| Entry |
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| Name |
haloalkane dehalogenase;
1-chlorohexane halidohydrolase;
1-haloalkane dehalogenase
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| Class |
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
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| Sysname |
1-haloalkane halidohydrolase
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| Reaction(IUBMB) |
1-haloalkane + H2O = a primary alcohol + halide [RN: R02337]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Acts on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds.
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| History |
EC 3.8.1.5 created 1989
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| Pathway |
| ec00361 | Chlorocyclohexane and chlorobenzene degradation |
| ec00625 | Chloroalkane and chloroalkene degradation |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K01563 | haloalkane dehalogenase |
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| Genes |
| SOF: | NCTC11214_01991(dhaA) |
| MAD: | HP15_2669 HP15_590(dhmA) |
| MARI: | ACP86_03560 ACP86_14360 |
| MARA: | D0851_06745 D0851_17020 |
| MSHE: | MAALD49_09200(dhmA1) |
| MANP: | EHN06_05025 EHN06_15475 |
| MSAN: | LPB19_07360 LPB19_16395 |
| PSPI: | PS2015_271 PS2015_2822 PS2015_2920 |
| SLJ: | EGC82_02430 EGC82_10920 EGC82_20365 EGC82_20380 EGC82_20400 EGC82_20495 |
| SPSR: | EGC80_06765 EGC80_15805 |
| COV: | EKO29_09940 EKO29_20035 |
| PLZ: | S4054249_06870 S4054249_20925 |
| PSMM: | PspMM1_29750 PspMM1_36860(dhaA) |
| PMES: | FX988_00337 FX988_00712 FX988_01336 |
| OSG: | BST96_13625 BST96_14490 |
| MII: | BTJ40_09040 BTJ40_09605 |
| MICT: | FIU95_06845(dhlA) FIU95_07325(dhmA) |
| HALC: | EY643_07960 EY643_13770 |
| PAQM: | E0F26_07125 E0F26_09315 |
| ASIP: | AQUSIP_11620(dhaAF_1) AQUSIP_24890(dhaAF_2) |
| MMEO: | OOT43_04430 OOT43_13670 |
| GAI: | IMCC3135_16825(linB) IMCC3135_16970(dhaA_1) IMCC3135_16985(dhmA2) IMCC3135_17030(dhaA_2) IMCC3135_28350(dhaA_3) |
| ALCA: | ASALC70_00179(dhaA) |
| OME: | OLMES_2995 OLMES_3176 OLMES_3894 |
| FCE: | JN531_008665 JN531_014015 |
| SALN: | SALB1_1196 SALB1_1651 |
| BCEN: | DM39_1977(dhaA) DM39_2021(dhaA) |
| BUM: | AXG89_24680 AXG89_28010 AXG89_31710 |
| RSB: | RS694_10230 RS694_11115 |
| PVAC: | HC248_01694(dhlA_1) |
| LIM: | L103DPR2_01777(dhlA) L103DPR2_02525(dhmA) |
| LIH: | L63ED372_01363(dhlA) |
| MNR: | ACZ75_23670 ACZ75_26230 |
| PMOB: | HG718_00320 HG718_02435 HG718_10970 |
| PECT: | BN1012_Phect1738 BN1012_Phect1773 BN1012_Phect2036 BN1012_Phect602 |
| RBS: | RHODOSMS8_00756(dhmA1) RHODOSMS8_01152(dhmA) RHODOSMS8_01877(dhaA) RHODOSMS8_01945(dhmA1) RHODOSMS8_02659(linB) |
| RBW: | RLCC275e_08460 RLCC275e_30100 |
| BJU: | BJ6T_11170 BJ6T_62180 |
| BJP: | RN69_05455 RN69_30125 |
