KEGG   ENZYME: 3.7.1.9
Entry
EC 3.7.1.9                  Enzyme                                 
Name
2-hydroxymuconate-6-semialdehyde hydrolase;
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
2-hydroxymuconic semialdehyde hydrolase;
HMSH;
HOD hydrolase;
xylF (gene name);
2-hydroxymuconate-semialdehyde formylhydrolase;
2-hydroxymuconate-semialdehyde hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
Sysname
2-hydroxymuconate-6-semialdehyde formylhydrolase
Reaction(IUBMB)
2-hydroxymuconate-6-semialdehyde + H2O = formate + 2-oxopent-4-enoate [RN:R02604]
Reaction(KEGG)
R02604;
(other) R05296 R05362 R05865
Substrate
2-hydroxymuconate-6-semialdehyde [CPD:C00682];
H2O [CPD:C00001]
Product
formate [CPD:C00058];
2-oxopent-4-enoate [CPD:C00596]
Comment
The enzyme is involved in the degradation of catechols.
History
EC 3.7.1.9 created 1990, modified 2013
Pathway
ec00362  Benzoate degradation
ec00622  Xylene degradation
ec00643  Styrene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10216  2-hydroxymuconate-semialdehyde hydrolase
Genes
RTGNCTC13098_00853(xylF_2)
PSDDSC_09175
RTHLRK53_10270
RBDALSL_0879
PFUWKF707C_15550(bzaE) KF707C_16080(salE)
PPIND087(nahN)
PPJRK21_04238
PFKPFAS1_28780
PCAVD3880_02335
PTRLOU419_14635
PLAUI0D68_00655 I0D68_15085
PPSEBN5_3615(nahN)
PALLUYA_06715 UYA_06985 UYA_20160
PSCA458_06525
PSTUUIB01_22735
PBMCL52_14705
HPEGEAO82_00560 EAO82_09420
HAESLO767_17665
PPHABVH74_06150
MADHP15_1112(dmpD) HP15_4033(xylF)
MSRAU15_09325 AU15_21085
MLQASQ50_09220
MSQBKP64_13855
MALLPBN92_01665
MSHEMAALD49_03850
MANPEHN06_02440
PRWPsycPRwf_0068
PSYYDLE54_00385
ALCOTEC02_08830
AEIAOY20_01960
AJORZ95_18625
ASJAsACE_CH00356
ADVDJ533_01800 DJ533_16950
ARJDOM24_01590
AWUBEN71_02710
ACUMC9E88_006025
ALWFOB21_11730
ATNFM020_13970
ACHICDG60_02975
ALJG8D99_13390
AWGGFH30_01725
ASHAG8E00_02265
ATGJ4G44_04400
AVBRYU24_27110
ABOUACBO_15400 ACBO_27720
ACIUA3K93_01280
APOTMZO21_10830
ATZM5E07_14180
ACIEKIP84_08200
ACIGBS636_03585
PPHEPP2015_462
PLZS4054249_08565
PAGAPAGA_a1999
PCARPC2016_1616
GAGGlaag_0079
PMESFX988_02538
PATPatl_0074
SPOIIMCC21906_00397 IMCC21906_02716
STAWNCG89_14270
ZALAZF00_03860 AZF00_17825
AFUSEYZ66_02710
CYQQ91_0515 Q91_1790(bphD1) Q91_2195
CZACYCME_0226 CYCME_0664 CYCME_2092
CYYCPC19_01825 CPC19_03865 CPC19_10485
THISHZT40_13305
AEHMlg_2456
TBNTBH_C0921
HCHHCH_03715
HAHEENC22_13740
APACS7S_13285
MGEOCFI10_04955
NIKF5I99_10110
SINIGT972_13725
GBIPG2T_02985 PG2T_07330 PG2T_09695
VFFVITFI_CDS1372
AQLBXU06_16870
RPIRpic_4621
RPFRpic12D_3545
REUReut_B5690
RMERmet_1306
CUPBKK80_32180
CCAXKZ686_10070
BVIBcep1808_7611
BURBcep18194_B1183 Bcep18194_B2956
BCENDM39_4829(xylF)
BCTGEM_5398
BCEDDM42_4988(xylF)
BCONNL30_24575
BDFWI26_16010
BTEIWS51_00585
BPSLWS57_12140
BSTLBBJ41_10595
