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Entry
EC 3.6.3.7                  Enzyme                                 

Name
Na+-exporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (Na+-exporting)
Reaction(IUBMB)
ATP + H2O + Na+in = ADP + phosphate + Na+out [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+ [CPD:C01330]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+ [CPD:C01330]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed.
History
EC 3.6.3.7 created 2000, modified 2001
Orthology
K01536  Na+-exporting ATPase
K09697  sodium transport system ATP-binding protein
Genes
PPP: 112273674 112276792 112295107
SCE: YDR038C(ENA5) YDR039C(ENA2) YDR040C(ENA1)
AGO: AGOS_AGL097C
ERC: Ecym_4150
KLA: KLLA0_E14587g KLLA0_F20658g
KMX: KLMA_40202(ENA5)
LTH: KLTH0F08030g
VPO: Kpol_1052p20
ZRO: ZYRO0E06930g
CGR: CAGL0K12034g
NCS: NCAS_0A10620(NCAS0A10620)
NDI: NDAI_0A05680(NDAI0A05680)
TPF: TPHA_0A04000(TPHA0A04000) TPHA_0A04010(TPHA0A04010)
TBL: TBLA_0E02620(TBLA0E02620)
TDL: TDEL_0D03490(TDEL0D03490) TDEL_0G04940(TDEL0G04940)
KAF: KAFR_0A01060(KAFR0A01060)
PIC: PICST_73371(ENA5) PICST_74899(ENA2)
SPAA: SPAPADRAFT_158103(ENA1) SPAPADRAFT_67476(ENA1.1)
SLB: AWJ20_3228(ENA5)
NCR: NCU05046(ena-1) NCU07966
NTE: NEUTE1DRAFT144929(NEUTE1DRAFT_144929) NEUTE1DRAFT88512(NEUTE1DRAFT_88512)
MBE: MBM_01457
ANG: ANI_1_1216134(An15g01830) ANI_1_64084(An09g00690)
CIM: CIMG_03108 CIMG_12859(CIMG00571)
PBL: PAAG_05329 PAAG_12330(PAAG_07077)
CNB: CNBA4950
WSE: WALSEDRAFT_53229(cta3)
MGL: MGL_3722
XFA: XF_2329
XFT: PD_1361(natA)
XCC: XCC3969(natA)
XCB: XC_4059
XCP: XCR_0302
XCV: XCV4144(natA)
XAX: XACM_3921(natA)
XAC: XAC4054(natA)
XCI: XCAW_00248(natA)
XOO: XOO0388(natA)
XOM: XOO0351(XOO0351)
XOP: PXO_02799
XOR: XOC_4105
XAL: XALC_3005(natA)
XPH: XppCFBP6546_14210(XppCFBP6546P_14210)
SML: Smlt4511
SMT: Smal_3873
SMZ: SMD_4058
PSUW: WQ53_08115
PSD: DSC_00955
LEZ: GLE_5353(natA)
LEM: LEN_4879
DKO: I596_3780
SON: SO_0070(natA)
SDN: Sden_0067
SFR: Sfri_3978
SAZ: Sama_3576
SBL: Sbal_4279
SLO: Shew_3781
SSE: Ssed_4461
SPL: Spea_4191
SHL: Shal_0061
SWD: Swoo_4865
SWP: swp_0106
SVO: SVI_4294(natA)
SPSW: Sps_05613
ILO: IL0481(natA_2)
CPS: CPS_0723(natA)
PHA: PSHAa1626
PAT: Patl_2951
PSM: PSM_A1599
PSEO: OM33_10845
PTN: PTRA_a2021(natA)
PEA: PESP_a2039(natA)
PSPO: PSPO_a1583(natA)
PART: PARC_a1897(natA)
PTU: PTUN_a2026(natA)
PNG: PNIG_a2133(natA)
PTD: PTET_a1850(natA)
PSEN: PNC201_08245(ybhF3) PNC201_10085(yxlF3)
AMAL: I607_04370
AMAE: I876_04580
AMAO: I634_04755
AMAD: I636_04600
AMAI: I635_04575
AMAG: I533_04330
AMAC: MASE_04215
AAUS: EP12_04560
GNI: GNIT_2230(natA)
GPS: C427_1723
FBL: Fbal_1484
CJA: CJA_0603(natA)
SDE: Sde_3736
SAGA: M5M_06480
MICC: AUP74_01352(ybhF_1)
GAI: IMCC3135_23080(natA_3)
KKO: Kkor_1935
