KEGG   ENZYME: 3.6.3.55Help
Entry
EC 3.6.3.55                 Enzyme                                 

Name
tungstate-importing ATPase;
tungstate transporter;
WtpABC;
TupABC;
tungstate-specific ABC transporter
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (tungstate-importing)
Reaction(IUBMB)
ATP + H2O + tungstate[side 1] = ADP + phosphate + tungstate[side 2] [RN:R10531]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
tungstate[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
tungstate[side 2]
Comment
An ABC-type (ATP-binding cassette-type) ATPase. The enzymes from the archaeon Pyrococcus furiosus, the Gram-positive bacterium Eubacterium acidaminophilum and the Gram-negative bacterium Campylobacter jejuni transport tungsten into the cell for incorporation into tungsten-dependent enzymes.
History
EC 3.6.3.55 created 2013
Orthology
K06857  tungstate transport system ATP-binding protein
K15497  molybdate/tungstate transport system ATP-binding protein
Genes
VCH: VC1525
VCF: IR04_12855
VCE: Vch1786_I1023
VCJ: VCD_002850
VCO: VC0395_A1132
VCR: VC395_1644
VCM: VCM66_1467
VCI: O3Y_07405
VCL: VCLMA_A1323
VCQ: EN18_10820
VCS: MS6_1310
VVU: VV1_2574
VVY: VV1715
VPA: VP1498
VAG: N646_0555
VSP: VS_1501
VSC: VSVS12_01724(tupC)
VTA: A0693
VFI: VF_1404(modC2)
PPR: PBPRA1891(RSC2632)
SON: SO_4721(tupC)
SFR: Sfri_3919
SAZ: Sama_0122
SBL: Sbal_0080
SLO: Shew_3685
SSE: Ssed_0122
SPL: Spea_4096
SHL: Shal_0147
SWD: Swoo_0085
SWP: swp_4981
SPSW: Sps_00169
MAD: HP15_4134
MBS: MRBBS_3422(yxeO)
FBL: Fbal_3603
MVS: MVIS_0727
MEJ: Q7A_2515
CYQ: Q91_1682
NHL: Nhal_0510
AEH: Mlg_2739
GAI: IMCC3135_12395(tupC)
CSA: Csal_2082
HAM: HALO3054
HCO: LOKO_01992(glnQ_2)
HBE: BEI_1423(tupC)
AHA: AHA_3076
ASA: ASA_3088(modC)
AVR: B565_1063
SVA: SVA_2349
ENM: EBS_0989(tupC)
RSO: RSc2632
RSE: F504_2529
RPI: Rpic_2867
REH: H16_A3086(h16_A3086)
RME: Rmet_2919
CGD: CR3_2272(tupC)
PNU: Pnuc_1393
PNE: Pnec_0567
BPE: BP1479
BPC: BPTD_1462
BPER: BN118_1135
BPET: B1917_2378
BPEU: Q425_13450
BPA: BPP1940
BPAR: BN117_2008
BBR: BB2128
BPT: Bpet4654
RFR: Rfer_2868
PNA: Pnap_1510
AJS: Ajs_3128
ACRA: BSY15_389
RTA: Rta_13240
LIM: L103DPR2_01246(glnQ_2)
LIH: L63ED372_00728(glnQ_2)
HYB: Q5W_12415
MPT: Mpe_A2222
HAR: HEAR1420
MMS: mma_1963
LCH: Lcho_1814
THI: THI_3498
EBA: ebA5014
AZO: azo2923(tupC)
AZA: AZKH_1623
AOA: dqs_3063
TCL: Tchl_1924
BPRC: D521_1184
WSU: WS1372
CJE: Cj1538c
CJU: C8J_1437
CJI: CJSA_1454
CJM: CJM1_1479
CJS: CJS3_1616