BANNJFN94_18695 JFN94_19150
BAENL3V59_23100 L3V59_30420
BUQAC233_11165
BURTBTHE68_57000
BGEBC1002_4118
BUZAYM40_21205
PARBCJU94_37815 CJU94_38205
PDIOPDMSB3_1995.1
PHUNU0042_26795
PPKU875_01820
PRBX636_07650
LIMNHKT17_03815
BPARBN117_2519
BPABPP3695
BBHBN112_0534 BN112_4274
BBRBB4129
BBMBN115_2405
BBXBBS798_2549 BBS798_3919
BOJCBF45_04515
APESFOC84_00325
PIGEGT29_06680
KGYEHF36_04900
RLHMIZ03_1021
AJSAjs_0221
ACIDCBP33_01100 CBP33_05470
ACIPCBP36_01195 CBP36_05920
ACINCBP34_01105 CBP34_05305
ACISCBP35_13025 CBP35_17755
AMONH9L24_14210
VEIVeis_2786
VBOCKY39_28510
VAVIG196_08125
VAERZE79_18255
CTTCtCNB1_3150
CSERCCO03_05855
COFFOZ74_08300
ADNAlide_0336
ADKAlide2_0281
HYLLPB072_18175
HPSEHPF_01875(xylF1)
HYNF9K07_02740 F9K07_09975 F9K07_30355
HTNKI616_01970
DIHG7047_01675
DRGH9K76_11640
SIMPC6571_19105
MJELVC68_01000
STHMIS481_10525
SAQAOMP39_09105
MPTMpe_A2274
METPC1M51_15405
SMIOCATMQ487_04090
IDCLRM40_19565
LCHLcho_3344
MASWAM586_18645
XYGR9X41_02940
RBUPG1C_08185 PG1C_11270
ABREpbN1_20610
DARDaro_1331 Daro_3786
DEYHYN24_14220
DDENKI615_16890
FLEKI610_15470
AZOazo1968(xylF)
AOAdqs_2123
AZIAzCIB_4406
AZDCDA09_10320 CDA09_21415
AZRCJ010_12815
TMZTmz1t_3110
THAUC4PIVTH_2802(dmpD)
THKCCZ27_04595 CCZ27_20840
AZQG3580_08265
ACOMCEW83_03630
NTUNTH_04516(xylF_2)
MESOBSQ44_10055
CHEAPVE73_26310
SAMESAMCFNEI73_pB0463
STEGQA637_28910
ABAWD5400_20365
MTUNMTUNDRAET4_3903(dmpD)
OCTFTO60_10545
CEHCEW89_11485
PFISJHX87_04715
MONG8E03_15160
NARSaro_3858 Saro_3884
NPPPP1Y_AT15435 PP1Y_AT15665 PP1Y_AT31623 PP1Y_AT31854
NPNJI59_24610
NREBES08_18550 BES08_20400
NOGGKE62_05115
SMAZLH19_27440
SGISGRAN_2799(thnD)
SINAKNJ79_00740
SPFDSPYCA_3468(xylFII)
SBARH5V43_22190 H5V43_22310
SPHYCHN51_06800 CHN51_06945 CHN51_18340
SPHJBSL82_11340
ALTNLBX01_06775
PMASNCF86_10580
TFVIDJ81_04985
CNAAB433_18150
ERYCP97_03160 CP97_14075 CP97_14200
HTQFRZ44_10720
HADHFRZ61_10400
HTLHPTL_0051
ACIBACBT_0256(bphD)
AFCAFAEC_1841(bphD)
AAQIAAQM_0986(bphD)
ACLOACLO_a0135(bphD)
ADZADFLV_2548(bphD)
ARCABLL_2439
AROSNJU99_01670
ALKALEK_0387(bphD)
AANAAANAER_1263(bphD)
BSMBSM4216_1785
BACIB1NLA3E_01490 B1NLA3E_14010
GMCGY4MC1_1593
GJFM493_17935
GTHGeoth_1676
PTLAOT13_14455
PCALBV455_00230(xylF)
PARGPspKH34_15450
LYGC1N55_08045 C1N55_08150
ACOPRI196_07895
PRDF7984_08670 F7984_12055 F7984_12065
NDTL1999_08970 L1999_09005
HYIK2M58_09765
PNPIJ22_06980 IJ22_48610
BTSBtus_0963 Btus_2330 Btus_2553 Btus_2900
KYRCVV65_11320
SIVSSIL_0071 SSIL_3698
SSILSOLI23_18480 SOLI23_19565
PLIQQWY22_10405 QWY22_10495 QWY22_17915
PSHEQWY16_10505 QWY16_10595 QWY16_17455 QWY16_17775
PSHXQWY21_10800 QWY21_10890 QWY21_17760
JPOG7058_08100
SAYTPY_0645(mhpC)
SAPSulac_2994
MIAOCU_07410
MIDMIP_01280
MYOOEM_07480
MCHIAN480_04855
MIROCQ_07550
MMMW7S_03620
MPAGC0J29_30965
MGORH0P51_00410
