KEGG   ENZYME: 3.7.1.19
Entry
EC 3.7.1.19                 Enzyme                                 
Name
2,6-dihydroxypseudooxynicotine hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
Sysname
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase
Reaction(IUBMB)
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O = 2,6-dihydroxypyridine + 4-methylaminobutanoate [RN:R07515]
Reaction(KEGG)
R07515
Substrate
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one [CPD:C15986];
H2O [CPD:C00001]
Product
2,6-dihydroxypyridine [CPD:C03056];
4-methylaminobutanoate
Comment
The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation.
History
EC 3.7.1.19 created 2012
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K19188  2,6-dihydroxypseudooxynicotine hydrolase
Genes
ROPROP_27470
ROAPd630_LPD07472
SGRFSGFS_017810
SCOAQU709_39165
ARXARZXY2_4560
PNVJMY29_20650
TEDU5C87_22570
NCANoca_0613
KBBccbrp13_01940
Reference
1  [PMID:5835946]
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
2  [PMID:16321959]
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.19
IUBMB Enzyme Nomenclature: 3.7.1.19
ExPASy - ENZYME nomenclature database: 3.7.1.19
BRENDA, the Enzyme Database: 3.7.1.19

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