Entry
Name
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
ATP phosphohydrolase (vesicle-fusing)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate
Substrate
Product
Comment
A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (_A_TPase _a_ssociated with a variety of cell _a_ctivities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger's syndrome.
History
EC 3.6.4.6 created 2000
Orthology
Genes
MYB : 102241084(NSF) 102249817
MDT : 132216264 132218533(NSF) 132218538
TVP : 118836590 118846979(NSF)
XLA : 100049722(nsf.L) 779070(nsf.S)
DRE : 368483(nsfa) 554200(nsfb)
SRX : 107709994 107723637 107733448 107753041
SANH : 107657277 107665886 107688085 107689618
SGH : 107584403 107590408 107601245
CCAR : 109059813 109099175
CAUA : 113044966 113056085 113079639 113100003
CGIB : 127950846 127952914 127969296 128025223
PTET : 122329430(nsfa) 122355246(nsfb)
OMC : 131533987(nsfa) 131551281(nsfb)
PPRM : 120471520(nsfb) 120490062(nsfa)
RKG : 130075858(nsfa) 130088646(nsfb)
MAMB : 125255327(nsfb) 125271137(nsfa)
CIDE : 127509128 127523739
CERY : 137007684(nsfb) 137012324(nsfa)
MASI : 127423110 127427489 127450926 127451565
TROS : 130561951(nsfa) 130569480(nsfb)
TDW : 130426976(nsfa) 130439218(nsfb)
MANU : 129421080(nsfb) 129434442(nsfa)
IPU : 108260232 108273757(nsfb)
IFU : 128616647(nsfb) 128622603
PHYP : 113527349 113528553(nsf)
SMEO : 124388609(nsfb) 124396792(nsfa)
TFD : 113655033(nsfb) 113659251(nsfa)
TVC : 132861420(nsfa) 132862439(nsfb)
TRN : 134321228(nsfb) 134335891(nsfa)
AMEX : 103030471(nsfb) 103037152(nsfa)
CMAO : 118809237(nsfb) 118821119(nsfa)
CHAR : 105888798 105908951
SPIL : 134070489 134076482(nsfa)
TNG : GSTEN00011477G001 GSTEN00021065G001
TBEN : 117473722 117479713
CGOB : 115012653 115024801
EMAC : 134870805 134878062
PLEP : 121956683 121958906
SLUC : 116052933 116061230
ECRA : 117937104 117957698(nsfa)
ESP : 116670824 116683397(nsf)
PFLV : 114548567 114570067
PPUG : 119213121 119220358
AFB : 129091093 129098487(nsfa)
CLUM : 117734779 117748940
PSWI : 130190474 130203608
CANA : 137786612 137789573
CVE : 137891949 137892110(nsfa)
MSAM : 119882401 119915953
SCHU : 122867595 122868409
SPUL : 138593939 138602758(nsfa)
LMIX : 132953948 132954994
ALAT : 119010070 119013384
ASTR : 137588202 137609590
OML : 112139337 112144862 112154076
CSAI : 133418802 133421969
XMA : 102217733 102222911(nsf)
XCO : 114148296(nsf) 114152039
XHE : 116727129 116735594(nsf)
PRET : 103468292(nsf) 103481708
PFOR : 103149223(nsf) 103151978
PLAI : 106945113 106956271(nsf)
PMEI : 106913104 106931820(nsf)
PPRL : 129363361 129367980
CVG : 107093238 107101841(nsf)
CTUL : 119791088 119797428(nsfa)
GMU : 124862244 124865053 124875284
NFU : 107376205(nsf) 107387615
ALIM : 106521948 106525242(nsf)
NWH : 119421464(nsfa) 119423829
AOCE : 111566414(nsf) 111567365
EJA : 138204697 138215230(nsfa)
BFRE : 138624405 138627503(nsfa)
MCEP : 124997409 125022651
CSEM : 103381862 103393665
SSEN : 122759177 122785051
HHIP : 117753059 117766168
SMAU : 118287300 118288420
SLAL : 111655429 111662501
SSCV : 125983034 125990987
SBIA : 133495769 133515032
PTAO : 133465834 133469111
BPEC : 110154189 110171223(nsf)
MALB : 109962797(nsf) 109972314
BSPL : 114846498 114860631(nsfa)
SASA : 100194814(nsf) 106579324 106583880 106589298
STRU : 115158457 115170863 115192093 115201052
