MICPUCDRAFT_28995

SCE:	YOR258W(HNT3)

SEUB:

DI49_5079

SPAO:

SPAR_O03740

AGO:	AGOS_AAL112C

KLA:	KLLA0_C09625g

KMX:	KLMA_30465(HNT3)

LTH:	KLTH0D11968g

VPO:	Kpol_1064p21

ZRO:	ZYRO0F11924g

CGR:	2890291(GVI51_K08789)

NCS:	NCAS_0B01160(NCAS0B01160)

NDI:	NDAI_0E01030(NDAI0E01030)

TBL:	TBLA_0B03650(TBLA0B03650)

TGB:	HG536_0A08080

TDL:	TDEL_0A06520(TDEL0A06520)

KAF:	KAFR_0A04000(KAFR0A04000)

KNG:	KNAG_0G02710(KNAG0G02710)

ZMK:	HG535_0A06400

SLUD:

SCDLUD_002192

DHA:	DEHA2F20284g

PIC:	PICST_33883(HNT3)

PGU:	PGUG_00302

SPAA:

SPAPADRAFT_59734

LEL:	PVL30_000268(HNT3)

LBG:	92206012(LODBEIA_P08160)

CAL:	CAALFM_CR03440WA(CaO19.2376) CAALFM_CR03590CA(CaO19.4383)

CTP:	CTRG_00756

COT:	CORT_0A02110

CDU:	CD36_28600 CD36_28780

CTEN:

18250574(HNT3)

CLU:	CLUG_03957

CLUS:

A9F13_01g01694

CAUR:

CJI96_0000491

ASAU:

88175556(PUMCH_004496)

OPA:	HPODL_02803

YLI:	2911961(YALI2_E01329g)

SLB:	AWJ20_1739(HNT3)

NCR:

NCU06572

NTE:	NEUTE1DRAFT136002(NEUTE1DRAFT_136002)

SMP:	10803913(SMAC4_04695)

PAN:	PODANS72p067

PBEL:

QC761_608770(HNT3)

PPSD:

QC762_608770(HNT3)

PPSP:

QC763_608770(HNT3)

PPSA:

QC764_608770(HNT3)

TTT:	THITE_2044821

MTM:	MYCTH_2310466

CTHR:

CTHT_0036990

RTHE:

98125725(VTJ83DRAFT_4577)

MGR:

MGG_07058

PPEI:

PpBr36_01684

PGRI:

PgNI_03304

TMN:	UCRPA7_1512

SSCK:

SPSK_09595

FPU:	FPSE_04109

FPOA:

FPOAC1_010917

FVN:	FVRRES_11929

FVR:	FVEG_16236

FOX:	FOXG_01657

NHE:	NECHADRAFT_49288

FFC:	NCS54_01133600

FKR:	NCS57_01124200

FMU:	J7337_002924

TRE:	TRIREDRAFT_53660

TRR:	M419DRAFT_69637

TATV:

25779411(TrAtP1_011137)

TASP:

36616225(TrAFT101_008947)

MAW:	19244812(HNT3)

MAJ:

MAA_07304

MBRN:

26241072(hnt3)

PCHM:

VFPPC_16474

AMUS:

LMH87_004406

PLJ:	28889959(PLICBS_008635)

PTKZ:

JDV02_005270(HNT3)

VAL:	VDBG_00048

VDA:	VDAG_08337

CFJ:	CFIO01_07552

CLUP:

CLUP02_08347

CHIG:

CH63R_04441

CDET:

87941497(CDEST_04994)

SAPO:

SAPIO_CDS10419

ELA:	UCREL1_4929

PFY:	PFICI_07637

SSL:	SS1G_11675

BFU:	BCIN_08g06920(Bchnt3)

MBE:

MBM_01023

PSCO:

LY89DRAFT_656717

GLZ:	GLAREA_06607

ANI:	ANIA_02139

AFM:	AFUA_2G16130

ACT:	ACLA_075090

NFI:	NFIA_091390

AOR:	AO090012000185

ANG:	An15g06480

AFV:	AFLA_001905

ALUC:

AKAW2_60132S(HNT3)

ACHE:

ACHE_60390S(HNT3)

APUU:

APUU_20435S(HNT3)

PCS:	N7525_006709

PDP:	PDIP_80490

POU:	POX_d05060

TMF:	EYB26_002272

TRG:	TRUGW13939_05042

CIM:	CIMG_09530

CPW:	9692892(HNT3)

URE:	UREG_04789

ABE:

ARB_03228

TVE:

TRV_02456

PBL:	PAAG_06653

PBN:	PADG_01109

AJE:	HCAG_06451

BGH:	BDBG_02719

PNO:	SNOG_10141

PTE:

PTT_12333

PTRR:

6343811(PtrM4_109000)

