KEGG   ENZYME: 3.6.4.3Help
Entry
EC 3.6.4.3                  Enzyme                                 

Name
microtubule-severing ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
ATP phosphohydrolase (tubulin-dimerizing)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
History
EC 3.6.4.3 created 2000
Orthology
K07767  katanin p60 ATPase-containing subunit A1
K13254  spastin
Genes
HSA: 11104(KATNA1) 6683(SPAST) 83473(KATNAL2) 84056(KATNAL1)
PTR: 452517(KATNAL1) 455404(KATNAL2) 459133(SPAST) 748379(KATNA1)
PPS: 100969467(KATNAL1) 100979314(KATNAL2) 100983006(SPAST) 100991443(KATNA1)
GGO: 101128946(KATNA1) 101133879(KATNAL2) 101141230(KATNAL1) 101142697(SPAST)
PON: 100431635(KATNA1) 100450053(SPAST) 100456453(KATNAL2) 100461041(KATNAL1)
NLE: 100585381(KATNAL2) 100594616(KATNAL1) 100599294(KATNA1) 100599689(SPAST)
MCC: 696856(KATNAL2) 698291(KATNA1) 706264(SPAST) 712636(KATNAL1)
MCF: 101864950(KATNA1) 102124785(KATNAL1) 102143804(SPAST) 102145873(KATNAL2)
CSAB: 103214218(KATNAL1) 103220531(SPAST) 103222469(KATNAL2) 103240154(KATNA1)
RRO: 104654376(KATNAL2) 104665316(KATNAL1) 104676261(KATNA1) 104681704(SPAST)
RBB: 108519033(KATNAL2) 108524834(KATNAL1) 108528688(SPAST) 108536657(KATNA1)
CJC: 100385433(KATNA1) 100390375(KATNAL1) 100392488(KATNAL2) 100408469(SPAST)
SBQ: 101031912(KATNAL1) 101039256(KATNA1) 101043087(KATNAL2) 101046408(SPAST)
MMU: 231912(Katnal1) 23924(Katna1) 50850(Spast) 71206(Katnal2)
RNO: 100910196 103690050 288449(Katnal1) 292464(Katna1) 307253(Katnal2) 362700(Spast)
CGE: 100755046(Katnal1) 100759022(Katna1) 100765919(Spast) 100772637(Katnal2)
NGI: 103727225(Katnal1) 103727840(Katnal2) 103731914(Katna1) 103746750(Spast) 103748420
HGL: 101706398(Katnal1) 101710272(Spast) 101711571(Katnal2) 101726567(Katna1)
CCAN: 109678112 109692081(Katnal2) 109692325(Spast) 109694197(Katna1) 109700360
OCU: 100328900(KATNAL1) 100341477(KATNA1) 100345919(SPAST) 100358099(KATNAL2)
TUP: 102474110(SPAST) 102474426(KATNA1) 102479506(KATNAL1) 102493611(KATNAL2)
CFA: 476240(KATNA1) 486020(KATNAL1) 490465(KATNAL2) 608582(SPAST)
AML: 100465290(SPAST) 100466820(KATNAL2) 100467330(KATNA1) 100468053(KATNAL1)
UMR: 103663874(KATNAL2) 103664329(KATNAL1) 103666922(KATNA1) 103671901(SPAST)
ORO: 101370713(KATNA1) 101374795(SPAST) 101384083(KATNAL2) 101384350(KATNAL1)
FCA: 101086184(KATNAL2) 101088156(SPAST) 101089567(KATNAL1) 101099465(KATNA1)
PTG: 102953217(SPAST) 102960267(KATNA1) 102962289(KATNAL1) 102973012(KATNAL2)
AJU: 106967929(SPAST) 106972953(KATNAL2) 106985551(KATNAL1) 106987186(KATNA1)
BTA: 506715(KATNA1) 514354(KATNAL2) 521442(SPAST) 537739(KATNAL1)
BOM: 102268274(KATNAL1) 102270181(SPAST) 102272801(KATNA1) 102280453(KATNAL2)
PHD: 102317958(KATNA1) 102322121 102325579(SPAST) 102330527(KATNAL2) 102337789(KATNAL1)
CHX: 102186493(KATNAL1) 102187910(KATNAL2) 102188222(KATNA1) 102190238(SPAST)
OAS: 101104819(SPAST) 101112580(KATNAL1) 101113378(KATNAL2) 101122604(KATNA1)
SSC: 100156612(KATNAL1) 100518101(KATNA1) 100627107(KATNAL2) 396584(SPAST)
CFR: 102516193(KATNAL2) 102516712(KATNA1) 102523471(KATNAL1) 102524344(SPAST)
CDK: 105086591(KATNAL1) 105095598(SPAST) 105097584(KATNAL2) 105100910(KATNA1)
