Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement

kinesin ATP phosphohydrolase (plus-end-directed)

ATP + H2O = ADP + phosphate [RN:R00086]

R00086

ATP [CPD:C00002];
H2O [CPD:C00001]

Microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (alpha) chains (110 kDa) and two or more light (beta) chains (65-75 kDa). Also hydrolyses GTP.

EC 3.6.4.4 created 2000

1  [PMID:3926325]

Vale RD, Reese TS, Sheetz MP.

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility.

Cell 42:39-50 (1985)
DOI:10.1016/S0092-8674(85)80099-4

2  [PMID:9335494]

Howard J.

Molecular motors: structural adaptations to cellular functions.

Nature 389:561-7 (1997)
DOI:10.1038/39247

3  [PMID:9275178]

Nakagawa T, Tanaka Y, Matsuoka E, Kondo S, Okada Y, Noda Y, Kanai Y, Hirokawa N.

Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.

Proc Natl Acad Sci U S A 94:9654-9 (1997)
DOI:10.1073/pnas.94.18.9654