KEGG   ENZYME: 4.1.1.1
Entry
EC 4.1.1.1                  Enzyme                                 
Name
pyruvate decarboxylase;
alpha-carboxylase (ambiguous);
pyruvic decarboxylase;
alpha-ketoacid carboxylase;
2-oxo-acid carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
2-oxo-acid carboxy-lyase (aldehyde-forming)
Reaction(IUBMB)
a 2-oxo carboxylate = an aldehyde + CO2 [RN:R00636]
Reaction(KEGG)
R00636 > R00224;
(other) R00014 R00755
Substrate
2-oxo carboxylate [CPD:C00161]
Product
aldehyde [CPD:C00071];
CO2 [CPD:C00011]
Comment
A thiamine-diphosphate protein. Also catalyses acyloin formation.
History
EC 4.1.1.1 created 1961
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01568  pyruvate decarboxylase
Genes
ATHAT4G33070 AT5G01320 AT5G01330(PDC3) AT5G54960(PDC2)
ALY9302143 9303277 9307000 9307001
CRB17875390 17880643 17882212
CSAT104708983 104716857 104721511 104726025 104729954 104731233 104734170 104761513
EUSEUTSA_v10013008mg EUTSA_v10013010mg
BRP103844946 103848377 103850424
BNA106371229 106411347 106423972 106423973 106427901 106435877
BOE106313582 106318780 106324500 106325144
RSZ108814219 108818099 108827930
THJ104805986 104816205 104823375 104827046
CPAP110809469 110809477 110821947
CIT102577973 102618817
CICCICLE_v10011317mg CICLE_v10014703mg
PVY116115141 116115143 116115170 116115171 116115174 116126738
MINC123192985 123201879 123216752 123217929
TCC18590978 18596726 18597501 18597502
GRA105769239 105781287 105789937 105799965 105799966
GHI107890944 107890945 107932439 107937059 107937060 107946921 107958418
GAB108453699 108453774 108453825 108482605
DZI111274987 111281095 111285332 111295226 111312073
EGR104422688 104422772 104422950 104423824 104426367 104427843 104429238 104429240 104429243 104440922 104442916
GMX100776332 100777690 100782747 100787315 100789053 100809553
GSJ114375906 114396326 114406109 114415946 114419097 114423891
PVUPHAVU_006G177600g PHAVU_008G095400g PHAVU_010G078000g
VRA106753391 106773761 106774550 106774984
VAR108320402 108341716 108342840 108346926
VUN114166544 114185083 114189040 114189071
CCAJ109815406 109817765 109818838
APRC113850416 113852036 113861001 113873786
MTRMTR_2g009330 MTR_2g015560 MTR_4g017200 MTR_5g046610 MTR_7g069500 MTR_7g069540
CAM101493012 101496685 101497155 101499611 101505047
LJALj0g3v0332289.1(Lj0g3v0332289.1) Lj1g3v2372300.1(Lj1g3v2372300.1) Lj6g3v1995950.1(Lj6g3v1995950.1)
ADU107468273 107475323 107484990
AIP107623050 107625783 107639705
AHF112714498 112728030 112743681 112750652 112782649 112797063
LANG109325581 109330058 109337231 109361217
FVE101303820 101310299 101314636
RCN112167547 112180095 112192290 112202804
PPER18774601 18775031 18779199 18780204
PMUM103321260 103324867 103341571 103342233
PAVI110755000 110758412 110758718 110768434
PDUL117624410 117628535 117631283 117632782
MDM103407654 103419936 103425929 103425939 103447363 103451198 114827769