MCOOMCOO_07730
MNED174_16970
MYNMyAD_16575 MyAD_16635
MHASMHAS_04027(xylF)
MANYMANY_01950
MAUSJN090_26240
CAMGCAMM_02590
CRFFRC0190_02107
CLIZG7Y31_11625
COKCOCCU_04420(xylF)
CORNBJP05_09075
NTCKHQ06_23915
NGPLTT66_32650
RHARHA1_ro08081
ROAPd630_LPD12026
RAVAAT18_00600
RRZCS378_10945 CS378_24170
RRT4535765_04589(xylF_2)
RCRNCTC10994_02703(bphD1)
RGOKYT97_18210
ROZCBI38_14185
RPSKJWS13_02075 JWS13_24120
RGORNMQ04_17770
RHOPD8W71_11840
RHOUKZJ41_10500
RHOWA4U64_15245
RHOJJVH1_19070
RHOSQWW67_27205
RHOQQWW98_27225
RHOYQNA09_06850
PSOWABI214_15940
GOQACH46_18245
SGRFSGFS_022160
SMALSMALA_1217
SGMGCM10017557_80400
SAUOBV401_09860
SNKCP967_06185
SPRACP972_28050
SANTQR300_03365
AGLAOIE69_42280
ARXARZXY2_3585
ARTPE5206_04555 E5206_14585
ASUNKG104_01700
ARTQCGQ24_03875
ARZAUT26_01405
PDELJCQ34_20720
NAEBHE16_09080
ICAIntca_1090 Intca_3172
JTEASJ30_00170
JLIEXU32_15285
JMEEEW87_015390
JAYH7A72_00170
JCRO9K63_12420 O9K63_12650
JAIV1351_16225
OCPNF557_14820
AUSIPK37_03225
GEZFE251_04640
RAINRai3103_08985 Rai3103_16615
NMARHPC71_01605 HPC71_03280
NFCKG111_01295
SROSros_4719
NOABKM31_20825
NOWGBF35_42640
NGNLCN96_15435
NFSOIE67_30555
MHAIOHB01_26475
FSYFsymDg_2032
NMLNamu_4111
AMQAMETH_2411(mhpC)
PDXPsed_6034
PSEEFRP1_12950
PSEQAD006_20630
PECQAD017_00210
PAUTPdca_36310
PBROHOP40_26765
PPELH6H00_08540
MICHFJK98_21300
MCABHXZ27_20900
VMAVAB18032_17465
MENOJiend_52580
MPRNQ3V37_18660
MCAYPVK37_26200
MICFQQG74_20775
ACTEACTI_45700
AFSAFR_13095 AFR_28670
PSUUPsuf_068110 Psuf_083190
DAURDaura_20400
RMARGBA65_17525
SBAEDSM104329_04655(todF_3)
CAUCaur_1353
CHLChy400_1475
CAPCLDAP_40940
KBSEPA93_11995
TROtrd_1390
TTJTTHB237(TTHB237)
TTLTtJL18_2419
TPITREPR_1321
FLASY85_23985
 » show all
Reference
1  [PMID:4325686]
  Authors
Sala-Trepat JM, Evans WC.
  Title
The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway.
  Journal
Eur J Biochem 20:400-13 (1971)
DOI:10.1111/j.1432-1033.1971.tb01406.x
Reference
2  [PMID:3481421]
  Authors
Harayama S, Rekik M, Wasserfallen A, Bairoch A.
  Title
Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids.
  Journal
Mol Gen Genet 210:241-7 (1987)
DOI:10.1007/bf00325689
Reference
3  [PMID:7890778]
  Authors
Diaz E, Timmis KN
  Title
Identification of functional residues in a 2-hydroxymuconic semialdehyde hydrolase. A new member of the alpha/beta hydrolase-fold family of enzymes which  cleaves carbon-carbon bonds.
  Journal
J Biol Chem 270:6403-411 (1995)
DOI:10.1074/jbc.270.11.6403
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.9
IUBMB Enzyme Nomenclature: 3.7.1.9
ExPASy - ENZYME nomenclature database: 3.7.1.9
UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.9
BRENDA, the Enzyme Database: 3.7.1.9
CAS: 54004-61-4

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