| BGQ: | X265_25760 X265_34605 |
| BSEP: | HAP48_0011875 HAP48_0038340 |
| BBAN: | J4G43_003820 J4G43_020060 |
| BAUT: | QA635_04890 QA635_18620 |
| PHB: | HYN04_04990 HYN04_07925 HYN04_08195 HYN04_09890 |
| TSV: | DSM104635_01627(dhmA) |
| APAH: | KB221_11595 KB221_11605 |
| RCON: | K3740_02905 K3740_03065 |
| TMD: | KUV46_01310 KUV46_03100 |
| SEDI: | EBB79_12975 EBB79_16760 |
| HBC: | AEM38_01000 AEM38_06545 |
| SPHM: | G432_07875 G432_22000 |
| SLAN: | GV829_06340 GV829_08900 |
| SPAP: | H3Z74_04025 H3Z74_11880 H3Z74_20070 |
| SPMI: | K663_20098 K663_22528 K663_22543 |
| SPHT: | K426_01100 K426_28865 |
| SFLA: | SPHFLASMR4Y_01800(dhlA) SPHFLASMR4Y_02611(dhmA2) |
| SPHY: | CHN51_02715 CHN51_07575 |
| BLAS: | BSY18_1050 BSY18_475(dhlA) |
| BFW: | B5J99_11610 B5J99_14610 |
| PALG: | HFP57_07790 HFP57_16825 |
| PARP: | HFP51_00555 HFP51_07325 HFP51_13085 |
| POQ: | KZX46_13015 KZX46_22315 |
| ADO: | A6F68_01339(dhmA) A6F68_02625(dhaAF) |
| EGN: | BMF35_a1264 BMF35_a1551 |
| PORC: | CBR61_10885 CBR61_12725 |
| LCK: | HN018_03895 HN018_27605 |
| KOZ: | KFF44_03135 KFF44_12385 |
| TMK: | QGN29_01245 QGN29_09340 |
| MSD: | MYSTI_05419 MYSTI_05980 MYSTI_07500 |
| MFB: | MFUL124B02_16945 MFUL124B02_37325 MFUL124B02_39825 |
| MLAN: | JY572_37070 JY572_40160 |
| PPAK: | JY651_29785 JY651_31585 JY651_44445 |
| AVM: | JQX13_09100 JQX13_10305 JQX13_29035 JQX13_38265 |
| MRM: | A7982_04452 A7982_04949 A7982_13493 |
| LLU: | AKJ09_00227 AKJ09_04913 |
| PCAY: | FRD00_16330 FRD00_17830 FRD00_24620 |
| PJD: | Pjdr2_1472 Pjdr2_1756 |
| PBJ: | VN24_05690 VN24_08605 |
| PRZ: | GZH47_00125 GZH47_08950 |
| EUZ: | DVS28_a0576 DVS28_a3817 |
| MTU: | Rv1833c Rv2296 Rv2579(dhaA) |
| MTV: | RVBD_1833c RVBD_2296 RVBD_2579 |
| MTC: | MT1881 MT2353 MT2656(linB) |
| MRA: | MRA_1844 MRA_2313 MRA_2608(dhaA) |
| MTF: | TBFG_11862 TBFG_12319 TBFG_12599 |
| MTB: | TBMG_01394 TBMG_01687 TBMG_02161 |
| MTK: | TBSG_01404 TBSG_01697 TBSG_02173 |
| MTZ: | TBXG_001381 TBXG_001671 TBXG_002144 |
| MTG: | MRGA327_11335 MRGA327_14130 MRGA327_15880 |
| MTI: | MRGA423_11465 MRGA423_14255 MRGA423_16130 |
| MTE: | CCDC5079_1690 CCDC5079_2123 CCDC5079_2378 |
| MTUR: | CFBS_1925 CFBS_2425 CFBS_2730(dhaA) |
| MTL: | CCDC5180_1670 CCDC5180_2095 CCDC5180_2348 |
| MTO: | MTCTRI2_1865 MTCTRI2_2331 MTCTRI2_2627(dhaA) |
| MTD: | UDA_1833c UDA_2296 UDA_2579(dhaA) |
| MTN: | ERDMAN_2022 ERDMAN_2511 ERDMAN_2838(dhaA) |
| MTJ: | J112_09780 J112_12290 J112_13835 |
| MTUB: | MT7199_1859 MT7199_2321 MT7199_2610 |
| MTUC: | J113_12715 J113_15945 J113_18010 |
| MTUE: | J114_09775 J114_12280 J114_13800 |
| MTX: | M943_09525 M943_11855 M943_13330 |
| MTUL: | TBHG_01789 TBHG_02234 TBHG_02515 |
| MTUT: | HKBT1_1922 HKBT1_2416 HKBT1_2721(dhaA) |
| MTUU: | HKBT2_1930 HKBT2_2418 HKBT2_2724(dhaA) |
| MTQ: | HKBS1_1926 HKBS1_2422 HKBS1_2728(dhaA) |
