Entry
Name
2-hydroxymuconate-6-semialdehyde hydrolase;
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
2-hydroxymuconic semialdehyde hydrolase;
HMSH;
HOD hydrolase;
xylF (gene name);
2-hydroxymuconate-semialdehyde formylhydrolase;
2-hydroxymuconate-semialdehyde hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
2-hydroxymuconate-6-semialdehyde formylhydrolase
Reaction(IUBMB)
2-hydroxymuconate-6-semialdehyde + H2O = formate + 2-oxopent-4-enoate [RN:
R02604 ]
Reaction(KEGG)
Substrate
2-hydroxymuconate-6-semialdehyde [CPD:
C00682 ];
H2O [CPD:
C00001 ]
Product
Comment
The enzyme is involved in the degradation of catechols.
History
EC 3.7.1.9 created 1990, modified 2013
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K10216 2-hydroxymuconate-semialdehyde hydrolase
Genes
RTG : NCTC13098_00853(xylF_2)
PFUW : KF707C_15550(bzaE) KF707C_16080(salE)
PLAU : I0D68_00655 I0D68_15085
PALL : UYA_06715 UYA_06985 UYA_20160
HPEG : EAO82_00560 EAO82_09420
MAD : HP15_1112(dmpD) HP15_4033(xylF)
MSR : AU15_09325 AU15_21085
ADV : DJ533_01800 DJ533_16950
ABOU : ACBO_15400 ACBO_27720
SPOI : IMCC21906_00397 IMCC21906_02716
ZAL : AZF00_03860 AZF00_17825
CYQ : Q91_0515 Q91_1790(bphD1) Q91_2195
CZA : CYCME_0226 CYCME_0664 CYCME_2092
CYY : CPC19_01825 CPC19_03865 CPC19_10485
GBI : PG2T_02985 PG2T_07330 PG2T_09695
BUR : Bcep18194_B1183 Bcep18194_B2956
BANN : JFN94_18695 JFN94_19150
BAEN : L3V59_23100 L3V59_30420
PARB : CJU94_37815 CJU94_38205
BBH : BN112_0534 BN112_4274
BBX : BBS798_2549 BBS798_3919
ACID : CBP33_01100 CBP33_05470
ACIP : CBP36_01195 CBP36_05920
ACIN : CBP34_01105 CBP34_05305
ACIS : CBP35_13025 CBP35_17755
HYN : F9K07_02740 F9K07_09975 F9K07_30355
RBU : PG1C_08185 PG1C_11270
AZD : CDA09_10320 CDA09_21415
THK : CCZ27_04595 CCZ27_20840
MTUN : MTUNDRAET4_3903(dmpD)
NPP : PP1Y_AT15435 PP1Y_AT15665 PP1Y_AT31623 PP1Y_AT31854
NRE : BES08_18550 BES08_20400
SBAR : H5V43_22190 H5V43_22310
SPHY : CHN51_06800 CHN51_06945 CHN51_18340
ERY : CP97_03160 CP97_14075 CP97_14200
BACI : B1NLA3E_01490 B1NLA3E_14010
LYG : C1N55_08045 C1N55_08150
PRD : F7984_08670 F7984_12055 F7984_12065
NDT : L1999_08970 L1999_09005
PNP : IJ22_06980 IJ22_48610
BTS : Btus_0963 Btus_2330 Btus_2553 Btus_2900
SSIL : SOLI23_18480 SOLI23_19565
PLIQ : QWY22_10405 QWY22_10495 QWY22_17915
PSHE : QWY16_10505 QWY16_10595 QWY16_17455 QWY16_17775
PSHX : QWY21_10800 QWY21_10890 QWY21_17760
MYN : MyAD_16575 MyAD_16635
RRZ : CS378_10945 CS378_24170
RRT : 4535765_04589(xylF_2)
RCR : NCTC10994_02703(bphD1)
RPSK : JWS13_02075 JWS13_24120
ARTP : E5206_04555 E5206_14585
ICA : Intca_1090 Intca_3172
JCR : O9K63_12420 O9K63_12650
RAIN : Rai3103_08985 Rai3103_16615
NMAR : HPC71_01605 HPC71_03280
PSUU : Psuf_068110 Psuf_083190
SBAE : DSM104329_04655(todF_3)
» show all
Taxonomy
Reference
Authors
Sala-Trepat JM, Evans WC.
Title
The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway.
Journal
Reference
Authors
Harayama S, Rekik M, Wasserfallen A, Bairoch A.
Title
Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids.
Journal
Reference
Authors
Diaz E, Timmis KN
Title
Identification of functional residues in a 2-hydroxymuconic semialdehyde hydrolase. A new member of the alpha/beta hydrolase-fold family of enzymes which cleaves carbon-carbon bonds.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.9
ExPASy - ENZYME nomenclature database: 3.7.1.9
UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.9
BRENDA, the Enzyme Database: 3.7.1.9