OTW : 112223562 112224157 112252241 112258431
OMY : 110491491 110499115 110521932 110537965
OGO : 124000733 124037918 124039882 124048251
ONE : 115106461 115110065 115143887 115145210
OKI : 109865404 109870120 109893154 109898251
OKE : 118357644 118358972 118367095 118384329
OMM : 135505031 135523993 135555912 135556065
SALP : 111967675 111981726
SNH : 120029523 120043958 120046192 120052157
CCLU : 121547285 121547409 121550436 121569763
AANG : 118217258 118220129
AROT : 135243306 135247651
CCOG : 133115305 133121798
SCLV : 120328127 120332581
DME : Dmel_CG1618(comt) Dmel_CG31495(CG31495) Dmel_CG33101(Nsf2)
DSI : Dsimw501_GD17110(Dsim_GD17110) Dsimw501_GD20472(Dsim_GD20472) Dsimw501_GD20473(Dsim_GD20473)
DYA : Dyak_GE17054 Dyak_GE24412 Dyak_GE24413
DSR : 110176629 110176631 110180379
DMO : Dmoj_GI21685 Dmoj_GI24416
DVI : 6634750(comt) 6634946
ASUA : 134202276 134205476
CPII : 120418081 120419864
BBIF : 117210120 117217052
BVAN : 117154517 117156986
BHUN : 126871428 126874649
BTER : 100647002 100648372
BAFF : 126921239 126925441
BPYO : 122573673 122576158
BPAS : 132913012 132914977
VCAN : 122405594 122405595
CCIN : 107270675 107274413
CFEL : 113375826 113376029
PHU : Phum_PHUM047300 Phum_PHUM047310
CSEC : 111868442 111874348
SGRE : 126298003 126318636
DPX : DAPPUDRAFT_118650 DAPPUDRAFT_240520 DAPPUDRAFT_240595 DAPPUDRAFT_240599 DAPPUDRAFT_48480 DAPPUDRAFT_60285
DPZ : 124310982 124314719 124314729 124318558
AFRA : 136034996 136038496
PMOO : 119599067 119599450
HAME : 121868299 121868309
PCLA : 123764259 123764292
PTRU : 123499538 123499751
ESN : 126990896 127004515 127004516
DPTE : 113791499 113796740
ABRU : 129984373 129985205
CEL : CELE_H15N14.2(nsf-1)
CBR : CBG_19441(Cbr-nsf-1)
BMY : BM_BM13759(Bma-nsf-1)
SHX : MS3_00009545(NSF2_1)
ATEN : 116292580 116306047
MFOO : 138010577 138011247
AQU : 100638291 109580865 109585831
ALY : 9304755 9305915 9310886
CSAT : 104707647 104716346 104722879 104733422 104737346
BRP : 103839802 103858677 103870057
BNA : 106362943 106366874 106376378 106404873 106407019 106438745
BOE : 106319486 106328335 106330061 106344373
CPAP : 110817824 110818850
MINC : 123209530 123221362
GHI : 107895350 107901816 107960208 121202878
HSYR : 120147363 120151667 120202943 120202946
RARG : 115750363 115750381 115750382 115750410
APRC : 113857510 113857514
LANG : 109331690 109349358
FVE : 101293960 101294098 101301725 101302830 101303994
AANS : 126788227 126797714
MDM : 103408928 103446406 114825187
MSYL : 126587191 126622345
CMAX : 111466302 111495493
CMOS : 111432603 111434206
CPEP : 111782851 111801908
JCU : 105628980 105628982 105628984 105628986 105649544
HBR : 110635135 110635136 110636373 110648003
MESC : 110603743 110604472
PALZ : 118031345 118047301
CAVE : 132168893 132169838 132170867
AGLU : 133867637 133868291
QSU : 111987692 112035641 112039166
QLO : 115963230 115983859 115989713 115991868
LBB : 132623086 132623125 132628812
NTA : 107774494 107794928 107795805 107795806 107797742 107817451
NTO : 104093939 104097183 104097184 104117416
SSPL : 121787596 121804954 121810037
SHIS : 125196157 125209543
APAN : 127250502 127254783
CCAV : 112506937 112513741
CSIN : 114261624 114275712 114293943 114300018 114301466 114316529
AEW : 130755301 130762871 130790018
CQI : 110693277 110714213 110720169 110725182
