KEGG ENZYME: 3.7.1.9

ENZYME: 3.7.1.9

Entry

EC 3.7.1.9                  Enzyme

Name

2-hydroxymuconate-6-semialdehyde hydrolase;
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
2-hydroxymuconic semialdehyde hydrolase;
HMSH;
HOD hydrolase;
xylF (gene name);
2-hydroxymuconate-semialdehyde formylhydrolase;
2-hydroxymuconate-semialdehyde hydrolase

Class

Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances

Sysname

2-hydroxymuconate-6-semialdehyde formylhydrolase

Reaction(IUBMB)

2-hydroxymuconate-6-semialdehyde + H2O = formate + 2-oxopent-4-enoate [RN:R02604]

Reaction(KEGG)

R02604;
(other) R05296 R05362 R05865

Substrate

2-hydroxymuconate-6-semialdehyde [CPD:C00682];
H2O [CPD:C00001]

Product

formate [CPD:C00058];
2-oxopent-4-enoate [CPD:C00596]

Comment

The enzyme is involved in the degradation of catechols.

History

EC 3.7.1.9 created 1990, modified 2013

Pathway

ec00362

Benzoate degradation

ec00622

Xylene degradation

ec00643

Styrene degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K10216

2-hydroxymuconate-semialdehyde hydrolase

Genes

RTG:	NCTC13098_00853(xylF_2)

PSD:

DSC_09175

RTH:	LRK53_10270

RBD:

ALSL_0879

PPSE:

BN5_3615(nahN)

PFUW:

KF707C_15550(bzaE) KF707C_16080(salE)

PPI:	ND087(nahN)

PPJ:	RK21_04238

PFK:	PFAS1_28780

PALL:

UYA_06715 UYA_06985 UYA_20160

PCAV:

D3880_02335

PTRL:

OU419_14635

PLAU:

I0D68_00655 I0D68_15085

PSC:	A458_06525

PSTU:

UIB01_22735

PBM:	CL52_14705

HPEG:

EAO82_00560 EAO82_09420

HAES:

LO767_17665

PPHA:

BVH74_06150

MAD:	HP15_1112(dmpD) HP15_4033(xylF)

MSR:	AU15_09325 AU15_21085

MLQ:	ASQ50_09220

MSQ:	BKP64_13855

MALL:

PBN92_01665

MSHE:

MAALD49_03850

MANP:

EHN06_02440

PRW:	PsycPRwf_0068

PSYY:

DLE54_00385

ALC:	OTEC02_08830

AEI:	AOY20_01960

AJO:	RZ95_18625

ASJ:	AsACE_CH00356

ADV:	DJ533_01800 DJ533_16950

ARJ:	DOM24_01590

AWU:	BEN71_02710

ACUM:

C9E88_006025

ALW:	FOB21_11730

ATN:	FM020_13970

ACHI:

CDG60_02975

ALJ:	G8D99_13390

AWG:	GFH30_01725

ASHA:

G8E00_02265

ATG:	J4G44_04400

AVB:	RYU24_27110

ABOU:

ACBO_15400 ACBO_27720

ACIU:

A3K93_01280

APOT:

MZO21_10830

ATZ:	M5E07_14180

ACIE:

KIP84_08200

ACIG:

BS636_03585

PPHE:

PP2015_462

PLZ:	S4054249_08565

PAGA:

PAGA_a1999

PCAR:

PC2016_1616

GAG:	Glaag_0079

PMES:

FX988_02538

PAT:

Patl_0074

SPOI:

IMCC21906_00397 IMCC21906_02716

STAW:

NCG89_14270

ZAL:	AZF00_03860 AZF00_17825

AFUS:

EYZ66_02710

CYQ:	Q91_0515 Q91_1790(bphD1) Q91_2195

CZA:	CYCME_0226 CYCME_0664 CYCME_2092

CYY:	CPC19_01825 CPC19_03865 CPC19_10485

THIS:

HZT40_13305

AEH:

Mlg_2456

TBN:

TBH_C0921

HCH:

HCH_03715

HAHE:

ENC22_13740

APAC:

S7S_13285

MGEO:

CFI10_04955

NIK:	F5I99_10110

SINI:

GT972_13725

GBI:	PG2T_02985 PG2T_07330 PG2T_09695

VFF:	VITFI_CDS1372

AQL:	BXU06_16870

RPI:

Rpic_4621

RPF:	Rpic12D_3545

REU:	Reut_B5690

RME:

Rmet_1306

CUP:	BKK80_32180

CCAX:

KZ686_10070

BVI:	Bcep1808_7611

BUR:	Bcep18194_B1183 Bcep18194_B2956

BCEN:

DM39_4829(xylF)

BCT:

GEM_5398

BCED:

DM42_4988(xylF)

BCON:

NL30_24575

BDF:	WI26_16010

BTEI:

WS51_00585

BPSL:

WS57_12140

BSTL:

BBJ41_10595

BANN:

JFN94_18695 JFN94_19150

BAEN:

L3V59_23100 L3V59_30420

BUQ:	AC233_11165

BGE:	BC1002_4118

BUZ:	AYM40_21205

PARB:

CJU94_37815 CJU94_38205

PDIO:

PDMSB3_1995.1

PHUN:

U0042_26795

PPK:	U875_01820

PRB:	X636_07650

LIMN:

HKT17_03815

BPAR:

BN117_2519

BPA:

BPP3695

BBH:	BN112_0534 BN112_4274

BBR:

BB4129

BBM:	BN115_2405

BBX:	BBS798_2549 BBS798_3919

BOJ:	CBF45_04515

APES:

FOC84_00325

PIG:	EGT29_06680

KGY:	EHF36_04900

RLH:	MIZ03_1021

AJS:

Ajs_0221

ACID:

CBP33_01100 CBP33_05470

ACIP:

CBP36_01195 CBP36_05920

ACIN:

CBP34_01105 CBP34_05305

ACIS:

CBP35_13025 CBP35_17755

AMON:

H9L24_14210

VEI:

Veis_2786

VBO:	CKY39_28510

VAV:	IG196_08125

CTT:	CtCNB1_3150

CSER:

CCO03_05855

COF:	FOZ74_08300

ADN:	Alide_0336

ADK:	Alide2_0281

HYL:	LPB072_18175

HPSE:

HPF_01875(xylF1)

HYN:	F9K07_02740 F9K07_09975 F9K07_30355

HTN:	KI616_01970

DIH:	G7047_01675

DRG:	H9K76_11640

SIMP:

C6571_19105

MJE:	LVC68_01000

STHM:

IS481_10525

SAQA:

OMP39_09105

MPT:

Mpe_A2274

METP:

C1M51_15405

SMIO:

CATMQ487_04090

IDC:	LRM40_19565

LCH:

Lcho_3344

MASW:

AM586_18645

XYG:	R9X41_02940

RBU:	PG1C_08185 PG1C_11270

ABRE:

pbN1_20610

DAR:	Daro_1331 Daro_3786

DEY:	HYN24_14220

DDEN:

KI615_16890

FLE:	KI610_15470

AZO:	azo1968(xylF)

AOA:

dqs_2123

AZI:	AzCIB_4406

AZD:	CDA09_10320 CDA09_21415

AZR:	CJ010_12815

TMZ:	Tmz1t_3110

THAU:

C4PIVTH_2802(dmpD)

THK:	CCZ27_04595 CCZ27_20840

AZQ:	G3580_08265

ACOM:

CEW83_03630

NTU:	NTH_04516(xylF_2)

MESO:

BSQ44_10055

CHEA:

PVE73_26310

SAME:

SAMCFNEI73_pB0463

STEG:

QA637_28910

ABAW:

D5400_20365

MTUN:

MTUNDRAET4_3903(dmpD)

OCT:	FTO60_10545

CEH:	CEW89_11485

PFIS:

JHX87_04715

MON:	G8E03_15160

NAR:	Saro_3858 Saro_3884

NPP:	PP1Y_AT15435 PP1Y_AT15665 PP1Y_AT31623 PP1Y_AT31854

NPN:	JI59_24610

NRE:	BES08_18550 BES08_20400

NOG:	GKE62_05115

SMAZ:

LH19_27440

SGI:	SGRAN_2799(thnD)

SINA:

KNJ79_00740

SPFD:

SPYCA_3468(xylFII)

SBAR:

H5V43_22190 H5V43_22310

SPHY:

CHN51_06800 CHN51_06945 CHN51_18340

SPHJ:

BSL82_11340

ALTN:

LBX01_06775

PMAS:

NCF86_10580

TFV:	IDJ81_04985

CNA:	AB433_18150

ERY:	CP97_03160 CP97_14075 CP97_14200

HTQ:	FRZ44_10720

HADH:

FRZ61_10400

HTL:

HPTL_0051

ACIB:

ACBT_0256(bphD)

AFC:	AFAEC_1841(bphD)

AAQI:

AAQM_0986(bphD)

ACLO:

ACLO_a0135(bphD)

ADZ:	ADFLV_2548(bphD)

ARC:

ABLL_2439

AROS:

NJU99_01670

ALK:	ALEK_0387(bphD)

AANA:

AANAER_1263(bphD)

BSM:	BSM4216_1785

BACI:

B1NLA3E_01490 B1NLA3E_14010

GMC:	GY4MC1_1593

GJF:	M493_17935

GTH:	Geoth_1676

PTL:	AOT13_14455

PCAL:

BV455_00230(xylF)

PARG:

PspKH34_15450

LYG:	C1N55_08045 C1N55_08150

ACOP:

RI196_07895

PRD:	F7984_08670 F7984_12055 F7984_12065

NDT:	L1999_08970 L1999_09005

HYI:	K2M58_09765

PNP:	IJ22_06980 IJ22_48610

BTS:	Btus_0963 Btus_2330 Btus_2553 Btus_2900

KYR:	CVV65_11320

SIV:	SSIL_0071 SSIL_3698

SSIL:

SOLI23_18480 SOLI23_19565

PLIQ:

QWY22_10405 QWY22_10495 QWY22_17915

PSHE:

QWY16_10505 QWY16_10595 QWY16_17455 QWY16_17775

PSHX:

