KEGG   ENZYME: 3.7.1.20Help
Entry
EC 3.7.1.20                 Enzyme                                 

Name
3-fumarylpyruvate hydrolase;
nagK (gene name);
naaD (gene name)
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
3-fumarylpyruvate hydrolase
Reaction(IUBMB)
3-fumarylpyruvate + H2O = fumarate + pyruvate [RN:R01085]
Reaction(KEGG)
Substrate
3-fumarylpyruvate [CPD:C02514];
H2O [CPD:C00001]
Product
fumarate [CPD:C00122];
pyruvate [CPD:C00022]
Comment
The enzyme is involved in bacterial degradation of 5-substituted salicylates, including gentisate (5-hydroxysalicylate), 5-nitrosalicylate and 5-halosalicylates.
History
EC 3.7.1.20 created 2012
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16165  fumarylpyruvate hydrolase
Genes
ECE: Z3392
ECS: ECs3029
ECF: ECH74115_3269
ETW: ECSP_3015
ELX: CDCO157_2792
ECOO: ECRM13514_5374
ECOH: ECRM13516_3726
EOK: G2583_2680
ELR: ECO55CA74_13250
ECW: EcE24377A_2432
STY: STY2407
STT: t0678
STM: STM2177
SENI: CY43_11710
SPT: SPA0674
SEK: SSPA0633
SEI: SPC_1525
SEC: SCH_2194(fst)
SHB: SU5_02769
SENS: Q786_10805
SED: SeD_A2524
SEG: SG2213
SEL: SPUL_0712
SET: SEN2170
SENA: AU38_10970
SENO: AU37_10980
SENV: AU39_10980
SENQ: AU40_12280
SENL: IY59_11275
SEEP: I137_03235
SENE: IA1_10890
SBG: SBG_1989
SBZ: A464_2301
KOX: KOX_25685
KOE: A225_4037
EAE: EAE_23885
EAR: CCG29099
CKO: CKO_00652
CRO: ROD_22651
CAMA: F384_11430
EBF: D782_1484
SMAR: SM39_2828(mhbH)
SMAC: SMDB11_2641(mhbH)
RAA: Q7S_08430
DKO: I596_1099
PAE: PA2471
PAEV: N297_2542
PAEI: N296_2542
PAEP: PA1S_13285
PAEM: U769_12870
PAEL: T223_14490
PAEU: BN889_02698(mhbB_1) BN889_02699(mhbB_2)
PAEG: AI22_20630
PAEC: M802_2539
PPU: PP_1709
PPF: Pput_4011
PPI: YSA_02366
PPX: T1E_4798(fahD1)
PFS: PFLU_2602
PEN: PSEEN2594(mhbB)
PSTT: CH92_21505
PSES: PSCI_0921
PSEM: TO66_18350
PANR: A7J50_2491
MCA: MCA0263
MMAI: sS8_5451
GAI: IMCC3135_03420(nagK_1)
KGE: TQ33_1800
PSPI: PS2015_409
PSE: NH8B_2045
RSO: RSc0383 RSc1086(nagK)
RPI: Rpic_0239
REH: H16_A0361(h16_A0361) H16_B0428(h16_B0428) H16_B0874(h16_B0874)
CGD: CR3_0283(nagK) CR3_1668(nagK)
BMA: BMAA1190
BMAL: DM55_4323
BMAE: DM78_3846
BMAQ: DM76_3275
BMAI: DM57_11040
BMAF: DM51_4853
BMAZ: BM44_4285
BMAB: BM45_3409
BPS: BPSS1019
BPSE: BDL_4315
BPSM: BBQ_5111
BPSU: BBN_4484
BPSD: BBX_6158
BPK: BBK_6121
BPSH: DR55_4313
BPSA: BBU_5005
BPSO: X996_4260
BUT: X994_6099
BTQ: BTQ_4677
BTJ: BTJ_5618
BTZ: BTL_4128
BTD: BTI_5829
BTV: BTHA_3799
BTHE: BTN_3540
BTHM: BTRA_4284
BTHA: DR62_3617
BTHL: BG87_4134
BOK: DM82_5168
BOC: BG90_5426
BVE: AK36_3837
BCJ: BCAM1272(mhbH) BCAM1692
BCEW: DM40_4529
BCEO: I35_5121(mhbH) I35_5555
BAM: Bamb_3945
BDL: AK34_3901
BUB: BW23_5342
BLAT: WK25_25085
BSEM: WJ12_28385
BSTG: WT74_27570
BGU: KS03_4697
BGO: BM43_5105
BUK: MYA_4163
BUL: BW21_5514
BPH: Bphy_0306
PNU: Pnuc_1321
BPE: BP2532
BPC: BPTD_2492
BPER: BN118_1948
BPET: B1917_1324
BPEU: Q425_20880
BPA: BPP2647
BPAR: BN117_1969
BBR: BB2090
BAV: BAV1783(nagK) BAV2295
BHZ: ACR54_01777(nagK_1) ACR54_02469(nagK_2) ACR54_03868(nagK_3)
BTRM: SAMEA390648703976(ycgM)
AXX: ERS451415_00545(ycgM_1) ERS451415_01770(ycgM_3)
TEA: KUI_0220
TEG: KUK_1442
TAS: TASI_0212
TAT: KUM_0773
PUT: PT7_1338
