Entry |
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Name |
nucleotide diphosphatase;
ENPP1 (gene name);
nucleotide pyrophosphatase;
nucleotide-sugar pyrophosphatase;
nucleoside-triphosphate diphosphatase
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Class |
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
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Sysname |
nucleoside-triphosphate diphosphohydrolase
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Reaction(IUBMB) |
a nucleoside triphosphate + H2O = a nucleotide + diphosphate [RN: R01532]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme preferentially hydrolyses ATP, but can also hydrolyse other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD+, NADP+, FAD, and CoA.
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History |
EC 3.6.1.9 created 1961 (EC 3.6.1.19 created 1972, incorporated 2016), modified 2016
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Pathway |
ec00500 | Starch and sucrose metabolism |
ec00760 | Nicotinate and nicotinamide metabolism |
ec00770 | Pantothenate and CoA biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K01513 | ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 |
K04765 | nucleoside triphosphate diphosphatase |
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Genes |
» show all
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Reference |
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Authors |
Chern CJ, MacDonald AB, Morris AJ. |
Title |
Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from red cells of the rabbit. |
Journal |
J Biol Chem 244:5489-95 (1969) |
Reference |
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Authors |
Kelly SJ, Dardinger DE, Butler LG |
Title |
Hydrolysis of phosphonate esters catalyzed by 5'-nucleotide phosphodiesterase. |
Journal |
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Reference |
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Authors |
Landt M, Butler LG |
Title |
5'-Nucleotide phosphodiesterase: isolation of covalently bound 5'-adenosine monophosphate, an intermediate in the catalytic mechanism. |
Journal |
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Reference |
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Authors |
Zhang J, Inouye M |
Title |
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 3.6.1.9 |
ExPASy - ENZYME nomenclature database: | 3.6.1.9 |
BRENDA, the Enzyme Database: | 3.6.1.9 |
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