CJEJ: N564_01529
CJEU: N565_01565
CJEN: N755_01566
CJEI: N135_01625
CJER: H730_08980
CJV: MTVDSCj20_1498(tupC)
CJY: QZ67_01664(cbiO)
CJQ: UC78_1465(cysA_3)
CJR: CJE1709
CCO: CCC13826_0204(tupC)
CCOC: CCON33237_0541(tupC)
CCQ: N149_1482
CCF: YSQ_01210
CCY: YSS_08245
CCOI: YSU_01235
CCOF: VC76_07590(ugpC)
CCOO: ATE51_00498(ugpC)
CGRA: CGRAC_1355(tupC)
CURE: CUREO_0581(tupC)
CHV: CHELV3228_0373(tupC)
CSPF: CSF_1454(tupC)
CPIN: CPIN18020_1274(tupC)
CCUN: CCUN_1869(tupC)
SDL: Sdel_2057
SHAL: SHALO_2650
SULJ: SJPD1_2551
NAM: NAMH_1311
GSU: GSU2702(tupC)
GSK: KN400_2648(tupC)
GME: Gmet_1039(tupC)
GUR: Gura_3542
GBM: Gbem_1695(tupC)
GEO: Geob_0275(tupC-1) Geob_1628(tupC-2)
GEM: GM21_2526
GEB: GM18_1507
PCA: Pcar_0927(tupC) Pcar_2085(wtpC)
PPD: Ppro_0892
DVU: DVU0747
DVL: Dvul_2223
DVM: DvMF_2782
DDE: Dde_0232
DDS: Ddes_1776
DMA: DMR_12530
DGG: DGI_0758
DAS: Daes_1321
DPI: BN4_10130
PPRF: DPRO_0166
DBA: Dbac_3404
DSF: UWK_03293
SFU: Sfum_0029
MES: Meso_2436
SMD: Smed_5504
OCA: OCAR_6707
BOS: BSY19_205
MEX: Mext_2851
MDI: METDI3619
MCH: Mchl_3077
MET: M446_3943
MPO: Mpop_2969
MNO: Mnod_3624
META: Y590_13765
MCG: GL4_3223
HDI: HDIA_1761(pstB_4)
RBM: TEF_06440
SIL: SPO1790
RDE: RD1_2910
DSH: Dshi_0627
PGD: Gal_00650
MALG: MALG_04790
RHC: RGUI_0708
RMM: ROSMUCSMR3_02207(tupC)
MAG: amb3045
MAGX: XM1_2192
MAGN: WV31_18695
AFR: AFE_2189
ACU: Atc_1435
BBEV: BBEV_2499(potA-2)
BSE: Bsel_2920
CBO: CBO1944(tupC)
CBA: CLB_1882(tupC)
CBH: CLC_1889(tupC)
CBY: CLM_2161(tupC)
CBL: CLK_1401
CBB: CLD_2680
CBI: CLJ_B2148
CBF: CLI_2011(tupC)
CBM: CBF_1996(tupC)
CPAS: Clopa_3480
CACE: CACET_c08680(pstB1)
AMT: Amet_1024
AOE: Clos_2215
CPRO: CPRO_17500(artM_1)
EAC: EAL2_c04410(tupC)
CST: CLOST_0874(tupC)
STH: STH382
SWO: Swol_1631
SLP: Slip_1759
DRM: Dred_2269
PTH: PTH_0471(CbiO) PTH_2264(CysA)
DAU: Daud_1540
HMO: HM1_0335
ELM: ELI_1209
CTHM: CFE_0886
THX: Thet_1513
TKI: TKV_c18720(tauB)
MTA: Moth_0069
ADG: Adeg_0642
TPZ: Tph_c27330(pstB2)
CSC: Csac_0974
ATE: Athe_0826
TOC: Toce_0195
PUF: UFO1_1830
KFL: Kfla_2123
AVA: Ava_4038
STI: Sthe_3397
ATM: ANT_30990
PBF: CFX0092_A2270(pstB)
TTH: TT_C1934
TTJ: TTHA0071
TSC: TSC_c00480(hisP)
IPA: Isop_0404
TAI: Taci_1648
TLI: Tlie_1740
TLE: Tlet_0837
PMO: Pmob_0377
CEX: CSE_00960(wtpC)
MOX: DAMO_1145
MJA: MJ_1367
MMP: MMP1518
MMD: GYY_08430
MAE: Maeo_0471
MVO: Mvol_1183
MAC: MA_0282
MMA: MM_1563
MMAC: MSMAC_3124
MTHE: MSTHC_2536
MHOR: MSHOH_1987
MTP: Mthe_1202
MHI: Mhar_1365