PXB103931243 103944123 103948850 103958998 103965128
ZJU107411322 107411501 107427602 107430892
MNT21384108 21384564 21389594 21395264
CSV101207348 101207963 101217060 101217174 101217304 101217534
CMO103484463(PDC2) 103486270(PDC1) 103497061 103502148 103502149 103502191
BHJ120072893 120072984 120072988 120073586 120073591 120074501 120083537 120092082
MCHA111012435 111013786 111013814 111013816 111013817 111015108 111018977
CMAX111470156 111478194 111478567 111482096 111497510
CMOS111433108 111433854 111438155 111441524 111452527 111452811 111453217
CPEP111781622 111782238 111788461 111791899 111800552 111803735 111804104
RCU8259205 8283141 8284421
JCU105649640
HBR110632597 110653920 110655831 110662751 110673623
MESC110600467 110603926 110605229 110620078 110622315
POP112323400 112326010 18106430 7460369 7468064 7472319 7476349
PEU105121918 105127933 105140681 105140794 105141365
PALZ118037516 118045836 118048424 118051901 118054104 118054106 118054876
JRE108989858 108994918 108995175 108998404 109004423
QSU111983637 111989839 112008143 112019413 112040129
QLO115952327 115953727 115956073 115991799
TWL119987540 119990949 119998218
VVI100232858(PDC1) 100242845 100267272
VRI117916594 117920461 117923839
SLY101246495 101247173 101254910 101256911
SPEN107009317 107022972 107032099
SOT102578941 102593029 102594081 102594418(StPDC)
CANN107845990 107859311 107874609
NTA107758965 107766552 107779126 107789890 107811683 107814772(NtPDC2) 107826075(PDC)
NSY104220230 104223295 104236795 104247575
NTO104090753 104101672 104114161 104118788
NAU109207643 109214104 109222793 109233225 109233457
INI109158976 109159059 109181768 109182806
ITR116006986 116024507 116028750 116030487
SIND105157189 105174135 105174592 105175619
OEU111370518 111392544 111401681 111403255
EGT105952210 105953117 105968443
SSPL121741764 121744813 121746920 121763416 121763720 121770148 121809971
HAN110885000 110885002 110909907 110912521 110926115 110941534 110941698 110945063 118479230
ECAD122582851 122586669 122595590 122606999 122609273
LSV111882751 111884747 111884755 111898600 111898601 111898603 111898604 111905920
CCAV112513429 112517878 112518045 112523514
DCR108209732 108216609 108217920 108222368 108223320
CSIN114261387 114262939 114270131 114284229
BVG104892526 104900580
SOE110791643 110792348
CQI110710712 110715063 110719301 110730551
NNU104594948 104594950 104597315 104602557 104612119 104613082 104613083
MING122059946 122071376 122086934
TSS122651788 122664003 122670986 122670987
PSOM113273545 113273556 113287496 113306918 113308313 113310237 113321843 113332973 113340209 113358753
NCOL116255153 116260890 116261786 116262786
OSA4324066 4332519 4339066 4339068 4344382
DOSAOs01t0160100-01(Os01g0160100) Os03t0293500-01(Os03g0293500) Os05t0469600-01(Os05g0469600) Os05t0469800-00(Os05g0469800) Os07t0693100-01(Os07g0693100)
OBR102700093 102710001 102719033 102719675
