Entry
Name
phloretin hydrolase;
ErPhy;
lactase-phlorerin hydrolase;
C-acylphenol hydrolase;
2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase (incorrect)
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
phloretin acylhydrolase (phloroglucinol-forming)
Reaction(IUBMB)
phloretin + H2O = phloretate + phloroglucinol [RN:
R02901 ]
Reaction(KEGG)
Substrate
Product
Comment
Also hydrolyses other C-acylated phenols related to phloretin. Isolated from the fungus Aspergillus niger and the bacteria Pantoea agglomerans and Eubacterium ramulus.
History
EC 3.7.1.4 created 1972, modified 2018
Pathway
Orthology
Genes
CLS : CXIVA_00870 CXIVA_01400 CXIVA_03650 CXIVA_10480 CXIVA_16390 CXIVA_20190
ETM : CE91St48_18380 CE91St48_29990
» show all
Taxonomy
Reference
Authors
Chatterjee AK, Gibbins LN
Title
Metabolism of phloridzin by Erwinia herbicola: nature of the degradation products, and the purification and properties of phloretin hydrolase.
Journal
Reference
Authors
Minamikawa T, Jayasankar NP, Bohm BA, Taylor IE, Towers GH.
Title
An inducible hydrolase from Aspergillus niger, acting on carbon-carbon bonds, for phlorrhizin and other C-acylated phenols.
Journal
Reference
Authors
Schoefer L, Braune A, Blaut M
Title
Cloning and expression of a phloretin hydrolase gene from Eubacterium ramulus and characterization of the recombinant enzyme.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.4
ExPASy - ENZYME nomenclature database: 3.7.1.4
BRENDA, the Enzyme Database: 3.7.1.4