AMIM: MIM_c18370
BPSI: IX83_06755
AFQ: AFA_10955
ODI: ODI_R2013
RFR: Rfer_2567
AJS: Ajs_2078
ACRA: BSY15_3411
VEI: Veis_3822
CTES: O987_16730
RTA: Rta_17920
LIM: L103DPR2_01526(nagK_2)
LIH: L63ED372_01174(nagK_1) L63ED372_02137(nagK_2)
CBAA: SRAA_2239
CBAB: SMCB_2261
MPT: Mpe_A1873
HAR: HEAR0851
MMS: mma_1296
JAG: GJA_822
CFU: CFU_3431(fst)
CARE: LT85_3922
TIN: Tint_1249
THI: THI_1573
RGE: RGE_23710
PBH: AAW51_2909(nagK)
EBA: ebA1377(nagK)
DSU: Dsui_1428
DAR: Daro_3368
AZO: azo0619 azo2421(nagK)
AZA: AZKH_3885
TCL: Tchl_1076
BPRC: D521_1122
HOH: Hoch_6184
MLO: mlr1134
AMIH: CO731_03082(nagK_2)
SME: SMc04240
SMER: DU99_10385
SMD: Smed_1692
EAD: OV14_3128
ATU: Atu1516
RLE: RL3169
RLG: Rleg_2706
RHT: NT26_0697
SHZ: shn_29730
BME: BMEI1882
BMEL: DK63_1606
BMEE: DK62_1343
BMF: BAB1_0060
BABO: DK55_81
BABR: DO74_1801
BABT: DK49_1931
BABB: DK48_2045
BABU: DK53_77
BABS: DK51_1387
BABC: DO78_2078
BMS: BR0063
BSZ: DK67_131
BOV: BOV_0062
BCAR: DK60_171
BCAS: DA85_00305
BMR: BMI_I66
BPP: BPI_I64
BPV: DK65_1299
OAN: Oant_0073
OAH: DR92_174
BJA: blr5933
BRA: BRADO5209
BBT: BBta_5676
BRS: S23_23100
AOL: S58_24810
BRAD: BF49_5712
RPA: RPA3992
RPB: RPB_1595
RPC: RPC_1425
RPD: RPD_1607
RPE: RPE_1446
RPT: Rpal_4515
NWI: Nwi_1063
NHA: Nham_1291
OCA: OCAR_5327
BOS: BSY19_525
VGO: GJW-30_1_02190(nagK)
XAU: Xaut_3262
AZC: AZC_0673
SNO: Snov_4146
MEX: Mext_3475
MDI: METDI4278
MCH: Mchl_3783
MPO: Mpop_3673
MET: M446_5002
MNO: Mnod_5307
MOR: MOC_3428
META: Y590_17075
MAQU: Maq22A_c19395(mhpD)
BID: Bind_1170
MSL: Msil_1106
PHL: KKY_3304
MSC: BN69_2415
MMED: Mame_02517(nagK_2)
HDI: HDIA_0385(nagK)
CCR: CC_3567
CAK: Caul_0072
CSE: Cseg_4054
PZU: PHZ_c0313
SIL: SPO3691
JAN: Jann_2909
RDE: RD1_1348
PAMN: JCM7685_2963(faaH)
DSH: Dshi_2538
KVL: KVU_1320
KRO: BVG79_01473(nagK)
OTM: OSB_28260(nagK)
MALG: MALG_01183
RSU: NHU_00274
RHC: RGUI_1297
SPSE: SULPSESMR1_03150(nagK)
RMM: ROSMUCSMR3_01320(nagK)
LVS: LOKVESSMR4R_01927(nagK)
HBA: Hbal_2639
SMAZ: LH19_00665
SGI: SGRAN_3568(nagK)
SPHD: HY78_10275
SSAN: NX02_06225
SPKC: KC8_11540
SSY: SLG_33500
BLAS: BSY18_3951
ACR: Acry_0415
GXY: GLX_16820
GXL: H845_42
KEU: S101446_02208(nagK)
KSC: CD178_01211(nagK)
ASZ: ASN_1615
RRU: Rru_A3697
RRF: F11_18910
RCE: RC1_0147
MAG: amb2875
MGRY: MSR1_02440(nagK)
MAGX: XM1_2786
MAGN: WV31_19645
TXI: TH3_02775
MAGQ: MGMAQ_3108
AFR: AFE_1472
HTL: HPTL_1747
SESP: BN6_22540
 » show all
Taxonomy
Reference
1  [PMID:11133965]
  Authors
Zhou NY, Fuenmayor SL, Williams PA
  Title
nag genes of Ralstonia (formerly Pseudomonas) sp. strain U2 encoding enzymes for  gentisate catabolism.
  Journal
J Bacteriol 183:700-8 (2001)
DOI:10.1128/JB.183.2.700-708.2001
  Sequence
Reference
2  [PMID:21498645]
  Authors
Qu Y, Spain JC
  Title
Molecular and biochemical characterization of the 5-nitroanthranilic acid degradation pathway in Bradyrhizobium sp. strain JS329.
  Journal
J Bacteriol 193:3057-63 (2011)
DOI:10.1128/JB.01188-10
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.20
IUBMB Enzyme Nomenclature: 3.7.1.20
ExPASy - ENZYME nomenclature database: 3.7.1.20
BRENDA, the Enzyme Database: 3.7.1.20

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