BDI100821811 100828933
ATS109733433 109756002 109773867 109777039 109785840 109785842
TDC119267172 119275027 119285408 119296425 119358890 119358891 119367123 119367187 119367204
TAES123038239 123040507 123042693 123048583 123048584 123051406 123060339 123077383 123077387 123085585 123092445 123097767 123172219 123184629 123187361
SBI8075118 8076982 8084715
ZMA103634444 541919 542376 542651
SITA101757538 101775698 101776753 101785721
SVS117836049 117846026 117847998 117858936
PVIR120650679 120652711 120665186 120690274 120698393 120705911
PHAI112877292 112882735 112886922 112893565
PDA103695776 103695777 103718137 103718173 103718720 120112312
EGU105038446 105044565 105045855 105047597
MUS103972345 103972888 103973721 103977807 103984175 103986187
DCT110100660 110109144
PEQ110023280 110029946
AOF109843566
ATR18433507
SMOSELMODRAFT_101858 SELMODRAFT_157772 SELMODRAFT_160305 SELMODRAFT_406669 SELMODRAFT_417071 SELMODRAFT_80644
PPP112272626 112279835 112280335 112280457 112294195
CRECHLRE_03g165700v5
VCNVOLCADRAFT_105183
MNGMNEG_6097 MNEG_7407
CSLCOCSUDRAFT_38356
CVRCHLNCDRAFT_35601(PDC1) CHLNCDRAFT_52583(PDC2)
APROF751_5081
SCEYDL080C(THI3) YGR087C(PDC6) YLR044C(PDC1) YLR134W(PDC5)
SEUBDI49_0987 DI49_2044 DI49_3572 DI49_3657
SPAOSPAR_D01560 SPAR_G03080 SPAR_L00990 SPAR_L01820
AGOAGOS_AAL073W AGOS_ACL134C AGOS_ADR254W
ERCEcym_2479 Ecym_3185 Ecym_6055
KLAKLLA0_E16303g KLLA0_F16962g
KMXKLMA_40053(THI3) KLMA_60075(PDC1)
LTHKLTH0B01188g KLTH0D00418g KLTH0D08272g KLTH0E09702g
VPOKpol_1010p48
ZROZYRO0A08426g ZYRO0F01606g
CGRCAGL0G02937g CAGL0L06842g CAGL0M07920g
NCSNCAS_0A04000(NCAS0A04000) NCAS_0A14240(NCAS0A14240) NCAS_0A14630(NCAS0A14630) NCAS_0D01660(NCAS0D01660)
NDINDAI_0A01400(NDAI0A01400) NDAI_0A02510(NDAI0A02510) NDAI_0C03110(NDAI0C03110) NDAI_0D03270(NDAI0D03270) NDAI_0E01700(NDAI0E01700)
TPFTPHA_0G02620(TPHA0G02620) TPHA_0H00950(TPHA0H00950)
TBLTBLA_0B07520(TBLA0B07520) TBLA_0B08820(TBLA0B08820) TBLA_0B10060(TBLA0B10060) TBLA_0D02840(TBLA0D02840) TBLA_0E03070(TBLA0E03070)
TDLTDEL_0C07020(TDEL0C07020) TDEL_0E05080(TDEL0E05080) TDEL_0F00150(TDEL0F00150) TDEL_0G03210(TDEL0G03210)
TGBHG536_0A03200 HG536_0E05180 HG536_0F00140
KAFKAFR_0E01520(KAFR0E01520) KAFR_0E02020(KAFR0E02020) KAFR_0F02990(KAFR0F02990)
KNGKNAG_0A05900(KNAG0A05900) KNAG_0J01330(KNAG0J01330) KNAG_0J01340(KNAG0J01340) KNAG_0M01250(KNAG0M01250)
ZMKHG535_0B00700 HG535_0D00970
PPAPAS_chr3_0188
DHADEHA2B03872g DEHA2D16984g DEHA2G18348g
PICPICST_64926(PDC1) PICST_86443(PDC2)
PGUPGUG_00638 PGUG_03175
SPAASPAPADRAFT_58642(PDC1) SPAPADRAFT_58954(PDC2)
LELLELG_02823 LELG_05713
CALCAALFM_C401850CA(PDC12) CAALFM_C406570CA(PDC11)
CTPCTRG_00232 CTRG_02361 CTRG_03826
COTCORT_0B01190 CORT_0C05190
CDUCD36_41740 CD36_46050(CaPDC11)
CTENCANTEDRAFT_111178 CANTEDRAFT_98543
YLIYALI0D06930g YALI0D10131g
CLUCLUG_01059 CLUG_03813
CLUSA9F13_01g03256 A9F13_09g01078
CAURCJI97_000919 CJI97_001552
