KEGG   ENZYME: 3.9.1.2
Entry
EC 3.9.1.2                  Enzyme                                 

Name
protein arginine phosphatase;
YwlE
Class
Hydrolases;
Acting on phosphorus-nitrogen bonds;
Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)
Sysname
[protein]-Nomega-phospho-L-arginine phosphohydrolase
Reaction(IUBMB)
a [protein]-Nomega-phospho-L-arginine + H2O = a [protein]-L-arginine + phosphate [RN:R11095]
Reaction(KEGG)
R11095
Substrate
[protein]-Nomega-phospho-L-arginine [CPD:C21101];
H2O [CPD:C00001]
Product
protein-L-arginine [CPD:C00613];
phosphate [CPD:C00009]
Comment
The enzyme, characterized from Gram-positive bacteria, hydrolyses the phosphoramidate (P-N) bond of Nomega-phospho-L-arginine residues in proteins and peptides that were phosphorylated by EC 2.7.14.1, protein-arginine-kinase.
History
EC 3.9.1.2 created 2014
Orthology
K20201  protein arginine phosphatase
Genes
LRI: NCTC12151_02280(ywlE_2)
BAC: BamMC406_3504
BSU: BSU36930(ywlE)
BSR: I33_3837
BSL: A7A1_1018
BSH: BSU6051_36930(ywlE)
BSY: I653_18065
BSUT: BSUB_03928(ywlE)
BSUL: BSUA_03928(ywlE)
BSUS: Q433_20305
BSO: BSNT_10347(ywlE)
BSQ: B657_36930(ywlE)
BSX: C663_3592(ywlE)
BSS: BSUW23_18230(ywlE)
BST: GYO_4069
BLI: BL03988(ywlE)
BLD: BLi03938(ywlE)
BLH: BaLi_c39530(ywlE)
BAQ: BACAU_3443(ywlE)
BYA: BANAU_3598(ywlE)
BAMP: B938_17495
BAML: BAM5036_3339(ywlE)
BAMA: RBAU_3545(ywlE)
BAMN: BASU_3321(ywlE)
BAMB: BAPNAU_3610(ywlE)
BAMT: AJ82_19250
BAMY: V529_36790(ywlE)
BMP: NG74_03585(ywlE)
BAO: BAMF_3530(ywlE)
BAZ: BAMTA208_18705(ywlE)
BQL: LL3_03841(ywlE)
BXH: BAXH7_03829(ywlE)
BQY: MUS_4064(ywlE)
BAMI: KSO_001980
BAMC: U471_35530
BAMF: U722_18305
BAN: BA_5561
BAR: GBAA_5561
BAT: BAS5168
BAI: BAA_5589
BANT: A16_55730
BANR: A16R_56380
BANS: BAPAT_5333
BANV: DJ46_4213(ywlE)
BCE: BC5319
BCA: BCE_5444
BCQ: BCQ_5159
BCX: BCA_5466
BNC: BCN_5249
BCF: bcf_26685
BCER: BCK_08765
BTL: BALH_4819
BTT: HD73_5726
BTHI: BTK_28155
BTM: MC28_4556
BTG: BTB_c55200(ywlE)
BTI: BTG_21800
BTW: BF38_1046(ywlE)
BWW: bwei_4460(ywlE)
BMYO: BG05_685
BMYC: DJ92_2413(ywlE)
BPU: BPUM_3338
BPUM: BW16_17745
BPUS: UP12_17240
BJS: MY9_3775
BACW: QR42_16755
BACP: SB24_11655
BACB: OY17_00720
BACO: OXB_1428
BACY: QF06_16875
BACL: BS34A_40080(ywlE)
BALM: BsLM_3720
BGY: BGLY_4343(ywlE)
BBEV: BBEV_0172
BFD: NCTC4823_00445(ywlE)
BEO: BEH_23455
BMQ: BMQ_5163
BMD: BMD_5149
BMEG: BG04_2157(ywlE)
BAG: Bcoa_1447
BCOA: BF29_2054
BHA: BH3769
BCL: ABC3867
BPF: BpOF4_06930(ywlE)
BKW: BkAM31D_24455(ywlE)
OIH: OB2988
GKA: GK3373
GTN: GTNG_3318
GGH: GHH_c34670(ywlE)