QWY21_10800 QWY21_10890 QWY21_17760

JPO:	G7058_08100

SAY:	TPY_0645(mhpC)

SAP:	Sulac_2994

MIA:

OCU_07410

MID:

MIP_01280

MYO:

OEM_07480

MCHI:

AN480_04855

MIR:

OCQ_07550

MMM:

W7S_03620

MPAG:

C0J29_30965

MGOR:

H0P51_00410

MCOO:

MCOO_07730

MNE:	D174_16970

MYN:	MyAD_16575 MyAD_16635

MHAS:

MHAS_04027(xylF)

MANY:

MANY_01950

MAUS:

JN090_26240

CAMG:

CAMM_02590

CRF:	FRC0190_02107

CLIZ:

G7Y31_11625

COK:	COCCU_04420(xylF)

CORN:

BJP05_09075

NTC:	KHQ06_23915

NGP:	LTT66_32650

RHA:	RHA1_ro08081

ROA:	Pd630_LPD12026

RAV:	AAT18_00600

RRZ:	CS378_10945 CS378_24170

RRT:	4535765_04589(xylF_2)

RCR:	NCTC10994_02703(bphD1)

RGO:	KYT97_18210

ROZ:	CBI38_14185

RPSK:

JWS13_02075 JWS13_24120

RGOR:

NMQ04_17770

RHOP:

D8W71_11840

RHOU:

KZJ41_10500

RHOW:

A4U64_15245

RHOJ:

JVH1_19070

GOQ:	ACH46_18245

SGRF:

SGFS_022160

SMAL:

SMALA_1217

SGM:	GCM10017557_80400

SAUO:

BV401_09860

SNK:	CP967_06185

SPRA:

CP972_28050

SANT:

QR300_03365

AGLA:

OIE69_42280

ARX:	ARZXY2_3585

ARTP:

E5206_04555 E5206_14585

ASUN:

KG104_01700

ARZ:	AUT26_01405

PDEL:

JCQ34_20720

NAE:	BHE16_09080

ICA:	Intca_1090 Intca_3172

JTE:	ASJ30_00170

JLI:	EXU32_15285

JME:	EEW87_015390

JAY:	H7A72_00170

JCR:	O9K63_12420 O9K63_12650

OCP:	NF557_14820

AUS:	IPK37_03225

GEZ:	FE251_04640

RAIN:

Rai3103_08985 Rai3103_16615

NMAR:

HPC71_01605 HPC71_03280

NFC:	KG111_01295

SRO:

Sros_4719

NOA:	BKM31_20825

NOW:	GBF35_42640

NGN:	LCN96_15435

NFS:	OIE67_30555

MHAI:

OHB01_26475

FSY:	FsymDg_2032

NML:

Namu_4111

AMQ:	AMETH_2411(mhpC)

PDX:

Psed_6034

PSEE:

FRP1_12950

PSEQ:

AD006_20630

PECQ:

AD017_00210

PAUT:

Pdca_36310

PBRO:

HOP40_26765

PPEL:

H6H00_08540

MICH:

FJK98_21300

MCAB:

HXZ27_20900

VMA:	VAB18032_17465

MENO:

Jiend_52580

MPRN:

Q3V37_18660

MCAY:

PVK37_26200

MICF:

QQG74_20775

ACTE:

ACTI_45700

AFS:	AFR_13095 AFR_28670

PSUU:

Psuf_068110 Psuf_083190

DAUR:

Daura_20400

RMAR:

GBA65_17525

SBAE:

DSM104329_04655(todF_3)

CAU:

Caur_1353

CHL:	Chy400_1475

CAP:	CLDAP_40940

KBS:	EPA93_11995

TRO:

trd_1390

TTJ:	TTHB237(TTHB237)

TTL:	TtJL18_2419

TPI:	TREPR_1321

FLA:	SY85_23985

» show all

Reference

1 [PMID:4325686]

Authors

Sala-Trepat JM, Evans WC.

Title

The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway.

Journal

Eur J Biochem 20:400-13 (1971)
DOI:10.1111/j.1432-1033.1971.tb01406.x

Reference

2 [PMID:3481421]

Authors

Harayama S, Rekik M, Wasserfallen A, Bairoch A.

Title

Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids.

Journal

Mol Gen Genet 210:241-7 (1987)
DOI:10.1007/bf00325689

Reference

3 [PMID:7890778]

Authors

Diaz E, Timmis KN

Title

Identification of functional residues in a 2-hydroxymuconic semialdehyde hydrolase. A new member of the alpha/beta hydrolase-fold family of enzymes which cleaves carbon-carbon bonds.

Journal

J Biol Chem 270:6403-411 (1995)
DOI:10.1074/jbc.270.11.6403

Other DBs

ExplorEnz - The Enzyme Database:

3.7.1.9

IUBMB Enzyme Nomenclature:

3.7.1.9

ExPASy - ENZYME nomenclature database:

3.7.1.9

UM-BBD (Biocatalysis/Biodegradation Database):

3.7.1.9

BRENDA, the Enzyme Database:

3.7.1.9

CAS:	54004-61-4

DBGET integrated database retrieval system