SLBAWJ20_1628(PDC1) AWJ20_4040(PDC1)
PKZC5L36_0A01560
BNNFOA43_003671
BBRXBRETT_001567
OPAHPODL_04375
NCRNCU02193(cfp) NCU02397(ilv-5)
NTENEUTE1DRAFT117898(NEUTE1DRAFT_117898) NEUTE1DRAFT123952(NEUTE1DRAFT_123952)
SMPSMAC_03488 SMAC_03633
PANPODANSg1307 PODANSg2335 PODANSg9253
TTTTHITE_2116720
MTMMYCTH_112121
CTHRCTHT_0048490
MGRMGG_01892
PPEIPpBr36_01424
TMNUCRPA7_1940 UCRPA7_7791
SSCKSPSK_00477
FGRFGSG_03019 FGSG_09834 FGSG_10446 FGSG_13946
FPUFPSE_02216 FPSE_07570 FPSE_09340 FPSE_09735 FPSE_10350
FVRFVEG_05069 FVEG_08321 FVEG_10543 FVEG_13338
FOXFOXG_06467 FOXG_06796 FOXG_07096 FOXG_07356 FOXG_08146 FOXG_09906 FOXG_10189 FOXG_10788 FOXG_11963 FOXG_14498 FOXG_15206 FOXG_16380 FOXG_17605
NHENECHADRAFT_32456 NECHADRAFT_56358 NECHADRAFT_59608 NECHADRAFT_82254 NECHADRAFT_82959 NECHADRAFT_85441 NECHADRAFT_99885
TRETRIREDRAFT_121534 TRIREDRAFT_59267
TRRM419DRAFT_141194 M419DRAFT_76031
MAWMAC_00102 MAC_09033
MAJMAA_04499 MAA_05245 MAA_09838
CMTCCM_01231 CCM_05869
PLJVFPFJ_02276 VFPFJ_06202 VFPFJ_11347
VALVDBG_03673 VDBG_07090 VDBG_09704
VDAVDAG_00903 VDAG_06729 VDAG_09443
CFJCFIO01_00984 CFIO01_06397 CFIO01_08087
CHIGCH63R_01146 CH63R_03986
SAPOSAPIO_CDS4223 SAPIO_CDS4525
ELAUCREL1_6617 UCREL1_9694
PFYPFICI_03540 PFICI_09490
SSLSS1G_10985
BFUBCIN_02g06580
MBEMBM_01626 MBM_02441 MBM_06853
PSCOLY89DRAFT_590742 LY89DRAFT_590882 LY89DRAFT_598617 LY89DRAFT_622576 LY89DRAFT_677187 LY89DRAFT_700588
GLZGLAREA_07922
ANIAN4888.2 AN8396.2
AFMAFUA_3G11070 AFUA_5G14810 AFUA_6G00750
ACTACLA_038990 ACLA_099190 ACLA_099400
NFINFIA_047900 NFIA_066190
AORAO090003000661 AO090010000261 AO090011000272 AO090012000752 AO090038000139 AO090124000047
ANGANI_1_1024084(An09g01030) ANI_1_2276014(An01g01590) ANI_1_796114(An13g03320) ANI_1_936024(An02g06820)
AFVAFLA_001027 AFLA_002466 AFLA_007673 AFLA_009166 AFLA_012410
ALUCAKAW2_10561S(PDC1) AKAW2_20353A AKAW2_40085S(ADH1_1) AKAW2_40086S
ACHEACHE_21079S(PDC1_1) ACHE_40833A ACHE_60566A(PDC1_2)
APUUAPUU_21571A APUU_30977S(PDC1) APUU_61365S APUU_70326S
PCSPc13g09300 Pc13g12760 Pc16g13320 Pc18g01490
PDPPDIP_30000 PDIP_58610 PDIP_65870 PDIP_74140
TMFPMAA_023270 PMAA_062380 PMAA_077620
TRGTRUGW13939_00339 TRUGW13939_02733 TRUGW13939_04620
CIMCIMG_03414 CIMG_03789
CPWCPC735_005250 CPC735_008040
UREUREG_07239 UREG_07495
PBLPAAG_02050 PAAG_02512
PBNPADG_00714 PADG_05657
ABEARB_05525 ARB_07745
TVETRV_02907 TRV_04531
AJEHCAG_02571 HCAG_08778
BGHBDBG_03162 BDBG_08232
PNOSNOG_04161 SNOG_11872 SNOG_12213
PTEPTT_12393 PTT_16162
BZECOCCADRAFT_109843 COCCADRAFT_27125
BSCCOCSADRAFT_165047 COCSADRAFT_79977
BORCOCMIDRAFT_105345 COCMIDRAFT_23005
AALTCC77DRAFT_1016629 CC77DRAFT_1018183
ZTRMYCGRDRAFT_40465(PDC1)
PFJMYCFIDRAFT_157428 MYCFIDRAFT_63192
FFUCLAFUR5_04875 CLAFUR5_06003 CLAFUR5_14041
BCOMBAUCODRAFT_118154
NPAUCRNP2_2107 UCRNP2_246 UCRNP2_8016 UCRNP2_8882
TMLGSTUM_00006321001
SPOSPAC13A11.06 SPAC186.09 SPAC1F8.07c SPAC3G9.11c
CNECNJ00950
CNBCNBJ2540
