KEGG   ENZYME: 3.6.3.10Help
Entry
EC 3.6.3.10                 Enzyme                                 

Name
H+/K+-exchanging ATPase;
H+-K+-ATPase;
H,K-ATPase;
(K+ + H+)-ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (H+/K+-exchanging)
Reaction(IUBMB)
ATP + H2O + H+in + K+out = ADP + phosphate + H+out + K+in [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
H+ [CPD:C00080];
K+ [CPD:C00238]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
H+ [CPD:C00080];
K+ [CPD:C00238]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed.
History
EC 3.6.3.10 created 1984 as EC 3.6.1.36, transferred 2000 to EC 3.6.3.10
Pathway
ec00190  Oxidative phosphorylation
Orthology
K01541  H+/K+-exchanging ATPase
K01542  H+/K+-exchanging ATPase alpha polypeptide
K01543  H+/K+-exchanging ATPase beta polypeptide
K01544  non-gastric H+/K+-exchanging ATPase
Genes
HSA: 479(ATP12A) 495(ATP4A) 496(ATP4B)
PTR: 452489(ATP12A) 738405(ATP4B) 747915(ATP4A)
PPS: 100979788(ATP12A) 100980523(ATP4A) 100991047(ATP4B)
GGO: 101138827(ATP4A) 101141471(ATP4B) 101142592(ATP12A) 109025341
PON: 100435235(ATP4A) 100435325(ATP12A) 100459814(ATP4B)
NLE: 100582869(ATP12A) 100593416(ATP4A) 100603851(ATP4B)
MCC: 100426215(ATP4A) 698222(ATP4B) 721488(ATP12A)
MCF: 102116356 102119167(ATP12A) 102124568(ATP4A) 102131451(ATP4B)
CSAB: 103214853(ATP4B) 103234521(ATP4A) 103249015(ATP12A)
RRO: 104659972(ATP12A) 104667094(ATP4A) 104671368(ATP4B)
RBB: 108512305 108512346(ATP4A) 108515377(ATP12A) 108521834(ATP4B)
CJC: 100400287(ATP12A) 100405348(ATP4A) 100414695(ATP4B)
SBQ: 101047397(ATP12A) 101047734(ATP4A) 101051285(ATP4B)
MMU: 11944(Atp4a) 11945(Atp4b) 192113(Atp12a)
RNO: 171028(Atp12a) 24216(Atp4a) 24217(Atp4b)
CGE: 100750430(Atp4b) 100765522(Atp12a) 100767384(Atp4a)
NGI: 103726773(Atp12a) 103729925(Atp4a) 103746296(Atp4b)
HGL: 101697924(Atp4b) 101711071(Atp12a) 101724247(Atp4a)
CCAN: 109674869(Atp12a) 109686917(Atp4b) 109689140(Atp4a)
OCU: 100008669(ATP12A) 100009125(ATP4B) 100009279(ATP4A)
TUP: 102472050(ATP4B) 102475043(ATP12A) 102480463(ATP4A)
CFA: 403820(ATP12A) 404020(ATP4B) 431686(ATP4A)
AML: 100465081(ATP4A) 100465461(ATP12A) 100477747(ATP4B)
UMR: 103657517(ATP4B) 103664389(ATP12A) 103682508(ATP4A)
ORO: 101367449(ATP12A) 101368519(ATP4A) 101369365(ATP4B)
FCA: 101091583(ATP12A) 101092078(ATP4B) 101100771(ATP4A)
PTG: 102957326(ATP12A) 102964110(ATP4A) 102971257(ATP4B)
AJU: 106974749(ATP4A) 106979787(ATP12A) 106986712(ATP4B)
BTA: 521163(ATP4A) 530703(ATP12A) 614308(ATP4B)
BOM: 102273487(ATP4A) 102275089(ATP12A) 102276541(ATP4B)
BIU: 109567033(ATP4B) 109567056(ATP12A) 109571697(ATP4A)
PHD: 102316191(ATP4B) 102336396(ATP4A)
CHX: 102172639(ATP12A) 102180792(ATP4A) 102185581(ATP4B)
OAS: 101116166(ATP4A) 101120253(ATP12A)
SSC: 100521921(ATP12A) 397131(ATP4B) 397552(ATP4A)
CFR: 102505116(ATP4A) 102505590(ATP12A) 102520241(ATP4B)
CDK: 105088096(ATP4A) 105091347(ATP4B) 105096383(ATP12A)
BACU: 103000639(ATP4B) 103012701(ATP4A) 103013174(ATP12A)
LVE: 103071695(ATP4B) 103071724(ATP4A) 103091328(ATP12A)
OOR: 101270907(ATP12A) 101275692(ATP4B) 101276734(ATP4A)
ECB: 100052912(ATP12A) 100069135(ATP4B) 100147108(ATP4A)
EPZ: 103540402(ATP12A) 103549650(ATP4B) 103560041(ATP4A)
EAI: 106827635(ATP12A) 106829240(ATP4A) 106848204(ATP4B)
MYB: 102246595(ATP12A) 102249396(ATP4A) 102259435(ATP4B)
