KEGG   ENZYME: 3.7.1.25
Entry
EC 3.7.1.25                 Enzyme                                 

Name
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
todF (gene name)
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
Sysname
(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate acetylhydrolase
Reaction(IUBMB)
(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate
Reaction(KEGG)
(other) R05138
Substrate
(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate;
H2O [CPD:C00001]
Product
(2Z)-2-hydroxypenta-2,4-dienoate;
acetate [CPD:C00033]
Comment
A bacterial enzyme that participates in the degradation of toluene and 2-nitrotoluene.
History
EC 3.7.1.25 created 2019
Pathway
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10702  2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
Genes
PPF: Pput_2882
PPX: T1E_4265(todF)
PMON: X969_10925
PMOT: X970_10580
BPT: Bpet3737
Reference
1  [PMID:1856161]
  Authors
Kukor JJ, Olsen RH
  Title
Genetic organization and regulation of a meta cleavage pathway for catechols produced from catabolism of toluene, benzene, phenol, and cresols by Pseudomonas  pickettii PKO1.
  Journal
J Bacteriol 173:4587-94 (1991)
DOI:10.1128/jb.173.15.4587-4594.1991
Reference
2  [PMID:1916282]
  Authors
Menn FM, Zylstra GJ, Gibson DT
  Title
Location and sequence of the todF gene encoding 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase in Pseudomonas putida F1.
  Journal
Gene 104:91-4 (1991)
DOI:10.1016/0378-1119(91)90470-V
  Sequence
[ppf:Pput_2882]
Reference
3  [PMID:7944378]
  Authors
Haigler BE, Wallace WH, Spain JC
  Title
Biodegradation of 2-nitrotoluene by Pseudomonas sp. strain JS42.
  Journal
Appl Environ Microbiol 60:3466-9 (1994)
DOI:10.1128/AEM.60.9.3466-3469.1994
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.25
IUBMB Enzyme Nomenclature: 3.7.1.25
ExPASy - ENZYME nomenclature database: 3.7.1.25
BRENDA, the Enzyme Database: 3.7.1.25

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