| MBO: | BQ2027_MB1864C BQ2027_MB2318 BQ2027_MB2610(dhaA) |
| MBB: | BCG_1868c BCG_2312 BCG_2602(dhaA) |
| MBT: | JTY_1852 JTY_2306 JTY_2596(dhaA) |
| MBM: | BCGMEX_1849c BCGMEX_2300 BCGMEX_2595(dhaA) |
| MBK: | K60_019190 K60_023790 K60_026820 |
| MBX: | BCGT_1664 BCGT_2118 BCGT_2423 |
| MAF: | MAF_18550 MAF_23030 MAF_25960(dhaA) |
| MMIC: | RN08_2037 RN08_2540 RN08_2858 |
| MCE: | MCAN_18481 MCAN_23221 MCAN_26211(dhaA) |
| MCQ: | BN44_40093 BN44_50246(dhmA) BN44_60039(dhaA) |
| MCV: | BN43_30971 BN43_31543(dhmA) BN43_40253(dhaA) |
| MCX: | BN42_40214(dhmA) BN42_40560(dhaA) |
| MCZ: | BN45_50096 BN45_50630(dhmA) BN45_50969(dhaA) |
| MORY: | MO_001930 MO_002403 MO_002707 |
| MAVI: | RC58_08840 RC58_17510 |
| MAVU: | RE97_08840 RE97_17545 |
| MCHI: | AN480_01590 AN480_10900 |
| MMAL: | CKJ54_01500 CKJ54_09225 |
| MMAN: | MMAN_19070(dhmA1) MMAN_45720 |
| MSER: | MTY59_21970 MTY59_37070(dhmA1) MTY59_43130(dhmA2) |
| MSA: | Mycsm_02742 Mycsm_06094 |
| MUL: | MUL_3052 MUL_3979(dhaA) |
| MMI: | MMAR_0112(dhaA_1) MMAR_2710 MMAR_3472 MMAR_4113(dhaA) MMAR_4428 |
| MMAE: | MMARE11_01010(dhaA_1) MMARE11_26310 MMARE11_33840 MMARE11_39230(dhaA) MMARE11_42540 |
| MLI: | MULP_00098(dhaA_1) MULP_04277(dhaA) MULP_04652 |
| MPSE: | MPSD_01070(dhaA_1) MPSD_17640(dhaA_2) MPSD_35470(dhmA1) MPSD_45810 |
| MSHO: | MSHO_01110(dhaA_1) MSHO_02230 MSHO_11780(dhaA_2) MSHO_40440(dhmA2) MSHO_49160(dhmA1) |
| MKN: | MKAN_00385 MKAN_04100 MKAN_13670 MKAN_29130 |
| MYE: | AB431_04420 AB431_27670 |
| MHAD: | B586_09725 B586_11785 |
| MDX: | BTO20_02845 BTO20_17135 BTO20_19105 |
| MSHG: | MSG_00594(dhmA) MSG_03236(dhmA1) MSG_04148 |
| MFJ: | MFLOJ_06360(dhmA2) MFLOJ_07610 MFLOJ_58400(dhmA1) |
| MSTO: | MSTO_00280(dhmA1) MSTO_07610(dhmA2) MSTO_08900 MSTO_53200 MSTO_61060 |
| MSIM: | MSIM_26840 MSIM_43640(dhmA2_1) MSIM_44440(dhmA1) MSIM_48750(dhmA) MSIM_48890(dhmA2_2) MSIM_48960(dhmA2_3) |
| MSAK: | MSAS_13400(dhmA1) MSAS_21670 MSAS_31600 |
| MKU: | I2456_13410 I2456_14100 |
| MLW: | MJO58_13765 MJO58_17555 MJO58_22175 MJO58_22190 MJO58_22200 |
| MXE: | MYXE_03100 MYXE_25740(dhmA2) |
| MNV: | MNVI_14610 MNVI_40790(dhmA2) |
| MPAG: | C0J29_15610 C0J29_16595 C0J29_19105 |
| MGOR: | H0P51_15485 H0P51_15695 |
| MCOO: | MCOO_28880(dhmA2) MCOO_29190 |
| MBAI: | MB901379_00096(dhaA_1) MB901379_02508(dhaA_2) MB901379_03096(dhmA_1) MB901379_04691(dhmA_2) |
| MSEO: | MSEO_14150(dhmA2) MSEO_20660(dhmA1) |
| MHEK: | JMUB5695_00280 JMUB5695_02523(dhmA2) |
| MGAU: | MGALJ_15560(dhaA) MGALJ_17260(dhmA2) MGALJ_26750(dhmA1) |
| MLJ: | MLAC_17770(dhmA2) MLAC_19510(dhmA1) |
| MBRD: | MBRA_09570(dhmA2) MBRA_17930 |
| MSHJ: | MSHI_13630(dhmA2) MSHI_19390(dhaA) |
| MMAM: | K3U93_00385 K3U93_15150 K3U93_23610 |
| MSPG: | F6B93_08815 F6B93_11210 F6B93_14305 F6B93_21510 |
