KEGG   ENZYME: 3.7.1.8
Entry
EC 3.7.1.8                  Enzyme                                 
Name
2,6-dioxo-6-phenylhexa-3-enoate hydrolase;
HOHPDA hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
Sysname
2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase
Reaction(IUBMB)
2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate [RN:R02606]
Reaction(KEGG)
R02606;
(other) R05359
Substrate
2,6-dioxo-6-phenylhexa-3-enoate [CPD:C01273];
H2O [CPD:C00001]
Product
benzoate [CPD:C00180];
2-oxopent-4-enoate [CPD:C00596]
Comment
Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.
History
EC 3.7.1.8 created 1989
Pathway
ec00621  Dioxin degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10222  2,6-dioxo-6-phenylhexa-3-enoate hydrolase
Genes
PSDDSC_09385
PNTG5B91_07370(bphD)
PCAVD3880_11795
PIZLAB08_R28810
PPHABVH74_16335
BAENL3V59_23200(bphD)
BXEBxe_C1186(bphD)
BXBDR64_8619(bphD)
PPAIE1956_45905(bphD)
PANXOYT13_24885(bphD)
PNAPnap_4141
ACKC380_15950(bphD)
CTESO987_08230
AZIAzCIB_4408
MFREEXE63_01915 EXE63_03130
JCRO9K63_12450
NMARHPC71_10545 HPC71_13590
AWNNQV15_16540
 » show all
Reference
1
  Authors
Omori T, Sugimura K, Ishigooka H, Minoda Y.
  Title
Purification and some properties of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme from Pseudomonas cruciviae S93 B1 involved in the degradation of biphenyl.
  Journal
Agric Biol Chem 50:931-937 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.8
IUBMB Enzyme Nomenclature: 3.7.1.8
ExPASy - ENZYME nomenclature database: 3.7.1.8
UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.8
BRENDA, the Enzyme Database: 3.7.1.8
CAS: 102925-38-2

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