MYD: 102753224(ATP4A) 102760948(ATP4B) 102774686(ATP12A)
HAI: 109372015(ATP4A) 109383950(ATP4B) 109387998(ATP12A)
RSS: 109433978(ATP4A) 109452821(ATP4B) 109457000(ATP12A)
PALE: 102881469(ATP12A) 102881537(ATP4B) 102882245(ATP4A)
MDO: 100013166(ATP4A) 100016220(ATP4B) 100022970(ATP12A) 100022999 100023029
SHR: 100914456(ATP12A) 100914716 100914816(ATP4B) 100926385(ATP4A)
OAA: 100092554(ATP12A) 107547886(ATP4B)
GGA: 386581(ATP4B) 419743(ATP12A)
MGP: 100548075(ATP4B) 100550873(ATP12A)
CJO: 107307398 107307930(ATP4B) 107324177(ATP12A)
APLA: 101793299(ATP4B) 101800708(ATP12A) 101802953
ACYG: 106029490 106040569(ATP12A) 106046430(ATP4B)
TGU: 100219097 100230086(ATP12A) 100230444(ATP4B)
GFR: 102031709(ATP4B) 102044487(ATP12A)
FAB: 101805703(ATP4B) 101807408(ATP12A)
PHI: 102099301(ATP4A) 102107731(ATP12A) 102110942(ATP4B)
PMAJ: 107200428(ATP4B) 107214473(ATP12A)
CCW: 104686103(ATP4B) 104692117(ATP12A)
FPG: 101911437(ATP4A) 101912680(ATP12A) 101923846(ATP4B)
FCH: 102051647(ATP4B) 102055866(ATP4A) 102056385(ATP12A)
CLV: 102085251 102088772 102093855(ATP4B) 102096447(ATP12A)
EGZ: 104126355(ATP4B) 104129213(ATP12A) 104132271
AAM: 106490229(ATP12A) 106493946(ATP4B) 106500266
ASN: 102374285(ATP4B) 102387741(ATP4A) 102388005(ATP12A)
AMJ: 102561484(ATP12A) 102575926(ATP4B) 102576311(ATP4A) 109283416
PSS: 102450978(ATP4A) 102452724(ATP12A) 102457968(ATP4B)
CMY: 102933065 102936245(ATP4A) 102942318(ATP4B)
CPIC: 101946000(ATP4A) 101947527(ATP12A) 101951389(ATP4B)
ACS: 100560046(atp4b) 100563430 100563553(atp4a)
PVT: 110074103(ATP4B) 110079317(ATP12A) 110089078(ATP4A)
PBI: 103053937(ATP12A) 103054731(ATP4A) 103064507(ATP4B)
GJA: 107110926(ATP4B) 107116203(ATP4A) 107120678(ATP12A)
XLA: 108696872 379283(atp12a.S) 379459(atp4b.S) 380512(atp12a.L) 399450(atp4a.L) 447127(atp4b.L) 733327
XTR: 100488221(atp4a) 448282(atp4b) 594945(atp12a-like)
NPR: 108790589(ATP12A) 108790966 108790973 108791690(ATP4B) 108797188(ATP4A)
IPU: 108256310(atp4a) 108259063(atp4b)
AMEX: 103023943(atp4b) 103024000(atp4a)
LCO: 104919947(atp4b) 104940311(atp4a)
NCC: 104957693(atp4a) 104958804(atp4b)
MZE: 101464178(atp4a) 101482966(atp4b) 112434842
LCF: 108888014(atp4b) 108892214(atp4a)
BPEC: 110171389(atp4a) 110173092(atp4b)
ELS: 105019136(atp4a) 105020060(atp4b)
SFM: 108919133(atp4a) 108931953(atp4b)
LCM: 102352096(ATP4A) 102355665(ATP4B)
PIC: PICST_60178(PMR2)
SPN: SP_2101
SPD: SPD_1927
SPR: spr1911(ctpC)
SPV: SPH_2289
SSO: SSO2896
 » show all
Taxonomy
Reference
1  [PMID:5682852]
  Authors
Sachs G, Collier RH, Shoemaker RL, Hirschowitz BI.
  Title
The energy source for gastric H+ secretion.
  Journal
Biochim Biophys Acta 162:210-9 (1968)
DOI:10.1016/0005-2728(68)90103-5
Reference
2  [PMID:2552824]
  Authors
Hersey SJ, Perez A, Matheravidathu S, Sachs G.
  Title
Gastric H+-K+-ATPase in situ: evidence for compartmentalization.
  Journal
Am J Physiol 257:G539-47 (1989)
DOI:10.1152/ajpgi.1989.257.4.G539
Reference
3  [PMID:2158765]
  Authors
Rabon EC, Reuben MA.
  Title
The mechanism and structure of the gastric H,K-ATPase.
  Journal
Annu Rev Physiol 52:321-44 (1990)
DOI:10.1146/annurev.ph.52.030190.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.6.3.10
IUBMB Enzyme Nomenclature: 3.6.3.10
ExPASy - ENZYME nomenclature database: 3.6.3.10
BRENDA, the Enzyme Database: 3.6.3.10

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