KEGG ENZYME: 4.1.1.100

ENZYME: 4.1.1.100

Entry

EC 4.1.1.100                Enzyme

Name

prephenate decarboxylase;
BacA;
AerD;
SalX;
non-aromatizing prephenate decarboxylase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

prephenate carboxy-lyase (3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate-forming)

Reaction(IUBMB)

prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 [RN:R10934]

Reaction(KEGG)

R10934

Substrate

prephenate [CPD:C00254]

Product

3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate [CPD:C20953];
CO2 [CPD:C00011]

Comment

The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme isomerizes only the pro-R double bond in prephenate.

History

EC 4.1.1.100 created 2015

Pathway

ec00998

Biosynthesis of various antibiotics

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K19546

prephenate decarboxylase

Genes

DAQ:	DAQ1742_03406(bacA)

DIC:	Dpoa569_001039

DLC:	O1Q98_16235

LPA:

lpa_03409

BSU:	BSU37740(bacA)

BSR:

I33_3922

BSL:

A7A1_0193

BSH:	BSU6051_37740(bacA)

BSY:	I653_18515

BSUT:

BSUB_04010(bacA)

BSUL:

BSUA_04010(bacA)

BSUS:

Q433_20785

BSO:	BSNT_10432

BSN:	BSn5_09860

BSQ:	B657_37740(bacA)

BSX:	C663_3679(bacA)

BSP:	U712_19020

BSS:	BSUW23_18640(bacA)

BST:

GYO_4160

BIT:	BIS30_08585

BAY:	RBAM_034930

BAQ:	BACAU_3522(bacA)

BYA:	BANAU_3675(bacA)

BAMP:

B938_17925(bacA)

BQY:	MUS_4152(bacA)

BAML:

BAM5036_3423(bacA)

BAMA:

RBAU_3631(bacA)

BAMN:

BASU_3407(bacA)

BAMB:

BAPNAU_3689(bacA)

BAMT:

AJ82_19710

BAMY:

V529_37650(bacA)

BMP:	NG74_03668

BAO:	BAMF_3607(bacA)

BAZ:	BAMTA208_19100(bacA)

BQL:	LL3_03918(bacA)

BXH:	BAXH7_03910(bacA)

BAMI:

KSO_001595

BAMC:

U471_36380

BAMF:

U722_18660

BSIA:

CWD84_01660

BVM:	B9C48_17875

BHT:	DIC78_12105

BMOJ:

HC660_36820(bacA)

BTEQ:

G4P54_19460(bacA)

BIQ:	AN935_19115

BSTR:

QI003_22375(bacA)

BPU:

BPUM_3420

BPUM:

BW16_18160

BPUS:

UP12_17605

BALT:

CFN77_18065

BAER:

BAE_05965

BSAF:

BSL056_18705

BCAB:

EFK13_19430(bacA)

BRY:	M0696_19180(bacA)

BJS:

MY9_3866

BACW:

QR42_17160

BACP:

SB24_11230

BACB:

OY17_01130

BACY:

QF06_17310

BACL:

BS34A_40920(bacA)

BALM:

BsLM_3804

BACS:

AUL54_12230

BZH:	NF868_15795

BAEI:

RE735_02185

BGI:	BGM20_13130

BMUR:

ABE28_019115

PSOP:

KP014_17420

STRM:

M444_35590

SPHV:

F9278_21515

SCOE:

CP976_00065

SDEC:

L3078_20880

SXT:	KPP03845_106161(bacA)

SGK:	PET44_33055

LEPT:

JVX88_12410

MAR:

MAE_56560

MPK:

VL20_295

MVZ:	myaer102_28820

PAGH:

NIES204_06210(aerD)

PPSU:

NO713_02126(aerD)

PRUN:

PCC7821_03672(aerD)

MPRO:

BJP34_16215

HBQ:	QI031_25715

NSP:	BMF81_03788(bacA_2)

NSPH:

BDGGKGIB_04044(suoD)

AFLO:

HEQ12_06185

SCYS:

NIES4073_42240

» show all

Reference

1 [PMID:20052993]

Authors

Mahlstedt SA, Walsh CT

Title

Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis.

Journal

Biochemistry 49:912-23 (2010)
DOI:10.1021/bi9021186

Reference

2 [PMID:20863139]

Authors

Mahlstedt S, Fielding EN, Moore BS, Walsh CT

Title

Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites.

Journal

Biochemistry 49:9021-3 (2010)
DOI:10.1021/bi101457h

Reference

3 [PMID:22483065]

Authors

Parker JB, Walsh CT

Title

Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis.

Journal

Biochemistry 51:3241-51 (2012)
DOI:10.1021/bi300254u

Other DBs

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