BACU: 103004310(KATNAL2) 103006341(SPAST) 103012410(KATNAL1) 103020498(KATNA1)
LVE: 103070774(KATNAL2) 103073133(KATNA1) 103074023(SPAST) 103077620(KATNAL1)
OOR: 101277173(KATNAL2) 101280463(KATNAL1) 101283454(KATNA1) 101286356(SPAST)
ECB: 100054514(SPAST) 100063699(KATNAL1) 100064649(KATNA1) 100068896(KATNAL2)
EPZ: 103543232(SPAST) 103548727(KATNA1) 103549229(KATNAL1) 103554245(KATNAL2)
EAI: 106829528 106831221(KATNAL2) 106832894(KATNAL1) 106837215(KATNA1) 106839899(SPAST)
MYB: 102241435(SPAST) 102247096 102250104(KATNA1) 102257914(KATNAL2) 102262837(KATNAL1)
MYD: 102752480 102756220(SPAST) 102756565(KATNAL2) 102765363(KATNA1) 102771741(KATNAL1)
HAI: 109380896(KATNA1) 109388196(KATNAL2) 109388782(SPAST) 109395401(KATNAL1)
RSS: 109441981 109449836(KATNAL1) 109451432(KATNAL2) 109452561(SPAST) 109455404(KATNA1)
PALE: 102885491(SPAST) 102890118(KATNAL1) 102895027(KATNAL2) 102897531(KATNA1)
LAV: 100656448(KATNA1) 100665100(KATNAL2) 100673010(KATNAL1) 100673698(SPAST)
MDO: 100018387(KATNAL2) 100020211(KATNAL1) 100026926(KATNA1) 100026979(SPAST)
SHR: 100913468(SPAST) 100916432(KATNAL2) 100932256(KATNAL1) 100933587(KATNA1)
OAA: 100074439(KATNAL2) 100074754(KATNA1) 100078093(SPAST) 100078117(KATNAL1)
GGA: 416384(KATNAL2) 418920(KATNAL1) 421481(SPAST) 421626(KATNA1)
MGP: 100539240(KATNA1) 100541341(KATNAL1) 100544993(KATNAL2) 100546443
CJO: 107308249(KATNAL1) 107311250(SPAST) 107311543(KATNA1) 107325920(KATNAL2)
APLA: 101791139(KATNA1) 101795600(SPAST) 101796302(KATNAL1) 101796326 101799865(KATNAL2)
ACYG: 106034223(KATNA1) 106037313(KATNAL2) 106041150(KATNAL1) 106049836(SPAST)
TGU: 100217690(KATNAL1) 100220307(KATNAL2) 100224472(SPAST) 100230482(KATNA1)
GFR: 102034963(KATNA1) 102041035(SPAST) 102043487(KATNAL1) 102044072(KATNAL2)
FAB: 101808663(SPAST) 101813658(KATNAL2) 101815060(KATNA1) 101821227(KATNAL1)
PHI: 102102027(KATNAL2) 102106285(KATNA1) 102109189(SPAST) 102109393(KATNAL1)
PMAJ: 107201549(KATNA1) 107202109(SPAST) 107202630(KATNAL1) 107216199(KATNAL2)
CCW: 104684473(SPAST) 104689900(KATNAL1) 104690319(KATNA1) 104695698(KATNAL2)
FPG: 101917785(KATNAL1) 101918199(KATNAL2) 101919693(KATNA1) 101924622(SPAST)
FCH: 102046052(SPAST) 102047381(KATNA1) 102048629(KATNAL2) 102059034(KATNAL1)
CLV: 102084097 102085198(KATNAL2) 102086141 102089637(KATNA1) 102093005(KATNAL1)
EGZ: 104124626(SPAST) 104131766(KATNAL1) 104133542(KATNA1) 104134178(KATNAL2)
ASN: 102371986(KATNAL1) 102377008(KATNAL2) 102380094(SPAST) 102381333(KATNA1)
AMJ: 102558354(KATNAL1) 102562239(KATNAL2) 102568221(KATNA1) 102573812(SPAST)
PSS: 102452286(KATNA1) 102453910(KATNAL1) 102457579(SPAST) 102459920(KATNAL2)
CMY: 102935395(KATNAL1) 102935890(SPAST) 102940946(KATNA1) 102941472(KATNAL2)
CPIC: 101933336(SPAST) 101938772(KATNAL2) 101941530(KATNAL1) 101946960(KATNA1)
ACS: 100553196(katna1) 100560906(katnal1) 100563650(spast) 100565087(katnal2)
PVT: 110076359(SPAST) 110076448(KATNAL1) 110085929(KATNAL2) 110086934(KATNA1)
PBI: 103049559(KATNAL1) 103051365(KATNAL2) 103054469(KATNA1) 103067475(SPAST)
GJA: 107107880(KATNA1) 107108061(SPAST) 107119353(KATNAL2) 107122487(KATNAL1)
XLA: 108708697(katnal1.L) 108709953(katnal1.S) 108716667(spast.L) 399380(katna1.S) 446560(spast.S) 734847(katnal2.L)
