KEGG ENZYME: 3.6.3.49

ENZYME: 3.6.3.49

Entry

EC 3.6.3.49 Enzyme

Name

channel-conductance-controlling ATPase

Class

Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances

Sysname

ATP phosphohydrolase (channel-conductance-controlling)

Reaction(IUBMB)

ATP + H2O = ADP + phosphate [RN:R00086]

Reaction(KEGG)

R00086

Substrate

ATP [CPD:C00002];
H2O [CPD:C00001]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009]

Comment

ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.

History

EC 3.6.3.49 created 2000

Orthology

K05031

cystic fibrosis transmembrane conductance regulator

Genes

HSA:	1080(CFTR)

PTR:	463674(CFTR)

PPS:	100989405(CFTR)

GGO:	101132066(CFTR)

PON:	100137035(CFTR)

NLE:	100601480(CFTR)

MCC:	574346(CFTR)

MCF:	102130331(CFTR)

CSAB:

103226777(CFTR)

RRO:	104682625(CFTR)

RBB:	108526537(CFTR)

CJC:	100415251(CFTR)

SBQ:	101036459(CFTR)

MMU:	12638(Cftr)

RNO:	24255(Cftr)

CGE:	100754506(Cftr)

NGI:	103737361(Cftr)

HGL:	101709472(Cftr)

CCAN:

109679300(Cftr) 109680514

OCU:	100009471(CFTR)

TUP:	102490714(CFTR)

CFA:	492302(CFTR)

AML:	100478723(CFTR)

UMR:	103676590(CFTR)

ORO:	101363648(CFTR)

FCA:	492308(CFTR)

PTG:	102956215(CFTR)

AJU:	106970664(CFTR)

BTA:	281067(CFTR)

BOM:	102264773(CFTR) 102266351

BIU:	109557891(CFTR)

PHD:	102332344(CFTR)

CHX:	102179446(CFTR)

OAS:	443347(CFTR)

SSC:	403154(CFTR)

CFR:	102505598(CFTR)

CDK:	105085325(CFTR)

BACU:

103004581(CFTR)

LVE:	103088529(CFTR)

OOR:	101278319(CFTR)

ECB:	100071259(CFTR)

EPZ:	103550601(CFTR)

EAI:	106829379(CFTR)

MYB:	102257625(CFTR)

MYD:	102773631(CFTR)

HAI:

109376431

RSS:	109453461(CFTR)

PALE:

102884577(CFTR)

LAV:	100662653(CFTR)

TMU:

101346801

MDO:	100014119(CFTR)

SHR:	100919086(CFTR)

OAA:	100078764(CFTR)

GGA:	100049619(CFTR)

MGP:	100545354(CFTR)

CJO:	107309076(CFTR)

APLA:

101803386(CFTR)

ACYG:

106042053(CFTR)

TGU:	100222243(CFTR)

GFR:	102041165(CFTR)

FAB:	101809710(CFTR)

PHI:	102114534(CFTR)

PMAJ:

107205064(CFTR)

CCW:	104698445(CFTR)

FPG:	101921929(CFTR)

FCH:	102050923(CFTR)

CLV:	102089481(CFTR)

EGZ:	104133415(CFTR)

AAM:	106488125(CFTR)

ASN:	102369471(CFTR)

AMJ:	102563163(CFTR)

PSS:	102447829(CFTR)

CMY:	102936252(CFTR)

CPIC:

101933840(CFTR)

ACS:	100559531(cftr)

PVT:	110077041(CFTR)

PBI:	103057487(CFTR)

GJA:	107114507(CFTR)

XLA:	108712361 373725(cftr-A)

XTR:	100486085(cftr)

NPR:	108802076(CFTR)

DRE:	559080(cftr)

SRX:	107708216 107738689

SANH:

107660943(cftr) 107672176

SGH:	107583749 107596947

CCAR:

109110485(cftr) 109110487

IPU:	108264684(cftr)

AMEX:

103032690(cftr)

TRU:	492310(cftr)

TNG:	GSTEN00029830G001

LCO:	104925520(cftr)

MZE:	101473042(cftr)

OLA:	101161380(cftr)

XMA:	102231389(cftr)

PRET:

103465638(cftr)

NFU:	107388351(cftr)

CSEM:

103379580(cftr)

LCF:	108893910(cftr)

HCQ:	109530830(cftr) 109530831

BPEC:

110155111(cftr)

SASA:

100136364 100136366

ELS:	105029518(cftr)

SFM:	108931616(cftr)

LCM:	102346483(CFTR)

CMK:	103179362(cftr)

» show all

Reference

1 [PMID:9147660]

Authors

Chen M, Zhang JT.

Title

Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes.

Journal

Mol Membr Biol 13:33-40 (1996)

Reference

2 [PMID:9013845]

Authors

Tusnady GE, Bakos E, Varadi A, Sarkadi B.

Title

Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters.

Journal

FEBS Lett 402:1-3 (1997)
DOI:10.1016/S0014-5793(96)01478-0

Reference

3 [PMID:9922375]

Authors

Sheppard DN, Welsh MJ.

Title

Structure and function of the CFTR chloride channel.

Journal

Physiol Rev 79:S23-45 (1999)
DOI:10.1152/physrev.1999.79.1.S23

Other DBs

ExplorEnz - The Enzyme Database:

3.6.3.49

IUBMB Enzyme Nomenclature:

3.6.3.49

ExPASy - ENZYME nomenclature database:

3.6.3.49

BRENDA, the Enzyme Database:

3.6.3.49

DBGET integrated database retrieval system