| MOT: | LTS72_07100 LTS72_07485 LTS72_10675 LTS72_21320 LTS72_26480 |
| MKY: | IWGMT90018_23780(dhmA2) IWGMT90018_28810(dhmA1) IWGMT90018_40830(dhaA) |
| MYW: | BVC93_27580 BVC93_28490 |
| MSM: | MSMEG_6314 MSMEG_6837 |
| MSG: | MSMEI_6149(dhmA1) MSMEI_6656(dhaA) |
| MSB: | LJ00_31225 LJ00_33790 |
| MSN: | LI99_31230 LI99_33795 |
| MSH: | LI98_31235 LI98_33800 |
| MNE: | D174_02620 D174_16225 D174_25540 |
| MYN: | MyAD_02555 MyAD_15940 MyAD_25080 |
| MLL: | B1R94_09055 B1R94_11540 B1R94_26845 |
| MRH: | MycrhN_3875 MycrhN_4820 MycrhN_4981 |
| MTHN: | 4412656_02462(dhaA_2) |
| MAUU: | NCTC10437_02223(dhmA) |
| MMAG: | MMAD_38310(dhaA) MMAD_50750 |
| MMOR: | MMOR_22630(dhmA1) MMOR_34470(dhaA) |
| MAIC: | MAIC_02950 MAIC_08290(dhmA2) |
| MARZ: | MARA_14110(dhaA) MARA_17010(dhmA1) |
| MGAD: | MGAD_07590(dhmA2) MGAD_09200(dhaA) MGAD_55850(dhmA1) |
| MANY: | MANY_06450 MANY_09360(dhaA) MANY_35460 |
| MAUB: | MAUB_29940(dhmA2) MAUB_46580(dhmA1) |
| MPOF: | MPOR_27000(dhaA) MPOR_50510(dhmA1) |
| MPHU: | MPHO_22680(dhmA1) MPHO_38240(dhmA2) |
| MMUC: | C1S78_007035 C1S78_027870 |
| MMAT: | MMAGJ_30270 MMAGJ_49360(dhaA) |
| MFLV: | NCTC10271_02418(dhmA_1) NCTC10271_04205(dhmA_2) |
| MCEE: | MCEL_06770(dhaA) MCEL_23970(dhmA1) |
| MGO: | AFA91_03915 AFA91_12820 |
| MHOL: | K3U96_10805 K3U96_12105 K3U96_14965 |
| MPAE: | K0O64_24375 K0O64_27180 |
| MCRO: | MI149_14980 MI149_24790 |
| MIZ: | BAB75_07550 BAB75_16500 |
| MSTE: | MSTE_02828 MSTE_02831(dhaA) |
| MTER: | 4434518_03970(dhmA) |
| MMIN: | MMIN_04590(dhmA2) MMIN_14740 |
| MHER: | K3U94_15770 K3U94_22025 |
| MVM: | MJO54_15755 MJO54_21955 |
| NBR: | O3I_000045 O3I_006590 |
| NNO: | NONO_c01140(dhmA1) NONO_c48280(dhmA2) NONO_c72790 |
| NSR: | NS506_01100(dhaA) NS506_04629 |
| NOZ: | DMB37_00515 DMB37_27530 |
| NOD: | FOH10_20845 FOH10_32195 |
| NAH: | F5544_07825 F5544_19050 F5544_23675 F5544_30665 F5544_31205 |
| NAD: | NCTC11293_00425(dhaA_1) |
| NWL: | NWFMUON74_68270(dhaA) |
| NIE: | KV110_07175 KV110_15800 |
| NHU: | H0264_21495 H0264_25150 H0264_37965 |
| NYA: | LTV02_16190 LTV02_33050 |
| NGP: | LTT66_05795 LTT66_31355 |
| NSPU: | IFM12276_51280(dhaA_1) |
| RHW: | BFN03_00170 BFN03_01065 BFN03_16165 |
| RHOD: | AOT96_16290 AOT96_31580 |
| RANT: | RHODO2019_04830 RHODO2019_07315 |
| RHOO: | RA302_05805 RA302_28485 RA302_31370 |
| TPUL: | TPB0596_20940(dhmA2) |
| SLIA: | HA039_00885 HA039_01600 |
| NAQU: | ENKNEFLB_04169(dhmA) |
| NPC: | KUV85_10700 KUV85_13650 |
| AEB: | C6I20_05195 C6I20_14585 C6I20_15120 |
| NBT: | KLP28_04805 KLP28_14170 |
| KQI: | F1D05_04700 F1D05_32920 |
| ACTQ: | OG417_05935 OG417_42345 |
| SRO: | Sros_5099 Sros_7423 Sros_7956 |
| NOA: | BKM31_22450 BKM31_39705 BKM31_58135 |
| NOW: | GBF35_15135 GBF35_29410 GBF35_38345 |
| NCX: | Nocox_05065(dhaA1) Nocox_23480(dhaA2) Nocox_31225(dhmA2) |