GEA: GARCT_03356(ywlE)
AFL: Aflv_2717
AAMY: GFC30_359
AXL: AXY_20530
LSP: Bsph_1000
HHD: HBHAL_4612(ywlE)
HLI: HLI_14410
VPN: A21D_00946(ywlE)
PASA: BAOM_4877
PSYO: PB01_03360
BLEN: NCTC4824_03884(ywlE)
BSE: Bsel_3170
LMO: lmo2540
LMOE: BN418_3006
LMOB: BN419_3017
LMOD: LMON_2554
LMOW: AX10_06770
LMOQ: LM6179_1663(ptpB)
LMR: LMR479A_2668(ptpB)
LMOM: IJ09_12100
LMOG: BN389_25020(ptpB)
LMP: MUO_12685
LMOX: AX24_10655
LMQ: LMM7_2583(wzb)
LMS: LMLG_1894
LMOK: CQ02_12895
LIN: lin2684
LWE: lwe2489
LSG: lse_2441
LIV: LIV_2450
LGZ: NCTC10812_02534(ptpB)
ESI: Exig_2696
EAN: Eab7_2504(wzb)
BBE: BBR47_54720(ptpB)
BLR: BRLA_c044480(ywlE)
PPY: PPE_04470
PPM: PPSC2_23325(ywlE)
PPO: PPM_4632(ywlE)
PPOL: X809_39860
PPOY: RE92_13935
PMW: B2K_00175
PSAB: PSAB_22550
PRI: PRIO_6331
PSWU: SY83_10650
ASOC: CB4_00580(ywlE)
AAD: TC41_3105
BTS: Btus_3249
EFF: skT53_26510(ywlE)
SIV: SSIL_3386
JEO: JMA_30210
KZO: NCTC404_00458(ywlE)
AMT: Amet_0337
HSD: SD1D_0167
ACEL: acsn021_42880(ywlE)
PDC: CDIF630_03792(ywlE)
EAC: EAL2_c03780(ywlE)
SLP: Slip_2295
DSY: DSY4930
DRM: Dred_3164
SGY: Sgly_3285
CTHM: CFE_0336
THX: Thet_0132
CHY: CHY_2559
CSC: Csac_1528
PIV: NCTC13079_00316(ywlE)
VRM: 44547418_01164(ywlE)
VDN: NCTC11831_00798(ywlE)
VNK: VEIT17_07380(ywlE)
PUF: UFO1_4284
STED: SPTER_35470(ywlE)
ACAD: UA74_06775
CAA: Caka_0386
FMR: Fuma_01451(ywlE)
SRU: SRU_0502
SRM: SRM_00583(etp)
MRU: mru_1295
LOKI: Lokiarch_32280(ywlE_2) Lokiarch_41390(ywlE_3)
 » show all
Reference
1  [PMID:23770242]
  Authors
Fuhrmann J, Mierzwa B, Trentini DB, Spiess S, Lehner A, Charpentier E, Clausen T
  Title
Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria.
  Journal
Cell Rep 3:1832-9 (2013)
DOI:10.1016/j.celrep.2013.05.023
  Sequence
[bsu:BSU36930]
Reference
2  [PMID:24825175]
  Authors
Trentini DB, Fuhrmann J, Mechtler K, Clausen T
  Title
Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap.
  Journal
Mol Cell Proteomics 13:1953-64 (2014)
DOI:10.1074/mcp.O113.035790
  Sequence
Reference
3  [PMID:22517742]
  Authors
Elsholz AK, Turgay K, Michalik S, Hessling B, Gronau K, Oertel D, Mader U, Bernhardt J, Becher D, Hecker M, Gerth U
  Title
Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis.
  Journal
Proc Natl Acad Sci U S A 109:7451-6 (2012)
DOI:10.1073/pnas.1117483109
  Sequence
[bsu:BSU36930]
Other DBs
ExplorEnz - The Enzyme Database: 3.9.1.2
IUBMB Enzyme Nomenclature: 3.9.1.2
ExPASy - ENZYME nomenclature database: 3.9.1.2
BRENDA, the Enzyme Database: 3.9.1.2

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