KEGG   ENZYME: 3.8.1.8Help
Entry
EC 3.8.1.8                  Enzyme                                 

Name
atrazine chlorohydrolase;
AtzA
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
BRITE hierarchy
Sysname
atrazine chlorohydrolase
Reaction(IUBMB)
atrazine + H2O = hydroxyatrazine + chloride [RN:R05558]
Reaction(KEGG)
R05558;
(other) R05569 R06968
Show
Substrate
atrazine [CPD:C06551];
H2O [CPD:C00001]
Product
hydroxyatrazine [CPD:C06552];
chloride [CPD:C00698]
Comment
Involved in the degradation of the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, in bacteria.
History
EC 3.8.1.8 created 2000, modified 2011
Pathway
ec00791  Atrazine degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05394  atrazine chlorohydrolase
Reference
1  [PMID:7574646]
  Authors
de Souza ML, Wackett LP, Boundy-Mills KL, Mandelbaum RT, Sadowsky MJ.
  Title
Cloning, characterization, and expression of a gene region from Pseudomonas sp. strain ADP involved in the dechlorination of atrazine.
  Journal
Appl Environ Microbiol 61:3373-8 (1995)
  Sequence
Reference
2  [PMID:8759853]
  Authors
de Souza ML, Sadowsky MJ, Wackett LP.
  Title
Atrazine chlorohydrolase from Pseudomonas sp. strain ADP: gene sequence, enzyme purification, and protein characterization.
  Journal
J Bacteriol 178:4894-900 (1996)
DOI:10.1128/JB.178.16.4894-4900.1996
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.8.1.8
IUBMB Enzyme Nomenclature: 3.8.1.8
ExPASy - ENZYME nomenclature database: 3.8.1.8
UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.8
BRENDA, the Enzyme Database: 3.8.1.8
CAS: 168680-16-8

DBGET integrated database retrieval system