| NGN: | LCN96_05580 LCN96_24815 LCN96_42725 LCN96_55315 |
| NFS: | OIE67_06495 OIE67_18460 OIE67_20685 |
| MHAI: | OHB01_28035 OHB01_36710 |
| BSD: | BLASA_0113(dhmA) BLASA_0238(dhaA) |
| AMD: | AMED_0191(dhaA) AMED_6398(dhaA) |
| AMM: | AMES_0187(dhaA) AMES_6306(dhaA) |
| AMZ: | B737_0188(dhaA) B737_6306(dhaA) |
| AOI: | AORI_0188(dhaA) AORI_2120(dhaA) |
| AJA: | AJAP_01000(dhmA) AJAP_28925(dhmA2) |
| AMQ: | AMETH_0214(dhaA) AMETH_5325(dhaA) |
| AMYB: | BKN51_15655 BKN51_35000 |
| AAB: | A4R43_02775 A4R43_08545 A4R43_28360 |
| AMYY: | YIM_00990(dhmA1) YIM_24780(dhaA2) YIM_29890(dhaA3) |
| AORI: | SD37_30335 SD37_40865 |
| APRT: | MUY14_02875 MUY14_04140 MUY14_35685 |
| AROO: | NQK81_26625 NQK81_43180 |
| AMOG: | QRX60_10475 QRX60_49005 QRX60_50765 |
| ACYN: | ORV05_01405 ORV05_21270 ORV05_31900 ORV05_34310 |
| PDX: | Psed_4195 Psed_4309 Psed_5292 |
| KUT: | JJ691_28640 JJ691_65430 |
| STP: | Strop_0665 Strop_2973 |
| ASER: | Asera_16660(dhaA_1) Asera_64780(dhaA_2) |
| ABAI: | IMCC26256_11530 IMCC26256_11572 IMCC26256_11615 |
| BALA: | DSM104299_01770(dhaA_2) DSM104299_04044(dhaA_4) |
| PBAJ: | LRS13_07780 LRS13_13565 |
| AYM: | YM304_07150(dhaA) YM304_31380(dhmA) |
| KBS: | EPA93_12765 EPA93_25490 EPA93_46420 |
| VBL: | L21SP4_02395(dhmA_3) |
| TALB: | FTW19_04625 FTW19_12750 |
| PSEG: | D3H65_01765 D3H65_21105 |
| FKA: | KM029_08095 KM029_21875 |
| FFA: | FFWV33_04025 FFWV33_04060 |
| AQD: | D1816_12015 D1816_20130 |
| NSAL: | HWV07_00040 HWV07_08625 |
| HJT: | DVR14_17295 DVR14_21425 |
| LOKI: | Lokiarch_30800(dhlA) |
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| Reference |
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| Authors |
Keuning S, Janssen DB, Witholt B |
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| Title |
Purification and characterization of hydrolytic haloalkane dehalogenase from Xanthobacter autotrophicus GJ10. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Scholtz R, Leisinger T, Suter F, Cook AM. |
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| Title |
Characterization of 1-chlorohexane halidohydrolase, a dehalogenase of wide substrate range from an Arthrobacter sp. |
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| Journal |
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| Reference |
|
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| Authors |
Yokota T, Omori T, Kodama T. |
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| Title |
Purification and properties of haloalkane dehalogenase from Corynebacterium sp. strain m15-3. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.8.1.5 |
| ExPASy - ENZYME nomenclature database: | 3.8.1.5 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 3.8.1.5 |
| BRENDA, the Enzyme Database: | 3.8.1.5 |
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