| Entry |
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| Name |
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (ring-opening);
IolD;
THcHDO hydrolase;
3D-3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (decyclizing);
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)
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| Class |
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
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| Sysname |
3D-3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (ring-opening)
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| Reaction(IUBMB) |
3D-3,5/4-trihydroxycyclohexa-1,2-dione + H2O = 5-deoxy-D-glucuronate [RN: R08603]
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| Reaction(KEGG) |
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| Substrate |
3D-3,5/4-trihydroxycyclohexane-1,2-dione [CPD: C04287];
H2O [CPD: C00001]
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| Product |
5-deoxy-D-glucuronate [CPD: C16737]
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| Comment |
The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol degradation pathway leading to acetyl-CoA.
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| History |
EC 3.7.1.22 created 2014, modified 2014
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| Pathway |
| ec00562 | Inositol phosphate metabolism |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K03336 | 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing) |
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| Genes |
| REE: | electrica_04534(iolD) |
| CLAP: | NCTC11466_00555(iolD) |
| KLE: | AO703_15570 AO703_18105 |
| PSHI: | SAMEA2665130_0884(iolD) |
| SLQ: | M495_12445 M495_23475 |
| SERA: | Ser39006_021300(iolD) |
| SFJ: | SAMEA4384070_4617(iolD) |
| SOF: | NCTC11214_01422(iolD_1) NCTC11214_01423(iolD_2) |
| GQU: | AWC35_14465 AWC35_19265 |
| PAQU: | DMB82_0013685(iolD) |
| BGJ: | AWC36_03585 AWC36_04090 |
| BIZ: | HC231_07615(iolD) HC231_14625(iolD) |
| ERWI: | GN242_01140(iolD) GN242_10075(iolD) |
| ERP: | LJN55_01440(iolD) LJN55_11780(iolD) |
| PAGG: | AL522_18860(iolD) AL522_22260(iolD) |
| PAO: | Pat9b_3720 Pat9b_4546 |
| PHEI: | NCTC12003_01187(iolD) |
| AVT: | NCTC3438_00169(iolD) |
| PAET: | NCTC13378_00175(ilvG_1) |
| VCY: | IX92_08945 IX92_09020 |
| VCT: | JV59_29435 JV59_29600 |
| PPR: | PBPRB0462(RS02747) PBPRB0476(AGR_L_71) |
| PGB: | H744_1c0021 H744_1c0617 H744_1c0641 |
| PVD: | CFBP1590__3372(iolD) |
| PPRC: | PFLCHA0_c26550(iolD) |
| PMUD: | NCTC8068_02986(iolD) |
| PFW: | PF1751_v1c22370(iolD) |
| PEZ: | HWQ56_16475(iolD) HWQ56_18830(iolD) |
| PTRT: | HU722_0012855(iolD) |
| PTAE: | NCTC10697_01803(iolD) |
| LCJ: | NCTC11976_00892(iolD) |
| LWA: | SAMEA4504053_1691(iolD) |
| GAI: | IMCC3135_21445(iolD) |
| HAF: | C8233_04530(iolD) C8233_04575(iolD) |
| CMAI: | BFX80_10755 BFX80_10800 |
| CAMH: | LCW13_06920(iolD) LCW13_06965(iolD) |
| MRZ: | KDW95_03315(iolD) KDW95_18335(iolD) |
| CDIZ: | CEDIAZO_01467(iolD) |
| RSM: | CMR15_10835 CMR15_20445 |
| BMV: | BMASAVP1_A1443(iolD) |
| BPL: | BURPS1106A_1676(iolD) |
| BCEN: | DM39_1315 DM39_5868 |
| JAL: | BZG29_12465 BZG29_24735 |
| JAH: | JAB4_026550(iolD_1) JAB4_050970(iolD_2) |