ATRI : 130809428 130817457
MOF : 131144685 131152145 131153871 131153873
MING : 122071779 122084510
PSOM : 113318184 113348821
TAES : 123063420 123140444 123182658
MFLO : 136513849 136516870 136517116
SITA : 101764358 101775636
PVIR : 120664896 120675682 120698097
PHAI : 112886334 112893776
PAUA : 133884677 133908719
SMO : SELMODRAFT_137147 SELMODRAFT_236078 SELMODRAFT_407213 SELMODRAFT_91155
OLU : OSTLU_30476 OSTLU_41487
OTA : OT_ostta03g01510 OT_ostta06g04170
BPG : Bathy05g04610 Bathy12g02880
MIS : MICPUN_106780 MICPUN_113384(NSFA)
MPP : MICPUCDRAFT_1003 MICPUCDRAFT_31131
CGR : 2887450(GVI51_E04367) 2891192(GVI51_M01683)
NCS : NCAS_0I01400(NCAS0I01400)
NDI : NDAI_0A07600(NDAI0A07600)
TPF : TPHA_0A03890(TPHA0A03890)
TBL : TBLA_0G03290(TBLA0G03290) TBLA_0I02090(TBLA0I02090)
TDL : TDEL_0D03210(TDEL0D03210)
KAF : KAFR_0C00290(KAFR0C00290)
KNG : KNAG_0J02320(KNAG0J02320)
LBG : 92206706(LODBEIA_P15100)
CAL : CAALFM_C113580WA(SEC18)
YLI : 2912727(YALI2_E00585g)
NTE : NEUTE1DRAFT123357(NEUTE1DRAFT_123357)
SMP : 10802591(SMAC4_08261)
PBEL : QC761_605220(SEC18)
PPSD : QC762_605220(SEC18)
PPSP : QC763_605220(SEC18)
PPSA : QC764_605220(SEC18)
TRE : TRIREDRAFT_62040(nsf1)
TATV : 25778644(TrAtP1_004794)
TASP : 36607332(TrAFT101_004219)
PLJ : 28888916(PLICBS_008599)
PTKZ : JDV02_006030(SEC18)
CDET : 87943983(CDEST_07480)
ALUC : AKAW2_10712S(SEC18)
PNO : SNOG_03196(SNOG_03195)
PTRR : 6339291(PtrM4_028470)
ADAC : 96088039(ACET3X_007717)
CDEP : 91088270(L203_104060)
KMG : 30161256(I203_105629)
KNE : 92183765(IAR55_006507)
CCAC : CcaHIS019_0304550(SEC18)
ABP : AGABI1DRAFT72628(AGABI1DRAFT_72628)
ABV : AGABI2DRAFT188589(AGABI2DRAFT_188589)
SCM : SCHCO_02498766(SCHCODRAFT_02498766)
MBR : MONBRDRAFT_21577 MONBRDRAFT_22669
SRE : PTSG_09791 PTSG_11682
DFA : DFA_03785 DFA_03786(nsfA)
EHI : EHI_004640(8.t00066)
PLAG : 39739877(PADL01_0301800)
PMAL : PMUG01_08053200(NSF)
PBRS : 92370650(MKS88_002562)
PREL : PRELSG_0832700(NSF)
PTM : GSPATT00006065001 GSPATT00010950001 GSPATT00014432001
PTI : PHATRDRAFT_12620 PHATR_13383
FCY : FRACYDRAFT_156624 FRACYDRAFT_184938 FRACYDRAFT_185338
TPS : THAPSDRAFT_11221 THAPSDRAFT_3575
NGD : NGA_0429800 NGA_0430301(NSF)
BLAC : 94345145(CCR75_001370)
SPAR : SPRG_09631 SPRG_21859
LMAT : 92516363(LSCM1_06422)
LOI : 92362014(LSCM4_06155)
LEIS : 94181336(GH5_05990)
LENR : 94173041(CUR178_05852)
LEIN : 94189324(JIQ42_05702)
PHET : 94291978(JKF63_05948)
NGR : NAEGRDRAFT_34168 NAEGRDRAFT_59102
SSAO : 94300456(SS50377_26433) 94300460(SS50377_26437)
EHX : EMIHUDRAFT_452918 EMIHUDRAFT_456468
GTT : GUITHDRAFT_148248(NSFA) GUITHDRAFT_84263(NSFB)
PKP : SK3146_01032(ftsH_1)
MTHO : MOTHE_c10370(ftsH2)
MTHZ : MOTHA_c11260(ftsH4)
NCD : ACONDI_01028(ftsH_1)
SACV : SPACI_032740(ftsH_5)
» show all
Taxonomy
Reference
Authors
Confalonieri F, Duguet M.
Title
A 200-amino acid ATPase module in search of a basic function.
Journal
Reference
Authors
Imamura A, Tamura S, Shimozawa N, Suzuki Y, Zhang Z, Tsukamoto T, Orii T, Kondo N, Osumi T, Fujiki Y.
Title
Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders.
Journal
Reference
Authors
Babst M, Wendland B, Estepa EJ, Emr SD.
Title
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.6.4.6
ExPASy - ENZYME nomenclature database: 3.6.4.6
BRENDA, the Enzyme Database: 3.6.4.6