BZE:	COCCADRAFT_6096

BOR:	COCMIDRAFT_35169

AALT:

CC77DRAFT_1006560

ADAC:

96084620(ACET3X_004298)

ARAB:

EKO05_0005527

ZTR:	MYCGRDRAFT_55061

PFJ:	MYCFIDRAFT_186479

FFU:	CLAFUR5_03493

CBET:

CB0940_03436

BCOM:

BAUCODRAFT_32290

NPA:	UCRNP2_8933

TML:	GSTUM_00001306001

SPO:	2539198(hnt3)

SOM:	SOMG_04898(hnt3)

CNE:

CNC04800

CNB:

CNBC2380

CNG:	CNAG_02862

CGI:	CGB_C7100C

CDEU:

CNBG_3513

CDEC:

89987830(IAS62_001055)

CTEG:

91989022(I308_102164)

CBAS:

91982213(I312_102165)

CDEP:

91089741(L203_105532)

KMG:	30167525(I203_106436)

KNE:	92178259(IAR55_001000)

KDJ:	28964778(I303_101076)

KBI:	30207303(I302_104195)

KPIN:

30169345(I206_100349)

KSH:	87953109(IL334_000978)

KER:	91106234(V865_007433)

TMS:	TREMEDRAFT_59866

TASA:

A1Q1_02217

CCAC:

CcaHIS019_0406190(HNT3)

PPL:	POSPLDRAFT_97392

TVS:	TRAVEDRAFT_136817

DSQ:	DICSQDRAFT_48615

SHS:	STEHIDRAFT_108538

HIR:	HETIRDRAFT_309237

PSQ:	PUNSTDRAFT_114838 PUNSTDRAFT_28176

ADL:	AURDEDRAFT_19811

FME:	FOMMEDRAFT_109677

GTR:	GLOTRDRAFT_56862

RSX:	RhiXN_01531

CCI:	CC1G_04299

ABP:	AGABI1DRAFT122637(AGABI1DRAFT_122637)

ABV:	AGABI2DRAFT187227(AGABI2DRAFT_187227)

MRR:	Moror_8948

E1B28_008668

SCM:	SCHCO_02605771(SCHCODRAFT_02605771)

CPUT:

CONPUDRAFT_117509

SLA:	SERLADRAFT_357670

WSE:	WALSEDRAFT_70138

WIC:	J056_003041

UMA:	UMAG_02669

PFP:	PFL1_03844

SGRA:

EX895_005321

MGL:

MGL_0877

MRT:

MRET_2631

RIE:	OCT59_017518

MBR:	MONBRDRAFT_29002

SRE:	PTSG_12341

DDI:	DDB_G0272839

DPP:	DICPUDRAFT_153568

DFA:

DFA_01715

ACAN:

ACA1_270320

SPAR:

SPRG_06657

TBR:	Tb927.3.3710

TBG:	TbgDal_III4010

TCR:	506989.50 510149.100

LMA:	LMJF_29_0640

LIF:	LINJ_29_0670

LDO:	LDBPK_290670

LMI:	LMXM_08_29_0640

LMAT:

92514372(LSCM1_04351)

LBZ:	LBRM_29_0650

LPAN:

LPMP_290630

LOI:	92359440(LSCM4_03506)

LEIS:

94179103(GH5_03630)

LENR:

94171338(CUR178_04117)

LEIN:

94187411(JIQ42_03738)

PHET:

94286741(JKF63_00613)

EHX:	EMIHUDRAFT_424881 EMIHUDRAFT_434812

GTT:	GUITHDRAFT_134117

» show all

Reference

1 [PMID:16964241]

Authors

Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW, West SC

Title

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates.

Journal

Nature 443:713-6 (2006)
DOI:10.1038/nature05164

Sequence

[gga:395173]

Reference

2 [PMID:24362567]

Authors

Tumbale P, Williams JS, Schellenberg MJ, Kunkel TA, Williams RS

Title

Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.

Journal

Nature 506:111-5 (2014)
DOI:10.1038/nature12824

Sequence

[hsa:54840]

Other DBs

ExplorEnz - The Enzyme Database:

3.6.1.71

IUBMB Enzyme Nomenclature:

3.6.1.71

ExPASy - ENZYME nomenclature database:

3.6.1.71

BRENDA, the Enzyme Database:

3.6.1.71

All links

Gene (238)   
   MGENES (238)   
Protein sequence (1973)   
   UniProt (1908)   
   SWISS-PROT (15)   
   RefSeq(pep) (50)   
DNA sequence (57)   
   RefSeq(nuc) (53)   
   GenBank (2)   
   EMBL (2)   
Protein domain (8)   
   InterPro (8)   
All databases (2276)   

Download RDF

DBGET integrated database retrieval system