| MLN: | A9174_02420 A9174_10635 |
| PHT: | BLM14_03400 BLM14_07695 |
| SMEL: | SM2011_c01166(iolD) |
| RHI: | NGR_b04500 NGR_c25970(iolD) NGR_c37020 |
| SFH: | SFHH103_02448(iold1) SFHH103_03954(iold3) |
| SFD: | USDA257_c25720(iolD) USDA257_c62090 |
| SIX: | BSY16_1809(iolD) BSY16_5992(iolD) |
| EAK: | EKH55_3599 EKH55_3851 |
| EAD: | OV14_1258 OV14_b1381(iolD) |
| ARA: | Arad_0105(iolD) Arad_1558(iolD) |
| ATF: | Ach5_42100(iolD) Ach5_50260(iolD) |
| ARO: | B0909_14975(iolD) B0909_20165(iolD) |
| ALF: | CFBP5473_19840(iolD) CFBP5473_21840(iolD) |
| AVV: | RvVAT039_17270(iolD) |
| AVF: | RvVAR031_04400(iolD) |
| ASAL: | CFBP5507_16765(iolD) |
| RIR: | BN877_II0237(iolD1) BN877_p0457(iolD2) |
| RPUS: | CFBP5875_15075(iolD) |
| ACUC: | KZ699_18270(iolD) KZ699_22565(iolD) |
| REC: | RHECIAT_CH0001440(iolD) |
| REL: | REMIM1_CH01352(iolD) |
| REP: | IE4803_CH01384(iolD) |
| REI: | IE4771_CH01431(iolD) |
| RTR: | RTCIAT899_CH05710(iolD) |
| RGA: | RGR602_CH01267(iolD-1) RGR602_PC00466(iolD-2) |
| RPHA: | AMC79_CH01397(iolD) |
| RJG: | CCGE525_06955(iolD) CCGE525_37670(iolD) |
| RGR: | FZ934_03390(iolD) FZ934_08485 FZ934_08505(iolD) FZ934_24905(iolD) |
| RII: | FFM53_005550(iolD) FFM53_036045(iolD) |
| RRG: | J3P73_08410(iolD) J3P73_33925(iolD) |
| RAW: | NE851_06695(iolD) NE851_17185(iolD) |
| RLW: | RlegWSM1455_05715(iolD) |
| NEN: | NCHU2750_52670(iolD) |
| BCAN: | BcanWSM471_16045(iolD) |
| LNE: | FZC33_06890(iolD) FZC33_12660(iolD) |
| MOC: | BB934_02685 BB934_10835 |
| LABR: | CHH27_13510(iolD) CHH27_15265(iolD) CHH27_23795(iolD) |
| LABP: | FJ695_08250(iolD) FJ695_17870(iolD) |
| TSV: | DSM104635_00352(iolD) |
| RLI: | RLO149_c000140(iolD) |
| PHP: | PhaeoP97_02467(iolD) |
| PPIC: | PhaeoP14_00645(iolD) |
| OAT: | OAN307_c07090(iolD1) OAN307_c20030(iolD2) |
| CMAR: | IMCC12053_199 IMCC12053_2610 |
| MALG: | MALG_02249 MALG_04893 |
| YAN: | AYJ57_20190 AYJ57_24495 |
| AHT: | ANTHELSMS3_00337(iolD) |
| SAGU: | CDO87_05555(iolD) CDO87_11705(iolD) |
| PKD: | F8A10_15585(iolD) F8A10_19095(iolD) |
| PSEW: | JHW44_06645(iolD) JHW44_14110(iolD) |
| PSAP: | JHX88_11010(iolD) JHX88_17335(iolD) |
| PFIS: | JHX87_08115(iolD) JHX87_18005(iolD) |
| LVS: | LOKVESSMR4R_00616(iolD) |
| TAW: | EI545_03285(iolD) EI545_10975(iolD) |
| AMV: | ACMV_25460(iolD) ACMV_P1_00980(iolD) ACMV_P1_01180(iolD) |
| BAZ: | BAMTA208_20015(iolD) |
| BSON: | S101395_04962(iolD) |
| BCZ: | BCE33L2254(iolD) pE33L466_0302(iolD) |
| BSHI: | LGQ02_18705(iolD) LGQ02_18830(iolD) |
| BMQ: | BMQ_0491(iolD) BMQ_3471(iolD) |
| BMD: | BMD_0494(iolD) BMD_3466(iolD) |
| OON: | NP440_03640(iolD) NP440_03750(iolD) |
| PARG: | PspKH34_20890(iolD) |
| SDP: | NCTC12225_00253(ilvB_1) |
| LMOC: | LMOSLCC5850_0389(iolD) |
| LMW: | LMOSLCC2755_0384(iolD) |
| LMX: | LMOSLCC2372_0390(iolD) |
| LMZ: | LMOSLCC2482_0384(iolD) |
| LMON: | LMOSLCC2376_0372(iolD) |
| LMOS: | LMOSLCC7179_0374(iolD) |
| LMOO: | LMOSLCC2378_0396(iolD) |
| LMOY: | LMOSLCC2479_0388(iolD) |
| LMOT: | LMOSLCC2540_0398(iolD) |
| LMOA: | LMOATCC19117_0404(iolD) |
| PMQ: | PM3016_2239 PM3016_5736 |
| PBK: | Back11_51060 Back11_57770(iolD) |
| PLYC: | GXP70_22420(iolD) GXP70_26475(iolD) |
| AFAS: | NZD89_14290(iolD) NZD89_15095(iolD) |
| EFU: | HMPREF0351_13047(iolD) |
| CPRF: | K7H06_01020(iolD) K7H06_03320(iolD) |
