| Entry |
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| Name |
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| Class |
Hydrolases;
Acting on acid anhydrides;
Acting on GTP to facilitate cellular and subcellular movement
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| Sysname |
GTP phosphohydrolase (microtubule-releasing)
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| Reaction(IUBMB) |
GTP + H2O = GDP + phosphate [RN: R00335]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.
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| History |
EC 3.6.5.6 created 2000 as EC 3.6.1.51, transferred 2003 to EC 3.6.5.6
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| Reference |
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| Authors |
Yu XC, Margolin W. |
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| Title |
Ca2+-mediated GTP-dependent dynamic assembly of bacterial cell division protein FtsZ into asters and polymer networks in vitro. |
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| Journal |
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| Reference |
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| Authors |
Tian G, Bhamidipati A, Cowan NJ, Lewis SA. |
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| Title |
Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer. |
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| Journal |
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| Reference |
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| Authors |
Roychowdhury S, Panda D, Wilson L, Rasenick MM. |
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| Title |
G protein alpha subunits activate tubulin GTPase and modulate microtubule polymerization dynamics. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.6.5.6 |
| ExPASy - ENZYME nomenclature database: | 3.6.5.6 |
| BRENDA, the Enzyme Database: | 3.6.5.6 |
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