KGE: TQ33_0605
TBN: TBH_C2829
MPT: Mpe_A3800
JAG: GJA_4608
RGE: RGE_00500(natA)
MXA: MXAN_6827(natA)
CCX: COCOR_07408(natA)
SCL: sce0659(natA)
HOH: Hoch_3195
BSU: BSU02750(natA)
BSR: I33_0316
BSL: A7A1_1923
BSH: BSU6051_02750(natA)
BSUT: BSUB_00324(natA)
BSUL: BSUA_00324(natA)
BSUS: Q433_01675
BST: GYO_0476
BSQ: B657_02750(natA)
BSX: C663_0266(natA)
BPU: BPUM_0252
BPUM: BW16_01610
BPUS: UP12_01590
BMQ: BMQ_1211(natA)
BMD: BMD_1196(natA)
BMEG: BG04_3512
BJS: MY9_0280
BACW: QR42_01565
BACY: QF06_00330
BACL: BS34A_03300(natA_1)
BALM: BsLM_0286
LWE: lwe0700
BBE: BBR47_07040(natA)
BLR: BRLA_c005380(ybhF_2)
BTS: Btus_3144
CAC: CA_C3551(natA)
CAE: SMB_G3592(natA)
CAY: CEA_G3557
CTC: CTC_01486(natA)
CTET: BN906_01651(natA)
CBO: CBO2239
CBA: CLB_2178
CBH: CLC_2161
CBY: CLM_2445
CBL: CLK_1679
CBB: CLD_2337
CBI: CLJ_B2450
CBF: CLI_2288
CBM: CBF_2277
CKL: CKL_3011
CKR: CKR_2659
CPAS: Clopa_0174
CPAT: CLPA_c08480(natA1)
CPAE: CPAST_c08480(natA1)
CLT: CM240_2696(natA)
CBV: U729_1171
CSQ: CSCA_1972
CTYK: CTK_C12230(natA)
CTH: Cthe_2942
RIX: RO1_21350
RIM: ROI_08690
CPY: Cphy_0114
HSD: SD1D_0177
TTE: TTE0410(CcmA2)
CSC: Csac_2502
ATE: Athe_0113
APAL: BN85409390
MBJ: KQ51_01784(ybhF)
ELE: Elen_1130
EYY: EGYY_10620(CcmA)
GPA: GPA_31410
GVI: gll0052
ATM: ANT_25720(natA)
PBF: CFX0092_A2520(natA)
DRA: DR_0927
DGE: Dgeo_1675
TRA: Trad_2343
TTH: TT_C1559
TTJ: TTHA1924
TSC: TSC_c24770(natA)
TAQ: TO73_2364
MRB: Mrub_1791
OTE: Oter_1528
OBG: Verru16b_00937(ybhF_1)
RBA: RB7633(natA)
PIR: VN12_01280(ybhF_1) VN12_03175(ybhF_3)
PLS: VT03_02120(ybhF_1) VT03_02900(ybhF_2)
PLH: VT85_13675(ybhF_1)
FMR: Fuma_02068(ybhF_5) Fuma_04071(ybhF_8)
TTF: THTE_0885
GES: VT84_38590(drrA_7)
SACI: Sinac_6078
PBOR: BSF38_00882(natA_2)
CBAL: M667_07640
CBAT: M666_07675
CACI: CLOAM0955(ccmA)
KOL: Kole_1193
 » show all
Taxonomy
Reference
1  [PMID:7664728]
  Authors
Wieland J, Nitsche AM, Strayle J, Steiner H, Rudolph HK.
  Title
The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.
  Journal
EMBO J 14:3870-82 (1995)
  Sequence
Reference
2  [PMID:9224683]
  Authors
Catty P, de Kerchove d'Exaerde A, Goffeau A.
  Title
The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases.
  Journal
FEBS Lett 409:325-32 (1997)
DOI:10.1016/S0014-5793(97)00446-8
Reference
3  [PMID:9106203]
  Authors
Cheng J, Guffanti AA, Krulwich TA.
  Title
A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore.
  Journal
Mol Microbiol 23:1107-20 (1997)
DOI:10.1046/j.1365-2958.1997.2951656.x
  Sequence
[bsu:BSU02750]
Reference
4  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 3.6.3.7
IUBMB Enzyme Nomenclature: 3.6.3.7
ExPASy - ENZYME nomenclature database: 3.6.3.7
BRENDA, the Enzyme Database: 3.6.3.7

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