XTR: 100036615(katnal2) 100489961(katnal1) 549207(spast) 779887(katna1)
NPR: 108786226(KATNAL1) 108787493(SPAST) 108790702(KATNAL2) 108794573(KATNA1)
DRE: 405851(spast) 492790(katnal1) 553631(katna1) 641431(katnal2)
IPU: 108256851(katna1) 108258412(spast) 108276615(katnal2) 108278131
AMEX: 103028825(katnal2) 103037638(katna1) 103039844(katnal1) 103047441(spast)
LCO: 104918210(spast) 104918314(katna1) 104928036(katnal2) 104938831(katnal1)
MZE: 101464095 101472618 101483121(katnal2) 101483397(spast) 101484367(katna1)
OLA: 101163120 101167644(spast) 101168474(katnal2) 101169256(katna1)
XMA: 102220952(katnal2) 102222160 102231738(spast) 102236802(katna1)
PRET: 103458036(katna1) 103473541(katnal2) 103477244(spast) 103479389
NFU: 107375446(spast) 107389744 107396031(katna1) 107396613(katnal2)
CSEM: 103380599(katna1) 103387626(spast) 103390302(katnal2) 103391940
HCQ: 109516275(spast) 109518317(katnal2) 109524846(katna1) 109531316
BPEC: 110156998(spast) 110168877(katnal2) 110170660 110175303(katna1)
SASA: 100195344(katna1) 106563824(katnal1) 106564821 106568597(katnal2) 106578778 106586197
ELS: 105010164(katnal1) 105017901(katna1) 105027127(katnal2) 105029456 105031438
LCM: 102345365 102348522(KATNAL2) 102354233(SPAST) 102355457 102367541(KATNAL1)
CMK: 103177613(spast) 103179275(katna1) 103183238(katnal1) 103190946(katnal2)
SPU: 373368(KATNA1) 577727 578636
DME: Dmel_CG10229(Kat60) Dmel_CG10793(CG10793) Dmel_CG1193(kat-60L1) Dmel_CG5977(spas)
DSI: Dsimw501_GD19637(Dsim_GD19637) Dsimw501_GD19820(Dsim_GD19820) Dsimw501_GD21056(Dsim_GD21056) Dsimw501_GD28101(Dsim_GD28101)
AGA: AgaP_AGAP001783 AgaP_AGAP002334(SPAST_ANOGA)
AME: 409576(spas) 413966 551788(GB14818)
TUT: 107365099
CEL: CELE_C24B5.2(spas-1) CELE_T01G9.5(mei-1)
CBR: CBG04086(Cbr-mei-1) CBG19220(Cbr-spas-1)
TSP: Tsp_10633
ATH: AT1G80350(ERH3) AT2G34560(CCP1) AT2G45500
LJA: Lj0g3v0359309.1(Lj0g3v0359309.1) Lj1g3v2583420.1(Lj1g3v2583420.1) Lj1g3v2583420.2(Lj1g3v2583420.2) Lj3g3v2247050.1(Lj3g3v2247050.1) Lj4g3v0254250.1(Lj4g3v0254250.1) Lj4g3v0254260.1(Lj4g3v0254260.1) Lj6g3v0216890.1(Lj6g3v0216890.1)
DOSA: Os01t0673500-01(Os01g0673500) Os01t0683100-01(Os01g0683100) Os01t0757400-01(Os01g0757400) Os06t0130000-01(Os06g0130000)
ATS: 109734004(LOC109734004) 109743497(LOC109743497) 109760866(LOC109760866) 109784958(LOC109784958)
APRO: F751_0064
DFA: DFA_01535
SMIN: v1.2.000808.t1(symbB.v1.2.000808.t1) v1.2.018186.t1(symbB.v1.2.018186.t1) v1.2.029690.t1(symbB.v1.2.029690.t1)
CDIV: CPM_0927
 » show all
Taxonomy
Reference
1  [PMID:8221885]
  Authors
McNally FJ, Vale RD.
  Title
Identification of katanin, an ATPase that severs and disassembles stable microtubules.
  Journal
Cell 75:419-29 (1993)
  Sequence
[spu:373368]
Reference
2  [PMID:9568719]
  Authors
Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ.
  Title
Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit.
  Journal
Cell 93:277-87 (1998)
DOI:10.1016/S0092-8674(00)81578-0
  Sequence
[spu:373368]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.4.3
IUBMB Enzyme Nomenclature: 3.6.4.3
ExPASy - ENZYME nomenclature database: 3.6.4.3
BRENDA, the Enzyme Database: 3.6.4.3

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