CNGCNAG_04659
CGICGB_D8620C
TMSTREMEDRAFT_71102
TASAA1Q1_01116 A1Q1_06560
TVSTRAVEDRAFT_147039
DSQDICSQDRAFT_168098
PCOPHACADRAFT_167159 PHACADRAFT_261809
SHSSTEHIDRAFT_66588
HIRHETIRDRAFT_440059
PSQPUNSTDRAFT_97634
ADLAURDEDRAFT_146038 AURDEDRAFT_169439
FMEFOMMEDRAFT_161036
GTRGLOTRDRAFT_116421
LBCLACBIDRAFT_188370 LACBIDRAFT_255862
MPRMPER_07351
MRRMoror_13990
MOREE1B28_012458
CCICC1G_03453
SCMSCHCODRAFT_76560 SCHCODRAFT_78485
ABPAGABI1DRAFT113984(AGABI1DRAFT_113984)
ABVAGABI2DRAFT193820(AGABI2DRAFT_193820)
CPUTCONPUDRAFT_82330
SLASERLADRAFT_469702
WSEWALSEDRAFT_59931
WICJ056_004725
UMAUMAG_03994
PFPPFL1_00963
MGLMGL_0408 MGL_4147 MGL_4153 MGL_4159
MRTMRET_2230
MSYMMSY001_3187
MLRMELLADRAFT_106352 MELLADRAFT_43199 MELLADRAFT_86255
NGDNGA_0377300(PDC)
EKOEKO11_2927
EKFKO11_18225(pdc-1) KO11_18265(pdc-2) KO11_18305(pdc-3) KO11_18345(pdc-4) KO11_18385(pdc-5) KO11_18425(pdc-6) KO11_18465(pdc-7) KO11_18505(pdc-8) KO11_18545(pdc-9) KO11_18585(pdc-10) KO11_18625(pdc-11) KO11_18665(pdc-12) KO11_18705(pdc-13) KO11_18745(pdc-14) KO11_18785(pdc-15) KO11_18825(pdc-16) KO11_18865(pdc-17) KO11_18905(pdc-18) KO11_18945(pdc-19) KO11_18985(pdc-20)
ECOLLY180_21020
MIIBTJ40_20050
MICTFIU95_19035(pdc)
LPNlpg1155
LPHLPV_1308
LPOLPO_1168
LPULPE509_02013
LPMLP6_1136
LPFlpl1162
LPPlpp1157
LPCLPC_0618
LPAlpa_01798
LPElp12_1135
LIBE4T55_14505
LCJNCTC11976_00923(pdc)
LWASAMEA4504053_2460(pdc)
LSSNCTC12082_00691(pdc)
ZPLZBT109_1072
BIDBind_3389
RHZRHPLAN_12660
ZMOZMO1360
ZMNZa10_1819
ZMMZmob_1740
ZMBZZ6_1712
ZMIZCP4_1765
ZMCA265_01761(pdc)
ZMRA254_01762(pdc)
ZMPZymop_1699
GOXGOX1081
GOHB932_1857
GOYGLS_c11500(pdc)
GALA0U94_13040 A0U94_14190
GTIFXF46_02270
GSPIGS75_06065 IGS75_13760
GFAMKW11_02680
GDIGDI0172(pdc)
GDJGdia_2242
GXYGLX_13670
GXLH845_2636
KNAB0W47_07340
KEUS101446_01947
KSCCD178_01418(pdc)
KREGWK63_12920
APTAPA01_23490
APWAPA42C_23490
APFAPA03_23490
APUAPA07_23490
APGAPA12_23490
APQAPA22_23490
APXAPA26_23490
APZAPA32_23490
APKAPA386B_1186(pdc)
ASZASN_888(pdc)
ASVWG31_11785
AACEA0U92_04655
APERA0U91_10675
APOMCPF11_08895
ATOCIW82_07655
AASCA4S02_00090
ACETDS739_11515
AOTAcetOri_orf04110
AOYEOV40_011035
ACEKFLP30_09815
KBAA0U89_06380 A0U89_10940
NCHA0U93_01580
COQD9V35_03595
COMMGN303_03465
NTND5366_04105
NEHE3E11_05755
SSAME3D00_04575
SWFE3E12_04385
EBLAJGUZn3_03450(pdc)
KHAIFJ82_03810
MCOOMCOO_01670
CUVCUREI_09450
CLUJIAU68_09550
GMRGmarT_51680(pdc)
GIMF1728_18575
GPNPan110_51970(pdc)
SDYNMal52_58040(pdc)
ACMAciX9_4429
CIVIMZ16_04440
 » show all
Reference
1  [PMID:12980978]
  Authors
SINGER TP, PENSKY J.
  Title
Isolation and properties of the carboxylase of wheat germ.
  Journal
J Biol Chem 196:375-88 (1952)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.1
IUBMB Enzyme Nomenclature: 4.1.1.1
ExPASy - ENZYME nomenclature database: 4.1.1.1
BRENDA, the Enzyme Database: 4.1.1.1
CAS: 9001-04-1

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