| BPRO: | PMF13cell1_05556(iolD) |
| VGU: | HYG85_05135(iolD) HYG85_18745(iolD) |
| VPY: | HZI73_02115(iolD) HZI73_17735(iolD) |
| SALX: | SALLE_v1c04680(iolD) |
| SCHI: | SCHIN_v1c06470(iolD) |
| MAUU: | NCTC10437_03764(iolD) |
| NWL: | NWFMUON74_20420(iolD) |
| ROP: | ROP_05090 ROP_10690(iolD) |
| ROA: | Pd630_LPD01851 Pd630_LPD05472 |
| RKO: | JWS14_03245(iolD) JWS14_06960(iolD) |
| RPSK: | JWS13_15240(iolD) JWS13_39470(iolD) |
| SMA: | SAVERM_5341(iolD1) SAVERM_7147(iolD2) |
| SCB: | SCAB_19071 SCAB_58921 |
| SAMB: | SAM23877_6515(iolD) |
| SCX: | AS200_08470 AS200_28730 |
| SLE: | sle_08730(sle_08730) |
| SGS: | AVL59_15555 AVL59_41285 |
| STSI: | A4E84_14390 A4E84_35130 |
| SGM: | GCM10017557_53810 GCM10017557_70650 GCM10017557_71600 |
| SLS: | SLINC_3147 SLINC_7270 |
| SGE: | DWG14_01328(iolD_1) DWG14_05396(iolD_2) |
| SGD: | ELQ87_04860(iolD) ELQ87_25035(iolD) |
| SCYA: | EJ357_16450(iolD) EJ357_41120(iolD) |
| SAST: | CD934_00600(iolD) CD934_02970(iolD) |
| SNQ: | CP978_03235(iolD) CP978_27170(iolD) |
| SHAW: | CEB94_14960(iolD) CEB94_35940(iolD) |
| SAQU: | EJC51_18820(iolD) EJC51_39975(iolD) |
| SPHV: | F9278_16200(iolD) F9278_38690(iolD) |
| SCHA: | CP983_05430(iolD) CP983_27695(iolD) |
| SCOE: | CP976_15860(iolD) CP976_37430(iolD) |
| STUI: | GCM10017668_24430 GCM10017668_61860 |
| SFEU: | IM697_07490(iolD) IM697_27785(iolD) IM697_31785(iolD) |
| SGOB: | test1122_07115(iolD) |
| SLF: | JEQ17_04960(iolD) JEQ17_07430(iolD) JEQ17_30050(iolD) JEQ17_39310(iolD) |
| SDEC: | L3078_16335(iolD) L3078_36250(iolD) |
| SAKB: | K1J60_09765(iolD) K1J60_28525(iolD) K1J60_41265(iolD) |
| SCAE: | IHE65_09230(iolD) IHE65_28950(iolD) |
| SSPN: | LXH13_15225(iolD) LXH13_33910(iolD) |
| SXT: | KPP03845_102898(iolD) |
| CMH: | VO01_12500 VO01_15935 |
| MPRT: | ET475_03725(iolD) ET475_06370(iolD) |
| LEU: | Leucomu_14675(iolD) Leucomu_14805(iolD) |
| LTR: | EVS81_01800 EVS81_09210(iolD) EVS81_09280(iolD) |
| LALL: | MUN78_14990(iolD) MUN78_15870(iolD) |
| LRP: | MUN76_09420(iolD) MUN76_09510(iolD) |
| ARR: | ARUE_c18100 ARUE_c21320 |
| ARZ: | AUT26_04615 AUT26_09645 |
| ARX: | ARZXY2_2031(iolD) ARZXY2_2959(iolD) |
| ARTH: | C3B78_03960(iolD) C3B78_08780(iolD) |
| ACIT: | HPK19_00490(iolD) HPK19_08780(iolD) |
| PUE: | FV140_05395(iolD) FV140_09915(iolD) |
| PSNI: | NIBR502771_00590(iolD) |
| RSA: | RSal33209_0362(iolD.2) |
| PAUS: | NCTC13651_01388(iolD) |
| AJI: | C0Z10_10055(iolD) C0Z10_10895(iolD) |
| MPH: | MLP_23710(iolD) MLP_39380(iolD) |
| RAIN: | Rai3103_04115(iolD) |
| AGRA: | AGRA3207_000893(iolD) |
| NOA: | BKM31_10635 BKM31_35360 |
| AHW: | NCTC11636_01042(iolD) |
| AIR: | NCTC12972_01360(iolD) |
| ASLA: | NCTC11923_01127(iolD) |
| AVC: | NCTC10951_00066(iolD) |
| MTAI: | Mtai_v1c12630(iolD) |
| AALG: | AREALGSMS7_02056(iolD) |
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| Reference |
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| Authors |
Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y. |
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| Title |
myo-Inositol catabolism in Bacillus subtilis. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.7.1.22 |
| ExPASy - ENZYME nomenclature database: | 3.7.1.22 |
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