MHU: Mhun_0519
MPI: Mpet_2424
MPL: Mpal_2304
MPD: MCP_2805
MEZ: Mtc_0215
RCI: RCIX666
MTH: MTH_477
METE: tca_00443(cysA)
METH: MBMB1_0118(wtpC)
MFV: Mfer_0982
AFU: AF_0092
GAH: GAH_00640
HHB: Hhub_3048
HALH: HTSR_1924
HHSR: HSR6_1995(tupC)
HMA: rrnAC3265(pstB3)
HHI: HAH_0512
NPH: NP_3044A(tupC) NP_3932A(abc13a)
NMO: Nmlp_1137(cysA) Nmlp_3742
HUT: Huta_1020
HMU: Hmuk_1404
HWA: HQ_1421A
HWC: Hqrw_1498
HVO: HVO_1886(tupC)
HME: HFX_1980(abc22A)
HTU: Htur_2294
NMG: Nmag_3967(tupC)
NAT: NJ7G_3553
TAC: Ta1050
PHO: PH0157(PH0157)
PAB: PAB0103
PFU: PF0082
PFI: PFC_07790
PYN: PNA2_0693
PYS: Py04_0155
TKO: TK0021
TON: TON_0016
TGA: TGAM_1437
TSI: TSIB_0163
THE: GQS_09665
THA: TAM4_1544
THM: CL1_1514
TLT: OCC_11477
THS: TES1_0540
TNU: BD01_1602
PPAC: PAP_00375
SMR: Smar_0282
IHO: Igni_0470
IAG: Igag_0890
HBU: Hbut_0333
SSO: SSO0367
SOL: Ssol_1342
SSOA: SULA_1385
SSOL: SULB_1386
SSOF: SULC_1384
STO: STK_20350
SAI: Saci_1484
SID: M164_1783
SII: LD85_1993
SIH: SiH_1712
SIR: SiRe_1632
SIC: SiL_1625
MSE: Msed_1613
MCN: Mcup_0616
AHO: Ahos_1271
PCL: Pcal_1397
POG: Pogu_0705
CMA: Cmaq_0505
TUZ: TUZN_0568
TTN: TTX_0254 TTX_0855(cysA)
VDI: Vdis_0931
VMO: VMUT_1779
TPE: Tpen_1795
ASC: ASAC_0369
KCR: Kcr_0874
LOKI: Lokiarch_15230(cysA_1)
 » show all
Taxonomy
Reference
1  [PMID:11292832]
  Authors
Makdessi K, Andreesen JR, Pich A
  Title
Tungstate Uptake by a highly specific ABC transporter in Eubacterium acidaminophilum.
  Journal
J Biol Chem 276:24557-64 (2001)
DOI:10.1074/jbc.M101293200
  Sequence
Reference
2  [PMID:16952940]
  Authors
Bevers LE, Hagedoorn PL, Krijger GC, Hagen WR
  Title
Tungsten transport protein A (WtpA) in Pyrococcus furiosus: the first member of a new class of tungstate and molybdate transporters.
  Journal
J Bacteriol 188:6498-505 (2006)
DOI:10.1128/JB.00548-06
  Sequence
[pfu:PF0082]
Reference
3  [PMID:19818021]
  Authors
Smart JP, Cliff MJ, Kelly DJ
  Title
A role for tungsten in the biology of Campylobacter jejuni: tungstate stimulates  formate dehydrogenase activity and is transported via an ultra-high affinity ABC  system distinct from the molybdate transporter.
  Journal
Mol Microbiol 74:742-57 (2009)
DOI:10.1111/j.1365-2958.2009.06902.x
  Sequence
[cje:Cj1538c]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.3.55
IUBMB Enzyme Nomenclature: 3.6.3.55
ExPASy - ENZYME nomenclature database: 3.6.3.55
BRENDA, the Enzyme Database: 3.6.3.55

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