| Entry |
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| Name |
phospholipid-translocating ATPase;
Mg2+-ATPase;
flippase;
aminophospholipid-transporting ATPase
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| Class |
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
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| Sysname |
ATP phosphohydrolase (phospholipid-flipping)
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| Reaction(IUBMB) |
ATP + H2O + phospholipid[side 1] = ADP + phosphate + phospholipid[side 2] [RN: R00086]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
ADP [CPD: C00008];
phosphate [CPD: C00009];
phospholipid[side 2]
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| Comment |
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme moves phospholipids such as phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine from one membrane face to the other ('flippase').
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| History |
EC 3.6.3.1 created 2000 (EC 3.6.3.13 created 2000, incorporated 2001)
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| Orthology |
| K01530 | phospholipid-translocating ATPase |
| K14802 | phospholipid-transporting ATPase |
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| Genes |
» show all
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| Reference |
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| Authors |
Morris MB, Auland ME, Xu YH, Roufogalis BD. |
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| Title |
Characterization of the Mg(2+)-ATPase activity of the human erythrocyte membrane. |
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| Journal |
Biochem Mol Biol Int 31:823-32 (1993) |
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| Reference |
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| Authors |
Vermeulen WP, Briede JJ, Roelofsen B. |
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| Title |
Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg2+-ATPase activity. |
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| Journal |
Mol Membr Biol 13:95-102 (1996) |
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| Reference |
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| Authors |
Suzuki H, Kamakura M, Morii M, Takeguchi N. |
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| Title |
The phospholipid flippase activity of gastric vesicles. |
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| Journal |
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| Reference |
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| Authors |
Auland ME, Roufogalis BD, Devaux PF, Zachowski A. |
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| Title |
Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes. |
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| Journal |
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| Reference |
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| Authors |
Alder-Baerens N, Lisman Q, Luong L, Pomorski T, Holthuis JC |
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| Title |
Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles. |
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| Journal |
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| Reference |
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| Authors |
Lopez-Marques RL, Poulsen LR, Hanisch S, Meffert K, Buch-Pedersen MJ, Jakobsen MK, Pomorski TG, Palmgren MG |
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| Title |
Intracellular targeting signals and lipid specificity determinants of the ALA/ALIS P4-ATPase complex reside in the catalytic ALA alpha-subunit. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.6.3.1 |
| ExPASy - ENZYME nomenclature database: | 3.6.3.1 |
| BRENDA, the Enzyme Database: | 3.6.3.1 |
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