| Entry |
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| Name |
minus-end-directed kinesin ATPase
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| Class |
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
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| Sysname |
kinesin ATP phosphohydrolase (minus-end-directed)
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| Reaction(IUBMB) |
ATP + H2O = ADP + phosphate [RN: R00086]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Structurally almost identical to EC 3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules.
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| History |
EC 3.6.4.5 created 2000
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| Reference |
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| Authors |
Henningsen U, Schliwa M. |
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| Title |
Reversal in the direction of movement of a molecular motor. |
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| Journal |
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| Reference |
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| Authors |
Sharp DJ, Kuriyama R, Essner R, Baas PW. |
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| Title |
Expression of a minus-end-directed motor protein induces Sf9 cells to form axon-like processes with uniform microtubule polarity orientation. |
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| Journal |
J Cell Sci 110 ( Pt 19):2373-80 (1997) |
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| Reference |
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| Authors |
Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale RD, Fletterick RJ. |
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| Title |
Direction determination in the minus-end-directed kinesin motor ncd. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.6.4.5 |
| ExPASy - ENZYME nomenclature database: | 3.6.4.5 |
| BRENDA, the Enzyme Database: | 3.6.4.5 |
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